Y.W. Kan, MD, FRS

Professor, Departments of Medicine and Laboratory Medicine, UCSF
Louis K. Diamond, MD, Chair in Hematology, UCSF

YW.Kan@ucsf.edu

Phone: (415) 476-5841 (voice)
Box 0793, UCSF
San Francisco, CA 94143-0793

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Education

University of Hong Kong, Hong Kong, M.B.B.S., 1958, Medicine
University of Hong Kong, Hong Kong, D.Sc., 1980, Medicine

Professional Experience

• 1970-1972
  Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA
• 1972-1977
  Assoc. Professor, Depts of Medicine & Laboratory Medicine, Univ of California, San Francisco, CA (UCSF)
• 1977-present
  Professor, Depts. of Medicine & Laboratory Medicine, UCSF
• 1983-present
  Louis K. Diamond Professor of Hematology, Dept. of Medicine, UCSF
• 1984-present
  Chief, Division of Molecular Medicine and Diagnostics, Dept. of Laboratory Medicine, UCSF
• 1990-1994
  1990-1994 Director (part-time), Institute of Molecular Biology, Hong Kong

Honors & Awards

• 1979
  Dameshek Award, American Society of Hematology
• 1980
  Stratton Award, International Society of Hematology
• 1980
  George Thorn Award, Howard Hughes Medical Institute
• 1984
  Gairdner Foundation International Award, Canada
• 1984
  Allan Award, American Society of Human Genetics
• 1984
  Lita Annenberg Hazen Award for Excellence in Clinical Research
• 1985
  NIH Career Development Award
• 1987
  Waterford Award
• 1988
  American College of Physicians Award
• 1989
  Sanremo International Award for Genetic Research, Italy
• 1989
  Warren Alpert Foundation Prize
• 1991
  Albert Lasker Clinical Medical Research Award
• 1992
  Christopher Columbus Discovery Award in Biomedical Research
• 1993
  City of Medicine Award
• 1995
  Helmut Horten Research Award (Switzerland)
• 2004
  Shaw Foundation Prize (Hong Kong)
• M.D. Honoris Causa, University of Cagliari, Sardenia; DSC. Honoris Causa: University of Hong Kong, Chinese University of Hong Kong, Open University of Hong Kong. Honorary Professor: University of Hong Kong; Peking Union Medical College, Beijing; Zhejiang University, Hangzhou; Jia Tong University, Xi'an; First Military Medical University, Guanzhou; Fourth Medical Military University, Xi'an, China.

Selected Publications

1. Tao Z, Chen B, Tan X, Zhao Y, Wang L, Zhu T, Cao K, Yang Z, Kan YW, Su H. Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):2064-9.
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2. Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D, Lippross S, Pufe T. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis. 2011 May; 70(5):844-50.
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3. Wruck CJ, Streetz K, Pavic G, Götz ME, Tohidnezhad M, Brandenburg LO, Varoga D, Eickelberg O, Herdegen T, Trautwein C, Cha K, Kan YW, Pufe T. Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J Biol Chem. 2011 Feb 11; 286(6):4493-9.
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4. Ye L, Chang JC, Lin C, Qi Z, Yu J, Kan YW. Generation of induced pluripotent stem cells using site-specific integration with phage integrase. Proc Natl Acad Sci U S A. 2010 Nov 9; 107(45):19467-72.
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5. Kan YW, Chang JC. Molecular diagnosis of hemoglobinopathies and thalassemia. Prenat Diagn. 2010 Jul; 30(7):608-10.
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6. Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y, Foster BA, Kan YW, Kong AN. Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS One. 2010; 5(1):e8579.
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7. Liu B, Feng D, Lin G, Cao M, Kan YW, Cunha GR, Baskin LS. Signalling molecules involved in mouse bladder smooth muscle cellular differentiation. Int J Dev Biol. 2010; 54(1):175-80.
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8. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53.
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9. Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9826-30.
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10. Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2933-8.
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11. Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71.
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12. Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW. Development of human single-chain antibodies against SARS-associated coronavirus. Intervirology. 2008; 51(3):173-81.
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13. Xu W, Hellerbrand C, Köhler UA, Bugnon P, Kan YW, Werner S, Beyer TA. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest. 2008 Oct; 88(10):1068-78.
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14. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 3; 133(2):191-7.
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15. Ye L, Chang JC, Lu R, Kan YW. High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):67-72.
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16. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41.
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17. Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J. 2008 Jan 9; 27(1):212-23.
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18. Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan YW, Grotta JC, Aronowski J. Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke. 2007 Dec; 38(12):3280-6.
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19. Han XD, Lin C, Chang J, Sadelain M, Kan YW. Fetal gene therapy of alpha-thalassemia in a mouse model. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9007-11.
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20. Su H, Kan YW. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 2007; 366:331-42.
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