Lawrence D. Kaplan, MD

Lawrence D. Kaplan, MD

Clinical Professor of Medicine; Director, Adult Lymphoma Program, Division of Hematology-Oncology, UCSF

Phone: (415) 353-2421
Box 0324, UCSF
San Francisco, CA 94143-0324

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Additional Websites


Brandeis University (Magna cum Laude), BA, 1974, Biology
University of California, Berkeley, MA, 1976, Biochemistry
University of California, Los Angeles, MD, 1980, Medicine

Professional Experience

  • 1980-1981
    Medical Intern, Boston City Hospital Department of Medicine
  • 1981 1983
    Medical Resident, Boston City Hospital Department of Medicine
  • 1983 1985
    Fellow in Hematology and Oncology, University of California San Francisco, Cancer Research Institute
  • 1985 1986
    Clinical Instructor in Medicine, University of California, San Francisco, AIDS Program/Oncology Division, San Francisco General Hospital
  • 1986-1982
    Assistant Clinical Professor of Medicine, University of California, San Francisco, San Francisco General Hospital, AIDS Program/Oncology Division
  • 1992-1998
    Associate Clinical Professor of Medicine, University of California, San Francisco AIDS Program/Oncology Division, San Francisco, San Francisco General Hospital
  • 1998-2002
    Clinical Professor of Medicine, University of California, San Francisco, Positive Health Program, San Francisco, San Francisco General Hospital
  • 2002- Present
    Clinical Professor of Medicine; Director, Adult Lymphoma Program, Division of Hematology-Oncology, University of California, San Francisco

Honors & Awards

  • 7/87-7/90
    American Cancer Society Career Development Award
  • 7/91-7/95
    National Cancer Institute RO-1 AIDS-Lymphoma Network Grant, "Novel Therapeutic Approaches for HIV-Associated NHL"
  • 1995-present
    National Cancer Institute UO-1 AIDS-Malignancies Consortium

Selected Publications

  1. Mannis GN, Logan AC, Leavitt AD, Yanada M, Hwang J, Olin RL, Damon LE, Andreadis C, Ai WZ, Gaensler KM, Greene CC, Gupta NK, Kaplan LD, Mahindra A, Miyazaki Y, Naoe T, Ohtake S, Sayre PH, Smith CC, Venstrom JM, Wolf JL, Caballero L, Emi N, Martin TG. Delayed hematopoietic recovery after auto-SCT in patients receiving arsenic trioxide-based therapy for acute promyelocytic leukemia: a multi-center analysis. Bone Marrow Transplant. 2014 Sep 22.
    View on PubMed
  2. Barta SK, Xue X, Wang D, Lee JY, Kaplan LD, Ribera JM, Oriol A, Spina M, Tirelli U, Boue F, Wilson WH, Wyen C, Dunleavy K, Noy A, Sparano JA. A new prognostic score for AIDS-related lymphomas in the rituximab-era. Haematologica. 2014 Nov; 99(11):1731-7.
    View on PubMed
  3. Du J, Lopez-Verges S, Pitcher BN, Johnson J, Jung SH, Zhou L, Hsu K, Czuczman MS, Cheson B, Kaplan L, Lanier LL, Venstrom JM. CALGB 150905 (Alliance): Rituximab Broadens the Antilymphoma Response by Activating Unlicensed NK Cells. Cancer Immunol Res. 2014 Sep; 2(9):878-89.
    View on PubMed
  4. Keller JW, Andreadis C, Damon LE, Kaplan LD, Martin TG, Wolf JL, Ai WZ, Venstrom JM, Smith CC, Gaensler KM, Hwang J, Olin RL. Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol. 2014 Jul; 5(3):238-44.
    View on PubMed
  5. Rubenstein JL, Cheson BD, Jung SH, Kaplan LD. Reply to m.C. Chamberlain. J Clin Oncol. 2014 Mar 10; 32(8):858-9.
    View on PubMed
  6. Kaplan LD, Deitcher SR, Silverman JA, Morgan G. Phase II Study of Vincristine Sulfate Liposome Injection (Marqibo) and Rituximab for Patients With Relapsed and Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma in Need of Palliative Therapy. Clin Lymphoma Myeloma Leuk. 2014 Feb; 14(1):37-42.
    View on PubMed
  7. Barta SK, Xue X, Wang D, Tamari R, Lee JY, Mounier N, Kaplan LD, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Wilson WH, Wyen C, Oriol A, Navarro JT, Dunleavy K, Little RF, Ratner L, Garcia O, Morgades M, Remick SC, Noy A, Sparano JA. Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: a pooled analysis of 1546 patients. Blood. 2013 Nov 7; 122(19):3251-62.
    View on PubMed
  8. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 6; 121(23):4740-8.
    View on PubMed
  9. Rubenstein JL, Hsi ED, Johnson JL, Jung SH, Nakashima MO, Grant B, Cheson BD, Kaplan LD. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol. 2013 Sep 1; 31(25):3061-8.
    View on PubMed
  10. Kaplan LD. Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma. Hematology Am Soc Hematol Educ Program. 2013; 2013:103-8.
    View on PubMed
  11. Kaplan LD. Management of HIV-associated Hodgkin lymphoma: how far we have come. J Clin Oncol. 2012 Nov 20; 30(33):4056-8.
    View on PubMed
  12. Kaplan LD. HIV-associated lymphoma. Best Pract Res Clin Haematol. 2012 Mar; 25(1):101-17.
    View on PubMed
  13. Barta SK, Lee JY, Kaplan LD, Noy A, Sparano JA. Pooled analysis of AIDS malignancy consortium trials evaluating rituximab plus CHOP or infusional EPOCH chemotherapy in HIV-associated non-Hodgkin lymphoma. Cancer. 2012 Aug 15; 118(16):3977-83.
    View on PubMed
  14. Armstrong EJ, Bhave P, Wong D, Ursell PC, Kaplan L, Yeghiazarians Y, Ai WZ. Left ventricular rupture due to HIV-associated T-cell lymphoma. Tex Heart Inst J. 2010; 37(4):457-60.
    View on PubMed
  15. Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH, Von Roenn J, Dezube BJ, Remick SC, Shah MH, Leichman L, Ratner L, Cesarman E, Chadburn A, Mitsuyasu R. Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma. Blood. 2010 Apr 15; 115(15):3008-16.
    View on PubMed
  16. Martin T, Sharma M, Damon L, Kaplan L, Guglielmo BJ, Working M, O'Malley R, Hwang J, Linker C. Voriconazole is safe and effective as prophylaxis for early and late fungal infections following allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2010 Feb; 12(1):45-50.
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  17. Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034. J Clin Oncol. 2009 Oct 20; 27(30):5039-48.
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  18. Lin L, Lee JY, Kaplan LD, Dezube BJ, Noy A, Krown SE, Levine AM, Yu Y, Hayward GS, Ambinder RF. Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol. 2009 May 20; 27(15):2496-502.
    View on PubMed
  19. Damon L, Damon LE, Gaensler K, Kaplan L, Martin T, Rubenstein J, Linker C. Impact of intensive PBSC mobilization therapy on outcomes following auto-SCT for non-Hodgkin's lymphoma. Bone Marrow Transplant. 2008 Nov; 42(10):649-57.
    View on PubMed
  20. Brinker BT, Krown SE, Lee JY, Cesarman E, Chadburn A, Kaplan LD, Henry DH, Von Roenn JH. Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1; 112(5):1083-8.
    View on PubMed

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