University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Brian Feldman, MD, PhD

Brian Feldman, MD, PhD

Associate Professor, Department of Pediatrics, UCSF
Walter L. Miller Distinguished Professorship in Pediatric Endocrinology, UCSF

Cancer Center Program Memberships

Breast Oncology

Research Summary

I am a physician-scientist with a PhD in Cancer Biology and subspecialty medical training in Endocrinology. I have established a broadly recognized international reputation for high-impact and cutting-edge research. My laboratory has a long-standing interest in understanding the role of hormonal signals on cancer. We aim to develop novel preventative and therapeutic approaches based on the insights gained from revealing the molecular mechanisms of these pathways.

Education

Brandeis University, Waltham, MA B.A. 06/1993 Political Science
Stanford University, Stanford, CA M.D. 06/2001 Medicine
Stanford University, Stanford, CA Ph.D. 06/2001 Cancer Biology
Harvard University, Boston, MA 07/2004 Pediatric Residency
UCSF, San Francisco, CA 07/2006 Pediatric Endocrinology Fellowship


Professional Experience

  • 2006- 2009
    Postdoctoral Fellow, UCSF School of Medicine 
  • 2010- 2018
  • Assistant Professor, Department of Pediatrics, Stanford University
  • 2010- 2018
    Member, Stanford Institute for Stem Cell Biology and Regenerative Medicine
  • 2018-present 
    Associate Professor, Department of Pediatrics, UCSF
  • 2018-present
    Walter L. Miller Distinguished Professorship in Pediatric Endocrinology, UCSF

Honors & Awards

  • 2002
    Von Meyer Scholar Award (Harvard University)
  • 2006
    NIH K08 Career Development Grant (NIDDK)
  • 2007
    Lawson Wilkins Clinical Scholar Award (Pediatric Endocrine Society)
  • 2008
    Young Investigator Award (Society for Pediatric Research)
  • 2010
    NIH Director's New Innovator Award
  • 2011
    Harvey Cohen Lectureship (Stanford University)
  • 2012-2018
    Bechtel Endowed Faculty Scholar (Stanford University)
  • 2013
    Early Investigator Award (Endocrine Society)
  • 2014-2018
    SPARK Scholar
  • 2016
    International Scientific Advisory Committee for Vitamin D Research
  • 2016
    Basic Science Research Award of Excellence (Stanford University)
  • 2017
    Elected Member, The American Society for Clinical Investigation (ASCI)
  • 2018
    Jack Omdahl Lectureship (University of New Mexico)
  • 2018-present
    Walter L. Miller Distinguished Professorship in Pediatric Endocrinology

Selected Publications

  1. Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. A novel platform for isotype-specific testing of autoantibodies. PLoS One. 2019; 14(2):e0211596.
    View on PubMed
  2. Jung Y, Feldman BJ. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte. 2018; 7(4):273-276.
    View on PubMed
  3. Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Rep. 2017 Nov 28; 21(9):2367-2375.
    View on PubMed
  4. Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nat Commun. 2017 09 22; 8(1):669.
    View on PubMed
  5. Wong JC, Feldman BJ. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte. 2017 Oct 02; 6(4):293-297.
    View on PubMed
  6. Aggarwal A, Feldman D, Feldman BJ. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. J Steroid Biochem Mol Biol. 2018 03; 177:155-158.
    View on PubMed
  7. Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight. 2017 01 26; 2(2):e90427.
    View on PubMed
  8. Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016 10 25; 9(451):ra103.
    View on PubMed
  9. Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology. 2016 Apr; 157(4):1341-7.
    View on PubMed
  10. Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer. 2016 Apr; 23(4):251-64.
    View on PubMed
  11. Ji L, Gupta M, Feldman BJ. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology. 2016 Jan; 157(1):91-7.
    View on PubMed
  12. Banerjee RR, Marina N, Katznelson L, Feldman BJ. Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics. 2015 Nov; 136(5):e1377-81.
    View on PubMed
  13. Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther. 2015 Aug; 14(8):1951-61.
    View on PubMed
  14. Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell Metab. 2015 Apr 07; 21(4):596-608.
    View on PubMed
  15. Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. J Lipid Res. 2015 May; 56(5):1068-78.
    View on PubMed
  16. Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PLoS One. 2015; 10(2):e0118449.
    View on PubMed
  17. Kumar RB, Gupta M, Feldman BJ. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Rev Mol Diagn. 2015 Mar; 15(3):291-4.
    View on PubMed
  18. Krueger KC, Costa MJ, Du H, Feldman BJ. Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. Stem Cell Reports. 2014 Dec 09; 3(6):1147-58.
    View on PubMed
  19. Zhang B, Kumar RB, Dai H, Feldman BJ. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nat Med. 2014 Aug; 20(8):948-53.
    View on PubMed
  20. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May; 14(5):342-57.
    View on PubMed

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