Research Summary

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.

Research Funding

  • September 15, 2022 - August 31, 2027 - The Cancer Cell Map Initiative v2.0 , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: 1U54CA274502
  • July 15, 2022 - April 30, 2027 - HARC: HIV accessory and regulatory complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54AI170792
  • August 1, 2021 - May 31, 2026 - Host Pathogen Variation & TB Pathogenesis , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI162583
  • September 1, 2022 - August 31, 2025 - Building an Interpretable Genomic Translator Using Maps of Cell Architecture , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: OT2OD032742
  • May 16, 2022 - April 30, 2025 - QCRG Pandemic Response Program , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI171110
  • April 22, 2020 - March 31, 2025 - Childhood ?Omics? and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152161
  • September 1, 2019 - August 31, 2024 - Combinatorial Regulation of Gene Networks During Cardiac Development and Disease , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL146366
  • September 15, 2019 - March 31, 2024 - Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RF1AG059751
  • March 1, 2019 - February 29, 2024 - Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI143292
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • January 20, 2018 - December 31, 2022 - Fluomics: The Next Generation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135972
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50GM082250
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50AI150476
  • August 17, 2018 - July 31, 2022 - HPMI: Host Pathogen Mapping Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135990
  • May 11, 2017 - April 30, 2022 - Research Center for Cancer Systems Biology: Cancer Cell Map Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA209891
  • February 15, 2019 - January 31, 2022 - CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA235303
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2004 - June 30, 2021 - Intracellular pathogens and innate immunity , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI063302
  • August 1, 2015 - January 31, 2021 - Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI120694
  • December 1, 2015 - November 30, 2020 - Decoding the Chlamydia inclusion membrane protein-host protein interactome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI122747
  • June 24, 2015 - May 31, 2020 - Dengue Human Immunology Project Consortium (DHIPC) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI118610
  • September 1, 2010 - July 31, 2019 - Exploring Design Principles of Cellular Control Circuits , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50GM081879
  • September 1, 2014 - June 30, 2019 - Physical and Genetic Interaction Landscape of the Tyrosine Kinome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM107671
  • August 1, 2008 - February 28, 2019 - Comparative Analysis of Genetic Interaction Networks , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084279
  • July 1, 2007 - July 31, 2018 - Transcriptional Networks During Cardiac Differentiation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL089707
  • June 26, 2013 - May 31, 2018 - Multiscale analysis of influenza host-pathogen interactions: Fluomics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI106754
  • December 15, 2015 - November 30, 2017 - Proteomics Analysis of Host-Pathogen Interactions in Histoplasma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122064
  • July 13, 2011 - June 30, 2016 - Protein homeostasis mechanisms underlying enterovirus replication and evolution , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091575
  • August 1, 2011 - May 31, 2016 - Integrating computation and genetics to quantify specificity in protein networks , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM098101
  • August 15, 2010 - July 31, 2015 - Global innate immune responses to HIV-1 infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI090935
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • June 1, 2008 - April 30, 2014 - Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084448
  • September 25, 2008 - July 31, 2012 - Global Genetic Interaction Profiling in Prokaryotes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM085697

Education

University of Regina, Canada, BS, 1997, Chemistry
University of Regina, Canada, MSc, 1999, Biochemistry
University of Toronto, Canada, PhD, 2005, Medical Genetics

Honors & Awards

  • 1995-1996
    Canadian Cancer Society Award
  • 1997
    Society of Chemical Industry Merit Award
  • 1999-2001
    Natural Sciences and Engineering Research Council (NSERC) PGS-B Award
  • 2001-2004
    Canadian Institute of Health Research (CIHR) Doctoral Fellowship
  • 2004
    Hannah Farkas-Himsley and Alexander Memorial Award
  • 2005
    L. W. Macpherson Microbiology Award
  • 2008
    Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006
  • 2009-2012
    Searle Scholar, Searle Foundation
  • 2009-2014
    Keck Distinguished Young Scholar, W. M. Keck Foundation
  • 2012
    Alumni Crowning Achievement Award, University of Regina
  • 2014
    "40 under 40," Cell

Selected Publications

  1. Akinsanya K, AlQuraishi M, Boija A, Chodera J, Cichonska A, Ghassemi M, Head M, Jin W, Kibbe WA, Krogan N, LeVine MV, Moult J, Stuart L, Tourassi G, Zou J, Barzilay R, Elemento O Redefining druggable targets with artificial intelligence.  View on PubMed
  2. Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Gordon M, Malpotra S, Cupic A, Kehrer T, Moen JM, Winters DM, Rojc A, Mena I, Aslam S, Martinez-Romero C, Conde Viñas I, Khalil Z, Farrugia K, Banerjee A, Tussia-Cohen D, Santos MD, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, Felipe CS, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi R, Ibáñez C, Juste J, Pache L, Taha TY, Jouvenet N, Verba KA, Fraser JS, Demeret C, Stroud RM, van Bakel H, Ott M, Hagai T, Polacco B, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication.  View on PubMed
  3. Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.  View on PubMed
  4. Wang S, Kovalski JR, Zapatero-Belinchón FJ, Bennett M, Kuzuoglu-Öztürk D, Li Q, Stevenson E, Liu J, Krogan NJ, Ott M, Swaney DL, Ruggero D, Lou K, Shokat KM Programmable translational inhibition by a molecular glue-oligonucleotide conjugate.  View on PubMed
  5. Vasudevan HN, Arang N, Sacconi Nunez M, Kennedy P, Payne E, Mohabeer S, Chien J, Wright A, Sale MJ, Krogan NJ, Forget A, McCormick F A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.  View on PubMed
  6. Meyerhöfer N, Krogan NJ, Polacco BJ, Blumenthal DB Inference of differential kinase interaction networks with KINference.  View on PubMed
  7. Olwal CO, Rathore U, Makanani S, Kaushal P, Ashley IA, Ummadi MR, Appiah V, Djomkam Zune AL, Blanc S, Winters D, Delgado Y, Muthoka K, Fabius JM, Eckhardt M, Kaake RM, Su M, Fregoso OI, Hultquist JF, Orang'o EO, Swaney DL, Kyei GB, Krogan NJ, Quashie PK, Bediako Y, Bouhaddou M Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways.  View on PubMed
  8. Baptista D, Gomez-Lucas L, Jänes J, Krogan NJ, Amorim MJ, Ivarsson Y, Beltrao P AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry.  View on PubMed
  9. Skinnider MA, Luck K, Mukhtar MS, Garrido-Rodriguez M, Saez-Rodriguez J, van Leeuwen J, Beltrao P, Carvunis AR, Taipale M, Emili A, Bulyk ML, Krogan NJ What is the current bottleneck in mapping molecular interaction networks?  View on PubMed
  10. Memisoglu G, Bohn S, Krogan NJ, Haber JE, Ruthenburg AJ The Mediator Kinase Module regulates cell cycle re-entry and transcriptional responses following DNA damage.  View on PubMed
  11. Walter Z, Li M, Molho M, Berish L, Isopi A, O'Mara M, Dittmar M, Nwaezeapu C, Richards A, McCullagh M, Krogan NJ, Cherry S, Johnson JR, Ramage H An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection.  View on PubMed
  12. Pessina P, Nevo M, Shi J, Kodali S, Casas E, Cui Y, Richards AL, Park EJ, Chen X, Levin-Ferreyra F, Stevenson E, Krogan NJ, Swaney DL, Ying Q, Chen Q, Brumbaugh J, Di Stefano B Selective RNA sequestration in biomolecular condensates directs cell fate transitions.  View on PubMed
  13. Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zaptero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Matsui Y, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz RJ, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS. Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy. Sci Adv. 2025 Apr 25; 11(17):eadt7836.  View on PubMed
  14. Sherry J, Pawar KI, Dolat L, Smith E, Chang IC, Pha K, Kaake R, Swaney DL, Herrera C, McMahon E, Bastidas RJ, Johnson JR, Valdivia RH, Krogan NJ, Elwell CA, Verba K, Engel JN. The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection. Cell Rep. 2025 Apr 22; 44(4):115509.  View on PubMed
  15. Taha TY, Ezzatpour S, Hayashi JM, Ye C, Zapatero-Belinchón FJ, Rosecrans JA, Kimmerly GR, Chen IP, Walcott K, Kurianowicz A, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Whittaker GR, Martinez-Sobrido L, Aguilar HC, Ott M Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.  View on PubMed
  16. Mei Y, Gosztyla ML, Tan X, Dozier LE, Wilkinson B, McKetney J, Lee J, Chen M, Tsai D, Kopalle H, Gritsenko MA, Hartel N, Graham NA, Flores I, Gilmore-Hall SK, Xu S, Marquez CA, Liu SN, Fong D, Chen J, Licon K, Hong D, Wright SN, Kreisberg JF, Nott A, Smith RD, Qian WJ, Swaney DL, Iakoucheva LM, Krogan NJ, Patrick GN, Zhou Y, Feng G, Coba MP, Yeo GW, Ideker T Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.  View on PubMed
  17. Krogsaeter EK, McKetney J, Valiente-Banuet L, Marquez A, Willis A, Cakir Z, Stevenson E, Jang GM, Rao A, Li E, Zhou A, Attili A, Chang TS, Kampmann M, Huang Y, Krogan NJ, Swaney DL. Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. bioRxiv. 2025 Mar 04.  View on PubMed
  18. Serrano LR, Pelin A, Arrey TN, Damoc NE, Richards AL, Zhou Y, Lancaster NM, Peters-Clarke TM, Pashkova A, Jang GM, Eckhardt M, Quarmby ST, Zeller M, Hermanson D, Stewart H, Hock C, Makarov A, Zabrouskov V, Krogan NJ, Coon JJ, Swaney DL. Affinity Purification Mass Spectrometry on the Orbitrap-Astral Mass Spectrometer Enables High-Throughput Protein-Protein Interaction Mapping. J Proteome Res. 2025 Mar 02.  View on PubMed
  19. San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS. Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response. bioRxiv. 2025 Feb 17.  View on PubMed
  20. Turnham RE, Pitea A, Jang GM, Xu Z, Lim HC, Choi AL, Von Dollen J, Levin RS, Webber JT, McCarthy E, Hu J, Li X, Che L, Singh A, Yoon A, Chan GKL, Kelley RK, Swaney DL, Zhang W, Bandyopadhyay S, Theis FJ, Eckhardt M, Chen X, Shokat KM, Ideker T, Krogan NJ, Gordan JD. HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma. Cancer Res. 2025 Feb 17; 85(4):660-674.  View on PubMed

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