University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Peyton Jacob, PhD

Peyton Jacob, PhD

Research Chemist, Departments of Medicine and Psychiatry, UCSF; Division of Cardiology, Clinical Pharmacology Program, Zuckerberg San Francisco General Hospital and Trauma Center

Cancer Center Program Memberships

Tobacco Control

Education

University of California, Davis, B.S., 1969, Chemistry
Purdue University, Lafayette, IN, Ph.D., 1975, Organic Chemistry
University of California, San Francisco, Postdoc, 1975-78, Pharmaceutical Chemistry

Honors & Awards

  • 1975-78
    NIH Postdoctoral Fellow
  • 1973-74
    Allied Chemical Corporation Fellow

Selected Publications

(20 selected from total of 231)

  1. Jacob P 3rd, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJ, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP. Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chem Res Toxicol. 2017 Jan 17;30(1):270-294.
    View on PubMed
  2. Jacob P, St Helen G, Yu L, Nardone N, Havel C, Cheung P, Benowitz NL. Biomarkers of Exposure for Dual Use of Electronic Cigarettes and Combustible Cigarettes: Nicotelline, NNAL, and Total Nicotine Equivalents. Nicotine Tob Res. 2020 Jun 12;22(7):1107-1113.
    View on PubMed
  3. Jacob P 3rd, Goniewicz ML, Havel CM, Schick SF, Benowitz NL. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18;26(11):1615-31.
    View on PubMed
  4. Jacob P 3rd, Abu Raddaha AH, Dempsey D, Havel C, Peng M, Yu L, Benowitz NL. Comparison of nicotine and carcinogen exposure with water pipe and cigarette smoking. Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):765-72.
    View on PubMed
  5. Jacob P 3rd, Havel C, Lee DH, Yu L, Eisner MD, Benowitz NL. Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry. Anal Chem. 2008 Nov 1;80(21):8115-21.
    View on PubMed
  6. Jacob P 3rd, Wilson M, Benowitz NL. Determination of phenolic metabolites of polycyclic aromatic hydrocarbons in human urine as their pentafluorobenzyl ether derivatives using liquid chromatography-tandem mass spectrometry. Anal Chem. 2007 Jan 15;79(2):587-98.
    View on PubMed
  7. Sarker AH, Trego KS, Zhang W, Jacob P 3rd, Snijders AM, Mao JH, Schick SF, Cooper PK, Hang B. Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells. Environ Mol Mutagen. 2020 Jul;61(6):635-646.
    View on PubMed
  8. Sleiman M, Gundel LA, Pankow JF, Jacob P 3rd, Singer BC, Destaillats H. Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6576-81.
    View on PubMed
  9. St Helen G, Liakoni E, Nardone N, Addo N, Jacob P 3rd, Benowitz NL. Comparison of Systemic Exposure to Toxic and/or Carcinogenic Volatile Organic Compounds (VOC) during Vaping, Smoking, and Abstention. Cancer Prev Res (Phila). 2020 Feb;13(2):153-162.
    View on PubMed
  10. Wang L, Bernert JT, Benowitz NL, Feng J, Jacob P 3rd, McGahee E, Caudill SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL. Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine. Cancer Epidemiol Biomarkers Prev. 2018 Sep;27(9):1083-1090.
    View on PubMed
  11. Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob P 3rd, Benowitz N, Destaillats H, Tang X, Xia Y, Jen KY, Gundel LA, Mao JH, Snijders AM. Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice. Clin Sci (Lond). 2018 Feb 28;132(4):475-488.
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  12. Benowitz NL, Nardone N, Jain S, Dempsey DA, Addo N, St Helen G, Jacob P 3rd. Comparison of Urine 4-(Methylnitrosamino)-1-(3)Pyridyl-1-Butanol and Cotinine for Assessment of Active and Passive Smoke Exposure in Urban Adolescents. Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):254-261.
    View on PubMed
  13. Aquilina NJ, Delgado-Saborit JM, Meddings C, Baker S, Harrison RM, Jacob P 3rd, Wilson M, Yu L, Duan M, Benowitz NL. Environmental and biological monitoring of exposures to PAHs and ETS in the general population. Environ Int. 2010 Oct;36(7):763-71.
    View on PubMed
  14. Whitehead TP, Havel C, Metayer C, Benowitz NL, Jacob P 3rd. Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users. Chem Res Toxicol. 2015 May 18;28(5):1007-14.
    View on PubMed
  15. Benowitz NL, Gan Q, Goniewicz ML, Lu W, Xu J, Li X, Jacob P 3rd, Glantz S. Different profiles of carcinogen exposure in Chinese compared with US cigarette smokers. Tob Control. 2015 Dec;24(e4):e258-63.
    View on PubMed
  16. St Helen G, Jacob P 3rd, Peng M, Dempsey DA, Hammond SK, Benowitz NL. Intake of toxic and carcinogenic volatile organic compounds from secondhand smoke in motor vehicles. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2774-82.
    View on PubMed
  17. St Helen G, Benowitz NL, Dains KM, Havel C, Peng M, Jacob P 3rd. Nicotine and carcinogen exposure after water pipe smoking in hookah bars. Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1055-66.
    View on PubMed
  18. Kassem NO, Daffa RM, Liles S, Jackson SR, Kassem NO, Younis MA, Mehta S, Chen M, Jacob P 3rd, Carmella SG, Chatfield DA, Benowitz NL, Matt GE, Hecht SS, Hovell MF. Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. Nicotine Tob Res. 2014 Jul;16(7):961-75.
    View on PubMed
  19. Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, Jacob P 3rd, Benowitz N. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014 Mar;23(2):133-9.
    View on PubMed
  20. Benowitz NL, Renner CC, Lanier AP, Tyndale RF, Hatsukami DK, Lindgren B, Stepanov I, Watson CH, Sosnoff CS, Jacob P 3rd. Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):934-42.
    View on PubMed