University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mark Looney, MD

Mark Looney, MD

Associate Professor, Department of Medicine and Laboratory Medicine, UCSF

Cancer Center Program Memberships

Affiliate Member

Research Summary

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.

Education

Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care


Professional Experience

  • 1995
    NIH Medical Student Research Fellow, University of Tennessee, Memphis
  • 1998-2001
    Intern and Resident, Internal Medicine, University of California, San Francisco
  • 2001-2004
    Fellow, Pulmonary & Critical Care Medicine, University of California, San Francisco
  • 2004-present
    Attending Physician, Moffitt-Long Hospital, University of California, San Francisco
  • 2004-2005
    Clinical Instructor, Department of Medicine, University of California, San Francisco
  • 2006-2011
    Assistant Professor, Department of Medicine, University of California, San Francisco
  • 2008-2011
    Assistant Professor, Department of Laboratory Medicine, Univ. of California, San Francisco
  • 2011-present
    Associate Professor, Department of Medicine and Laboratory Medicine, UCSF
  • 2011-present
    Member, UCSF Biomedical Sciences Graduate Program

Honors & Awards

  • 1994
    Summa cum laude, Lipscomb University
  • 1995
    McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis
  • 1996
    Herman Bensdorf Scholarship, University of Tennessee, Memphis
  • 1997
    Alpha Omega Alpha, University of Tennessee, Memphis
  • 1998
    Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis
  • 1998
    Faculty Medal for Academic Achievement, University of Tennessee, Memphis
  • 2002
    Will Rogers Fellowship Award, University of California, San Francisco
  • 2004
    GlaxoSmithKline Pulmonary Fellowship Award
  • 2009
    Carl Booberg Research Award, American Thoracic Society
  • 2010
    Jean Julliard Prize, International Society of Blood Transfusion (ISBT)
  • 2013
    Member, The American Society for Clinical Investigation

Selected Publications

  1. Lefrançais E, Looney MR. Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway. Am J Respir Crit Care Med. 2017 Jul 15; 196(2):122-124.
    View on PubMed
  2. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PLoS One. 2017; 12(6):e0178725.
    View on PubMed
  3. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 Jul; 57(7):1684-1690.
    View on PubMed
  4. Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28; 2(10).
    View on PubMed
  5. Santhosh L, Babik J, Looney MR, Hollander H. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Ann Am Thorac Soc. 2017 Apr; 14(4):565-568.
    View on PubMed
  6. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109.
    View on PubMed
  7. Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 Jan 12.
    View on PubMed
  8. Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2017 Jan; 47(1):13-21.
    View on PubMed
  9. Toy P, Kleinman SH, Looney MR. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion. 2017 Mar; 57(3):709-713.
    View on PubMed
  10. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63.
    View on PubMed
  11. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 Nov 15; 7:13464.
    View on PubMed
  12. Henry TS, Naeger DM, Looney MR, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860.
    View on PubMed
  13. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 Sep 08; 1(14):e86704.
    View on PubMed
  14. Toy P, Kleinman SH, Looney MR. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 Sep; 56(9):2394-5.
    View on PubMed
  15. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7.
    View on PubMed
  16. Mallavia B, Liu F, Sheppard D, Looney MR. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11.
    View on PubMed
  17. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022.
    View on PubMed
  18. Looney MR. Selectin' for NETs. Blood. 2015 Jul 09; 126(2):129-30.
    View on PubMed
  19. Ortiz-Muñoz G, Looney MR. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12).
    View on PubMed
  20. Sayah DM, Mallavia B, Looney MR. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 01; 191(9):1089.
    View on PubMed

Go to UCSF Profiles, powered by CTSI