Professor, Department of Biochemistry and Biophysics, UCSF
Additional Websites
Education
Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
University of California, San Francisco, Ph.D., 1993, Genetics
University of California, San Francisco, M.D., 1995, Medicine
Whitehead Institute, Cambridge, Massachusetts, Postdoctoral, 1995-1999, Signal Transduction
Professional Experience
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1986-1987
Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
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1989-1993
Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
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1995-1999
Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
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1999-2005
Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
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2008-present
Professor, Dept of Biochemistry and Biophysics, UCSF
Honors & Awards
- 1987
Dean's Prize for Student Research, University of California, San Francisco - 1988
Dean's Prize for Student Research, University of California, San Francisco - 1991-1992
Chancellor's Fellowship, University of California, San Francisco - 1996
Finalist, Pharmacia-Science Prize - 1995-1998
Helen Hay Whitney Foundation Postdoctoral Research Fellowship - 1998-1999
Burroughs-Wellcome Fund Career Development Award - 2000-2005
David and Lucile Packard Foundation Fellowship for Scientists and Engineers - 1999-2002
Burroughs-Wellcome Fund Career Development Award - 2005-2010
Leukemia and Lymphoma Society Scholar
Selected Publications
- Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
View on PubMed - Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense. Cell. 2013 Feb 28; 152(5):957-68.
View on PubMed - Brown JC, Madhani HD. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012 Dec; 8(12):e1003168.
View on PubMed - Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD. Timing of Transcriptional Quiescence during Gametogenesis Is Controlled by Global Histone H3K4 Demethylation. Dev Cell. 2012 Nov 13; 23(5):1059-71.
View on PubMed - Braun S, Madhani HD. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012 Jul; 13(7):619-30.
View on PubMed - Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63.
View on PubMed - Madhani HD. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011 Oct; 7(10):e1002301.
View on PubMed - Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol. 2011 Oct; 31(20):4193-204.
View on PubMed - El-Samad H, Madhani HD. Can a systems perspective help us appreciate the biological meaning of small effects? Dev Cell. 2011 Jul 19; 21(1):11-3.
View on PubMed - Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5.
View on PubMed - Chun CD, Brown JC, Madhani HD. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe. 2011 Mar 17; 9(3):243-51.
View on PubMed - Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011 Jan 7; 144(1):41-54.
View on PubMed - Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 7; 41(1):67-81.
View on PubMed - McCullagh E, Seshan A, El-Samad H, Madhani HD. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol. 2010 Oct; 12(10):954-62.
View on PubMed - Chun CD, Madhani HD. Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans. PLoS One. 2010; 5(9).
View on PubMed - Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD. Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions. Genes Dev. 2010 Aug 15; 24(16):1758-71.
View on PubMed - Chun CD, Madhani HD. Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans. Methods Enzymol. 2010; 470:797-831.
View on PubMed - Bao MZ, Shock TR, Madhani HD. Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo. Eukaryot Cell. 2010 Jan; 9(1):31-6.
View on PubMed - Hwang WW, Madhani HD. Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genet. 2009 Aug; 5(8):e1000588.
View on PubMed - Hartley PD, Madhani HD. Mechanisms that specify promoter nucleosome location and identity. Cell. 2009 May 1; 137(3):445-58.
View on PubMed
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