Joanne Netter Engel, MD, PhD

Joanne Netter Engel, MD, PhD

Professor, Departments of Medicine and Microbiology/Immunology, UCSF

Phone: (415) 476-7355 (voice)
Box 0654, UCSF
San Francisco, CA 94143-0654

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Cancer Center Membership

Associate Member » Non-aligned

Additional Websites


Yale University, New Haven, CT, B.S., 1976, Biochemistry
Stanford University, Palo Alto, CA, Ph.D., 1982, Biophysics
Stanford University, Palo Alto, CA, M.D., 1983, Medicine

Professional Experience

  • June 1983 - June 1984
    Hospital of the University of Pennsylvania,Internship, Department of Medicine
  • June 1984 - Jan 1986
    Hospital of the University of Pennsylvania, Residency, Department of Medicine
  • Jan 1986 - July 1986
    Residency, Department of Medicine, UCSF
  • July 1986 - June 1990
    Clinical and Postdoctoral Fellowship, Div. of Infectious Diseases, Department of Microbiology and Immunology, UCSF
  • July 1990 - June 1998
    Assistant Professor in Residence, Div. of Infectious Diseases, Department of Medicine, UCSF
  • July 1998 - June 2004
    Associate Professor, Division of Infectious Disease and Department of Microbiology and Immunology
  • July 2004 - present
    Professor in Residence, University of California, San Francisco, Depts. of Medicine and Microbiology and Immunology
  • July 2004 - present
    Director, Microbial Pathogenesis and Host Defense Program
  • January 2005 - present
    Interim Chief, Division of Infectious Disease

Honors & Awards

  • 1976
    Phi Beta Kappa
  • 1976
    Sigma Xi
  • 1976
    Magna cum laude, Yale University
  • 1977
    Medical Scientist Training Program
  • 1988
    Lucille Markey Biomedical Scholar
  • 1994
    NIH Career Development Award
  • 1998
    American Lung Association Career Investigator
  • 2004
    President-Elect, Division B of American Society for Microbiology

Selected Publications

  1. Persat A, Inclan YF, Engel JN, Stone HA, Gitai Z. Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7563-8.
    View on PubMed
  2. Tran CS, Rangel SM, Almblad H, Kierbel A, Givskov M, Tolker-Nielsen T, Hauser AR, Engel JN. The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier. PLoS Pathog. 2014 Nov; 10(11):e1004479.
    View on PubMed
  3. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43.
    View on PubMed
  4. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L352-63.
    View on PubMed
  5. Bastidas RJ, Elwell CA, Engel JN, Valdivia RH. Chlamydial intracellular survival strategies. Cold Spring Harb Perspect Med. 2013 May; 3(5):a010256.
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  6. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71.
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  7. Elwell CA, Engel JN. Lipid acquisition by intracellular Chlamydiae. Cell Microbiol. 2012 Jul; 14(7):1010-8.
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  8. Bucior I, Pielage JF, Engel JN. Pseudomonas aeruginosa pili and flagella mediate distinct binding and signaling events at the apical and basolateral surface of airway epithelium. PLoS Pathog. 2012; 8(4):e1002616.
    View on PubMed
  9. Kim JH, Jiang S, Elwell CA, Engel JN. Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection. PLoS Pathog. 2011 Oct; 7(10):e1002285.
    View on PubMed
  10. Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, Engel JN. Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog. 2011 Sep; 7(9):e1002198.
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  11. Engel J, Eran Y. Subversion of mucosal barrier polarity by pseudomonas aeruginosa. Front Microbiol. 2011; 2:114.
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  12. Elwell CA, Kierbel A, Engel JN. Species-specific interactions of Src family tyrosine kinases regulate Chlamydia intracellular growth and trafficking. MBio. 2011; 2(3):e00082-11.
    View on PubMed
  13. Wood S, Sivaramakrishnan G, Engel J, Shafikhani SH. Cell migration regulates the kinetics of cytokinesis. Cell Cycle. 2011 Feb 15; 10(4):648-54.
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  14. Inclan YF, Huseby MJ, Engel JN. FimL regulates cAMP synthesis in Pseudomonas aeruginosa. PLoS One. 2011; 6(1):e15867.
    View on PubMed
  15. Bucior I, Mostov K, Engel JN. Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium. Infect Immun. 2010 Mar; 78(3):939-53.
    View on PubMed
  16. Bertrand JJ, West JT, Engel JN. Genetic analysis of the regulation of type IV pilus function by the Chp chemosensory system of Pseudomonas aeruginosa. J Bacteriol. 2010 Feb; 192(4):994-1010.
    View on PubMed
  17. Endoh T, Engel JN. CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa. J Bacteriol. 2009 Dec; 191(23):7193-205.
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  18. Engel J, Balachandran P. Role of Pseudomonas aeruginosa type III effectors in disease. Curr Opin Microbiol. 2009 Feb; 12(1):61-6.
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  19. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76.
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  20. Barken KB, Pamp SJ, Yang L, Gjermansen M, Bertrand JJ, Klausen M, Givskov M, Whitchurch CB, Engel JN, Tolker-Nielsen T. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. Environ Microbiol. 2008 Sep; 10(9):2331-43.
    View on PubMed

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