Mark Looney, MD
Associate Professor, Department of Medicine and Laboratory Medicine, UCSF
Cancer Center Program Memberships
Affiliate MemberResearch Summary
I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.Education
Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care
Professional Experience
-
1995
NIH Medical Student Research Fellow, University of Tennessee, Memphis -
1998-2001
Intern and Resident, Internal Medicine, University of California, San Francisco -
2001-2004
Fellow, Pulmonary & Critical Care Medicine, University of California, San Francisco -
2004-present
Attending Physician, Moffitt-Long Hospital, University of California, San Francisco -
2004-2005
Clinical Instructor, Department of Medicine, University of California, San Francisco -
2006-2011
Assistant Professor, Department of Medicine, University of California, San Francisco -
2008-2011
Assistant Professor, Department of Laboratory Medicine, Univ. of California, San Francisco -
2011-present
Associate Professor, Department of Medicine and Laboratory Medicine, UCSF -
2011-present
Member, UCSF Biomedical Sciences Graduate Program
Honors & Awards
- 1994
Summa cum laude, Lipscomb University - 1995
McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis - 1996
Herman Bensdorf Scholarship, University of Tennessee, Memphis - 1997
Alpha Omega Alpha, University of Tennessee, Memphis - 1998
Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis - 1998
Faculty Medal for Academic Achievement, University of Tennessee, Memphis - 2002
Will Rogers Fellowship Award, University of California, San Francisco - 2004
GlaxoSmithKline Pulmonary Fellowship Award - 2009
Carl Booberg Research Award, American Thoracic Society - 2010
Jean Julliard Prize, International Society of Blood Transfusion (ISBT) - 2013
Member, The American Society for Clinical Investigation
Selected Publications
- Santhosh L, Babik J, Looney MR, Hollander H. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Ann Am Thorac Soc. 2017 Apr; 14(4):565-568.
View on PubMed - Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 Jan 12.
View on PubMed - Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2017 Jan; 47(1):13-21.
View on PubMed - Toy P, Kleinman SH, Looney MR. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion. 2016 Dec 26.
View on PubMed - Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2016 Dec 21.
View on PubMed - Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 Nov 15; 7:13464.
View on PubMed - Henry TS, Naeger DM, Looney MR, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860.
View on PubMed - Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 Sep 08; 1(14):e86704.
View on PubMed - Toy P, Kleinman SH, Looney MR. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 Sep; 56(9):2394-5.
View on PubMed - Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7.
View on PubMed - Mallavia B, Liu F, Sheppard D, Looney MR. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11.
View on PubMed - Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022.
View on PubMed - Looney MR. Selectin' for NETs. Blood. 2015 Jul 9; 126(2):129-30.
View on PubMed - Ortiz-Muñoz G, Looney MR. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12).
View on PubMed - Sayah DM, Mallavia B, Looney MR. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 1; 191(9):1089.
View on PubMed - Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513.
View on PubMed - Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46.
View on PubMed - Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63.
View on PubMed - Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5.
View on PubMed - Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52.
View on PubMed