Patrick Ha, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Patrick Ha, MD

Distinguished Professor, Department of Otolaryngology, UCSF

Patrick.Ha@ucsf.edu

Box 3213, UCSF
San Francisco, CA 94143

UCSF Profiles

Cancer Center Membership

Program Member ยป Cancer Genetics

Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery


Professional Experience

  • 1999 – 2000
    Surgical Internship, Johns Hopkins Department of Surgery
  • 2000 – 2002
    Research Fellow, Head and Neck Cancer Division, Johns Hopkins Department of Otolaryngology
  • 2002 – 2005
    Resident, Johns Hopkins Department of Otolaryngology
  • 2006 – 2006
    Assistant, Johns Hopkins Department of Otolaryngology
  • 2006 – 2010
    Assistant Professor, Johns Hopkins Department of Otolaryngology
  • 2010 – 2015
    Associate Professor, Johns Hopkins Department of Otolaryngology
  • 2015 -
    Distinguished Professor, University of California San Francisco Department of Otolaryngology

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Rosculet N, Zhou XC, Ha P, Tang M, Levine MA, Neuner G, Califano J. Neutrophil-to-lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma. Head Neck. 2017 Jan 11.
    View on PubMed
  2. D'Souza G, Westra WH, Wang SJ, van Zante A, Wentz A, Kluz N, Rettig E, Ryan WR, Ha PK, Kang H, Bishop J, Quon H, Kiess AP, Richmon JD, Eisele DW, Fakhry C. Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method. JAMA Oncol. 2016 Dec 08.
    View on PubMed
  3. Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016 Oct 04; 7(40):66239-66254.
    View on PubMed
  4. D'Souza G, Zhang Y, Merritt S, Gold D, Robbins HA, Buckman V, Gerber J, Eisele DW, Ha P, Califano J, Fakhry C. Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncol. 2016 Sep; 60:90-5.
    View on PubMed
  5. Kang H, Tan M, Bishop JA, Jones S, Sausen M, Ha PK, Agrawal N. Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res. 2016 Jun 23.
    View on PubMed
  6. Ling S, Rettig EM, Tan M, Chang X, Wang Z, Brait M, Bishop JA, Fertig EJ, Considine M, Wick MJ, Ha PK. Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol. 2016 Jul; 49(1):225-34.
    View on PubMed
  7. Sobel RH, Blanco R, Ha PK, Califano JA, Kumar R, Richmon JD. Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models. Head Neck. 2016 Oct; 38(10):1553-63.
    View on PubMed
  8. Ha PK, Stenman G. Molecular Pathology and Biomarkers. Adv Otorhinolaryngol. 2016; 78:17-24.
    View on PubMed
  9. Bishop JA, Ha PK. Human papillomavirus detection in a "Digital" age. Cancer. 2016 May 15; 122(10):1502-4.
    View on PubMed
  10. Yin LX, Ha PK. Genetic alterations in salivary gland cancers. Cancer. 2016 Jun 15; 122(12):1822-31.
    View on PubMed
  11. Rettig EM, Talbot CC, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig EJ, Wheelan SJ, Marchionni L, Considine M, Fakhry C, Papadopoulos N, Kinzler KW, Vogelstein B, Ha PK, Agrawal N. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila). 2016 Apr; 9(4):265-74.
    View on PubMed
  12. Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha PK, Duvvuri U. TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. Sci Rep. 2015; 5:16657.
    View on PubMed
  13. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 Apr; 38 Suppl 1:E1501-9.
    View on PubMed
  14. Park E, Ha PK, Eisele DW, Francis HW, Kim YJ. Personal characteristics of residents may predict competency improvement. Laryngoscope. 2016 Aug; 126(8):1746-52.
    View on PubMed
  15. Li RJ, Zhou XC, Fakhry C, Negrin J, Lee G, Ha P, Blanco R, Saunders J, Califano JA. Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention. Otolaryngol Head Neck Surg. 2015 Dec; 153(6):927-34.
    View on PubMed
  16. Wang Z, Ling S, Rettig E, Sobel R, Tan M, Fertig EJ, Considine M, El-Naggar AK, Brait M, Fakhry C, Ha PK. Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. Oral Oncol. 2015 Dec; 51(12):1120-5.
    View on PubMed
  17. Baxter M, Chan JY, Mydlarz WK, Labruzzo SV, Kiess A, Ha PK, Nafi A, Nishant A. Retropharyngeal lymph node involvement in human papillomavirus-associated oropharyngeal squamous cell carcinoma. Laryngoscope. 2015 Nov; 125(11):2503-8.
    View on PubMed
  18. Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, Gourin CG, Ha PK, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015 Jun 24; 7(293):293ra104.
    View on PubMed
  19. Rettig EM, Tan M, Ling S, Yonescu R, Bishop JA, Fakhry C, Ha PK. MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma. Laryngoscope. 2015 Sep; 125(9):E292-9.
    View on PubMed
  20. Guo T, Qualliotine JR, Ha PK, Califano JA, Kim Y, Saunders JR, Blanco RG, D'Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fakhry C. Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer. Cancer. 2015 Jun 15; 121(12):1977-84.
    View on PubMed

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