Thomas Kornberg, PhD

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Additional Websites

• Lab Website

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Education

Juilliard School of Music
Columbia College, B.A., 1970, Biology
Columbia University, Ph.D., 1973, Biochemistry
Princeton University, postdoctoral, 1973-1975, Biochemistry
Cambridge MRC Laboratory of Molecular Biology, postdoctoral, 1975-1976, Developmental Genetics

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Professional Experience

• 1976-1977
  Assistant Professor, Molecular Biology Institute and Department of Chemistry, University of California, Los Angeles
• 1986-present
  Assistant Professor, Associate Professor, Professor, Department of Biochemistry and Biophysics, University of California San Francisco

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Honors & Awards

• 1978
  American Cancer Society Career Development Award
• 2001
  Member, American Academy of Arts and Sciences

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Selected Publications

1. Ali-Murthy Z, Lott SE, Eisen MB, Kornberg TB. An essential role for zygotic expression in the pre-cellular Drosophila embryo. PLoS Genet. 2013 Apr; 9(4):e1003428.
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2. Kornberg TB. The imperatives of context and contour for morphogen dispersion. Biophys J. 2012 Dec 5; 103(11):2252-6.
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3. Casso DJ, Liu S, Biehs B, Kornberg TB. Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. PLoS One. 2012; 7(3):e33827.
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4. Roy S, Kornberg TB. Direct delivery mechanisms of morphogen dispersion. Sci Signal. 2011; 4(200):pt8.
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5. Kornberg TB. Barcoding Hedgehog for intracellular transport. Sci Signal. 2011; 4(200):pe44.
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6. Roy S, Hsiung F, Kornberg TB. Specificity of Drosophila cytonemes for distinct signaling pathways. Science. 2011 Apr 15; 332(6027):354-8.
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7. Casso DJ, Biehs B, Kornberg TB. A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics. 2011 Feb; 187(2):485-99.
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8. Biehs B, Kechris K, Liu S, Kornberg TB. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010 Nov; 137(22):3887-98.
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9. Kechris KJ, Biehs B, Kornberg TB. Generalizing moving averages for tiling arrays using combined p-value statistics. Stat Appl Genet Mol Biol. 2010; 9(1):Article29.
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10. Baig J, Chanut F, Kornberg TB, Klebes A. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics. 2010 Mar; 184(3):731-44.
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11. Guha A, Lin L, Kornberg TB. Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol. 2009 Nov 15; 335(2):317-26.
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12. Kawamura S, Hervold K, Ramirez-Weber FA, Kornberg TB. Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem. 2008 Nov 7; 283(45):30964-9.
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13. Guha A, Lin L, Kornberg TB. Organ renewal and cell divisions by differentiated cells in Drosophila. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10832-6.
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14. Casso DJ, Liu S, Iwaki DD, Ogden SK, Kornberg TB. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008 Mar; 178(3):1399-413.
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15. Klebes A, Kornberg TB. Linear RNA amplification for the production of microarray hybridization probes. Methods Mol Biol. 2008; 420:303-17.
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16. Kornberg TB, Guha A. Understanding morphogen gradients: a problem of dispersion and containment. Curr Opin Genet Dev. 2007 Aug; 17(4):264-71.
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17. Lu X, Liu S, Kornberg TB. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 2006 Sep 15; 20(18):2539-51.
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18. Ogden SK, Casso DJ, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem. 2006 Mar 17; 281(11):7237-43.
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19. Guha A, Kornberg TB. Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev Biol. 2005 Nov 1; 287(1):192-200.
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20. Hsiung F, Ramirez-Weber FA, Iwaki DD, Kornberg TB. Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature. 2005 Sep 22; 437(7058):560-3.
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