Richard M. Locksley, MD

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Additional Websites

• Locksley Lab Website

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Education

Harvard College, Cambridge, MA, B.A., 1970, Biochemistry
Univ. of Rochester, Rochester, NY, M.D., 1976, Medicine
Univ. of California, San Francisco, CA, 1976-80, Resident, Chief Resident
Univ. Wash. School of Medicine, Seattle, WA, 1980-83, Infectious Diseases

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Professional Experience

• 1986-2003
  Chief, Division of Infectious Diseases, UCSF Medical Center, San Francisco, CA
• 1988-93
  Member and Chair (1991-93), Tropical Medicine and Parasitology Study Section, NIH
• 1991-94
  Co-Director, Immunology Section, Biology of Parasitism Course, Woods Hole, MA
• 1994-99
  Chair, Parasitology Pathogenesis Committee, WHO, Geneva
• 1995-05
  Council, Chair (1998), Midwinter Conference of Immunologists, Asilomar
• 1995-01
  Faculty, Assoc. of American Immunology Annual Course, Advanced Immunology
• 1997-present
  Investigator, Howard Hughes Medical Institute, UCSF
• 1998-01
  Member, Chair (2000-01), US-Japan Immunology Board, NIH
• 2002-05
  Council, NIAID, National Institutes of Health
• 2003-present
  Director, Strategic Asthma Basic Research Center, UCSF

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Honors & Awards

• American Society for Clinical Investigation, 1991
• Burroughs Wellcome Fund Scholar in Molecular Parasitology, 1992-97
• Fellow, Infectious Diseases Society of American, 1992
• Association of American Physicians, 1994
• Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene, 1994
• Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001-05
• Distinguished Service Award, American Association of Immunologists, 2003
• Inspirational Teacher Award, UCSF class of 2006
• Sandler Distinguished Professorship, 2003
• American Academy of Arts & Sciences, 2005
• R37 MERIT Award, NIAID/NIH, 2006

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Selected Publications

1. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88.
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2. Locksley RM. Raggin' on T-bet. Cell Metab. 2013 Apr 2; 17(4):473-4.
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3. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49.
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4. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse. J Immunol. 2013 Mar 1; 190(5):2229-40.
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5. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells - a proposal for uniform nomenclature. Nat Rev Immunol. 2013 Jan 7; 13(2):145-9.
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6. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin e. Immunity. 2013 Jan 24; 38(1):166-75.
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7. Van Dyken SJ, Locksley RM. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013 Mar 21; 31:317-43.
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8. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol. 2012 Nov; 92(5):999-1009.
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9. Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012; 7(6):e39750.
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10. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 4; 209(6):1183-99.
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11. Nussbaum JC, Locksley RM. Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol. 2012 May; 4(5).
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12. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2012 Jan; 13(1):58-66.
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13. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Dec 1; 480(7375):104-8.
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14. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30.
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15. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55.
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16. Fahy JV, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2.
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17. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol. 2011 Sep 1; 187(5):2261-7.
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18. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35.
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19. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 8; 332(6026):243-7.
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20. Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. Parasite Immunol. 2011 Jan; 33(1):1-11.
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