Matthias Hebrok, PhD

Professor in Residence and Director, Diabetes Center, UCSF
Hurlbut-Johnson Distinguished Professor in Diabetes Research

mhebrok@diabetes.ucsf.edu

Phone: (415) 514-0820 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

View on UCSF Profiles

Additional Websites

• Diabetes Center profile
• Lab Website

Education

Professional Experience

• 1991-1992
  Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor
• 1992-1995
  Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter, Head of Department
• 1995
  Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology
• 1996-1999
  Postdoctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton, advisor
• 1999-2005
  Assistant Professor in Residence, Diabetes Center, University of California, San Francisco
• 2005-2009
  Associate Professor, Diabetes Center, University of California, San Francisco
• 2008
  Interim Director, Diabetes Center, University of California, San Francisco
• 2009-2010
  Associate Director of Research, Diabetes Center, University of California, San Francisco
• 2009-present
  Professor of Medicine, Diabetes Center, University of California, San Francisco
• 2010
  Interim Director, Diabetes Center, University of California, San Francisco
• 2010-present
  Director, Diabetes Center, University of California, San Francisco

Honors & Awards

• 1994
  Graduate Student Research Award of the Hoechst AG, Frankfurt
• 1995
  Post-doctoral Fellowship from the Max-Planck Society
• 1996
  Post-doctoral Fellowship from the German Research Society (DFG)
• 1997-1999
  Howard Hughes Medical Institute Postdoctoral Fellowship
• 1999
  Sandler Program in Basic Sciences Junior Faculty Start-up Award
• 2000
  Sandler Award in Basic Sciences
• 2000
  Career Development Award, Juvenile Diabetes Foundation
• 2004
  Guest-Professor, University of Ulm, Germany
• 2006
  Scholar Award, Juvenile Diabetes Research Foundation
• 2013-present
  Chair, CADO/NIH study section

Selected Publications

1. Russ HA, Hebrok M. Taming the young and restless-epigenetic gene regulation in pancreas and beta-cell precursors. EMBO J. 2014 Oct 1; 33(19):2135-6.
   View on PubMed
2. Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M. Aberrant Innate Immune Activation following Tissue Injury Impairs Pancreatic Regeneration. PLoS One. 2014; 9(7):e102125.
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3. Morris JP, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M. Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation. PLoS One. 2014; 9(5):e95486.
   View on PubMed
4. Folias AE, Hebrok M. Diabetes: Solving human ß-cell development-what does the mouse say? Nat Rev Endocrinol. 2014 May; 10(5):253-5.
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5. von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014 Mar; 16(3):255-67.
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6. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 6; 14(2):228-36.
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7. Puri S, Akiyama H, Hebrok M. VHL-mediated disruption of Sox9 activity compromises ß-cell identity and results in diabetes mellitus. Genes Dev. 2013 Dec 1; 27(23):2563-75.
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8. Puri S, García-Núñez A, Hebrok M, Cano DA. Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice. PLoS One. 2013; 8(8):e72213.
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9. Greer RL, Staley BK, Liou A, Hebrok M. Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. Gastroenterology. 2013 Nov; 145(5):1088-1097.e8.
   View on PubMed
10. Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res. 2013 Aug 1; 73(15):4909-22.
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11. Stanger BZ, Hebrok M. Control of cell identity in pancreas development and regeneration. Gastroenterology. 2013 Jun; 144(6):1170-9.
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12. Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell. 2013 Aug 1; 13(2):219-29.
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13. von Figura G, Morris JP, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut. 2014 Apr; 63(4):656-64.
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14. Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU. Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res. 2013 Mar 15; 73(6):1821-30.
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15. Guo T, Landsman L, Li N, Hebrok M. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes. 2013 May; 62(5):1581-92.
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16. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50.
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17. Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, Stanger BZ, Holt J, Serrano J, James SP, Rustgi AK. Advances in acute and chronic pancreatitis: from development to inflammation and repair. Gastroenterology. 2013 Jan; 144(1):e1-4.
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18. Puri S, Hebrok M. Diabetic ß Cells: To Be or Not To Be? Cell. 2012 Sep 14; 150(6):1103-4.
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19. Hebrok M. Generating ß cells from stem cells-the story so far. Cold Spring Harb Perspect Med. 2012 Jun; 2(6):a007674.
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20. Fukuda A, Morris JP, Hebrok M. Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology. 2012 Sep; 143(3):821-31.e1-2.
    View on PubMed

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