Joanne Netter Engel, MD, PhD

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Additional Websites

• Lab Website

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Education

Yale University, New Haven, CT, B.S., 1976, Biochemistry
Stanford University, Palo Alto, CA, Ph.D., 1982, Biophysics
Stanford University, Palo Alto, CA, M.D., 1983, Medicine

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Professional Experience

• June 1983 - June 1984
  Hospital of the University of Pennsylvania,Internship, Department of Medicine
• June 1984 - Jan 1986
  Hospital of the University of Pennsylvania, Residency, Department of Medicine
• Jan 1986 - July 1986
  Residency, Department of Medicine, UCSF
• July 1986 - June 1990
  Clinical and Postdoctoral Fellowship, Div. of Infectious Diseases, Department of Microbiology and Immunology, UCSF
• July 1990 - June 1998
  Assistant Professor in Residence, Div. of Infectious Diseases, Department of Medicine, UCSF
• July 1998 - June 2004
  Associate Professor, Division of Infectious Disease and Department of Microbiology and Immunology
• July 2004 - present
  Professor in Residence, University of California, San Francisco, Depts. of Medicine and Microbiology and Immunology
• July 2004 - present
  Director, Microbial Pathogenesis and Host Defense Program
• January 2005 - present
  Interim Chief, Division of Infectious Disease

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Honors & Awards

• 1976
  Phi Beta Kappa
• 1976
  Sigma Xi
• 1976
  Magna cum laude, Yale University
• 1977
  Medical Scientist Training Program
• 1988
  Lucille Markey Biomedical Scholar
• 1994
  NIH Career Development Award
• 1998
  American Lung Association Career Investigator
• 2004
  President-Elect, Division B of American Society for Microbiology

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Selected Publications

1. Bastidas RJ, Elwell CA, Engel JN, Valdivia RH. Chlamydial intracellular survival strategies. Cold Spring Harb Perspect Med. 2013; 3(5).
   View on PubMed
2. Elwell CA, Engel JN. Lipid acquisition by intracellular Chlamydiae. Cell Microbiol. 2012 Jul; 14(7):1010-8.
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3. Bucior I, Pielage JF, Engel JN. Pseudomonas aeruginosa Pili and Flagella Mediate Distinct Binding and Signaling Events at the Apical and Basolateral Surface of Airway Epithelium. PLoS Pathog. 2012 Apr; 8(4):e1002616.
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4. Kim JH, Jiang S, Elwell CA, Engel JN. Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection. PLoS Pathog. 2011 Oct; 7(10):e1002285.
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5. Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, Engel JN. Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog. 2011 Sep; 7(9):e1002198.
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6. Engel J, Eran Y. Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol. 2011; 2:114.
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7. Elwell CA, Kierbel A, Engel JN. Species-specific interactions of Src family tyrosine kinases regulate Chlamydia intracellular growth and trafficking. MBio. 2011; 2(3):e00082-11.
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8. Wood S, Sivaramakrishnan G, Engel J, Shafikhani SH. Cell migration regulates the kinetics of cytokinesis. Cell Cycle. 2011 Feb 15; 10(4):648-54.
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9. Inclan YF, Huseby MJ, Engel JN. FimL regulates cAMP synthesis in Pseudomonas aeruginosa. PLoS One. 2011; 6(1):e15867.
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10. Bucior I, Mostov K, Engel JN. Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium. Infect Immun. 2010 Mar; 78(3):939-53.
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11. Bertrand JJ, West JT, Engel JN. Genetic analysis of the regulation of type IV pilus function by the Chp chemosensory system of Pseudomonas aeruginosa. J Bacteriol. 2010 Feb; 192(4):994-1010.
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12. Endoh T, Engel JN. CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa. J Bacteriol. 2009 Dec; 191(23):7193-205.
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13. Engel J, Balachandran P. Role of Pseudomonas aeruginosa type III effectors in disease. Curr Opin Microbiol. 2009 Feb; 12(1):61-6.
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14. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76.
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15. Barken KB, Pamp SJ, Yang L, Gjermansen M, Bertrand JJ, Klausen M, Givskov M, Whitchurch CB, Engel JN, Tolker-Nielsen T. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. Environ Microbiol. 2008 Sep; 10(9):2331-43.
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16. Pielage JF, Powell KR, Kalman D, Engel JN. RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization. PLoS Pathog. 2008 Mar; 4(3):e1000031.
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17. Elwell CA, Ceesay A, Kim JH, Kalman D, Engel JN. RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry. PLoS Pathog. 2008 Mar; 4(3):e1000021.
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18. Shafikhani SH, Morales C, Engel J. The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Cell Microbiol. 2008 Apr; 10(4):994-1007.
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19. Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, König W, Engel J, Backert S. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol Med Microbiol. 2007 Jul; 50(2):190-205.
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20. Kierbel A, Gassama-Diagne A, Rocha C, Radoshevich L, Olson J, Mostov K, Engel J. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. J Cell Biol. 2007 Apr 9; 177(1):21-7.
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