University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Patrick Ha, MD

Patrick Ha, MD

Distinguished Professor, Department of Otolaryngology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery


Professional Experience

  • 1999 – 2000
    Surgical Internship, Johns Hopkins Department of Surgery
  • 2000 – 2002
    Research Fellow, Head and Neck Cancer Division, Johns Hopkins Department of Otolaryngology
  • 2002 – 2005
    Resident, Johns Hopkins Department of Otolaryngology
  • 2006 – 2006
    Assistant, Johns Hopkins Department of Otolaryngology
  • 2006 – 2010
    Assistant Professor, Johns Hopkins Department of Otolaryngology
  • 2010 – 2015
    Associate Professor, Johns Hopkins Department of Otolaryngology
  • 2015 -
    Distinguished Professor, University of California San Francisco Department of Otolaryngology

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Raghavan K, Wen KW, Small EJ, Ha P, Flavell RR. Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT. Clin Nucl Med. 2019 Mar 01.
    View on PubMed
  2. Wang L, Zhang SK, Ma Y, Ha PK, Wang ZM. Papillary cystadenoma of the parotid gland: A case report. World J Clin Cases. 2019 Feb 06; 7(3):366-372.
    View on PubMed
  3. Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 Jan 25.
    View on PubMed
  4. Chan JW, Yeh I, El-Sayed IH, Algazi AP, Glastonbury CM, Ha PK, Yom SS, van Zante A. Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site. Head Neck. 2019 Jan 11.
    View on PubMed
  5. Wu TJ, Ha PK, El-Sayed IH, George JR, Heaton CM, Ryan WR, Russell MD. Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease. Head Neck. 2019 Mar; 41(3):715-721.
    View on PubMed
  6. Califano JA, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha PK, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I. Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018 Dec 01; 24(23):6100.
    View on PubMed
  7. Plonowska KA, Strohl MP, Wang SJ, Ha PK, George JR, Heaton CM, El-Sayed IH, Mallen-St Clair J, Ryan WR. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal Disease. Otolaryngol Head Neck Surg. 2018 Oct 02; 194599818801907.
    View on PubMed
  8. Plonowska KA, Ha PK, Ryan WR. Advanced head and neck surgical techniques: A survey of US otolaryngology resident perspectives. Auris Nasus Larynx. 2018 Aug 28.
    View on PubMed
  9. Panuganti B, Qiu Y, Messing B, Lee G, Fakhry C, Blanco R, Ha P, Messer K, Califano JA. Effects of a Comprehensive Performance Improvement Strategy on Postoperative Adverse Events in Head and Neck Surgery. Otolaryngol Head Neck Surg. 2018 Aug 28; 194599818793887.
    View on PubMed
  10. Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH. Subjugation of TGFß Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining. Clin Cancer Res. 2018 Dec 01; 24(23):6001-6014.
    View on PubMed
  11. Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 Aug; 24(8):1178-1191.
    View on PubMed
  12. Formeister EJ, Sean Alemi A, El-Sayed I, George JR, Ha P, Daniel Knott P, Ryan WR, Seth R, Tamplen ML, Heaton CM. Shorter interval between radiation therapy and salvage laryngopharyngeal surgery increases complication rates following microvascular free tissue transfer. Am J Otolaryngol. 2018 Sep - Oct; 39(5):548-552.
    View on PubMed
  13. Afsari B, Guo T, Considine M, Florea L, Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Zambo KD, Ha PK, Geman D, Ochs MF, Califano JA, Gaykalova DA, Favorov AV, Fertig EJ. Splice Expression Variation Analysis (SEVA) for inter-tumor heterogeneity of gene isoform usage in cancer. Bioinformatics. 2018 06 01; 34(11):1859-1867.
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  14. Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE. Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. Int J Mol Sci. 2018 May 30; 19(6).
    View on PubMed
  15. Windon MJ, D'Souza G, Rettig EM, Westra WH, van Zante A, Wang SJ, Ryan WR, Mydlarz WK, Ha PK, Miles BA, Koch W, Gourin C, Eisele DW, Fakhry C. Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults. Cancer. 2018 Jul 15; 124(14):2993-2999.
    View on PubMed
  16. Xu MJ, Wu TJ, van Zante A, El-Sayed IH, Algazi AP, Ryan WR, Ha PK, Yom SS. Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2018 Apr 25; 47(1):28.
    View on PubMed
  17. Yin LX, D'Souza G, Westra WH, Wang SJ, van Zante A, Zhang Y, Rettig EM, Ryan WR, Ha PK, Wentz A, Koch W, Eisele DW, Fakhry C. Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas. Laryngoscope. 2018 08; 128(8):E287-E295.
    View on PubMed
  18. Xu MJ, Lazar AA, Garsa AA, Arron ST, Ryan WR, El-Sayed IH, George JR, Algazi AP, Heaton CM, Ha PK, Yom SS. Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy. Head Neck. 2018 Jul; 40(7):1406-1414.
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  19. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 2017 10 01; 77(19):5248-5258.
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  20. Yom SS, Mallen-St Clair J, Ha PK. Controversies in Postoperative Irradiation of Oropharyngeal Cancer After Transoral Surgery. Surg Oncol Clin N Am. 2017 07; 26(3):357-370.
    View on PubMed

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