University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Richard M. Locksley, MD

Richard M. Locksley, MD

Professor, Department of Medicine (Infectious Diseases), UCSF
Marion and Herbert Sandler Distinguished Professorship in Asthma Research, UCSF

Cancer Center Program Memberships

Affiliate Member

Education

Harvard College, Cambridge, MA, B.A., 1970, Biochemistry
Univ. of Rochester, Rochester, NY, M.D., 1976, Medicine
Univ. of California, San Francisco, CA, 1976-80, Resident, Chief Resident
Univ. Wash. School of Medicine, Seattle, WA, 1980-83, Infectious Diseases


Professional Experience

  • 1986-2003
    Chief, Division of Infectious Diseases, UCSF Medical Center, San Francisco, CA
  • 1988-93
    Member and Chair (1991-93), Tropical Medicine and Parasitology Study Section, NIH
  • 1991-94
    Co-Director, Immunology Section, Biology of Parasitism Course, Woods Hole, MA
  • 1994-99
    Chair, Parasitology Pathogenesis Committee, WHO, Geneva
  • 1995-05
    Council, Chair (1998), Midwinter Conference of Immunologists, Asilomar
  • 1995-01
    Faculty, Assoc. of American Immunology Annual Course, Advanced Immunology
  • 1997-present
    Investigator, Howard Hughes Medical Institute, UCSF
  • 1998-01
    Member, Chair (2000-01), US-Japan Immunology Board, NIH
  • 2002-05
    Council, NIAID, National Institutes of Health
  • 2003-present
    Director, Strategic Asthma Basic Research Center, UCSF

Honors & Awards

  • American Society for Clinical Investigation, 1991
  • Burroughs Wellcome Fund Scholar in Molecular Parasitology, 1992-97
  • Fellow, Infectious Diseases Society of American, 1992
  • Association of American Physicians, 1994
  • Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene, 1994
  • Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001-05
  • Distinguished Service Award, American Association of Immunologists, 2003
  • Inspirational Teacher Award, UCSF class of 2006
  • Sandler Distinguished Professorship, 2003
  • American Academy of Arts & Sciences, 2005
  • R37 MERIT Award, NIAID/NIH, 2006
  • 2017
    Member, National Academy of Sciences

Selected Publications

  1. Locksley R. Turning the light on. Nat Rev Immunol. 2017 Jul 31.
    View on PubMed
  2. Savage AK, Liang HE, Locksley RM. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017 Sep 01; 199(5):1912-1922.
    View on PubMed
  3. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7.
    View on PubMed
  4. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20; 169(3):497-509.e13.
    View on PubMed
  5. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2016 Dec 23.
    View on PubMed
  6. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693.
    View on PubMed
  7. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Oct 17.
    View on PubMed
  8. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Jul 20.
    View on PubMed
  9. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10).
    View on PubMed
  10. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 May 1; 193(9):935-6.
    View on PubMed
  11. von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14; 529(7585):221-5.
    View on PubMed
  12. Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016 Jan; 9(1):275-86.
    View on PubMed
  13. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74.
    View on PubMed
  14. Molofsky AB, Savage AK, Locksley RM. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015 Jun 16; 42(6):1005-19.
    View on PubMed
  15. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5.
    View on PubMed
  16. Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. Eosinophil-specific deletion of I?Ba in mice reveals a critical role of NF-?B-induced Bcl-xL for inhibition of apoptosis. Blood. 2015 Jun 18; 125(25):3896-904.
    View on PubMed
  17. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6; 212(4):513-24.
    View on PubMed
  18. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. A novel model for IFN-?-mediated autoinflammatory syndromes. J Immunol. 2015 Mar 1; 194(5):2358-68.
    View on PubMed
  19. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87.
    View on PubMed
  20. Bando JK, Liang HE, Locksley RM. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol. 2015 Feb; 16(2):153-60.
    View on PubMed

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