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Thomas Kornberg, PhD


Professor, Department of Biochemistry and Biophysics, UCSF


Phone: (415) 476-8821 (voice)
Box 2711, UCSF
San Francisco, CA 94143-2711

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Additional Websites


Juilliard School of Music
Columbia College, B.A., 1970, Biology
Columbia University, Ph.D., 1973, Biochemistry
Princeton University, postdoctoral, 1973-1975, Biochemistry
Cambridge MRC Laboratory of Molecular Biology, postdoctoral, 1975-1976, Developmental Genetics

Professional Experience

  • 1976-1977
    Assistant Professor, Molecular Biology Institute and Department of Chemistry, University of California, Los Angeles
  • 1986-present
    Assistant Professor, Associate Professor, Professor, Department of Biochemistry and Biophysics, University of California San Francisco

Honors & Awards

  • 1978
    American Cancer Society Career Development Award
  • 2001
    Member, American Academy of Arts and Sciences

Selected Publications

  1. Ibrahim DM, Biehs B, Kornberg TB, Klebes A. Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes. G3 (Bethesda). 2013 Aug; 3(8):1353-62.
    View on PubMed
  2. Kornberg TB. Cytonemes extend their reach. EMBO J. 2013 Jun 12; 32(12):1658-9.
    View on PubMed
  3. Ali-Murthy Z, Lott SE, Eisen MB, Kornberg TB. An essential role for zygotic expression in the pre-cellular Drosophila embryo. PLoS Genet. 2013 Apr; 9(4):e1003428.
    View on PubMed
  4. Kornberg TB. The imperatives of context and contour for morphogen dispersion. Biophys J. 2012 Dec 5; 103(11):2252-6.
    View on PubMed
  5. Casso DJ, Liu S, Biehs B, Kornberg TB. Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. PLoS One. 2012; 7(3):e33827.
    View on PubMed
  6. Roy S, Kornberg TB. Direct delivery mechanisms of morphogen dispersion. Sci Signal. 2011; 4(200):pt8.
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  7. Kornberg TB. Barcoding Hedgehog for intracellular transport. Sci Signal. 2011; 4(200):pe44.
    View on PubMed
  8. Roy S, Hsiung F, Kornberg TB. Specificity of Drosophila cytonemes for distinct signaling pathways. Science. 2011 Apr 15; 332(6027):354-8.
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  9. Casso DJ, Biehs B, Kornberg TB. A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics. 2011 Feb; 187(2):485-99.
    View on PubMed
  10. Biehs B, Kechris K, Liu S, Kornberg TB. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010 Nov; 137(22):3887-98.
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  11. Kechris KJ, Biehs B, Kornberg TB. Generalizing moving averages for tiling arrays using combined p-value statistics. Stat Appl Genet Mol Biol. 2010; 9:Article29.
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  12. Baig J, Chanut F, Kornberg TB, Klebes A. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics. 2010 Mar; 184(3):731-44.
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  13. Guha A, Lin L, Kornberg TB. Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. Dev Biol. 2009 Nov 15; 335(2):317-26.
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  14. Kawamura S, Hervold K, Ramirez-Weber FA, Kornberg TB. Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem. 2008 Nov 7; 283(45):30964-9.
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  15. Guha A, Lin L, Kornberg TB. Organ renewal and cell divisions by differentiated cells in Drosophila. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10832-6.
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  16. Casso DJ, Liu S, Iwaki DD, Ogden SK, Kornberg TB. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008 Mar; 178(3):1399-413.
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  17. Klebes A, Kornberg TB. Linear RNA amplification for the production of microarray hybridization probes. Methods Mol Biol. 2008; 420:303-17.
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  18. Kornberg TB, Guha A. Understanding morphogen gradients: a problem of dispersion and containment. Curr Opin Genet Dev. 2007 Aug; 17(4):264-71.
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  19. Lu X, Liu S, Kornberg TB. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 2006 Sep 15; 20(18):2539-51.
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  20. Ogden SK, Casso DJ, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem. 2006 Mar 17; 281(11):7237-43.
    View on PubMed

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