Scott C. Kogan, MD

Professor, Department of Laboratory Medicine, UCSF
Co-Director, Mouse Pathology Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center

scott.kogan@ucsf.edu

Phone: (415) 514-1590 (voice)
Box 0100, UCSF
San Francisco, CA 94143-0100

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Education

Harvard College, Cambridge, MA, A.B., 1986, Biochemical Sciences
University of California San Francisco, M.D., 1991, Medicine
Laboratory Medicine Residency, UCSF, 1991-1993, Laboratory Medicine
Hematopathology Fellowship, UCSF, 1997-1998, Hematopathology

Professional Experience

• 1984-1985
  Laboratory of Dr. David Calhoun, Mount Sinai Medical Center, New York City, NY.
• 1985-1986
  Laboratory of Dr. Leonard Guarente, Massachusetts Institute of Technology, Cambridge, MA.
• 1986-1991
  Laboratory of Dr. Jane Gitschier, Howard Hughes Medical Institute of California, UCSF
• 1991-1992
  Resident, Department of Laboratory Medicine, UCSF
• 1992-1993
  Chief Resident, Department of Laboratory Medicine, UCSF
• 1993-1997
  Laboratory of Dr. J. Michael Bishop, G.W. Hooper Foundation, UCSF
• 1997-1998
  Hematopathology Fellow, Department of Laboratory Medicine, UCSF
• 1998-2003
  Assistant Professor In-Residence, Department of Laboratory Medicine, UCSF
• 2003-2008
  Associate Professor In-Residence, Department of Laboratory Medicine, UCSF
• 2008-present
  Professor, Department of Laboratory Medicine, UCSF
• 2000-2004
  Chair, Hematopathology Subcommittee, Mouse Models of Human Cancer Consortium, NCI
• 2001-present
  Co-director, Mouse Pathology Shared Resource, UCSF Comprehensive Cancer Center
• 2004-2007
  Member Scientific Committee Clinical Laboratory Hematology, American Society of Hematology
• 2008-2009
  Chair Scientific Committee Hematopathology & Clinical Laboratory Hematology, ASH

Honors & Awards

• 1986
  Summa Cum Laude, Phi Beta Kappa
• 1986
  Joseph L. Barrett Award for Teaching, Harvard University
• 1993
  National Committee for Clinical Laboratory Standards, Honored Graduate Award
• 1993
  UCSF Molecular Medicine Training Program
• 1993
  American Cancer Society Physician Research Training Award
• 1994
  Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians
• 1997
  Burroughs Wellcome Fund Career Award
• 2000
  32nd Edward Mallinckrodt Jr. Scholar Award
• 2001
  Medical Student Teaching Award, Excellence for Small Group Instruction
• 2002
  Department of Laboratory Medicine Resident Teaching Award
• 2004
  Leukemia & Lymphoma Society Scholar Award
• 2007
  Mentor Award, UCSF Department of Pediatrics

Selected Publications

1. Arteaga MF, Mikesch JH, Qiu J, Christensen J, Helin K, Kogan SC, Dong S, So CW. The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia. Cancer Cell. 2013 Mar 18; 23(3):376-89.
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2. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan 2; 123(1):335-9.
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3. Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC. PML-RARa co-operates with Sox4 in acute myeloid leukemia development in mice. Haematologica. 2013 Mar; 98(3):424-7.
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4. Bagley BN, Keane TM, Maklakova VI, Marshall JG, Lester RA, Cancel MM, Paulsen AR, Bendzick LE, Been RA, Kogan SC, Cormier RT, Kendziorski C, Adams DJ, Collier LS. A dominantly acting murine allele of mcm4 causes chromosomal abnormalities and promotes tumorigenesis. PLoS Genet. 2012 Nov; 8(11):e1003034.
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5. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34.
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6. Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA. An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 2012 May 10; 119(19):4512-23.
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7. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW. Control of the senescence-associated secretory phenotype by NF-?B promotes senescence and enhances chemosensitivity. Genes Dev. 2011 Oct 15; 25(20):2125-36.
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8. Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ. PML-RARa enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy. 2011 Oct; 7(10):1132-44.
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9. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90.
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10. Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011 Oct 27; 478(7370):524-8.
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11. Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 2011 Aug 1; 25(15):1628-40.
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12. Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. 2011 Apr 1; 145(1):145-58.
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13. Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP. Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model. Genes Cancer. 2011 Feb; 2(2):160-5.
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14. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1; 71(1):106-15.
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15. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32.
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16. Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med. 2010 Nov 22; 207(12):2581-94.
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17. Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010 Nov 1; 70(21):8792-801.
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18. Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev. 2010 Jul 1; 24(13):1389-402.
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19. Kogan SC. Medicine. Poisonous contacts. Science. 2010 Apr 9; 328(5975):184-5.
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20. Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 2010 Jun 3; 115(22):4524-32.
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