University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Karla Kerlikowske, MD

Karla Kerlikowske, MD

Professor, Departments of Medicine and Epidemiology/Biostatistics, UCSF

Cancer Center Program Memberships

Breast Oncology

Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians

Selected Publications

  1. Bissell MCS, Kerlikowske K, Sprague BL, Tice JA, Gard CC, Tossas KY, Rauscher GH, Trentham-Dietz A, Henderson LM, Onega T, Keegan THM, Miglioretti DL. Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status. Cancer Epidemiol Biomarkers Prev. 2020 Jul 29.
    View on PubMed
  2. Lowry KP, Coley RY, Miglioretti DL, Kerlikowske K, Henderson LM, Onega T, Sprague BL, Lee JM, Herschorn S, Tosteson ANA, Rauscher G, Lee CI. Screening Performance of Digital Breast Tomosynthesis vs Digital Mammography in Community Practice by Patient Age, Screening Round, and Breast Density. JAMA Netw Open. 2020 Jul 01; 3(7):e2011792.
    View on PubMed
  3. Kenny JD, Karliner LS, Kerlikowske K, Kaplan CP, Fernandez-Lamothe A, Burke NJ. Organization Communication Factors and Abnormal Mammogram Follow-up: a Qualitative Study Among Ethnically Diverse Women Across Three Healthcare Systems. J Gen Intern Med. 2020 Jun 29.
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  4. Lowry KP, Trentham-Dietz A, Schechter CB, Alagoz O, Barlow WE, Burnside ES, Conant EF, Hampton JM, Huang H, Kerlikowske K, Lee SJ, Miglioretti DL, Sprague BL, Tosteson ANA, Yaffe MJ, Stout NK. Long-Term Outcomes and Cost-Effectiveness of Breast Cancer Screening With Digital Breast Tomosynthesis in the United States. J Natl Cancer Inst. 2020 Jun 01; 112(6):582-589.
    View on PubMed
  5. Demb J, Abraham L, Miglioretti DL, Sprague BL, O'Meara ES, Advani S, Henderson LM, Onega T, Buist DSM, Schousboe JT, Walter LC, Kerlikowske K, Braithwaite D. Screening Mammography Outcomes: Risk of Breast Cancer and Mortality by Comorbidity Score and Age. J Natl Cancer Inst. 2020 Jun 01; 112(6):599-606.
    View on PubMed
  6. Gastounioti A, Kasi CD, Scott CG, Brandt KR, Jensen MR, Hruska CB, Wu FF, Norman AD, Conant EF, Winham SJ, Kerlikowske K, Kontos D, Vachon CM. Evaluation of LIBRA Software for Fully Automated Mammographic Density Assessment in Breast Cancer Risk Prediction. Radiology. 2020 Jul; 296(1):24-31.
    View on PubMed
  7. Sprague BL, Miglioretti DL, Lee CI, Perry H, Tosteson AAN, Kerlikowske K. New mammography screening performance metrics based on the entire screening episode. Cancer. 2020 Jul 15; 126(14):3289-3296.
    View on PubMed
  8. Henderson LM, O'Meara ES, Haas JS, Lee CI, Kerlikowske K, Sprague BL, Alford-Teaster J, Onega T. The Role of Social Determinants of Health in Self-Reported Access to Health Care Among Women Undergoing Screening Mammography. J Womens Health (Larchmt). 2020 May 05.
    View on PubMed
  9. Sprague BL, Coley RY, Kerlikowske K, Rauscher GH, Henderson LM, Onega T, Lee CI, Herschorn SD, Tosteson ANA, Miglioretti DL. Assessment of Radiologist Performance in Breast Cancer Screening Using Digital Breast Tomosynthesis vs Digital Mammography. JAMA Netw Open. 2020 Mar 02; 3(3):e201759.
    View on PubMed
  10. Shieh Y, Ziv E, Kerlikowske K. Interval breast cancers - insights into a complex phenotype. Nat Rev Clin Oncol. 2020 03; 17(3):138-139.
    View on PubMed
  11. Buist DSM, Ichikawa L, Wernli KJ, Lee CI, Henderson LM, Kerlikowske K, Bowles EJA, Miglioretti DL, Specht J, Rauscher GH, Sprague BL, Onega T, Lee JM. Facility Variability in Examination Indication Among Women With Prior Breast Cancer: Implications and the Need for Standardization. J Am Coll Radiol. 2020 Jun; 17(6):755-764.
    View on PubMed
  12. Schifferdecker KE, Tosteson ANA, Kaplan C, Kerlikowske K, Buist DSM, Henderson LM, Johnson D, Jaworski J, Jackson-Nefertiti G, Ehrlich K, Marsh MW, Vu L, Onega T, Wernli KJ. Knowledge and Perception of Breast Density, Screening Mammography, and Supplemental Screening: in Search of "Informed". J Gen Intern Med. 2020 Jun; 35(6):1654-1660.
    View on PubMed
  13. Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska C, Ma L, Wu FF, Cummings SR, Norman AD, Engmann NJ, Shepherd JA, Winham SJ, Kerlikowske K, Vachon CM. Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer. Breast Cancer Res. 2019 10 28; 21(1):118.
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  14. Henderson LM, Ichikawa L, Buist DSM, Lee JM, Bush M, Johnson D, Onega T, Nekhlyudov L, Kerlikowske K, Miglioretti DL, Sprague BL, Wernli KJ. Patterns of Breast Imaging Use Among Women with a Personal History of Breast Cancer. J Gen Intern Med. 2019 10; 34(10):2098-2106.
    View on PubMed
  15. Lee JM, Smith R, Kerlikowske K. Benefits of Supplemental Ultrasonography With Mammography-Reply. JAMA Intern Med. 2019 08 01; 179(8):1150-1151.
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  16. Kerlikowske K, Miglioretti DL, Vachon CM. Discussions of Dense Breasts, Breast Cancer Risk, and Screening Choices in 2019. JAMA. 2019 Jul 02; 322(1):69-70.
    View on PubMed
  17. Kerlikowske K, Sprague BL, Tosteson ANA, Wernli KJ, Rauscher GH, Johnson D, Buist DSM, Onega T, Henderson LM, O'Meara ES, Miglioretti DL. Strategies to Identify Women at High Risk of Advanced Breast Cancer During Routine Screening for Discussion of Supplemental Imaging. JAMA Intern Med. 2019 Jul 01.
    View on PubMed
  18. Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe B, Lee V, Kerlikowske K, Shepherd J. Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study. Cancer Imaging. 2019 Jun 22; 19(1):41.
    View on PubMed
  19. Engmann NJ, Scott C, Jensen MR, Winham SJ, Ma L, Brandt KR, Mahmoudzadeh A, Whaley DH, Hruska CB, Wu FF, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM. Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition. Cancer Epidemiol Biomarkers Prev. 2019 08; 28(8):1324-1330.
    View on PubMed
  20. Wernli KJ, Ichikawa L, Kerlikowske K, Buist DSM, Brandzel SD, Bush M, Johnson D, Henderson LM, Nekhlyudov L, Onega T, Sprague BL, Lee JM, Lehman CD, Miglioretti DL. Surveillance Breast MRI and Mammography: Comparison in Women with a Personal History of Breast Cancer. Radiology. 2019 08; 292(2):311-318.
    View on PubMed

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