University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sarah Knox, PhD

Sarah Knox, PhD

Assistant Professor, Dept. of Cell and Tissue Biology, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Education

University of New South Wales, Sydney, Australia, Ph.D., 4/2002, Biomedical Engineering
University of New South Wales, Sydney, Australia, B.S (Hon), 4/1998, Biochemistry


Professional Experience

  • 2002
    Post-Doctoral Associate, Molecular, Cell and Developmental Biology, Feb 2002-May 2003, Mount Sinai School of Medicine, New York, NY
  • 2003
    Post-Doctoral Associate, Genetics, Cell Biology and Development, July 2003-July 2005, University of Minnesota, MN
  • 2005
    Post-Doctoral Fellow, Graduate School of Biomedical Engineering, August 2005-May 2006, University of NSW, Sydney, Australia
  • 2006
    Senior Postdoctoral Visiting Fellow, Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology. NIDCR, NIH
  • 2012
    Assistant Professor, Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA

Honors & Awards

  • 1998
    Pacific Dunlop Postgraduate Scholarship
  • 1998
    Australian Postgraduate Award (APA)
  • 2005
    Australian Post-Doctoral Industrial Fellowship (APDI)
  • 2005
    UNSW Faculty of Engineering Research Grant
  • 2008
    NIH Pathway to Independence Award (K99/R00)
  • 2008
    Pathway to Independence Award (K99/R00)

Selected Publications

  1. Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A. 2018 May 24.
    View on PubMed
  2. Emmerson E, Knox SM. Salivary gland stem cells: A review of development, regeneration and cancer. Genesis. 2018 Apr 16; e23211.
    View on PubMed
  3. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 Jan 15.
    View on PubMed
  4. Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome. PLoS One. 2017; 12(9):e0184916.
    View on PubMed
  5. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. SOX2 regulates acinar cell development in the salivary gland. Elife. 2017 06 17; 6.
    View on PubMed
  6. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 Jun 14; 7(1):3484.
    View on PubMed
  7. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528.
    View on PubMed
  8. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 07 01; 427(1):12-20.
    View on PubMed
  9. Mattingly A, Finley JK, Knox SM. Salivary gland development and disease. Wiley Interdiscip Rev Dev Biol. 2015 Nov-Dec; 4(6):573-90.
    View on PubMed
  10. Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP. Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell. 2015 Mar 23; 32(6):667-77.
    View on PubMed
  11. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM. Manipulating the murine lacrimal gland. J Vis Exp. 2014 Nov 18; (93):e51970.
    View on PubMed
  12. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62.
    View on PubMed
  13. Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013; 4:1494.
    View on PubMed
  14. Knosp WM, Knox SM, Hoffman MP. Salivary gland organogenesis. Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb; 1(1):69-82.
    View on PubMed
  15. Chuang CY, Lord MS, Melrose J, Rees MD, Knox SM, Freeman C, Iozzo RV, Whitelock JM. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry. 2010 Jul 06; 49(26):5524-32.
    View on PubMed
  16. Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007 Dec; 134(23):4177-86.
    View on PubMed
  17. Knox S, Ge H, Dimitroff BD, Ren Y, Howe KA, Arsham AM, Easterday MC, Neufeld TP, O'Connor MB, Selleck SB. Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One. 2007 Apr 18; 2(4):e375.
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  18. Melrose J, Roughley P, Knox S, Smith S, Lord M, Whitelock J. The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages. J Biol Chem. 2006 Dec 01; 281(48):36905-14.
    View on PubMed
  19. Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB. The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. 2006 Dec 15; 300(2):570-82.
    View on PubMed
  20. Di Giusto DA, Knox SM, Lai Y, Tyrelle GD, Aung MT, King GC. Multitasking by multivalent circular DNA aptamers. Chembiochem. 2006 Mar; 7(3):535-44.
    View on PubMed

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