University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Bruce Faddegon, PhD

Bruce Faddegon, PhD

Professor in Residence, Department of Radiation Oncology, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Dr. Faddegon is a board certified clinical medical physics who is internationally recognized for his research in developing and using Monte Carlo methods for treatment head simulation and dose calculation with an eye to improving accuracy and precision in radiotherapy. The overall objective of Dr. Faddegon’s research is to allow for more aggressive treatment in sites where side effects, local control, and even metastases are a problem through cost-effective solutions to improve the therapeutic ratio.

Current research includes developing TOPAS, the Tool for Particle Simulation, a collaboration of UCSF, MGH and SLAC supported by NIH to improve advanced simulation of proton therapy, and developing XPERT, X-ray Plus Electron Radiotherapy, adding electrons to intensity-modulated radiotherapy with x-rays to reduce serious side-effects of radiation, especially in children. Dr. Faddegon is also working to establish image-guided radiotherapy with portal imaging for more precise targeting of tumors and avoidance of critical structures.

Dr. Faddegons clinical responsibility is physics support of linear accelerators (linacs). This includes management, installation, commissioning, maintenance and quality assurance. Highlights of Dr. Faddegon’s published clinical development work at UCSF include developing the means to treat the whole body over a short distance (3 meters), developing new x-ray targets to reduce downtime that are implemented on linacs worldwide, implementing high precision graticules for patient localization, and determining the means to detect and correct defective circuitry in treatments using virtual wedges.

Education

University of Victoria, Victoria, Canada, B.Sc., 1977, Physics (honors)
University of British Columbia, Vancouver, Canada, M.Sc., 1983, Physics (radiobiology)
Carleton University, Ottawa, Canada, Ph.D., 1990, Physics (radiotherapy)


Professional Experience

  • 1977-80
    Geophysicist, Amoco Canada, Calgary, Alberta
  • 1982-84
    Sessional Lecturer and Laboratory Instructor, University of Victoria, Victoria, BC
  • 1984-86
    Medical Physics Resident, Ottawa Regional Cancer Center, Ottawa, Ontario
  • 1990-92
    Research Associate, Ionizing Radiation Standards, National Research Council of Canada, Ottawa, Ontario
  • 1992-93
    Medical Physicist, BC Cancer Agency, Vancouver, BC
  • 1994-98
    Medical Physicist, Toronto-Sunnybrook Regional Cancer Center, Toronto, Ontario
  • 1994-2000
    Assistant Member, School of Graduate Studies, University of Toronto, Toronto, Ontario
  • 1998-2000
    Senior Medical Physicist, Toronto-Sunnybrook Regional Cancer Center, Ontario
  • 2000-2010
    Associate Professor in Residence, Department of Radiation Oncology, University of California San Francisco
  • 2010-present
    Professor in Residence, Department of Radiation Oncology, University of California San Francisco

Honors & Awards

  • 1980
    National Science and Engineering Research Council of Canada (NSERC) scholarship for M.Sc. studies
  • 1982
    NSERC scholarship for Ph.D. studies - declined
  • 1986
    Ontario Cancer Foundation fellowship for Ph.D. studies
  • 1988
    Ontario Graduate Scholarship for Ph.D. studies
  • 1989
    American Association Physicists in Medicine (AAPM) Young Investigator's Award, Second Prize
  • 1991
    Farrington Daniels Award (AAPM)
  • 1992
    Runner-up to Sylvia Fedoruk Prize (Canadian Organization of Medical Physics)
  • 1996
    Runner-up to Sylvia Fedoruk Prize (Canadian Organization of Medical Physics)
  • 2007
    Appointed Fellow of the American Association of Physicists in Medicine

Selected Publications

  1. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby K, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2018 Nov 08.
    View on PubMed
  2. Lazar AA, Schulte R, Faddegon B, Blakely EA, Roach M. Clinical trials involving carbon-ion radiation therapy and the path forward. Cancer. 2018 Oct 11.
    View on PubMed
  3. McNamara AL, Ramos-Mendez J, Perl J, Held K, Dominguez N, Moreno EB, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 Aug 08.
    View on PubMed
  4. Piersimoni P, Faddegon BA, Méndez JR, Schulte RW, Volz L, Seco J. Helium CT: Monte Carlo simulation results for an ideal source and detector with comparison to proton CT. Med Phys. 2018 May 04.
    View on PubMed
  5. Ramos-Mendez JA, Perl J, Schuemann J, McNamara AL, Paganetti H, Faddegon BA. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 Apr 26.
    View on PubMed
  6. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925.
    View on PubMed
  7. Piersimoni P, Ramos-Méndez J, Geoghegan T, Bashkirov VA, Schulte RW, Faddegon BA. The effect of beam purity and scanner complexity on proton CT accuracy. Med Phys. 2017 Jan; 44(1):284-298.
    View on PubMed
  8. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215.
    View on PubMed
  9. Sudhyadhom A, Kirby N, Faddegon B, Chuang CF. Technical Note: Preferred dosimeter size and associated correction factors in commissioning high dose per pulse, flattening filter free x-ray beams. Med Phys. 2016 Mar; 43(3):1507-13.
    View on PubMed
  10. Roach M, Schulte R, Mishra K, Faddegon B, Barani I, Lazar A, Blakely EA. New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective. Int J Part Ther. 2016; 2(3):471-473.
    View on PubMed
  11. Geng C, Moteabbed M, Seco J, Gao Y, Xu XG, Ramos-Méndez J, Faddegon B, Paganetti H. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95.
    View on PubMed
  12. Faddegon BA, Shin J, Castenada CM, Ramos-Méndez J, Daftari IK. Experimental depth dose curves of a 67.5 MeV proton beam for benchmarking and validation of Monte Carlo simulation. Med Phys. 2015 Jul; 42(7):4199-210.
    View on PubMed
  13. Ramos-Méndez J, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5037-52.
    View on PubMed
  14. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70.
    View on PubMed
  15. Méndez JR, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5019-35.
    View on PubMed
  16. Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy. Cancer Immunol Res. 2015 May; 3(5):518-25.
    View on PubMed
  17. Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, Paganetti H. Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy. Med Phys. 2013 Dec; 40(12):121719.
    View on PubMed
  18. Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H. Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718.
    View on PubMed
  19. Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37.
    View on PubMed
  20. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34.
    View on PubMed

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