Michelle Hermiston, MD, PhD

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Education

University of Iowa, B.S August, 1988, Physiology
Washington University School of Medicine, Ph.D., May, 1997, Developmental Biology
Washington University School of Medicine, M.D., May, 1997, Medicine
University of California, San Francisco, Resident, 1997-99, Pediatrics
University of Caliofrnia, San Francisco, Fellow, 1999-02, Hematology/Oncology

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Professional Experience

• 1988-1986
  Laboratory Technician/Phlebotomist, Universty of Iowa Hospital
• 1988-1989
  Research Assistant, University of Iowa, Laboratory of Robert E. Malone (Project: Isolation and characterization of genes involved in early events of meiotic recombination in S. Cervisiae.
• 1991
  Teaching Assistant, Anatomy, Washington University School of Medicine
• 1997-1999
  Resident, Department of Pediatrics, University of California, San Francisco
• 1999-2002
  Fellow, Pediatric Hematology/Oncology, University of California, San Francisco
• 2002-2004
  Adjunct Instructor, Pediatric Hematology/Oncology, University of California, San Francisco
• 2004-present
  Adjunct Assistant Professor, Pediatric Hematology/Oncology, University of California, San Francisco
• 2006-present
  Assistant Professor, Pediatric Hematology/Oncology, University of California, San Francisco

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Honors & Awards

• 1987
  Mortar Board Honor Society, University of Iowa
• 1988
  Honors Graduate, University of Iowa
• 1988
  University of Iowa Homecoming Award for Excellence in Scholarship, Leadership, and Service
• 1990
  Medical Scientist Training Program Fellowship, Washington University
• 1990
  Edmond V. Cowdry Prize in Histology, Washington University
• 1993
  Spencer T. and Ann W. Olin Foundation Medical Scientist Fellowship, Washington University
• 1995
  Barbara Jackshik Award for Excellence in the Field of Cellular Regulation, Washington University
• 1996
  American College of Physicians Award for Excellence in Physical Diagnosis
• 1997
  American Medical Women's Association Janet M. Glasgow Memorial Achievement Citation, presented to women graduating in the top ten percent of their medical school class
• 1997
  Missouri State Medical Association Award for Outstanding Achievement in Medicine
• 1997
  Alpha Omega Alpha, Washington University School of Medicine
• 1997
  UCSF Molecular Medicine Research Fellowship Program
• 2001
  Molecular Oncology Investigator, University of California San Francisco Cancer Center
• 2004
  FASEB Summer Protein Phosphatase Research Conference Poster Award

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Selected Publications

1. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
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2. Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 12; 481(7380):157-63.
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3. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90.
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4. Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol. 2009 Apr 1; 182(7):4093-106.
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5. Grochowy G, Hermiston ML, Kuhny M, Weiss A, Huber M. Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems. Cell Signal. 2009 Aug; 21(8):1277-86.
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6. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59.
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7. Hermiston ML, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev. 2009 Mar; 228(1):288-311.
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8. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):546-51.
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9. Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J Exp Med. 2008 Nov 24; 205(12):2755-61.
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10. Modica R, Emery H, Lam W, Hermiston M, Grenert J, Wirt M, von Scheven E. Epstein-Barr virus-associated B cell lymphoproliferative disease in a child with neonatal-onset multisystem inflammatory disease. Arthritis Rheum. 2006 Oct 15; 55(5):823-5.
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11. Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):7012-7.
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12. Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity. 2005 Dec; 23(6):635-47.
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13. Hermiston ML, Mentzer WC. A practical approach to the evaluation of the anemic child. Pediatr Clin North Am. 2002 Oct; 49(5):877-91.
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14. Hermiston ML, Xu Z, Majeti R, Weiss A. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest. 2002 Jan; 109(1):9-14.
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15. Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol. 2003; 21:107-37.
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16. Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature. 1997 Apr 24; 386(6627):796-804.
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17. Wong MH, Hermiston ML, Syder AJ, Gordon JI. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc Natl Acad Sci U S A. 1996 Sep 3; 93(18):9588-93.
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18. Hermiston ML, Wong MH, Gordon JI. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev. 1996 Apr 15; 10(8):985-96.
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19. Hermiston ML, Gordon JI. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science. 1995 Nov 17; 270(5239):1203-7.
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20. Hermiston ML, Gordon JI. Organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development. Am J Physiol. 1995 May; 268(5 Pt 1):G813-22.
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