University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Janel R. Long-Boyle, PharmD, PhD

Janel R. Long-Boyle, PharmD, PhD

Associate Professor, Department of Clinical Pharmacy, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Dr. Boyle is a translational scientist with research interests that include pediatric cancer therapeutics, pharmacokinetics, pharmacodynamics, pharmacogenomics, and clinical trial design. The majority of her research resides within the complex setting of hematopoietic cell transplantation (HCT) and is focused around chemotherapeutic and immunosuppressive agents used in the preparative regimens of pediatric HCT. Specifically, Dr. Boyle studies how covariates such as age, renal function, or genetic variants involved in drug metabolism or distribution may influence drug clearance in the pediatric HCT population.

Education

University of Minnesota, Minneapolis, BS, 2000, Biochemistry
University of Minnesota, Minneapolis, PharmD, 2006, Pharmacy
University of Minnesota, Minneapolis, PhD, 2009, Experimental and Clinical Pharmacology


Professional Experience

  • 2000-2001
    Junior Scientist (full-time), Department of Medicine, University of Minnesota, Minneapolis, MN
  • 2001-2003
    Assistant Scientist (full-time), Department of Medicine, University of Minnesota, Minneapolis, MN
  • 2006-2009
    Clinical Pharmacist (part-time), Department of Pharmacy, University of Minnesota, Medical Center-Fairview, Minneapolis, MN
  • 2008-2009
    Clinical Pharmacist (part-time), Department of Pharmacy, Minneapolis, Children’s Hospitals of Minnesota, MN
  • 2010-2015
    Assistant Professor, Department of Clinical Pharmacy, UCSF
  • 2016-present
    Associate Professor, Department of Clinical Pharmacy, UCSF
  • 2016-present
    Associate Professor, Allergy, Immunology, and Bone Marrow Transplantation, UCSF

Honors & Awards

  • 2010
    Early Career Research Award, Thrasher Pediatric Research Fund
  • 2011
    Travel Award for Early Career Researchers, UCSF Academic Senate
  • 2011
    Loan Repayment Recipient (2-year contract), National Institutes of Health Pediatric LRP
  • 2012
    Gary Rifkind Research Award for Junior Faculty, UCSF School of Pharmacy
  • 2013
    Loan Repayment Recipient (renewal, 2-year contract), National Institutes of Health Pediatric LRP
  • 2017
    Mid-Career Level Travel Award, UCSF Academic Senate

Selected Publications

  • Slungaard A, Fernandez JA, Griffen JH, Key NS, Long JR, Peigors DJ, Lents SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 2003, 102 (1): 146-51
  • Jacobson P, Rogosheske J, Barker JN, Green K, Ng J, Weisdorf D, Tan Y, Long J, Remmel R, Sawchuk R, McGlave P. Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation. Journal of Clinical Pharmacology and Therapeutics. 2005, 78 (5): 486-500
  • Jacobson P, Long J, Rogosheske J, Brunstein C, Weisdorf D. High unbound mycophenolic acid concentrations in a hematopoietic cell transplantation patient with sepsis and renal and hepatic dysfunction. Biology of Blood Marrow Transplantation. 2005, 11: 977-978
  • Jacobson PA, El-Massah SF, Rogosheske J, Kerr A, Long-Boyle J, Defor T, Jennissen C, Brunstein C, Wagner J, Tomblyn M, Weisdorf D. Comparison of two mycophenolate mofetil dosing regimens following hematopoietic cell transplantation. Blood Marrow Transplantation. 2009, 44: 113-120
  • Long-Boyle J, Green GE, Brunstein C, Cao Q, Rogosheske J, Weisdorf D, Miller J, Wagner J, McGlave P, Jacobson P. High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. Bone Marrow Transplantation. 2011, 46(1):20-6. PMCID: 2904846.
  • Long-Boyle J, Huang J, Rydholm N, Smith A, Orchard P, Tolar J, Jacobson P. Pharmacokinetics of Clofarabine in Patients with High Risk Inherited Metabolic Disorders Undergoing Brain Sparing Hematopoietic Cell Transplantation (BS-HCT). Journal of Clinical Pharmacology. 2010. June 4. [Epub ahead of print] PMC Journal- In Process.