Zev Gartner, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Zev Gartner, PhD

Associate Professor, Dept. of Pharmaceutical Chemistry

Zev.Gartner@ucsf.edu

Box 2280, UCSF
San Francisco, CA 94158-2290

UCSF Profiles

Research Summary

My lab aims to define the rules used by cells to self-organize into structurally ordered tissues, and to reveal how tissue structure guides the flow of chemical, mechanical, and electrical information between cells to coordinate collective decisions and behaviors. A better understanding of these processes will guide the development of new therapies for regenerative medicine and new strategies to block the progression of cancer. My lab’s multidisciplinary approach is uniquely suited to tackling these problems. We apply concepts and methods from chemistry, biology, and engineering, and develop new and enabling technologies when existing methods are insufficient for our experimental needs.

Education

University of California, Berkeley B.S. 1994-1999 Chemistry
Harvard University M.S. Ph.D. 1999-2004 Chemical Biology
University of California, Berkeley Postdoctoral 2005-2008 Chemical Biology


Professional Experience

  • 1998-1999
    Undergraduate Researcher, Laboratory of Professor Y. K. Shin
  • 1999-2004
    Graduate Student Researcher, Laboratory of Professor D. R. Liu
  • 2004
    Full Time Research Consultant, Ensemble Pharmaceuticals (formerly Ensemble Discovery)
  • 2005-2008
    Postdoctoral Researcher, Laboratory of Professor C. R. Bertozzi
  • 2008-present
    Assistant Professor, Dept. of Pharmaceutical Chemistry, University of California, San Francisco

Honors & Awards

  • 2000
    National Science Foundation Graduate Research Fellowship
  • 2003
    Bristol-Myers Squibb Fellowship
  • 2003
    Harvard Merit Fellowship
  • 2005
    IUPAC Prize for Young Chemists
  • 2006
    Jane Coffin Childs Postdoctoral Fellow
  • 2008
    Sandler Opportunity Award
  • 2010
    Kimmel Scholar Award
  • 2010
    Era of Hope Scholar Award
  • 2013
    NIH New Innovator Award
  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

  1. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2016 Oct 4.
    View on PubMed
  2. Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA. Probing the luminal microenvironment of reconstituted epithelial microtissues. Sci Rep. 2016; 6:33148.
    View on PubMed
  3. Coyle M, Hu J, Gartner Z. Mysteries in a Minimal Genome. ACS Cent Sci. 2016 May 25; 2(5):274-7.
    View on PubMed
  4. Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nat Commun. 2016; 7:10309.
    View on PubMed
  5. Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ. Programmed synthesis of three-dimensional tissues. Nat Methods. 2015 Oct; 12(10):975-81.
    View on PubMed
  6. Cole RH, de Lange N, Gartner ZJ, Abate AR. Compact and modular multicolour fluorescence detector for droplet microfluidics. Lab Chip. 2015 Jul 7; 15(13):2754-8.
    View on PubMed
  7. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92.
    View on PubMed
  8. Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner ZJ. Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods. 2015 Jun; 21(6):541-7.
    View on PubMed
  9. Weber RJ, Liang SI, Selden NS, Desai TA, Gartner ZJ. Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly. Biomacromolecules. 2014 Dec 8; 15(12):4621-6.
    View on PubMed
  10. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014; (92):e52198.
    View on PubMed
  11. Liang SI, McFarland JM, Rabuka D, Gartner ZJ. A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc. 2014 Aug 6; 136(31):10850-3.
    View on PubMed
  12. Rosenblatt J, Gartner Z. Cells: Shaping tissues and organs. Mol Biol Cell. 2014 Mar; 25(6):730.
    View on PubMed
  13. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5.
    View on PubMed
  14. Sogi KM, Gartner ZJ, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi CR. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080.
    View on PubMed
  15. Liu JS, Gartner ZJ. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol. 2012 Dec; 22(12):683-91.
    View on PubMed
  16. Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ. Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep. 2012 Nov 29; 2(5):1461-70.
    View on PubMed
  17. Onoe H, Hsiao SC, Douglas ES, Gartner ZJ, Bertozzi CR, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6.
    View on PubMed
  18. Selden NS, Todhunter ME, Jee NY, Liu JS, Broaders KE, Gartner ZJ. Chemically programmed cell adhesion with membrane-anchored oligonucleotides. J Am Chem Soc. 2012 Jan 18; 134(2):765-8.
    View on PubMed
  19. Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner ZJ, Mathies RA, Bertozzi CR, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91.
    View on PubMed
  20. Gartner ZJ, Bertozzi CR. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10.
    View on PubMed

Go to UCSF Profiles, powered by CTSI