Nalin Gupta, MD, PhD

Nalin Gupta, MD, PhD

Associate Professor, Departments of Neurological Surgery and Pediatrics, UCSF
Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
Benioff UCSF Professorship in Children’s Health

Phone: (415) 353-7500 (appts)
Box 0112, UCSF
San Francisco, CA 94143-0112

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Cancer Center Membership

Associate Member » Neurologic Oncology» Cancer Genetics

Research Summary

Nalin Gupta is Chief of the Division of Pediatric Neurosurgery at UCSF, and a Professor in the Departments of Neurological Surgery and Pediatrics. His clinical and research interests are directed towards neuro-oncology and congenital anomalies. He was the lead neurosurgeon at UCSF for a randomized clinical trials examining the effectiveness of fetal surgery for myelomeningocele. He also participated in a phase I clinical study examining the safety of stem cell transplantation for a disorder of myelination in humans.


Faculty of Science, McGill University, Montreal, Canada, 1981-1983, Program in Biology
Faculty of Medicine, University of Toronto, Canada, MD, 1987, Medicine
Mt. Sinai Hospital, Faculty of Medicine, University of Toronto, Canada, Internship, 1987-1988, Surgery
Dept. of Surgery, University of Ottawa and University of Toronto, Canada, Residency, 1988-1996, Neurosurgery
University of California, San Francisco, PhD, 1996, Biochemistry / Biophysics
Hospital for Sick Children, Toronto, Canada, 1997-98, Peds Neurosurgery

Professional Experience

  • 1998 - 2000
    Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago
  • 2000 - 2007
    Assistant Professor, Departments of Neurosurgery and Pediatrics, University of California San Francisco
  • 2000 - present
    Principal Investigator, Brain Tumor Research Center, Department of Neurosurgery, UCSF
  • 2001 - present
    Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
  • 2001-present
    Chief, Division of Pediatric Neurosurgery, UCSF
  • 2007 - present
    Associate Professor, Departments of Neurosurgery and Pediatrics, UCSF

Honors & Awards

  • 1981
    J.W. McConnell Scholarship, McGill University
  • 1988
    Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
  • 1989
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1994
    Student Travel Award, Radiation Research Society
  • 1995
    Junior Scientist Travel Award, International Congress of Radiation Research
  • 1995

    T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
  • 1997
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1997
    Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
  • 2003
    Hellman Family Research Award for Junior Faculty, UCSF
  • 2004
    Career Development Award, SPORE Grant, UCSF

Selected Publications

  1. Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas. Childs Nerv Syst. 2013 Nov; 29(11):2057-64.
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  2. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst. 2013 Aug; 29(8):1313-9.
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  3. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013 May 1; 27(9):985-90.
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  4. A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 2013 Jun; 11(6):673-81.
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  5. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103.
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  6. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013 Feb; 29(2):231-8.
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  7. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137.
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  8. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec; 110(3):305-13.
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  9. Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012 Oct; 10(4):293-301.
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  10. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One. 2012; 7(8):e43339.
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  11. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 2; 488(7409):49-56.
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  12. High-grade gliomas in children. Neurosurg Clin N Am. 2012 Jul; 23(3):515-23.
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  13. Open fetal surgery for myelomeningocele. J Neurosurg Pediatr. 2012 Mar; 9(3):265-73.
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  14. Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous system. Clin Exp Metastasis. 2012 Apr; 29(4):371-80.
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  15. An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing. J Neurooncol. 2012 May; 108(1):29-35.
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  16. Corridors of migrating neurons in the human brain and their decline during infancy. Nature. 2011 Oct 20; 478(7369):382-6.
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  17. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 2011 Aug 16; 20(2):143-57.
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  18. Self-reported functional outcome after surgical intervention in patients with idiopathic normal pressure hydrocephalus. J Clin Neurosci. 2011 May; 18(5):649-54.
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  19. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011 Mar 17; 364(11):993-1004.
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  20. Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing. Neuro Oncol. 2010 Apr; 12(4):366-76.
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