Matthias Hebrok, PhD

Professor in Residence and Director, Diabetes Center, UCSF
Hurlbut-Johnson Distinguished Professor in Diabetes Research

mhebrok@diabetes.ucsf.edu

Phone: (415) 514-0820 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

View on UCSF Profiles

Additional Websites

• Diabetes Center profile
• Lab Website

Education

Professional Experience

• 1991-1992
  Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor
• 1992-1995
  Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter, Head of Department
• 1995
  Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology
• 1996-1999
  Postdoctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton, advisor
• 1999-2005
  Assistant Professor in Residence, Diabetes Center, University of California, San Francisco
• 2005-2009
  Associate Professor, Diabetes Center, University of California, San Francisco
• 2008
  Interim Director, Diabetes Center, University of California, San Francisco
• 2009-2010
  Associate Director of Research, Diabetes Center, University of California, San Francisco
• 2009-present
  Professor of Medicine, Diabetes Center, University of California, San Francisco
• 2010
  Interim Director, Diabetes Center, University of California, San Francisco
• 2010-present
  Director, Diabetes Center, University of California, San Francisco

Honors & Awards

• 1994
  Graduate Student Research Award of the Hoechst AG, Frankfurt
• 1995
  Post-doctoral Fellowship from the Max-Planck Society
• 1996
  Post-doctoral Fellowship from the German Research Society (DFG)
• 1997-1999
  Howard Hughes Medical Institute Postdoctoral Fellowship
• 1999
  Sandler Program in Basic Sciences Junior Faculty Start-up Award
• 2000
  Sandler Award in Basic Sciences
• 2000
  Career Development Award, Juvenile Diabetes Foundation
• 2004
  Guest-Professor, University of Ulm, Germany
• 2006
  Scholar Award, Juvenile Diabetes Research Foundation

Selected Publications

1. Puri S, Akiyama H, Hebrok M. VHL-mediated disruption of Sox9 activity compromises ß-cell identity and results in diabetes mellitus. Genes Dev. 2013 Dec 1; 27(23):2563-75.
   View on PubMed
2. Puri S, García-Núñez A, Hebrok M, Cano DA. Elimination of von hippel-lindau function perturbs pancreas endocrine homeostasis in mice. PLoS One. 2013; 8(8):e72213.
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3. Greer RL, Staley BK, Liou A, Hebrok M. Numb Regulates Acinar Cell Dedifferentiation and Survival During Pancreatic Damage and Acinar-to-Ductal Metaplasia. Gastroenterology. 2013 Nov; 145(5):1088-1097.e8.
   View on PubMed
4. Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res. 2013 Aug 1; 73(15):4909-22.
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5. Stanger BZ, Hebrok M. Control of cell identity in pancreas development and regeneration. Gastroenterology. 2013 Jun; 144(6):1170-9.
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6. Parent AV, Russ HA, Khan IS, Laflam TN, Metzger TC, Anderson MS, Hebrok M. Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development. Cell Stem Cell. 2013 Aug 1; 13(2):219-29.
   View on PubMed
7. Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU. Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res. 2013 Mar 15; 73(6):1821-30.
   View on PubMed
8. Guo T, Landsman L, Li N, Hebrok M. Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs. Diabetes. 2013 May; 62(5):1581-92.
   View on PubMed
9. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50.
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10. Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, Stanger BZ, Holt J, Serrano J, James SP, Rustgi AK. Advances in acute and chronic pancreatitis: from development to inflammation and repair. Gastroenterology. 2013 Jan; 144(1):e1-4.
    View on PubMed
11. Puri S, Hebrok M. Diabetic ß Cells: To Be or Not To Be? Cell. 2012 Sep 14; 150(6):1103-4.
    View on PubMed
12. Hebrok M. Generating ß Cells from Stem Cells-The Story So Far. Cold Spring Harb Perspect Med. 2012 Jun; 2(6):a007674.
    View on PubMed
13. Fukuda A, Morris JP, Hebrok M. Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology. 2012 Sep; 143(3):821-31.e1-2.
    View on PubMed
14. Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh RF, Hebrok M, Ramalho-Santos M. Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet. 2012 May 1; 21(9):2054-67.
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15. Landsman L, Parent A, Hebrok M. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17010-5.
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16. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep; 9(9):e1001143.
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17. Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited. Diabetes. 2011 May; 60(5):1370-9.
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18. Ohi Y, Qin H, Hong C, Blouin L, Polo JM, Guo T, Qi Z, Downey SL, Manos PD, Rossi DJ, Yu J, Hebrok M, Hochedlinger K, Costello JF, Song JS, Ramalho-Santos M. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol. 2011 May; 13(5):541-9.
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19. Fukuda A, Wang SC, Morris JP, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell. 2011 Apr 12; 19(4):441-55.
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20. Morris JP, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010 Oct; 10(10):683-95.
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