University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Michelle Hermiston, MD, PhD

Michelle Hermiston, MD, PhD

Associate Professor, Department of Pediatrics (Pediatric Hematology/Oncology), UCSF

Cancer Center Program Memberships

Pediatric Malignancies


University of Iowa, B.S August, 1988, Physiology
Washington University School of Medicine, Ph.D., May, 1997, Developmental Biology
Washington University School of Medicine, M.D., May, 1997, Medicine
University of California, San Francisco, Resident, 1997-99, Pediatrics
University of California, San Francisco, Fellow, 1999-03, Hematology/Oncology
University of California, San Francisco, Post-Doctoral Fellow,2001-2007,Immunology

Professional Experience

  • 1988-1989
    Research Assistant I. Project: Isolation and characterization of genes involved in early events of meiotic recombination in S. Cerevisiae Dr. Robert E. Malone, University of Iowa
  • 1990-1997
    Pre-doctoral Fellow, Medical Scientist Training Program. Thesis: Chimeric transgenic mouse models of gut epithelial biology. Mentor: Dr. Jeffrey I. Gordon, Washington University
  • 1999-2003
    Clinical Fellow, Pediatric Hematology/Oncology. UCSF
  • 2001-2007
    Post-doctoral Fellow, Immunology. Research project: Role of CD45 in autoimmunity and lymphoproliferation. Mentor: Dr. Arthur Weiss, UCSF
  • 2002-2004
    Adjunct Instructor, Pediatric Hematology/Oncology. UCSF
  • 2004-2007
    Adjunct Assistant Professor, Pediatric Hematology/Oncology. UCSF
  • 2007-2011
    Assistant Professor, In Residence, Pediatric Hematology/Oncology. UCSF
  • 2011-present
    Associate Professor, In Residence, Pediatric Hematology/Oncology. UCSF

Honors & Awards

  • 1987
    Mortar Board Honor Society, University of Iowa
  • 1988
    Honors Graduate, University of Iowa
  • 1988
    University of Iowa Homecoming Award for Excellence in Scholarship, Leadership, and Service
  • 1990
    Medical Scientist Training Program Fellowship, Washington University
  • 1990
    Edmond V. Cowdry Prize in Histology, Washington University
  • 1993
    Spencer T. and Ann W. Olin Foundation Medical Scientist Fellowship, Washington University
  • 1995
    Barbara Jackshik Award for Excellence in the Field of Cellular Regulation, Washington University
  • 1996
    American College of Physicians Award for Excellence in Physical Diagnosis
  • 1997
    American Medical Women's Association Janet M. Glasgow Memorial Achievement Citation, presented to women graduating in the top ten percent of their medical school class
  • 1997
    Missouri State Medical Association Award for Outstanding Achievement in Medicine
  • 1997
    Alpha Omega Alpha, Washington University School of Medicine
  • 1997
    UCSF Molecular Medicine Research Fellowship Program
  • 2001
    Molecular Oncology Investigator, University of California San Francisco Cancer Center
  • 2004
    FASEB Summer Protein Phosphatase Research Conference Poster Award
  • 2005
    Nominee, Department of Pediatrics Housestaff Teaching Award, UCSF
  • 2007-10
    Nominee, Fellow Mentoring Award, Department of Pediatrics, UCSF
  • 2008
    St. Baldrick's Foundation, Young Investigator Career Development Award
  • 2009
    Alex Lemonade Stand Young Investigator Career Development Award
  • 2010
    Histiocyte Society Nezelof Prize in Basic Science

Selected Publications

  1. Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2019 Nov 05.
    View on PubMed
  2. Jordan MB, Allen CE, Greenberg J, Henry M, Hermiston ML, Kumar A, Hines M, Eckstein O, Ladisch S, Nichols KE, Rodriguez-Galindo C, Wistinghausen B, McClain KL. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Pediatr Blood Cancer. 2019 Nov; 66(11):e27929.
    View on PubMed
  3. Meyer LK, Delgado-Martin C, Maude SL, Shannon KM, Teachey DT, Hermiston ML. CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. PLoS One. 2019; 14(7):e0220026.
    View on PubMed
  4. Zinter MS, Hermiston ML. Calming the storm in HLH. Blood. 2019 Jul 11; 134(2):103-104.
    View on PubMed
  5. Burkhardt B, Hermiston ML. Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities. Br J Haematol. 2019 Jun; 185(6):1158-1170.
    View on PubMed
  6. Chu Y, Lee S, Shah T, Yin C, Barth M, Miles RR, Ayello J, Morris E, Harrison L, Van de Ven C, Galardy P, Goldman SC, Lim MS, Hermiston M, McAllister-Lucas LM, Giulino-Roth L, Perkins SL, Cairo MS. Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model. Oncoimmunology. 2019; 8(1):e1512455.
    View on PubMed
  7. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693.
    View on PubMed
  8. Perez DR, Nickl CK, Waller A, Delgado-Martin C, Woods T, Sharma ND, Hermiston ML, Loh ML, Hunger SP, Winter SS, Chigaev A, Edwards B, Sklar LA, Matlawska-Wasowska K. High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL. SLAS Discov. 2018 08; 23(7):732-741.
    View on PubMed
  9. Sun W, Malvar J, Sposto R, Verma A, Wilkes JJ, Dennis R, Heym K, Laetsch TW, Widener M, Rheingold SR, Oesterheld J, Hijiya N, Sulis ML, Huynh V, Place AE, Bittencourt H, Hutchinson R, Messinger Y, Chang B, Matloub Y, Ziegler DS, Gardner R, Cooper T, Ceppi F, Hermiston M, Dalla-Pozza L, Schultz KR, Gaynon P, Wayne AS, Whitlock JA. Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study. Leukemia. 2018 11; 32(11):2316-2325.
    View on PubMed
  10. Bride KL, Vincent TL, Im SY, Aplenc R, Barrett DM, Carroll WL, Carson R, Dai Y, Devidas M, Dunsmore KP, Fuller T, Glisovic-Aplenc T, Horton TM, Hunger SP, Loh ML, Maude SL, Raetz EA, Winter SS, Grupp SA, Hermiston ML, Wood BL, Teachey DT. Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia. Blood. 2018 03 01; 131(9):995-999.
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  11. Yeh EA, Greenberg J, Abla O, Longoni G, Diamond E, Hermiston M, Tran B, Rodriguez-Galindo C, Allen CE, McClain KL. Evaluation and treatment of Langerhans cell histiocytosis patients with central nervous system abnormalities: Current views and new vistas. Pediatr Blood Cancer. 2018 Jan; 65(1).
    View on PubMed
  12. McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB. Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):E4782-E4791.
    View on PubMed
  13. Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576.
    View on PubMed
  14. Galardy PJ, Bedekovics T, Hermiston ML. Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons. Br J Haematol. 2016 05; 173(4):625-36.
    View on PubMed
  15. Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood. 2015 Nov 05; 126(19):2202-12.
    View on PubMed
  16. Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. J Immunol. 2015 Apr 15; 194(8):3675-86.
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  17. Maude SL, Dolai S, Delgado-Martin C, Vincent T, Robbins A, Selvanathan A, Ryan T, Hall J, Wood AC, Tasian SK, Hunger SP, Loh ML, Mullighan CG, Wood BL, Hermiston ML, Grupp SA, Lock RB, Teachey DT. Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia. Blood. 2015 Mar 12; 125(11):1759-67.
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  18. Dandekar S, Romanos-Sirakis E, Pais F, Bhatla T, Jones C, Bourgeois W, Hunger SP, Raetz EA, Hermiston ML, Dasgupta R, Morrison DJ, Carroll WL. Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia. Br J Haematol. 2014 Oct; 167(1):87-99.
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  19. Shannon K, Hermiston M. A(nother) RAF mutation in LCH. Blood. 2014 May 15; 123(20):3063-5.
    View on PubMed
  20. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
    View on PubMed

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