University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Thomas Hope, MD

Thomas Hope, MD

Assistant Professor, Abdominal Imaging and Nuclear Medicine, UCSF

Cancer Center Program Memberships

Prostate Cancer | Experimental Therapeutics

Research Summary

My research program is focused on imaging cancer using MRI and novel PET tracers. At UCSF, I have developed the gallium-68 DOTA-TOC imaging program for neuroendocrine tumor staging, and am the principle investigator on the FDA IND. I have also successfully brought Ga-68 PSMA imaging to UCSF and am currently drafting the IND submission to allow for the evaluation of the clinical use of this agent. I am interested in using somatostatin receptor and PSMA based PET agents in order to distinguish neuroendocrine prostate cancer from adenocarcinoma. Additionally, I believe that the combination of MR and PET parameters will aid in the staging of cancers. Most straightforward is a study we are carrying out in low risk prostatectomy patients where we are evaluating the use of PET/MRI using Ga-68 PSMA and MR imaging of the primary tumor. In the setting of patients with metastatic disease, PET/MRI will likely have an even more important role, as response to treatment will change uptake of non-FDG tracers in ways that are not immediately clear and intepretation will likely rely on changes in MR imaging parameters such as diffusion weighted imaging (DWI).

Education

Duke University, Durham, NC, BA/BS, 6/2001, Biology, Economics
Stanford University, MD, 6/2007 Medicine
Kaiser San Francisco, 6/2008, Internal Medicine
University of California, San Francisco, 6/2012, Diagnostic Radiology Residency
Stanford University, 6/2013, Body MRI/nuclear medicine Fellowship


Professional Experience

  • 2007-2008
    Intern, Department of Medicine, Kaiser San Francisco, CA
  • 2008-2012
    Resident, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA
  • 2012-2013
    Fellow, Department of Radiology, Stanford University, Stanford, CA
  • 2013-present
    Assistant Professor, Department of Radiology, UCSF, San Francisco, CA

Honors & Awards

  • 2001
    Summa Cum Laude, Duke University
  • 2001
    Phi Beta Kappa, Duke University
  • 2006
    Trainee Research Prize, Radiological Society of North America
  • 2007
    W. S. Moore Award, Nominee, International Society of Magnetic Resonance in Medicine
  • 2011
    Magnum Cum Laude Merit Award, International Society of Magnetic Resonance in Medicine
  • 2012
    Roentgen Resident/Fellow Research Award, Radiological Society of North America
  • 2012
    Alexander Margulis Society Excellence in Research Award, UCSF
  • 2014
    Wylie J. Dodds Research Award, Society of Abdominal Radiology

Selected Publications

  1. Leynes AP, Yang J, Wiesinger F, Kaushik SS, Shanbhag DD, Seo Y, Hope TA, Larson PEZ. Direct PseudoCT Generation for Pelvis PET/MRI Attenuation Correction using Deep Convolutional Neural Networks with Multi-parametric MRI: Zero Echo-time and Dixon Deep pseudoCT (ZeDD-CT). J Nucl Med. 2017 Oct 30.
    View on PubMed
  2. Jiang W, Ong F, Johnson KM, Nagle SK, Hope TA, Lustig M, Larson PEZ. Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator. Magn Reson Med. 2017 Oct 11.
    View on PubMed
  3. Lake ST, Greene KL, Westphalen AC, Behr SC, Zagoria R, Small EJ, Carroll PR, Hope TA. Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer. EJNMMI Res. 2017 Sep 19; 7(1):77.
    View on PubMed
  4. Huo E, Wilson DM, Eisenmenger L, Hope TA. The Role of PET/MR Imaging in Precision Medicine. PET Clin. 2017 Oct; 12(4):489-501.
    View on PubMed
  5. Hicks RM, Loening AM, Ohliger MA, Vasanawala SS, Hope TA. Variable refocusing flip angle single-shot fast spin echo imaging of liver lesions: increased speed and lesion contrast. Abdom Radiol (NY). 2017 Jul 08.
    View on PubMed
  6. Fowler KJ, Potretzke TA, Hope TA, Costa EA, Wilson SR. LI-RADS M (LR-M): definite or probable malignancy, not specific for hepatocellular carcinoma. Abdom Radiol (NY). 2017 Jun 03.
    View on PubMed
  7. Fendler WP, Eiber M, Beheshti M, Bomanji J, Ceci F, Cho S, Giesel F, Haberkorn U, Hope TA, Kopka K, Krause BJ, Mottaghy FM, Schöder H, Sunderland J, Wan S, Wester HJ, Fanti S, Herrmann K. 68Ga-PSMA PET/CT: Joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0. Eur J Nucl Med Mol Imaging. 2017 Jun; 44(6):1014-1024.
    View on PubMed
  8. Ohliger MA, Hope TA, Chapman JS, Chen LM, Behr SC, Poder L. PET/MR Imaging in Gynecologic Oncology. Magn Reson Imaging Clin N Am. 2017 Aug; 25(3):667-684.
    View on PubMed
  9. Hope TA, Aggarwal R, Chee B, Tao D, Greene KL, Cooperberg M, Feng F, Chang A, Ryan CJ, Small EJ, Carroll PR. Impact of Ga-68 PSMA-11 PET on Management in Patients with Biochemically Recurrent Prostate Cancer. J Nucl Med. 2017 May 18.
    View on PubMed
  10. Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope TA, Larson PEZ, Seo Y. Evaluation of sinus/edge corrected ZTE-based attenuation correction in brain PET/MRI. J Nucl Med. 2017 May 04.
    View on PubMed
  11. Hope TA, Aslam R, Weinstein S, Yeh BM, Corvera CU, Monto A, Yee J. Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography. J Comput Assist Tomogr. 2017 May/Jun; 41(3):376-381.
    View on PubMed
  12. Fendler WP, Calais J, Allen-Auerbach M, Bluemel C, Eberhardt N, Emmett L, Gupta P, Hartenbach M, Hope TA, Okamoto S, Pfob CH, Pöppel TD, Rischpler C, Schwarzenböck S, Stebner V, Unterrainer M, Zacho HD, Maurer T, Gratzke C, Crispin A, Czernin J, Herrmann K, Eiber M. 68Ga-PSMA-11 PET/CT interobserver agreement for prostate cancer assessments: an international multicenter prospective study. J Nucl Med. 2017 Apr 13.
    View on PubMed
  13. Yang J, Khalighi M, Hope TA, Ordovas K, Seo Y. Technical Note: Fast respiratory motion estimation using sorted singles without unlist processing: A feasibility study. Med Phys. 2017 May; 44(5):1632-1637.
    View on PubMed
  14. Lawhn-Heath C, Flavell RR, Glastonbury C, Hope TA, Behr SC. Incidental Detection of Head and Neck Squamous Cell Carcinoma on 68Ga-PSMA-11 PET/CT. Clin Nucl Med. 2017 Apr; 42(4):e218-e220.
    View on PubMed
  15. Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PE, Hope TA. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017 Mar 30.
    View on PubMed
  16. Ikram NS, Yee J, Weinstein S, Yeh BM, Corvera CU, Monto A, Hope TA. Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement. Abdom Radiol (NY). 2017 Mar; 42(3):870-876.
    View on PubMed
  17. Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope TA, Wiesinger F, Larson PE. Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI. Med Phys. 2017 Mar; 44(3):902-913.
    View on PubMed
  18. Yang J, Jian Y, Jenkins N, Behr SC, Hope TA, Larson PEZ, Vigneron D, Seo Y. Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System. Radiology. 2017 Jul; 284(1):169-179.
    View on PubMed
  19. Kluijfhout WP, Pasternak JD, Gosnell JE, Shen WT, Duh QY, Vriens MR, de Keizer B, Hope TA, Glastonbury CM, Pampaloni MH, Suh I. 18F Fluorocholine PET/MR Imaging in Patients with Primary Hyperparathyroidism and Inconclusive Conventional Imaging: A Prospective Pilot Study. Radiology. 2017 Aug; 284(2):460-467.
    View on PubMed
  20. Kluijfhout WP, Pasternak JD, Beninato T, Drake FT, Gosnell JE, Shen WT, Duh QY, Allen IE, Vriens MR, de Keizer B, Hope TA, Suh I. Diagnostic performance of computed tomography for parathyroid adenoma localization; a systematic review and meta-analysis. Eur J Radiol. 2017 Mar; 88:117-128.
    View on PubMed

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