University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Yun-Fai Chris Lau, PhD

Yun-Fai Chris Lau, PhD

Professor, Department of Medicine, UCSF; Senior Career Scientist, VAMC San Francisco

Cancer Center Program Memberships

Prostate Cancer | Cancer Genetics

Education

Harpur College, SUNY-Binghamtom, B.A., 1973, Chemistry
University of Texas, Houston, M.S., 1976, Cell Biology
University of Texas, Houston, Ph.D., 1979, Cell Biology


Professional Experience

  • 1979-82
    Giannini Research Fellow, Department of Medicine, University of California, San Francisco
  • 1982-84
    Assistant Research Biochemist, Department of Medicine, University of California, San Francisco
  • 1984-90
    Associate Investigator, Howard Hughes Medical Institute, University of California, San Francisco
  • 1984-90
    Assistant Professor, Department of Physiology, University of California, San Francisco
  • 1990-present
    Head, Division of Cell and Developmental Genetics, and Member, Cardiology Section, VA Medical Center, San Francisco, California
  • 1988-1992
    Assistant Professor, Dept. of Medicine, University of California, San Francisco
  • 1992-2000
    Associate Professor, Dept. of Medicine, University of California, San Francisco
  • 2001-preesnt
    Professor, Dept. of Medicine, University of California, San Francisco
  • 1992-present
    Scientist and Senior Scientist Northern California Institute of Research and Education, SF
  • 1994-present
    Research Career Scientist, VA Medical Center, San Francisco
  • 1998-present
    Member, Cancer Genetics, Cell Cycling/Signaling and Prostate Cancer Programs Cancer Center, UCSF

Honors & Awards

  • 1973-76
    Robert A. Welch Predoctoral Fellowship, University of Texas Health Science Center, Houston
  • 1976-79
    Rosalie B. Hite Predoctoral Fellowship, University of Texas Health Science Center, Houston
  • 1975-77
    Merit Awards, Excellent Student Research, University of Texas Health Science Center, Houston
  • 1979-82
    A.P. Giannini Postdoctoral Fellowship, University of California, San Francisco

Selected Publications

  1. Rozenblum E, Sotelo-Silveira JR, Kim GY, Zhu JY, Lau CC, McNeil N, Korolevich S, Liao H, Cherry JM, Munroe DJ, Ried T, Meltzer PS, Kuehl WM, Roschke AV. Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor. PLoS One. 2017; 12(8):e0182610.
    View on PubMed
  2. Kido T, Sun Z, Lau YC. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Sci Rep. 2017 Jun 23; 7(1):4113.
    View on PubMed
  3. Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. Hum Mol Genet. 2017 Mar 01; 26(5):901-912.
    View on PubMed
  4. Kido T, Lau YC. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. J Genet Genomics. 2016 Oct 20; 43(10):577-585.
    View on PubMed
  5. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget. 2015 Jun 30; 6(18):16341-51.
    View on PubMed
  6. Kido T, Lau YF. Roles of the Y chromosome genes in human cancers. Asian J Androl. 2015 May-Jun; 17(3):373-80.
    View on PubMed
  7. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet. 2015 Feb 01; 24(3):685-97.
    View on PubMed
  8. Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. Cell Rep. 2014 Aug 07; 8(3):723-33.
    View on PubMed
  9. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol. 2014 Sep; 45(9):1847-58.
    View on PubMed
  10. Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochem Biophys Res Commun. 2014 Mar 28; 446(1):206-11.
    View on PubMed
  11. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell Biosci. 2014 Feb 17; 4(1):9.
    View on PubMed
  12. Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods Mol Biol. 2013; 1067:185-202.
    View on PubMed
  13. Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods Mol Biol. 2012; 825:3-16.
    View on PubMed
  14. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979.
    View on PubMed
  15. Kido T, Schubert S, Schmidtke J, Chris Lau YF. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. J Genet Genomics. 2011 May 20; 38(5):181-91.
    View on PubMed
  16. Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Syst Biol Reprod Med. 2011 Feb; 57(1-2):27-34.
    View on PubMed
  17. Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes (Basel). 2010 Sep 14; 1(2):283-93.
    View on PubMed
  18. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6.
    View on PubMed
  19. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem. 2009 Dec 18; 284(51):35670-80.
    View on PubMed
  20. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38.
    View on PubMed

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