University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Karla Kerlikowske, MD

Karla Kerlikowske, MD

Professor, Departments of Medicine and Epidemiology/Biostatistics, UCSF

Cancer Center Program Memberships

Breast Oncology

Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine


Professional Experience

  • 1988-89
    Medicine Internship, University of California San Francisco, San Francisco, CA
  • 1989-91
    Primary Care Medicine Residency, University of California San Francisco, San Francisco, CA
  • 1991-93
    Fellow in General Internal Medicine, Veterans Affairs Medical Center, San Francisco, CA
  • 1991-93
    Clinical Instructor, Assistant Physician, UCSF Department of Medicine, San Francisco, CA
  • 1993-1999
    Associate Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1999-present
    Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Medicine, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Epidemiology & Biostatistics, San Francisco, CA
  • 2000-present
    Associate Professor, In Residence, Department of Medicine, Univ. of California, San Francisco
  • 2000-present
    Associate Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco
  • 2000-present
    Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians

Selected Publications

  1. Buist DSM, Abraham L, Lee CI, Lee JM, Lehman C, O'Meara ES, Stout NK, Henderson LM, Hill D, Wernli KJ, Haas JS, Tosteson ANA, Kerlikowske K, Onega T. Breast Biopsy Intensity and Findings Following Breast Cancer Screening in Women With and Without a Personal History of Breast Cancer. JAMA Intern Med. 2018 Apr 01; 178(4):458-468.
    View on PubMed
  2. Braithwaite D, Miglioretti DL, Zhu W, Demb J, Trentham-Dietz A, Sprague B, Tice JA, Onega T, Henderson LM, Buist DSM, Ziv E, Walter LC, Kerlikowske K. Family History and Breast Cancer Risk Among Older Women in the Breast Cancer Surveillance Consortium Cohort. JAMA Intern Med. 2018 Apr 01; 178(4):494-501.
    View on PubMed
  3. Onega T, Zhu W, Weiss JE, Goodrich M, Tosteson ANA, DeMartini W, Virnig BA, Henderson LM, Buist DSM, Wernli KJ, Kerlikowske K, Hubbard RA. Preoperative breast MRI and mortality in older women with breast cancer. Breast Cancer Res Treat. 2018 Mar 07.
    View on PubMed
  4. Rice MS, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Norman AD, Visscher DW, Chen YY, Brandt KR, Couch FJ, Shepherd JA, Fan B, Wu FF, Ma L, Collins LC, Cummings SR, Kerlikowske K, Vachon CM. Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics. Breast Cancer Res Treat. 2018 Mar 03.
    View on PubMed
  5. Henderson LM, Hubbard RA, Zhu W, Weiss J, Wernli KJ, Goodrich ME, Kerlikowske K, DeMartini W, Ozanne EM, Onega T. Preoperative Breast Magnetic Resonance Imaging Use by Breast Density and Family History of Breast Cancer. J Womens Health (Larchmt). 2018 Jan 15.
    View on PubMed
  6. Hill DA, Haas JS, Wellman R, Hubbard RA, Lee CI, Alford-Teaster J, Wernli KJ, Henderson LM, Stout NK, Tosteson ANA, Kerlikowske K, Onega T. Utilization of breast cancer screening with magnetic resonance imaging in community practice. J Gen Intern Med. 2018 Mar; 33(3):275-283.
    View on PubMed
  7. Onega T, Weiss JE, Goodrich ME, Zhu W, DeMartini WB, Kerlikowske K, Ozanne E, Tosteson ANA, Henderson LM, Buist DSM, Wernli KJ, Herschorn SD, Hotaling E, O'Donoghue C, Hubbard R. Relationship between preoperative breast MRI and surgical treatment of non-metastatic breast cancer. J Surg Oncol. 2017 Dec; 116(8):1008-1015.
    View on PubMed
  8. Ray KM, Kerlikowske K, Lobach IV, Hofmann MB, Greenwood HI, Arasu VA, Hylton NM, Joe BN. Effect of Background Parenchymal Enhancement on Breast MR Imaging Interpretive Performance in Community-based Practices. Radiology. 2018 Mar; 286(3):822-829.
    View on PubMed
  9. Shiyanbola OO, Arao RF, Miglioretti DL, Sprague BL, Hampton JM, Stout NK, Kerlikowske K, Braithwaite D, Buist DSM, Egan KM, Newcomb PA, Trentham-Dietz A. Emerging Trends in Family History of Breast Cancer and Associated Risk. Cancer Epidemiol Biomarkers Prev. 2017 Dec; 26(12):1753-1760.
    View on PubMed
  10. Yu J, Nagler RH, Fowler EF, Kerlikowske K, Gollust SE. Women's Awareness and Perceived Importance of the Harms and Benefits of Mammography Screening: Results From a 2016 National Survey. JAMA Intern Med. 2017 Sep 01; 177(9):1381-1382.
    View on PubMed
  11. Engmann NJ, Golmakani MK, Miglioretti DL, Sprague BL, Kerlikowske K. Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. JAMA Oncol. 2017 Sep 01; 3(9):1228-1236.
    View on PubMed
  12. Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd JA. Combining quantitative and qualitative breast density measures to assess breast cancer risk. Breast Cancer Res. 2017 Aug 22; 19(1):97.
    View on PubMed
  13. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JWT, Tice JA, Ziv E, Kerlikowske K, Cummings SR. Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones. Breast Cancer Res Treat. 2017 Nov; 166(2):603-612.
    View on PubMed
  14. Yaghjyan L, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Pankratz VS, Brandt K, Visscher D, Norman A, Couch F, Shepherd J, Fan B, Chen YY, Ma L, Beck AH, Cummings SR, Kerlikowske K, Vachon CM. Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes. Breast Cancer Res Treat. 2017 Sep; 165(2):421-431.
    View on PubMed
  15. Nguyen KH, Pasick RJ, Stewart SL, Kerlikowske K, Karliner LS. Disparities in abnormal mammogram follow-up time for Asian women compared with non-Hispanic white women and between Asian ethnic groups. Cancer. 2017 Sep 15; 123(18):3468-3475.
    View on PubMed
  16. Lee JM, Ichikawa L, Valencia E, Miglioretti DL, Wernli K, Buist DSM, Kerlikowske K, Henderson LM, Sprague BL, Onega T, Rauscher GH, Lehman CD. Performance Benchmarks for Screening Breast MR Imaging in Community Practice. Radiology. 2017 Oct; 285(1):44-52.
    View on PubMed
  17. Tice JA, Kerlikowske K. Supplemental Breast Cancer Screening: A Density Conundrum. J Gen Intern Med. 2017 Jun; 32(6):593-594.
    View on PubMed
  18. Miglioretti DL, Ichikawa L, Smith RA, Buist DSM, Carney PA, Geller B, Monsees B, Onega T, Rosenberg R, Sickles EA, Yankaskas BC, Kerlikowske K. Correlation Between Screening Mammography Interpretive Performance on a Test Set and Performance in Clinical Practice. Acad Radiol. 2017 Oct; 24(10):1256-1264.
    View on PubMed
  19. Sprague BL, Arao RF, Miglioretti DL, Henderson LM, Buist DS, Onega T, Rauscher GH, Lee JM, Tosteson AN, Kerlikowske K, Lehman CD. National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr; 283(1):59-69.
    View on PubMed
  20. Engmann NJ, Scott CG, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh AP, Malkov S, Whaley DH, Hruska CB, Wu FF, Winham SJ, Miglioretti DL, Norman AD, Heine JJ, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors. Cancer Epidemiol Biomarkers Prev. 2017 06; 26(6):930-937.
    View on PubMed

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