University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Patrick Ha, MD

Patrick Ha, MD

Distinguished Professor, Department of Otolaryngology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery


Professional Experience

  • 1999 – 2000
    Surgical Internship, Johns Hopkins Department of Surgery
  • 2000 – 2002
    Research Fellow, Head and Neck Cancer Division, Johns Hopkins Department of Otolaryngology
  • 2002 – 2005
    Resident, Johns Hopkins Department of Otolaryngology
  • 2006 – 2006
    Assistant, Johns Hopkins Department of Otolaryngology
  • 2006 – 2010
    Assistant Professor, Johns Hopkins Department of Otolaryngology
  • 2010 – 2015
    Associate Professor, Johns Hopkins Department of Otolaryngology
  • 2015 -
    Distinguished Professor, University of California San Francisco Department of Otolaryngology

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 Jul 21.
    View on PubMed
  2. Qualliotine JR, Califano JA, Li RJ, Gold D, Messing B, Lee G, Ha P, Fakhry C. Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer. J Laryngol Otol. 2017 Sep; 131(9):760-767.
    View on PubMed
  3. Yom SS, Mallen-St Clair J, Ha PK. Controversies in Postoperative Irradiation of Oropharyngeal Cancer After Transoral Surgery. Surg Oncol Clin N Am. 2017 Jul; 26(3):357-370.
    View on PubMed
  4. Fakhry C, Westra WH, Wang SJ, van Zante A, Zhang Y, Rettig E, Yin LX, Ryan WR, Ha PK, Wentz A, Koch W, Richmon JD, Eisele DW, D'Souza G. The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer. Cancer. 2017 May 01; 123(9):1566-1575.
    View on PubMed
  5. Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J. Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma. Head Neck. 2017 Apr; 39(4):662-667.
    View on PubMed
  6. D'Souza G, Westra WH, Wang SJ, van Zante A, Wentz A, Kluz N, Rettig E, Ryan WR, Ha PK, Kang H, Bishop J, Quon H, Kiess AP, Richmon JD, Eisele DW, Fakhry C. Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method. JAMA Oncol. 2016 Dec 08.
    View on PubMed
  7. Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016 Oct 04; 7(40):66239-66254.
    View on PubMed
  8. D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C. Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncol. 2016 Sep; 60:90-5.
    View on PubMed
  9. Kang H, Tan M, Bishop JA, Jones S, Sausen M, Ha PK, Agrawal N. Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res. 2017 Jan 01; 23(1):283-288.
    View on PubMed
  10. Ling S, Rettig EM, Tan M, Chang X, Wang Z, Brait M, Bishop JA, Fertig EJ, Considine M, Wick MJ, Ha PK. Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol. 2016 Jul; 49(1):225-34.
    View on PubMed
  11. Sobel RH, Blanco R, Ha PK, Califano JA, Kumar R, Richmon JD. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Head Neck. 2016 Oct; 38(10):1553-63.
    View on PubMed
  12. Ha PK, Stenman G. Molecular Pathology and Biomarkers. Adv Otorhinolaryngol. 2016; 78:17-24.
    View on PubMed
  13. Bishop JA, Ha PK. Human papillomavirus detection in a "Digital" age. Cancer. 2016 05 15; 122(10):1502-4.
    View on PubMed
  14. Yin LX, Ha PK. Genetic alterations in salivary gland cancers. Cancer. 2016 06 15; 122(12):1822-31.
    View on PubMed
  15. Rettig EM, Talbot CC, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig EJ, Wheelan SJ, Marchionni L, Considine M, Fakhry C, Papadopoulos N, Kinzler KW, Vogelstein B, Ha PK, Agrawal N. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila). 2016 Apr; 9(4):265-74.
    View on PubMed
  16. Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha PK, Duvvuri U. TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. Sci Rep. 2015 Nov 13; 5:16657.
    View on PubMed
  17. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 Apr; 38 Suppl 1:E1501-9.
    View on PubMed
  18. Park E, Ha PK, Eisele DW, Francis HW, Kim YJ. Personal characteristics of residents may predict competency improvement. Laryngoscope. 2016 Aug; 126(8):1746-52.
    View on PubMed
  19. Li RJ, Zhou XC, Fakhry C, Negrin J, Lee G, Ha P, Blanco R, Saunders J, Califano JA. Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention. Otolaryngol Head Neck Surg. 2015 Dec; 153(6):927-34.
    View on PubMed
  20. Wang Z, Ling S, Rettig E, Sobel R, Tan M, Fertig EJ, Considine M, El-Naggar AK, Brait M, Fakhry C, Ha PK. Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. Oral Oncol. 2015 Dec; 51(12):1120-5.
    View on PubMed

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