University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Nalin Gupta, MD, PhD

Nalin Gupta, MD, PhD

Professor, Departments of Neurological Surgery and Pediatrics, UCSF; Chief, Division of Pediatric Neurosurgery, UCSF
Benioff UCSF Professorship in Children's Health; and Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Nalin Gupta is Chief of the Division of Pediatric Neurosurgery at UCSF, and a Professor in the Departments of Neurological Surgery and Pediatrics. His clinical and research interests are directed towards neuro-oncology and congenital anomalies. He was the lead neurosurgeon at UCSF for a randomized clinical trials examining the effectiveness of fetal surgery for myelomeningocele. He also participated in a phase I clinical study examining the safety of stem cell transplantation for a disorder of myelination in humans. He is currently clinical PI of a phase I study examining the safety of gene therapy for children with primary AADC deficiency.

Education

Faculty of Science, McGill University, Montreal, Canada, 1981-1983, Program in Biology
Faculty of Medicine, University of Toronto, Canada, MD, 1987, Medicine
Mt. Sinai Hospital, Faculty of Medicine, University of Toronto, Canada, Internship, 1987-1988, Surgery
Dept. of Surgery, University of Ottawa and University of Toronto, Canada, Residency, 1988-1996, Neurosurgery
University of California, San Francisco, PhD, 1996, Biochemistry / Biophysics
Hospital for Sick Children, Toronto, Canada, 1997-98, Peds Neurosurgery


Professional Experience

  • 1998 - 2000
    Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago
  • 2000 - 2007
    Assistant Professor, Departments of Neurosurgery and Pediatrics, University of California San Francisco
  • 2000 - present
    Principal Investigator, Brain Tumor Research Center, Department of Neurosurgery, UCSF
  • 2001 - present
    Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
  • 2001-present
    Chief, Division of Pediatric Neurosurgery, UCSF
  • 2007 - present
    Associate Professor, Departments of Neurosurgery and Pediatrics, UCSF

Honors & Awards

  • 1981
    J.W. McConnell Scholarship, McGill University
  • 1988
    Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
  • 1989
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1994
    Student Travel Award, Radiation Research Society
  • 1995
    Junior Scientist Travel Award, International Congress of Radiation Research
  • 1995
    T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
  • 1997
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1997
    Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
  • 2003
    Hellman Family Research Award for Junior Faculty, UCSF
  • 2004
    Career Development Award, SPORE Grant, UCSF

Selected Publications

  1. Bot GM, Burkhardt JK, Gupta N, Lawton MT. Superficial temporal artery-to-middle cerebral artery bypass in combination with indirect revascularization in moyamoya patients = 3 years of age. J Neurosurg Pediatr. 2018 11 16; 23(2):198-203.
    View on PubMed
  2. Feng X, Liu S, Chen D, Rosi S, Gupta N. Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model. Elife. 2018 11 13; 7.
    View on PubMed
  3. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2019 01; 29(1):85-96.
    View on PubMed
  4. Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, Gupta N. Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr. 2018 Nov 01; 22(5):528-531.
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  5. Panditharatna E, Kilburn LB, Aboian MS, Kambhampati M, Gordish-Dressman H, Magge SN, Gupta N, Myseros JS, Hwang EI, Kline C, Crawford JR, Warren KE, Cha S, Liang WS, Berens ME, Packer RJ, Resnick AC, Prados M, Mueller S, Nazarian J. Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy. Clin Cancer Res. 2018 Dec 01; 24(23):5850-5859.
    View on PubMed
  6. Gupta N, Goumnerova LC, Manley P, Chi SN, Neuberg D, Puligandla M, Fangusaro J, Goldman S, Tomita T, Alden T, DiPatri A, Rubin JB, Gauvain K, Limbrick D, Leonard J, Geyer JR, Leary S, Browd S, Wang Z, Sood S, Bendel A, Nagib M, Gardner S, Karajannis MA, Harter D, Ayyanar K, Gump W, Bowers DC, Weprin B, MacDonald TJ, Aguilera D, Brahma B, Robison NJ, Kiehna E, Krieger M, Sandler E, Aldana P, Khatib Z, Ragheb J, Bhatia S, Mueller S, Banerjee A, Bredlau AL, Gururangan S, Fuchs H, Cohen KJ, Jallo G, Dorris K, Handler M, Comito M, Dias M, Nazemi K, Baird L, Murray J, Lindeman N, Hornick JL, Malkin H, Sinai C, Greenspan L, Wright KD, Prados M, Bandopadhayay P, Ligon KL, Kieran MW. Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol. 2018 Oct 09; 20(11):1547-1555.
    View on PubMed
  7. Kline C, Liu SJ, Duriseti S, Banerjee A, Nicolaides T, Raber S, Gupta N, Haas-Kogan D, Braunstein S, Mueller S. Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience. J Neurooncol. 2018 Dec; 140(3):629-638.
    View on PubMed
  8. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 Jan; 137(1):139-150.
    View on PubMed
  9. Singh M, Gupta N, Zadeng Z, Singh N, Kaur M, Gupta P. Long-Term Outcomes of Oral Anti-Tubercular Therapy in Patient with Tubercular Dacryoadenitis: A Case Series. Ocul Immunol Inflamm. 2018 Jun 29; 1-7.
    View on PubMed
  10. Rocque BG, Agee BS, Thompson EM, Piedra M, Baird LC, Selden NR, Greene S, Deibert CP, Hankinson TC, Lew SM, Iskandar BJ, Bragg TM, Frim D, Grant G, Gupta N, Auguste KI, Nikas DC, Vassilyadi M, Muh CR, Wetjen NM, Lam SK. Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study. J Neurosurg Pediatr. 2018 Sep; 22(3):225-232.
    View on PubMed
  11. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 06 07; 6(1):47.
    View on PubMed
  12. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 04; 135(4):635-638.
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  13. Farmer DL, Thom EA, Brock JW, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol. 2018 02; 218(2):256.e1-256.e13.
    View on PubMed
  14. Louis N, Liu S, He X, Drummond DC, Noble CO, Goldman S, Mueller S, Bankiewicz K, Gupta N, Hashizume R. New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model. J Neurooncol. 2018 Feb; 136(3):475-484.
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  15. Rohilla M, Singh P, Rajwanshi A, Gupta N, Srinivasan R, Dey P, Vashishta RK. Three-year cytohistological correlation of salivary gland FNA cytology at a tertiary center with the application of the Milan system for risk stratification. Cancer Cytopathol. 2017 Oct; 125(10):767-775.
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  16. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673.
    View on PubMed
  17. Gupta N. Surgical techniques for open fetal repair of myelomeningocele. Childs Nerv Syst. 2017 Jul; 33(7):1143-1148.
    View on PubMed
  18. Bharani V, Kumar R, Gupta N, Srinivasan R, Rajwanshi A, Nahar U, Dey P. Fine-needle aspiration cytology in primary cutaneous tumors. Diagn Cytopathol. 2017 Aug; 45(8):681-688.
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  19. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709.
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  20. Rutkowski MJ, Birk HS, Wood MD, Perry A, Nicolaides T, Ames CP, Gupta N. Metastatic clival chordoma: a case report of multiple extraneural metastases following resection and proton beam radiotherapy in a 5-year old boy. J Neurosurg Pediatr. 2017 May; 19(5):531-537.
    View on PubMed

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