University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Nevan J. Krogan, PhD

Nevan J. Krogan, PhD

Professor, Department of Cellular and Molecular Pharmacology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.

Education

University of Regina, Canada, BS, 1997, Chemistry
University of Regina, Canada, MSc, 1999, Biochemistry
University of Toronto, Canada, PhD, 2005, Medical Genetics


Professional Experience

  • 2006-2007
    Sandler Fellow, Dept. of Cellular and Molecular Pharmacology/QB3, UCSF
  • 2007-2009
    Assistant Professor, Dept. of Cellular & Molecular Pharmacology/QB3, UCSF
  • 2009-2012
    Associate Professor, Department of Cellular and Molecular Pharmacology/QB3, UCSF
  • 2012-present
    Professor, Department of Cellular and Molecular Pharmacology/QB3, UCSF
  • 2013-present
    Director, California Institute for Quantitative Biosciences, UCSF/QB3@UCSF
  • 2015-present
    Co-Director, Cancer Cell Mapping Initiative, UCSF/UCSD

Honors & Awards

  • 1995-1996
    Canadian Cancer Society Award
  • 1997
    Society of Chemical Industry Merit Award
  • 1999-2001
    Natural Sciences and Engineering Research Council (NSERC) PGS-B Award
  • 2001-2004
    Canadian Institute of Health Research (CIHR) Doctoral Fellowship
  • 2004
    Hannah Farkas-Himsley and Alexander Memorial Award
  • 2005
    L. W. Macpherson Microbiology Award
  • 2008
    Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006
  • 2009-2012
    Searle Scholar, Searle Foundation
  • 2009-2014
    Keck Distinguished Young Scholar, W. M. Keck Foundation
  • 2012
    Alumni Crowning Achievement Award, University of Regina
  • 2014
    “40 under 40”, Cell

Selected Publications

  1. Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 2018 May 30; 7.
    View on PubMed
  2. Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML. Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep. 2018 May 14; 8(1):7782.
    View on PubMed
  3. Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G. The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. Mol Cell. 2018 Mar 22.
    View on PubMed
  4. Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L. SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. J Neurosci. 2018 Apr 11; 38(15):3680-3688.
    View on PubMed
  5. Masand R, Paulo E, Wu D, Wang Y, Swaney DL, Jimenez-Morales D, Krogan NJ, Wang B. Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018 Mar 06; 27(3):616-629.e4.
    View on PubMed
  6. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 Feb 14; 14(3):206-214.
    View on PubMed
  7. Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018 May 01; 78(9):2383-2395.
    View on PubMed
  8. Roguev A, Xu J, Krogan N. Genetic Interaction Mapping in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a ROTOR HDA Colony Replicating Robot in a 1536 Array Format. Cold Spring Harb Protoc. 2018 Feb 01; 2018(2):pdb.prot091975.
    View on PubMed
  9. Roguev A, Ryan CJ, Xu J, Colson I, Hartsuiker E, Krogan N. Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast. Cold Spring Harb Protoc. 2018 Feb 01; 2018(2):pdb.prot091983.
    View on PubMed
  10. Roguev A, Ryan CJ, Hartsuiker E, Krogan NJ. High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2018 Feb 01; 2018(2):pdb.top079905.
    View on PubMed
  11. Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML. SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep. 2018 Feb 01; 8(1):2092.
    View on PubMed
  12. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 Jan; 14(1):e1006830.
    View on PubMed
  13. Roguev A, Xu J, Krogan NJ. DNA Preparation from Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2018 Jan 02; 2018(1):pdb.prot091959.
    View on PubMed
  14. Roguev A, Xu J, Krogan NJ. Transformation of Schizosaccharomyces pombe in a 96-Well Format. Cold Spring Harb Protoc. 2018 Jan 02; 2018(1):pdb.prot091942.
    View on PubMed
  15. Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11.
    View on PubMed
  16. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 Jan 02; 215(1):51-62.
    View on PubMed
  17. Rujano MA, Cannata Serio M, Panasyuk G, Péanne R, Reunert J, Rymen D, Hauser V, Park JH, Freisinger P, Souche E, Guida MC, Maier EM, Wada Y, Jäger S, Krogan NJ, Kretz O, Nobre S, Garcia P, Quelhas D, Bird TD, Raskind WH, Schwake M, Duvet S, Foulquier F, Matthijs G, Marquardt T, Simons M. Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects. J Exp Med. 2017 Dec 04; 214(12):3707-3729.
    View on PubMed
  18. Espinosa-Cantú A, Ascencio D, Herrera-Basurto S, Xu J, Roguev A, Krogan NJ, DeLuna A. Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Genetics. 2018 Jan; 208(1):419-431.
    View on PubMed
  19. Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R. The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017 09 15; 91(18).
    View on PubMed
  20. Shiver AL, Osadnik H, Kritikos G, Li B, Krogan N, Typas A, Gross CA. Correction: A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S. PLoS Genet. 2017 Jul; 13(7):e1006902.
    View on PubMed

Go to UCSF Profiles, powered by CTSI