Yun-Fai Chris Lau, PhD

Yun-Fai Chris Lau, PhD

Professor, Department of Medicine, UCSF; Senior Career Scientist, VAMC San Francisco

Phone: (415) 379-5526 (voice)
VAMC 111C5, San Francisco, CA 94121

UCSF Profiles

Cancer Center Membership

Member » Prostate Cancer» Cancer Genetics


Harpur College, SUNY-Binghamtom, B.A., 1973, Chemistry
University of Texas, Houston, M.S., 1976, Cell Biology
University of Texas, Houston, Ph.D., 1979, Cell Biology

Professional Experience

  • 1979-82
    Giannini Research Fellow, Department of Medicine, University of California, San Francisco
  • 1982-84
    Assistant Research Biochemist, Department of Medicine, University of California, San Francisco
  • 1984-90
    Associate Investigator, Howard Hughes Medical Institute, University of California, San Francisco
  • 1984-90
    Assistant Professor, Department of Physiology, University of California, San Francisco
  • 1990-present
    Head, Division of Cell and Developmental Genetics, and Member, Cardiology Section, VA Medical Center, San Francisco, California
  • 1988-1992
    Assistant Professor, Dept. of Medicine, University of California, San Francisco
  • 1992-2000
    Associate Professor, Dept. of Medicine, University of California, San Francisco
  • 2001-preesnt
    Professor, Dept. of Medicine, University of California, San Francisco
  • 1992-present
    Scientist and Senior Scientist Northern California Institute of Research and Education, SF
  • 1994-present
    Research Career Scientist, VA Medical Center, San Francisco
  • 1998-present
    Member, Cancer Genetics, Cell Cycling/Signaling and Prostate Cancer Programs Cancer Center, UCSF

Honors & Awards

  • 1973-76
    Robert A. Welch Predoctoral Fellowship, University of Texas Health Science Center, Houston
  • 1976-79
    Rosalie B. Hite Predoctoral Fellowship, University of Texas Health Science Center, Houston
  • 1975-77
    Merit Awards, Excellent Student Research, University of Texas Health Science Center, Houston
  • 1979-82
    A.P. Giannini Postdoctoral Fellowship, University of California, San Francisco

Selected Publications

  1. Du C, Pusey BN, Adams CJ, Lau CC, Bone WP, Gahl WA, Markello TC, Adams DR. Explorations to improve the completeness of exome sequencing. BMC Med Genomics. 2016; 9(1):56.
    View on PubMed
  2. Lopez-Chavez A, Thomas A, Rajan A, Raffeld M, Morrow B, Kelly R, Carter CA, Guha U, Killian K, Lau CC, Abdullaev Z, Xi L, Pack S, Meltzer PS, Corless CL, Sandler A, Beadling C, Warrick A, Liewehr DJ, Steinberg SM, Berman A, Doyle A, Szabo E, Wang Y, Giaccone G. Molecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial. J Clin Oncol. 2015 Mar 20; 33(9):1000-7.
    View on PubMed
  3. Killian JK, Miettinen M, Walker RL, Wang Y, Zhu YJ, Waterfall JJ, Noyes N, Retnakumar P, Yang Z, Smith WI, Killian MS, Lau CC, Pineda M, Walling J, Stevenson H, Smith C, Wang Z, Lasota J, Kim SY, Boikos SA, Helman LJ, Meltzer PS. Recurrent epimutation of SDHC in gastrointestinal stromal tumors. Sci Transl Med. 2014 Dec 24; 6(268):268ra177.
    View on PubMed
  4. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet. 2015 Feb 1; 24(3):685-97.
    View on PubMed
  5. Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. Cell Rep. 2014 Aug 7; 8(3):723-33.
    View on PubMed
  6. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol. 2014 Sep; 45(9):1847-58.
    View on PubMed
  7. Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochem Biophys Res Commun. 2014 Mar 28; 446(1):206-11.
    View on PubMed
  8. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell Biosci. 2014; 4(1):9.
    View on PubMed
  9. Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods Mol Biol. 2013; 1067:185-202.
    View on PubMed
  10. Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods Mol Biol. 2012; 825:3-16.
    View on PubMed
  11. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979.
    View on PubMed
  12. Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Syst Biol Reprod Med. 2011 Feb; 57(1-2):27-34.
    View on PubMed
  13. Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes (Basel). 2010; 1(2):283-93.
    View on PubMed
  14. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6.
    View on PubMed
  15. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem. 2009 Dec 18; 284(51):35670-80.
    View on PubMed
  16. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38.
    View on PubMed
  17. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics. 2009 Apr; 36(4):215-27.
    View on PubMed
  18. Lau YF, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. J Genet Genomics. 2009 Apr; 36(4):193-202.
    View on PubMed
  19. Lau YF, Li Y, Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today. 2009 Mar; 87(1):114-22.
    View on PubMed
  20. Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. Int J Exp Pathol. 2008 Oct; 89(5):342-9.
    View on PubMed

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