University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mi-Ok Kim, PhD

Mi-Ok Kim, PhD

Director, Biostatistics Core, UCSF Helen Diller Family Comprehensive Cancer Center
Professor in Residence, Dept. of Epidemiology & Biostatistics, UCSF

Cancer Center Program Memberships

Cancer Control

Research Summary

Dr. Mi-Ok Kim has joined the HDFCCC as Director of the Biostatistics Core. The Core is responsible for providing support for protocol development, review and analysis for clinical studies, and statistical expertise for research collaborations with Cancer Center investigators in all disciplines across the spectrum of basic, clinical and population sciences. Dr. Kim will lead the Core and work directly with Cancer Center leadership on developing and implementing a strategic and integrated shared resource plan.

Dr. Kim joins us from Cincinnati Children’s Hospital Medical Center in Cincinnati, OH, where she directed the Biostatistics Unit for the Cancer and Blood Diseases Institute. Notable collaborations included Children's Tumor Foundation’s Neurofibromatosis (NF) Therapeutic Consortium that builds up a preclinical pipeline for screening candidate drug therapies in animal model systems. Dr. Kim also developed a research program in novel clinical trial designs that incorporate biomarker information and aim to optimize patient benefits. With the expertise in the trial design she served on the faculty for the American Association for Cancer Research (AACR) sponsored 2015 Methods in Cancer Biostatistics Workshop.

Dr. Kim will also join the Department of Epidemiology and Biostatistics as Professor of Biostatistics, continuing academic contributions to the field of biostatistics and providing biostatistical support broadly on campus. Trained as a mathematical statistician, Dr. Kim is an independent statistical method researcher with research interest in non- and semi-parametric statistics, and longitudinal and survival data analysis. She has been supported by NIH and National Science Foundation (NSF) awards, and published in prestigious journals such as the Annals of Statistics and the Journal of the American Statistical Association. Her recent research focuses on causal inference using structured data for comparative effectiveness research (CER) and patient-centered outcome research (PCOR). Registries, network databases and Electronic Health Record (EHR) often impose a hierarchical structure where subjects or patients are clustered, for example, by geographical area of residence, health care provider or health plan. The data structure is often associated with unmeasured characteristics of individuals or health care providers. Supported by the Patient-Centered Outcome Research Institute (PCORI), Dr. Kim and her research team study optimal handling of the complex data structure both in the treatment selection decision process and the outcome analysis in order to minimize bias and maximize efficiency of the causal inference. Application studies of the project include pediatric Crohn’s disease (CD) and kidney transplant study.

Education

MS: Statistics, University of Illinois, Urbana-Champaign, IL, 2000
PhD: Statistics, University of Illinois, Urbana-Champaign, IL, 2003


Professional Experience

  • 2003 - 2006
    University of Kentucky, Assistant Professor, Department of Statistics and Biostatistics
  • 2006 - 2010
    University of Cincinnati College of Medicine Assistant Professor of Pediatrics Department of Pediatrics/ Division of Biostatistics and Epidemiology
  • 2008 - 2010
    University of Cincinnati, Assistant Professor (Affiliated), Department of Mathematical Sciences
  • 2010 - 2016
    University of Cincinnati College of Medicine Associate Professor, Department of Pediatrics/ Division of Biostatistics and Epidemiology
  • 2010 - 2016
    University of Cincinnati, Associate Professor (Affiliated), Department of Mathematical Sciences
  • 2016 - present
    Director, Biostatistics Core, UCSF Helen Diller Family Comprehensive Cancer Center

Honors & Awards

  • 1997
    Fellowship,University of Illinois at Urbana-Champaign
  • 2001
    First Prize,Capital One Financial Data Challenge Competition2002
    Norton Prize, Robert Bohrer Workshop for Student Papers in Statistics, University of Illinois at Urbana-Champaign
  • 2004
    Junior Faculty Travel Award,International Conference on Robust Statistics (ICORS)
  • 2008
    Travel Award, American Association for Cancer Research (AACR) Cancer Biostatistics Workshop

Selected Publications

  1. Kim MO, Harun N, Liu C, Khoury JC, Broderick JP. Bayesian selective response-adaptive design using the historical control. Stat Med. 2018 Jun 13.
    View on PubMed
  2. Chandradevan R, Hofmekler T, Mondal K, Harun N, Venkateswaran S, Somineni HK, Ballengee CR, Kim MO, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Walters TD, Bertha M, Dubinsky MC, Denson LA, Sauer CG, Markowitz JF, LeLeiko NS, Hyams JS, Kugathasan S. Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles. Inflamm Bowel Dis. 2018 May 30.
    View on PubMed
  3. Wright SS, Trauernicht A, Bonkowski E, McCall CA, Maier EA, Bezold R, Lake K, Chalk C, Trapnell BC, Kim MO, Kugathasan S, Denson LA. Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2018 May; 66(5):767-772.
    View on PubMed
  4. Kim MO, Zhou M. Size and Shape of Confidence Regions from Extended Empirical Likelihood Tests. Statistica Sinica. 2018; in press.
    View on PubMed
  5. Marigorta UM, Denson LA, Hyams JS, Mondal K, Prince J, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, Kellermayer R, Heyman MB, Baker SS, Stephens MC, Baldassano RN, Markowitz JF, Kim MO, Dubinsky MC, Cho J, Aronow BJ, Kugathasan S, Gibson G. Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease. Nat Genet. 2017 Oct; 49(10):1517-1521.
    View on PubMed
  6. Chien AJ, Chambers J, Mcauley F, Kaplan T, Letourneau J, Hwang J, Kim MO, Melisko ME, Rugo HS, Esserman LJ, Rosen MP. Erratum to: Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy. Breast Cancer Res Treat. 2017 08; 165(1):161.
    View on PubMed
  7. Nehus EJ, Liu C, Lu B, Macaluso M, Kim MO. Graft survival of pediatric kidney transplant recipients selected for de novo steroid avoidance-a propensity score-matched study. Nephrol Dial Transplant. 2017 Aug 01; 32(8):1424-1431.
    View on PubMed
  8. Chien AJ, Chambers J, Mcauley F, Kaplan T, Letourneau J, Hwang J, Kim MO, Melisko ME, Rugo HS, Esserman LJ, Rosen MP. Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy. Breast Cancer Res Treat. 2017 Aug; 165(1):151-159.
    View on PubMed
  9. Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet. 2017 04 29; 389(10080):1710-1718.
    View on PubMed
  10. Cho H, Kim S, Kim MO. Multiple quantile regression analysis of longitudinal data: Heteroscedasticity and efficient estimation. Journal of Multivariate Analysis. 2017; 155:334-343.
    View on PubMed
  11. Müller LU, Milsom MD, Kim MO, Schambach A, Schuesler T, Williams DA. Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca-/- Hematopoietic Stem Cells. Mol Ther. 2008 Jun; 16(6):1154-1160.
    View on PubMed
  12. Dorris K, Liu C, Li D, Hummel TR, Wang X, Perentesis J, Kim MO, Fouladi M. A comparison of safety and efficacy of cytotoxic versus molecularly targeted drugs in pediatric phase I solid tumor oncology trials. Pediatr Blood Cancer. 2017 03; 64(3).
    View on PubMed
  13. Ciricillo J, Haslam D, Blum S, Kim MO, Liu C, Paulsen G, Courter J, Danziger-Isakov L. Frequency and risks associated with Clostridium difficile-associated diarrhea after pediatric solid organ transplantation: a single-center retrospective review. Transpl Infect Dis. 2016 Oct; 18(5):706-713.
    View on PubMed
  14. Kim MO, Wang X, Liu C, Dorris K, Fouladi M, Song S. Random-effects meta-analysis for systematic reviews of phase I clinical trials: Rare events and missing data. Res Synth Methods. 2017 Jun; 8(2):124-135.
    View on PubMed
  15. Minar P, Saeed SA, Afreen M, Kim MO, Denson LA. Practical Use of Infliximab Concentration Monitoring in Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. 2016 05; 62(5):715-22.
    View on PubMed
  16. Cho H, Hong HG, Kim MO. Efficient quantile marginal regression for longitudinal data with dropouts. Biostatistics. 2016 Jul; 17(3):561-75.
    View on PubMed
  17. Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Rep. 2016 Mar 01; 14(8):1979-90.
    View on PubMed
  18. Kang J, Chan W, Kim MO, Steiner PM. Practice of Causal Inference with the Propensity of Being Zero or One: Assessing the Effect of Arbitrary Cutoffs of Propensity Scores. Communications for Statistical Applications and Methods. 2016; 23:1-20.
    View on PubMed
  19. Jousma E, Rizvi TA, Wu J, Janhofer D, Dombi E, Dunn RS, Kim MO, Masters AR, Jones DR, Cripe TP, Ratner N. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatr Blood Cancer. 2015 Oct; 62(10):1709-16.
    View on PubMed
  20. Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2015 Mar 02; 125(3):1363.
    View on PubMed

Go to UCSF Profiles, powered by CTSI