University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Matthew Kutys, PhD

Matthew Kutys, PhD

Assistant Professor, Department of Cell and Tissue Biology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

The Kutys Lab spans disciplinary boundaries between cell biology and engineering to investigate tissue morphogenic processes associated with human development, regeneration and disease. Ultimately, we are interested in uncovering fundamental molecular and mechanical mechanisms that conspire across time and length scales to organize and shape human tissues. To do so, we develop microfluidic, biomimetic human tissue models that recapitulate 3D in vivo architectures, microenvironments, cellular heterogeneity, and morphogenic behaviors that can be examined mechanistically by biochemical and cell biological approaches. Combined with advanced microscopy, cellular and molecular engineering, and 'omic' technologies, our multidisciplinary approach allows us to model, control, and dissect complex multicellular behaviors at a level previously only accessible in vivo.

At the molecular level, we are experts in elucidating new mechanisms underlying adhesion biology, the interactions of cells with their neighbors and their microenvironment. We study how core adhesion molecules like cadherins and integrins integrate and orchestrate chemical and mechano-signaling to specify multicellular behavior, proper organization and differentiation of complex tissues, as well as facilitate the progression of disease.

At the cellular level, we develop and apply quantitative imaging and molecular tools (optogenetics, synthetic biology, microenvironment biomaterials/patterning) that allow us to measure, direct, and perturb cellular behaviors to understand how collective decisions initiate and propagate within tissues.

At the tissue level, we engineer organotypic 3D microfluidic models of human tissues with defined architectures and microenvironments in vitro that permit the simulation, molecular dissection, and quantitative analysis of in vivo-like morphogenic processes. We are working to combine these platforms with organoid systems, unbiased proteomics, and single-cell analyses to build spatio-temporal road maps of human development and disease.

Education

Pennsylvania State University, BS, 2009, Bioengineering
University of North Carolina Chapel Hill, PhD, 2014, Cell and Developmental Biology
Boston University, Postdoctoral Fellow, 2020, Biomedical Engineering


Professional Experience

  • 2006 – 2009
    Undergraduate Research Fellow, Molecular Biomechanics Laboratory, Department of Bioengineering. Pennsylvania State University
  • 2009
    Visiting Ph.D. Candidate, Department of Cell and Developmental Biology, University of North Carolina-Chapel Hill 
  • 2009 – 2014
    Graduate Fellow, Laboratory of Cell and Developmental Biology, National Institute for Dental and Craniofacial Research, National Institutes of Health
  • 2014 - 2019
    Postdoctoral Fellow, Tissue Microfabrication Laboratory, Biomedical Engineering, Boston University
  • 2016 – 2019
    Visiting Research Fellow, Wyss Institute for Biologically Inspired Engineering, Harvard University
  • 2020 – present
    Assistant Professor, Department of Cell and Tissue Biology, University of California San Francisco

Honors & Awards

  • 2005 - 2009
    Pennsylvania State University Dean's List
  • 2007 - 2008
    Biomaterials and Bionanotechnology Summer Institute (BBSI) Undergraduate Fellowship
  • 2007 - 2009
    Penn State Schreyer Honors Scholar
  • 2009
    Graduation with honors and high distinction in research, Penn State
  • 2010 - 2014
    National Institutes of Health Graduate Partnership Program (GPP) Fellowship
  • 2011 - present
    Faculty of 1000 Associate Faculty Member in Cell Adhesion
  • 2013
    National Institutes of Health Fellows Award for Research Excellence (FARE)
  • 2015 - 2016
    NIH T32 NRSA Fellowship in Translational Research in Regenerative Medicine
  • 2016 - 2018
    The Hartwell Foundation Postdoctoral Fellowship
  • 2018
    Boston University BME Wallace H. Coulter Translational Research Partnership Award
  • 2018 - present
    NIH K99/R00 Pathway to Independence Award (NCI, K99CA226366)

Selected Publications

  1. Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020 Jul 06; 11(1):3377.
    View on PubMed
  2. Polacheck WJ, Kutys ML, Tefft JB, Chen CS. Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. 2019 05; 14(5):1425-1454.
    View on PubMed
  3. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107.
    View on PubMed
  4. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via ß-Cardiac Myosin, Titin, and a-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5.
    View on PubMed
  5. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262.
    View on PubMed
  6. Kutys ML, Chen CS. Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol. 2016 10; 42:73-79.
    View on PubMed
  7. Kutys ML, Yamada KM. Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases. 2015; 6(1):16-9.
    View on PubMed
  8. Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep; 16(9):909-17.
    View on PubMed
  9. Doyle AD, Petrie RJ, Kutys ML, Yamada KM. Dimensions in cell migration. Curr Opin Cell Biol. 2013 Oct; 25(5):642-9.
    View on PubMed
  10. Kutys ML, Doyle AD, Yamada KM. Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res. 2013 Oct 01; 319(16):2434-9.
    View on PubMed
  11. Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C. Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I ? by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci. 2013 Jun 15; 126(Pt 12):2617-28.
    View on PubMed
  12. Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM. Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci. 2012 May 01; 125(Pt 9):2244-56.
    View on PubMed
  13. Kutys ML, Fricks J, Hancock WO. Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol. 2010 Nov 04; 6(11):e1000980.
    View on PubMed

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