University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Karla Kerlikowske, MD

Karla Kerlikowske, MD

Professor, Departments of Medicine and Epidemiology/Biostatistics, UCSF

Cancer Center Program Memberships

Breast Oncology

Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine


Professional Experience

  • 1988-89
    Medicine Internship, University of California San Francisco, San Francisco, CA
  • 1989-91
    Primary Care Medicine Residency, University of California San Francisco, San Francisco, CA
  • 1991-93
    Fellow in General Internal Medicine, Veterans Affairs Medical Center, San Francisco, CA
  • 1991-93
    Clinical Instructor, Assistant Physician, UCSF Department of Medicine, San Francisco, CA
  • 1993-1999
    Associate Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1999-present
    Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Medicine, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Epidemiology & Biostatistics, San Francisco, CA
  • 2000-present
    Associate Professor, In Residence, Department of Medicine, Univ. of California, San Francisco
  • 2000-present
    Associate Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco
  • 2000-present
    Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians

Selected Publications

  1. Yu J, Nagler RH, Fowler EF, Kerlikowske K, Gollust SE. Women's Awareness and Perceived Importance of the Harms and Benefits of Mammography Screening: Results From a 2016 National Survey. JAMA Intern Med. 2017 Sep 01; 177(9):1381-1382.
    View on PubMed
  2. Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd JA. Combining quantitative and qualitative breast density measures to assess breast cancer risk. Breast Cancer Res. 2017 Aug 22; 19(1):97.
    View on PubMed
  3. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JWT, Tice JA, Ziv E, Kerlikowske K, Cummings SR. Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones. Breast Cancer Res Treat. 2017 Aug 08.
    View on PubMed
  4. Nguyen KH, Pasick RJ, Stewart SL, Kerlikowske K, Karliner LS. Disparities in abnormal mammogram follow-up time for Asian women compared with non-Hispanic white women and between Asian ethnic groups. Cancer. 2017 Sep 15; 123(18):3468-3475.
    View on PubMed
  5. Lee JM, Ichikawa L, Valencia E, Miglioretti DL, Wernli K, Buist DSM, Kerlikowske K, Henderson LM, Sprague BL, Onega T, Rauscher GH, Lehman CD. Performance Benchmarks for Screening Breast MR Imaging in Community Practice. Radiology. 2017 Jun 05; 162033.
    View on PubMed
  6. Tice JA, Kerlikowske K. Supplemental Breast Cancer Screening: A Density Conundrum. J Gen Intern Med. 2017 Jun; 32(6):593-594.
    View on PubMed
  7. Miglioretti DL, Ichikawa L, Smith RA, Buist DSM, Carney PA, Geller B, Monsees B, Onega T, Rosenberg R, Sickles EA, Yankaskas BC, Kerlikowske K. Correlation Between Screening Mammography Interpretive Performance on a Test Set and Performance in Clinical Practice. Acad Radiol. 2017 May 24.
    View on PubMed
  8. Sprague BL, Arao RF, Miglioretti DL, Henderson LM, Buist DS, Onega T, Rauscher GH, Lee JM, Tosteson AN, Kerlikowske K, Lehman CD. National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr; 283(1):59-69.
    View on PubMed
  9. Engmann NJ, Golmakani MK, Miglioretti DL, Sprague BL, Kerlikowske K. Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. JAMA Oncol. 2017 Feb 02.
    View on PubMed
  10. Engmann NJ, Scott C, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh A, Malkov S, Whaley DH, Hruska C, Wu FF, Winham S, Miglioretti DL, Norman AD, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Longitudinal changes in volumetric breast density with tamoxifen and aromatase inhibitors. Cancer Epidemiol Biomarkers Prev. 2017 Feb 01.
    View on PubMed
  11. Brandzel S, Rosenberg DE, Johnson D, Bush M, Kerlikowske K, Onega T, Henderson L, Nekhlyudov L, DeMartini W, Wernli KJ. Women's experiences and preferences regarding breast imaging after completing breast cancer treatment. Patient Prefer Adherence. 2017; 11:199-204.
    View on PubMed
  12. Ziv E, Tice JA, Sprague B, Vachon CM, Cummings SR, Kerlikowske K. Using Breast Cancer Risk Associated Polymorphisms to Identify Women for Breast Cancer Chemoprevention. PLoS One. 2017; 12(1):e0168601.
    View on PubMed
  13. Ahern TP, Sprague BL, Bissell MC, Miglioretti DL, Buist DS, Braithwaite D, Kerlikowske K. Family history of breast cancer, breast density, and breast cancer risk in a U.S. breast cancer screening population. Cancer Epidemiol Biomarkers Prev. 2017 Jan 17.
    View on PubMed
  14. Malkov S, Shepherd JA, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch F, Jensen MR, Mahmoudzadeh AP, Fan B, Norman A, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K. Erratum to: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status. Breast Cancer Res. 2017 Jan 04; 19(1):1.
    View on PubMed
  15. Menes TS, Kerlikowske K, Lange J, Jaffer S, Rosenberg R, Miglioretti DL. Subsequent Breast Cancer Risk Following Diagnosis of Atypical Ductal Hyperplasia on Needle Biopsy. JAMA Oncol. 2017 Jan 01; 3(1):36-41.
    View on PubMed
  16. Kerlikowske K, Gard CC, Tice JA, Ziv E, Cummings SR, Miglioretti DL. Risk Factors That Increase Risk of Estrogen Receptor-Positive and -Negative Breast Cancer. J Natl Cancer Inst. 2017 May; 109(5).
    View on PubMed
  17. Malkov S, Shepherd JA, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch F, Jensen MR, Mahmoudzadeh AP, Fan B, Norman A, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K. Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status. Breast Cancer Res. 2016 Dec 06; 18(1):122.
    View on PubMed
  18. Lehman CD, Arao RF, Sprague BL, Lee JM, Buist DS, Kerlikowske K, Henderson LM, Onega T, Tosteson AN, Rauscher GH, Miglioretti DL. National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr; 283(1):49-58.
    View on PubMed
  19. Onega T, Smith M, Miglioretti DL, Carney PA, Geller BA, Kerlikowske K, Buist DS, Rosenberg RD, Smith RA, Sickles EA, Haneuse S, Anderson ML, Yankaskas B. Radiologist Agreement for Mammographic Recall by Case Difficulty and Finding Type. J Am Coll Radiol. 2016 Nov; 13(11S):e72-e79.
    View on PubMed
  20. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JW, Tice JA, Vachon CM, Cummings SR, Kerlikowske K, Ziv E. Breast cancer risk prediction using a clinical risk model and polygenic risk score. Breast Cancer Res Treat. 2016 Aug 26.
    View on PubMed

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