Professor, Department of Medicine, UCSF; Senior Career Scientist, VAMC San Francisco
Harpur College, SUNY-Binghamtom, B.A., 1973, Chemistry
University of Texas, Houston, M.S., 1976, Cell Biology
University of Texas, Houston, Ph.D., 1979, Cell Biology
Giannini Research Fellow, Department of Medicine, University of California, San Francisco
Assistant Research Biochemist, Department of Medicine, University of California, San Francisco
Associate Investigator, Howard Hughes Medical Institute, University of California, San Francisco
Assistant Professor, Department of Physiology, University of California, San Francisco
Head, Division of Cell and Developmental Genetics, and Member, Cardiology Section, VA Medical Center, San Francisco, California
Assistant Professor, Dept. of Medicine, University of California, San Francisco
Associate Professor, Dept. of Medicine, University of California, San Francisco
Professor, Dept. of Medicine, University of California, San Francisco
Scientist and Senior Scientist Northern California Institute of Research and Education, SF
Research Career Scientist, VA Medical Center, San Francisco
Member, Cancer Genetics, Cell Cycling/Signaling and Prostate Cancer Programs Cancer Center, UCSF
Honors & Awards
Robert A. Welch Predoctoral Fellowship, University of Texas Health Science Center, Houston
Rosalie B. Hite Predoctoral Fellowship, University of Texas Health Science Center, Houston
Merit Awards, Excellent Student Research, University of Texas Health Science Center, Houston
A.P. Giannini Postdoctoral Fellowship, University of California, San Francisco
- Recent Publications (2005 – present)
- Oh HJ, Li YM and Lau Y-FC (2005). Sry associates with a gene-silencing complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-415.
- Taketo T, Lee C-H, Zhang JQ, Li YM, Lee G and Lau Y-FC (2005). Expression of Sry proteins in both normal and sex-reversed XY fetal mouse gonads. Devel Dyn, 233:612-622.
- Williams K, Fernandex S, Stien X, Ishii K, Love HD, Lau Y-FC, Roberts RL and Hayward SW (2005). Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. The Prostate, 63:369-384.
- Kido T and Lau Y-FC (2005). A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis, 42:263-275.
- Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau Y-FC, Oosterhuis JW, Looijenga LH (2005). Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol, 36:512-21.
- Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau Y-FC, Looijenga LH, Oosterhuis JW (2006). Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol, 208:395-400.
- Oh HJ and Lau Y-FC (2006). KRAB: A partner for SRY action on chromatin. Mol Cell Endocrinol, 247:47-52.
- Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau Y-FC, Drop SL, Looijenga LH (2006). Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol, 37:101-11.
- Hoei-Hansen C, Sehested A, Juhler M, Lau Y-FC, Skakkebaek NE, Laursen H and Rajpert-De Meyts E (2006). New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Path, 209:25-33.
- Oram SW, Liu XX, Lee T-L, Chan WY and Lau Y-FC (2006). TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer, 6: 154.
- Vong QP, Li Y, Lau Y-FC, Dym M, Rennert OM, Chan WY (2006). Structural characterization and expression studies of Dby and its homologs in the mouse. J Andrology, 27:653-661.
- Li YM, Oh HJ and Lau Y-FC (2006). Poly(ADP-ribose) polymerase I interacts with Sry and modulates its biological activities. Mol Cell Endocrin, 257-258:35-46.
- Kido T and Lau Y-FC (2006). The rat Tspy is preferentially expressed in elongated spermatid and interacts with core histones, Biochem Biophys Res Comm, 250:56-67.
- Li YM, Vilain E, Conte F, Rajpert-De Meyts E and Lau Y-FC (2007). TSPY is expressed in early and late stages of gonadoblastoma and testicular carcinoma-in-situ. Urol Oncol, 25:141-146 .
- Oh HJ, Kido T and Lau Y-FC (2007). PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Develop, 74:1446-55.
- Li YM, Tabatabi ZL, Lee T-L, Hatakeyama S, Ohyama C, Chan W-Y, Looijenga LH and Lau Y-FC (2007). The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors, Human Pathology, 38:1470-81.
- de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau Y-FC, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. (2007). JKT-1 is not a human seminoma cell line. International J Andrology, 30:350-65.
- Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. (2007). Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clinical Endocrin, 67:184-92.
- Kido T and Lau Y-FC (2008). The human Y-encoded testis-specific protein interacts functionally with the translation elongation factor 1A, International Journal of Cancer, 123:1573-85.
- Li YM and Lau Y-FC (2008). TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin dependent kinase 1 activities, Oncogene, 27:6141:50.
- Li YM, Kido T, Luo S, Dobrinski I, and Lau Y-FC (2008). Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumors. International J Exp Pathology, 89:342-9.
- Lau Y-FC and Li YM (2009). The human and mouse sex-determining SRY genes repress the Rspo1/β-catenin signaling. J Genomics Genet, 36:193-202.
- Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau Y-FC, Chan WY. (2009). Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics, 36:215-27.
- Lau Y-FC, Li YM and Kido T (2009). Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today, 87:114-22.
- Peng H, Ivanov AV, Oh HJ, Lau Y-FC, and Rauscher III FJ (2009). Epigenetuc gene silencing by the SRY protein is mediated by a KRAB-O protein which recruits the KAP1 co-repressor machinery. J Biol Chem, 284:35670-80.
- Wu JB, Chen K, Li YM, Lau Y-FC and Shih JC (2009). Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J,23:4029-38.
- Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau Y-FC and Chan WY (2010). GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics, 26:585-6.
- Kido T, Hatakeyama S, Ohyama C and Lau Y-FC (2010). Expression of the Y-encoded TSPY is associated with progression of prostate cancer. Genes 1:283-293.
- Lau Y-FC, Li YM and Kido T (2011). Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Systems Biol in Reprod Med, 57:27-34.
- Kido T, Schubert S, Schmidtke J and Lau Y-FC (2011). Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions, J Genetics and Genomics 38:181-192.
- Kido T, Ou JT-H, Lau Y-FC (2011). The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the ubiquitin-proteasome pathway, PLOS One, 6:e22979.
- BOOK CHAPTERS (from 11 book chapters)
- Lau Y-FC, Kido T and Li YM (2007). TSPY family of multi-functional proteins. In Y Chromosome and Male Germ Cell Biology (Y-FC Lau and WY Chan, eds). World Scientific Press, New Jersey, pp73-90.
- Li YM, Taketo T and Lau Y-FC (2010). Isolation of fetal gonads from embryos of timed pregnant mice for morphological and molecular studies. In Methods in Molecular Biology (WY Chan, ed). Humana Press, New York, in press.
- BOOKS (from 2 books)
- Lau Y-FC and Chan W-Y (2007). Editors, Y Chromosome and Male Germ Cell Biology. World Scientific Press, New Jersey.