Research Summary

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.

Research Funding

  • September 17, 2021 - August 31, 2026 - Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI160167
  • January 1, 2019 - December 31, 2022 - Mechanisms of antibody-mediated lung Injury after blood transfusion , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL138673
  • June 1, 2016 - May 31, 2021 - Fine-tuning the Neutrophilic Response to Pneumonia , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI125445
  • April 1, 2011 - April 30, 2021 - Platelet and megakaryocyte biology in the normal and injured lung , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL107386

Education

Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care

Honors & Awards

  • 1994
    Summa cum laude, Lipscomb University
  • 1995
    McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis
  • 1996
    Herman Bensdorf Scholarship, University of Tennessee, Memphis
  • 1997
    Alpha Omega Alpha, University of Tennessee, Memphis
  • 1998
    Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis
  • 1998
    Faculty Medal for Academic Achievement, University of Tennessee, Memphis
  • 2002
    Will Rogers Fellowship Award, University of California, San Francisco
  • 2004
    GlaxoSmithKline Pulmonary Fellowship Award
  • 2009
    Carl Booberg Research Award, American Thoracic Society
  • 2010
    Jean Julliard Prize, International Society of Blood Transfusion (ISBT)
  • 2013
    Member, The American Society for Clinical Investigation

Selected Publications

  1. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023 Oct 03.  View on PubMed
  2. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. Am J Physiol Lung Cell Mol Physiol. 2023 08 01; 325(2):L262-L269.  View on PubMed
  3. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. bioRxiv. 2023 Jun 29.  View on PubMed
  4. Sorrells MG, Seo Y, Magnen M, Broussard B, Sheybani R, Shah AM, O'Neal HR, Tse HTK, Looney MR, Di Carlo D. Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis. Diagnostics (Basel). 2023 Apr 16; 13(8).  View on PubMed
  5. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653.  View on PubMed
  6. Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24).  View on PubMed
  7. Conrad C, Looney MR. Is neutrophilic inflammation treatable in COVID-19? Lancet Respir Med. 2022 12; 10(12):1100-1101.  View on PubMed
  8. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT. New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. Am J Respir Cell Mol Biol. 2022 09; 67(3):284-308.  View on PubMed
  9. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.  View on PubMed
  10. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.  View on PubMed
  11. Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA. Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021). Ann Am Thorac Soc. 2022 05; 19(5):705-712.  View on PubMed
  12. D.R. Calabrese, J.P. Singer, S.R. Hays, L.E. Leard, J.A. Golden, N.A. Kolaitis, M. Kleinhenz, R. Shah, A. Venado, J. Kukreja, J.A. Belperio, S.S. Weigt, J.R. Greenland, M.R. Looney. Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post-Transplant FEV1 in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation. 2022 Apr 1; 41(4):s76.  View on PubMed
  13. Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022 04 01; 132(7).  View on PubMed
  14. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell. 2022 Mar 17; 185(6):1103-1104.  View on PubMed
  15. Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 02 11; 375(6581):eabi5965.  View on PubMed
  16. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell. 2022 03 03; 185(5):815-830.e19.  View on PubMed
  17. Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 02 08; 7(3).  View on PubMed
  18. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14.  View on PubMed
  19. Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS. In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. ACS Cent Sci. 2021 Oct 27; 7(10):1638-1649.  View on PubMed
  20. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Aug; 596(7872):E8.  View on PubMed

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