Alexander (Sandy) D. Johnson, PhD

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Additional Websites

• Lab Website

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Education

Vanderbilt University, Nashville TN, B.A., 1974, Biochemistry
Harvard University, Cambridge MA, M.A., Ph.D., 1980, Biochemistry
University of California, San Francisco, Postdoctoral, 1981-85, Biochemistry

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Professional Experience

• 1975-1980
  Graduate student with Mark Ptashne, Dept. of Biochemistry & Molecular Biology, Harvard University
• 1980-1981
  Postdoctoral fellow with Mark Ptashne, Dept. Biochemistry & Molecular Biology, Harvard University
• 1981-1985
  Postdoctoral fellow with Ira Herskowitz, Department of Biochemistry and Biophysics, UCSF
• 1985-1990
  Assistant Professor, Department of Microbiology & Immunology; Joint Appointment in Biochemistry & Biophysics, UCSF
• 1991-1995
  Associate Professor, Departments of Microbiology & Immunology; Biochemistry & Biophysics, UCSF
• 1995-present
  Professor, Departments of Microbiology & Immunology; Biochemistry and Biophysics, UCSF
• 2003-present
  Vice Chair, Department of Microbiology & Immunology, UCSF
• 2005-present
  Director of The Tetrad (Biochemistry, Genetics, Cell Biology, and Developmental Biology) Graduate Program, UCSF

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Honors & Awards

• B.A. summa cum laude, 1974
• Phi Beta Kappa, 1974
• Dreyfus Scholarship, 1974-1977
• Damon Runyon-Walter Winchell Postdoctoral Fellowship, 1981-1983
• Pew Scholarship, 1986-1990
• Elected to American Academy of Microbiology, 1998
• Burroughs Wellcome Merit Award, 1999 - 2004
• Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2004-2008
• Elected to American Academy of Arts and Sciences, 2007
• The Emil Christian Hansen Award for Microbiology, 2009
• Elected to the National Academy of Sciences, 2011

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Selected Publications

1. Lohse MB, Hernday AD, Fordyce PM, Noiman L, Sorrells TR, Hanson-Smith V, Nobile CJ, Derisi JL, Johnson AD. Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proc Natl Acad Sci U S A. 2013 May 7; 110(19):7660-5.
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2. Pérez JC, Kumamoto CA, Johnson AD. Candida albicans Commensalism and Pathogenicity Are Intertwined Traits Directed by a Tightly Knit Transcriptional Regulatory Circuit. PLoS Biol. 2013 Mar; 11(3):e1001510.
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3. Baker CR, Booth LN, Sorrells TR, Johnson AD. Protein modularity, cooperative binding, and hybrid regulatory States underlie transcriptional network diversification. Cell. 2012 Sep 28; 151(1):80-95.
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4. Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell. 2012 Jan 20; 148(1-2):126-38.
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5. Cain CW, Lohse MB, Homann OR, Sil A, Johnson AD. A conserved transcriptional regulator governs fungal morphology in widely diverged species. Genetics. 2012 Feb; 190(2):511-21.
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6. Baker CR, Tuch BB, Johnson AD. Extensive DNA-binding specificity divergence of a conserved transcription regulator. Proc Natl Acad Sci U S A. 2011 May 3; 108(18):7493-8.
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7. Booth LN, Tuch BB, Johnson AD. Intercalation of a new tier of transcription regulation into an ancient circuit. Nature. 2010 Dec 16; 468(7326):959-63.
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8. Mitrovich QM, Tuch BB, De La Vega FM, Guthrie C, Johnson AD. Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science. 2010 Nov 5; 330(6005):838-41.
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9. Li H, Johnson AD. Evolution of transcription networks--lessons from yeasts. Curr Biol. 2010 Sep 14; 20(17):R746-53.
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10. Lohse MB, Johnson AD. Temporal anatomy of an epigenetic switch in cell programming: the white-opaque transition of C. albicans. Mol Microbiol. 2010 Oct; 78(2):331-43.
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11. Tuch BB, Mitrovich QM, Homann OR, Hernday AD, Monighetti CK, De La Vega FM, Johnson AD. The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation. PLoS Genet. 2010 Aug; 6(8):e1001070.
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12. Lohse MB, Zordan RE, Cain CW, Johnson AD. Distinct class of DNA-binding domains is exemplified by a master regulator of phenotypic switching in Candida albicans. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14105-10.
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13. Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet. 2010 Jul; 42(7):590-8.
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14. Homann OR, Johnson AD. MochiView: versatile software for genome browsing and DNA motif analysis. BMC Biol. 2010; 8:49.
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15. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. Genetics and molecular biology in Candida albicans. Methods Enzymol. 2010; 470:737-58.
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16. Homann OR, Dea J, Noble SM, Johnson AD. A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 2009 Dec; 5(12):e1000783.
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17. Lohse MB, Johnson AD. White-opaque switching in Candida albicans. Curr Opin Microbiol. 2009 Dec; 12(6):650-4.
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18. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6.
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19. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 2009 Sep; 5(9):e1000664.
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20. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
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