Richard M. Locksley, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
locksley_richard

Professor, Department of Medicine (Infectious Diseases), UCSF
Marion and Herbert Sandler Distinguished Professorship in Asthma Research, UCSF

locksley@medicine.ucsf.edu

Phone: (415) 476-5859 (voice)
Box 0654, UCSF
San Francisco, CA 94143-0654

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Additional Websites


Education

Harvard College, Cambridge, MA, B.A., 1970, Biochemistry
Univ. of Rochester, Rochester, NY, M.D., 1976, Medicine
Univ. of California, San Francisco, CA, 1976-80, Resident, Chief Resident
Univ. Wash. School of Medicine, Seattle, WA, 1980-83, Infectious Diseases

Professional Experience

  • 1986-2003
    Chief, Division of Infectious Diseases, UCSF Medical Center, San Francisco, CA
  • 1988-93
    Member and Chair (1991-93), Tropical Medicine and Parasitology Study Section, NIH
  • 1991-94
    Co-Director, Immunology Section, Biology of Parasitism Course, Woods Hole, MA
  • 1994-99
    Chair, Parasitology Pathogenesis Committee, WHO, Geneva
  • 1995-05
    Council, Chair (1998), Midwinter Conference of Immunologists, Asilomar
  • 1995-01
    Faculty, Assoc. of American Immunology Annual Course, Advanced Immunology
  • 1997-present
    Investigator, Howard Hughes Medical Institute, UCSF
  • 1998-01
    Member, Chair (2000-01), US-Japan Immunology Board, NIH
  • 2002-05
    Council, NIAID, National Institutes of Health
  • 2003-present
    Director, Strategic Asthma Basic Research Center, UCSF

Honors & Awards

  • American Society for Clinical Investigation, 1991
  • Burroughs Wellcome Fund Scholar in Molecular Parasitology, 1992-97
  • Fellow, Infectious Diseases Society of American, 1992
  • Association of American Physicians, 1994
  • Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene, 1994
  • Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001-05
  • Distinguished Service Award, American Association of Immunologists, 2003
  • Inspirational Teacher Award, UCSF class of 2006
  • Sandler Distinguished Professorship, 2003
  • American Academy of Arts & Sciences, 2005
  • R37 MERIT Award, NIAID/NIH, 2006

Selected Publications

  1. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5 producing group 2 innate lymphoid cells (ILC2) control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Oct 16.
    View on PubMed
  2. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014 Jun 5; 157(6):1292-308.
    View on PubMed
  3. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8.
    View on PubMed
  4. O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP. Eosinophils Are Recruited in Response to Chitin Exposure and Enhance Th2-Mediated Immune Pathology in Aspergillus fumigatus Infection. Infect Immun. 2014 Aug; 82(8):3199-205.
    View on PubMed
  5. Locksley RM, Fahy JV. Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May; 92(5):389-91.
    View on PubMed
  6. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and ?d T Cells. Immunity. 2014 Mar 20; 40(3):414-24.
    View on PubMed
  7. Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice. J Immunol. 2013 Dec 1; 191(11):5349-53.
    View on PubMed
  8. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
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  9. Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013 Nov; 94(5):877-84.
    View on PubMed
  10. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22.
    View on PubMed
  11. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9.
    View on PubMed
  12. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88.
    View on PubMed
  13. Locksley RM. Raggin' on T-bet. Cell Metab. 2013 Apr 2; 17(4):473-4.
    View on PubMed
  14. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49.
    View on PubMed
  15. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol. 2013 Feb; 13(2):145-9.
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  16. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol. 2013 Mar 1; 190(5):2229-40.
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  17. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75.
    View on PubMed
  18. Van Dyken SJ, Locksley RM. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013; 31:317-43.
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  19. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol. 2012 Nov; 92(5):999-1009.
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  20. Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012; 7(6):e39750.
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