Research Summary

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.

Research Funding

  • September 17, 2021 - August 31, 2026 - Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI160167
  • January 1, 2019 - December 31, 2022 - Mechanisms of antibody-mediated lung Injury after blood transfusion , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL138673
  • June 1, 2016 - May 31, 2021 - Fine-tuning the Neutrophilic Response to Pneumonia , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI125445
  • April 1, 2011 - April 30, 2021 - Platelet and megakaryocyte biology in the normal and injured lung , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL107386
  • January 1, 2016 - December 31, 2020 - Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL130324
  • December 8, 2006 - November 30, 2011 - Experimental transfusion-related acute lung injury , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08HL082742

Education

Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care

Honors & Awards

  • 1994
    Summa cum laude, Lipscomb University
  • 1995
    McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis
  • 1996
    Herman Bensdorf Scholarship, University of Tennessee, Memphis
  • 1997
    Alpha Omega Alpha, University of Tennessee, Memphis
  • 1998
    Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis
  • 1998
    Faculty Medal for Academic Achievement, University of Tennessee, Memphis
  • 2002
    Will Rogers Fellowship Award, University of California, San Francisco
  • 2004
    GlaxoSmithKline Pulmonary Fellowship Award
  • 2009
    Carl Booberg Research Award, American Thoracic Society
  • 2010
    Jean Julliard Prize, International Society of Blood Transfusion (ISBT)
  • 2013
    Member, The American Society for Clinical Investigation

Selected Publications

  1. Conrad C, Magnen M, Tsui J, Wismer HJ, Naser M, Venkataramani U, Samad B, Cleary SJ, Qiu L, Tian JJ, De Giovanni M, Mende N, Leavitt AD, Passegue E, Laurenti E, Combes AJ, Looney MR. Decoding functional hematopoietic progenitor cells in the adult human lung. Blood. 2025 Feb 27.  View on PubMed
  2. Cleary SJ, Qiu L, Seo Y, Baluk P, Liu D, Serwas NK, Taylor CA, Zhang D, Cyster JG, McDonald DM, Krummel MF, Looney MR. Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer. J Exp Med. 2025 May 05; 222(5).  View on PubMed
  3. Jin X, Pirenne J, Vos R, Hooft C, Kaes J, Van Slambrouck J, Kortleven P, Vandervelde C, Beeckmans H, Kerckhof P, Carlon MS, Van Raemdonck D, Looney MR, Vanaudenaerde BM, Ceulemans LJ. Donor-Specific Blood Transfusion in Lung Transplantation. Transpl Int. 2024; 37:12822.  View on PubMed
  4. Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR. Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury. J Clin Invest. 2024 Oct 01; 134(24).  View on PubMed
  5. Tsao T, Qiu L, Bharti R, Shemesh A, Hernandez AM, Cleary SJ, Greenland NY, Santos J, Shi R, Bai L, Richardson J, Dilley K, Will M, Tomasevic N, Sputova T, Salles A, Kang J, Zhang D, Hays SR, Kukreja J, Singer JP, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CD94+ natural killer cells potentiate pulmonary ischaemia-reperfusion injury. Eur Respir J. 2024 Sep; 64(3).  View on PubMed
  6. Cleary SJ, Qiu L, Seo Y, Baluk P, Liu D, Serwas NK, Cyster JG, McDonald DM, Krummel MF, Looney MR. Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer. bioRxiv. 2024 Sep 17.  View on PubMed
  7. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Sci Adv. 2024 Aug 02; 10(31):eadm8836.  View on PubMed
  8. Chen S, Looney MR. Understanding megakaryocyte phenotypes and the impact on platelet biogenesis. Transfusion. 2024 Jul; 64(7):1372-1380.  View on PubMed
  9. Simon J. Cleary, Mark R. Looney. Reply: The importance of disrupting complement activation in acute lung injury. Journal of Clinical Investigation. 2024 Jun 17; 134(12):e182451.  View on PubMed
  10. Pandey A, Chopra S, Cleary SJ, López-Álvarez M, Quimby FM, Alanizi AAA, Sakhamuri S, Zhang N, Looney MR, Craik CS, Wilson DM, Evans MJ. Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography. ACS Infect Dis. 2024 Jun 14; 10(6):2108-2117.  View on PubMed
  11. Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR. Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury. bioRxiv. 2024 May 28.  View on PubMed
  12. T. Tsao, L. Qiu, A. Shemesh, A. Millan Hernandez, K. Shi, J. Richardson, R. Bharti, J. Santos, L. Lanier, M. Looney, J. Greenland, D.R. Calabrese. (225) Novel Anti-CD94 Treatment Reduces Mouse and Human Experimental Pulmonary Ischemia-Reperfusion Injury. The Journal of Heart and Lung Transplantation. 2024 Apr 1; 43(4):s119.  View on PubMed
  13. Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AE, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR. IgG hexamers initiate complement-dependent acute lung injury. J Clin Invest. 2024 Mar 26; 134(11).  View on PubMed
  14. Conrad C, Magnen M, Tsui J, Wismer H, Naser M, Venkataramani U, Samad B, Cleary SJ, Qiu L, Tian JJ, De Giovanni M, Mende N, Passegue E, Laurenti E, Combes AJ, Looney MR. Decoding functional hematopoietic progenitor cells in the adult human lung. Res Sq. 2024 Feb 16.  View on PubMed
  15. Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR. IgG hexamers initiate acute lung injury. bioRxiv. 2024 Jan 27.  View on PubMed
  16. Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR. MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. Am J Respir Crit Care Med. 2024 01 01; 209(1):70-82.  View on PubMed
  17. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023 11 08; 8(21).  View on PubMed
  18. M Sorrells, Y Seo, M Magnen, R Sheybani, A M Shah, H T Tse, M R Looney, H O'Neal. B-075 Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis. Clinical Chemistry. 2023 Sep 27; 69(Supplement_1):hvad097.414.  View on PubMed
  19. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. Am J Physiol Lung Cell Mol Physiol. 2023 08 01; 325(2):L262-L269.  View on PubMed
  20. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. bioRxiv. 2023 Jun 29.  View on PubMed

Go to UCSF Profiles, powered by CTSI