Matthew F. Krummel, PhD

Associate Professor, Department of Pathology, UCSF

matthew.krummel@ucsf.edu

Phone: (415) 514-3130 (voice)
Box 0511, UCSF
San Francisco, CA 94143-0511

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Additional Websites

• Lab Website

Education

University of Illinois at Champaign-Urbana, B.S.+B.S., 1985-1989, Biology and Chemistry
University of California at Berkeley, Ph.D., 1989-1995, Immunology
Walter and Eliza Hall Institute, Melbourne Aus., 1996-1997, Immunology
Stanford University, 1997-2001, Immunology

Professional Experience

• Summer 1987
  Summer Undergraduate Research Fellow. University of Texas Health Science Center at Dallas
• Summer 1988
  Stagiare (Technician) Institut Pasteur, Paris, Unite de Genie Micro-Biologique
• Aug 1989-May 1995
  Graduate Student, University of California at Berkeley, Department of Molecular and Cell Biology
• June 1995-May 1996
  Postdoctoral Fellow, University of California at Berkeley
• Aug 1996-Sept 1997
  Postdoctoral Fellow, Walter and Eliza Hall Institute of Medical Research, Melbourne Australia
• Nov 1997-August 2001
  Postdoctoral Fellow, Beckman Institute, Stanford University, Stanford, CA
• August 2001-2006
  Assistant Professor, Department of Pathology, University of California at San Francisco
• July 2006-present
  Associate Professor, Department of Pathology, University of California at San Francisco

Honors & Awards

• 1986
  University of Illinois: James Scholar
• 1996-1997
  Postdoctoral Fellowship, Juvenile Diabetes Foundation International
• 1997-2000
  NRSA Postdoctoral Fellowship, National Institutes of Health
• 2004-2007
  Investigator Award, Cancer Research Institute

Selected Publications

1. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol. 2013 Apr; 14(4):356-63.
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2. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin e. Immunity. 2013 Jan 24; 38(1):166-75.
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3. Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan; 251(1):80-96.
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4. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24.
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5. Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol. 2012 Aug; 13(8):787-95.
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6. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 4; 209(6):1183-99.
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7. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17.
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8. Gilden JK, Peck S, Chen YC, Krummel MF. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. 2012 Jan 9; 196(1):103-14.
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9. Khan O, Headley M, Gerard A, Wei W, Liu L, Krummel MF. Regulation of T cell priming by lymphoid stroma. PLoS One. 2011; 6(11):e26138.
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10. Krummel MF, Allison JP. Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465. J Immunol. 2011 Oct 1; 187(7):3459-65.
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11. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6.
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12. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22; 207(12):2733-49.
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13. Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18085-90.
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14. Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct; 11(10):953-61.
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15. Beemiller P, Krummel MF. Mediation of T-cell activation by actin meshworks. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002444.
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16. Gilden J, Krummel MF. Control of cortical rigidity by the cytoskeleton: emerging roles for septins. Cytoskeleton (Hoboken). 2010 Aug; 67(8):477-86.
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17. Krummel MF. Illuminating emergent activity in the immune system by real-time imaging. Nat Immunol. 2010 Jul; 11(7):554-7.
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18. Krummel MF, Cahalan MD. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72.
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19. Doh J, Kim M, Krummel MF. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials. 2010 Apr; 31(12):3422-8.
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20. Doh J, Krummel MF. Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol. 2010; 340:25-50.
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