Nalin Gupta, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Nalin Gupta, MD, PhD

Associate Professor, Departments of Neurological Surgery and Pediatrics, UCSF
Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
Benioff UCSF Professorship in Children’s Health

Phone: (415) 353-7500 (appts)
Box 0112, UCSF
San Francisco, CA 94143-0112

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Cancer Center Membership

Associate Member » Neurologic Oncology» Cancer Genetics

Research Summary

Nalin Gupta is Chief of the Division of Pediatric Neurosurgery at UCSF, and a Professor in the Departments of Neurological Surgery and Pediatrics. His clinical and research interests are directed towards neuro-oncology and congenital anomalies. He was the lead neurosurgeon at UCSF for a randomized clinical trials examining the effectiveness of fetal surgery for myelomeningocele. He also participated in a phase I clinical study examining the safety of stem cell transplantation for a disorder of myelination in humans.

Education

Faculty of Science, McGill University, Montreal, Canada, 1981-1983, Program in Biology
Faculty of Medicine, University of Toronto, Canada, MD, 1987, Medicine
Mt. Sinai Hospital, Faculty of Medicine, University of Toronto, Canada, Internship, 1987-1988, Surgery
Dept. of Surgery, University of Ottawa and University of Toronto, Canada, Residency, 1988-1996, Neurosurgery
University of California, San Francisco, PhD, 1996, Biochemistry / Biophysics
Hospital for Sick Children, Toronto, Canada, 1997-98, Peds Neurosurgery


Professional Experience

  • 1998 - 2000
    Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago
  • 2000 - 2007
    Assistant Professor, Departments of Neurosurgery and Pediatrics, University of California San Francisco
  • 2000 - present
    Principal Investigator, Brain Tumor Research Center, Department of Neurosurgery, UCSF
  • 2001 - present
    Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
  • 2001-present
    Chief, Division of Pediatric Neurosurgery, UCSF
  • 2007 - present
    Associate Professor, Departments of Neurosurgery and Pediatrics, UCSF

Honors & Awards

  • 1981
    J.W. McConnell Scholarship, McGill University
  • 1988
    Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
  • 1989
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1994
    Student Travel Award, Radiation Research Society
  • 1995
    Junior Scientist Travel Award, International Congress of Radiation Research
  • 1995

    T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
  • 1997
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1997
    Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
  • 2003
    Hellman Family Research Award for Junior Faculty, UCSF
  • 2004
    Career Development Award, SPORE Grant, UCSF

Selected Publications

  1. Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas. Childs Nerv Syst. 2013 Nov; 29(11):2057-64.
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  2. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst. 2013 Aug; 29(8):1313-9.
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  3. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013 May 1; 27(9):985-90.
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  4. A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 2013 Jun; 11(6):673-81.
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  5. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103.
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  6. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013 Feb; 29(2):231-8.
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  7. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137.
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  8. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec; 110(3):305-13.
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  9. Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012 Oct; 10(4):293-301.
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  10. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One. 2012; 7(8):e43339.
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  11. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 2; 488(7409):49-56.
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  12. High-grade gliomas in children. Neurosurg Clin N Am. 2012 Jul; 23(3):515-23.
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  13. Open fetal surgery for myelomeningocele. J Neurosurg Pediatr. 2012 Mar; 9(3):265-73.
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  14. Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous system. Clin Exp Metastasis. 2012 Apr; 29(4):371-80.
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  15. An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing. J Neurooncol. 2012 May; 108(1):29-35.
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  16. Corridors of migrating neurons in the human brain and their decline during infancy. Nature. 2011 Oct 20; 478(7369):382-6.
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  17. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 2011 Aug 16; 20(2):143-57.
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  18. Self-reported functional outcome after surgical intervention in patients with idiopathic normal pressure hydrocephalus. J Clin Neurosci. 2011 May; 18(5):649-54.
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  19. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011 Mar 17; 364(11):993-1004.
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  20. Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing. Neuro Oncol. 2010 Apr; 12(4):366-76.
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