University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Amy Mimi Lin, MD

Amy Mimi Lin, MD

Associate Clinical Professor, Department of Medicine, UCSF

Research Summary

Amy M Lin is a genitourinary medical oncologist who joined the UCSF faculty in 2005. Dr. Lin works with a multidisciplinary team of medical oncologists, radiation oncologists, and urologic surgical oncologists at UCSF and the San Francisco Veterans Administration Medical Center where she sees all types of genitourinary malignancies including prostate, kidney, bladder and testicular cancer. Dr. Lin is also a member of the core UCSF Cancer Immunotherapy Clinic team and cares for patients with all cancer types on novel immunotherapy studies. She is currently an Associate Professor of Medicine and Urology.

Dr. Lin’s focus is on improving clinical care workflows to optimize health care delivery. She is interested in how health care technology can enhance certain aspects of patient care and believes that increasing the quality of health care data collection, integration of multi-source patient health care data, and data interoperability are key to these efforts. Dr. Lin has been an active subject matter expert on electronic health record (EHR) clinical workflows within the Cancer Center. She is also a member of the American Society of Clinical Oncology (ASCO) CancerLinQ Research and Publications Committee which is a large scale national effort to collect and analyze real world (non-clinical trial) oncology patient data and outcomes.


Harvard University, Cambridge, MA, AB, 1989-1993, Biology
UCLA School of Medicine, Los Angeles, CA, 1994-1996
University of Chicago, Pritzker School of Medicine, Chicago, IL MD, 1996-1999, Medicine
New York Presbyterian Hospital-Cornell, New York, NY, Internship/ residency, 1999-2002, Internal Medicine
University of California, San Francisco, San Francisco, CA, Fellowship, 2002-2005, Medicine (Hematology Oncology)
University of California, San Francisco, San Francisco, CA, Fellowship, 2005-2006, Medicine (Urologic Oncology)

Professional Experience

  • 2006-2008
    Clinical Instructor of Medicine, Division of Hematology Oncology, UCSF
  • 2006-present
    Staff physician, San Francisco Veterans Administration Medical Center (SF VAMC), Medicine (Hematology/Oncology
  • 2008-2017
    Assistant Clinical Professor, Medicine, UCSF
  • 2017-present
    Associate Clinical Professor, Medicine, UCSF

Honors & Awards

  • 1990-1991
    Harvard College Scholarship for Academic Excellence (Harvard University)
  • 1991-1992, 1990-1991
    Elizabeth Agassiz Award for Academic Excellence (Harvard University)
  • 1991-1992
    John Harvard Scholarship for Academic Excellence (Harvard University
  • 1993
    Magna cum laude in Field of Biology (Harvard University)
  • 1994
    Dr. Ursula Mandel Scholarship (UCLA School of Medicine)
  • 1995
    Short-Term Training Program (STTP) grant (UCLA School of Medicine)
  • 1998-1999
    Calvin Fentress Research Fellowship Award, University of Chicago
  • 2004
    American Association of Clinical Research (AACR)/American Society of Clinical Oncology (ASCO) Methods in Clinical Cancer Research Workshop
  • 2005
    ASCO Multi-disciplinary Prostate Cancer Symposium Merit award
  • 2005-2006
    ASCO Young Investigator Award
  • 2007-2008
    Cancer and Leukemia Group B (CALGB) Foundation Young Investigator Award

Selected Publications

  1. Wei XX, Siegel AP, Aggarwal R, Lin AM, Friedlander TW, Fong L, Kim W, Louttit M, Chang E, Zhang L, Ryan CJ. A Phase II Trial of Selinexor, an Oral Selective Inhibitor of Nuclear Export Compound, in Abiraterone- and/or Enzalutamide-Refractory Metastatic Castration-Resistant Prostate Cancer. Oncologist. 2018 Feb 27.
    View on PubMed
  2. Friedlander TW, Graff JN, Zejnullahu K, Anantharaman A, Zhang L, Paz R, Premasekharan G, Russell C, Huang Y, Kim W, Aggarwal RR, Lin AM, Fong L, Alumkal JJ, Beer TM, Sharifi N, Alyamani M, Dittamore R, Small EJ, Paris PL, Ryan CJ. High-Dose Abiraterone Acetate in Men With Castration Resistant Prostate Cancer. Clin Genitourin Cancer. 2017 Dec; 15(6):733-741.e1.
    View on PubMed
  3. Wei XX, Hsieh AC, Kim W, Friedlander T, Lin AM, Louttit M, Ryan CJ. A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. Oncologist. 2017 May; 22(5):503-e43.
    View on PubMed
  4. Aggarwal R, Bryce A, Ryan CJ, Harzstark A, Derleth C, Kim W, Friedlander T, Lin AM, Rodvelt-Bagchi T, Dhawan M, Zhang L, Lee M, Siebeneck E, Hough J, Small EJ. A multicenter phase I study of cabazitaxel, mitoxantrone, and prednisone for chemotherapy-naïve patients with metastatic castration-resistant prostate cancer: A department of defense prostate cancer clinical trials consortium study. Urol Oncol. 2017 Apr; 35(4):149.e7-149.e13.
    View on PubMed
  5. Wei XX, Chan S, Kwek S, Lewis J, Dao V, Zhang L, Cooperberg MR, Ryan CJ, Lin AM, Friedlander TW, Rini B, Kane C, Simko JP, Carroll PR, Small EJ, Fong L. Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer. Cancer Immunol Res. 2016 11; 4(11):948-958.
    View on PubMed
  6. Kwek SS, Lewis J, Zhang L, Weinberg V, Greaney SK, Harzstark AL, Lin AM, Ryan CJ, Small EJ, Fong L. Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab. Cancer Immunol Res. 2015 Sep; 3(9):1008-16.
    View on PubMed
  7. Aggarwal RR, Beer TM, Weinberg VK, Higano C, Taplin ME, Ryan CJ, Lin AM, Alumkal J, Graff JN, Nordquist LT, Herrera I, Small EJ. Intermittent Chemotherapy as a Platform for Testing Novel Agents in Patients With Metastatic Castration-Resistant Prostate Cancer: A Department of Defense Prostate Cancer Clinical Trials Consortium Randomized Phase II Trial of Intermittent Docetaxel With Prednisone With or Without Maintenance GM-CSF. Clin Genitourin Cancer. 2015 Jun; 13(3):e191-8.
    View on PubMed
  8. Kim W, Zhang L, Wilton JH, Fetterly G, Mohler JL, Weinberg V, Morse A, Szmulewitz RZ, Friedlander TW, Fong L, Lin AM, Harzstark AL, Molina A, Small EJ, Ryan CJ. Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens. Clin Cancer Res. 2014 Dec 15; 20(24):6269-76.
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  9. Friedlander TW, Weinberg VK, Huang Y, Mi JT, Formaker CG, Small EJ, Harzstark AL, Lin AM, Fong L, Ryan CJ. A phase II study of insulin-like growth factor receptor inhibition with nordihydroguaiaretic acid in men with non-metastatic hormone-sensitive prostate cancer. Oncol Rep. 2012 Jan; 27(1):3-9.
    View on PubMed
  10. Harzstark AL, Small EJ, Weinberg VK, Sun J, Ryan CJ, Lin AM, Fong L, Brocks DR, Rosenberg JE. A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma. Cancer. 2011 Sep 15; 117(18):4194-200.
    View on PubMed
  11. Chow H, Jung A, Talbott J, Lin AM, Daud AI, Coakley FV. Tumor fistulization associated with targeted therapy: computed tomographic findings and clinical consequences. J Comput Assist Tomogr. 2011 Jan-Feb; 35(1):86-90.
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  12. Friedlander TW, Weinberg VK, Small EJ, Sharib J, Harzstark AL, Lin AM, Fong L, Ryan CJ. Effect of the somatostatin analog octreotide acetate on circulating insulin-like growth factor-1 and related peptides in patients with non-metastatic castration-resistant prostate cancer: results of a phase II study. Urol Oncol. 2012 Jul-Aug; 30(4):408-14.
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  13. Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V, Lin AM, Rosenberg J, Ryan CJ, Rini BI, Small EJ. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res. 2009 Jan 15; 69(2):609-15.
    View on PubMed
  14. Lin AM, Small EJ. Prostate cancer update: 2007. Curr Opin Oncol. 2008 May; 20(3):294-9.
    View on PubMed
  15. Lin AM, Small EJ. Management of hormone refractory prostate cancer. Curr Opin Support Palliat Care. 2007 Oct; 1(3):187-91.
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  16. Lin AM, Rini BI, Derynck MK, Weinberg V, Park M, Ryan CJ, Rosenberg JE, Bubley G, Small EJ. A phase I trial of docetaxel/estramustine/imatinib in patients with hormone-refractory prostate cancer. Clin Genitourin Cancer. 2007 Jun; 5(5):323-8.
    View on PubMed
  17. Lin AM, Small EJ. Prostate cancer update: 2006. Curr Opin Oncol. 2007 May; 19(3):229-33.
    View on PubMed
  18. Lin AM, Ryan CJ, Small EJ. Intermittent chemotherapy for metastatic hormone refractory prostate cancer. Crit Rev Oncol Hematol. 2007 Mar; 61(3):243-54.
    View on PubMed
  19. Lin AM, Rini BI, Weinberg V, Fong K, Ryan CJ, Rosenberg JE, Fong L, Small EJ. A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapy. BJU Int. 2006 Oct; 98(4):763-9.
    View on PubMed
  20. Lin AM, Hershberg RM, Small EJ. Immunotherapy for prostate cancer using prostatic acid phosphatase loaded antigen presenting cells. Urol Oncol. 2006 Sep-Oct; 24(5):434-41.
    View on PubMed

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