Hiten Madhani, MD, PhD

Hiten Madhani, MD, PhD

Professor, Department of Biochemistry and Biophysics, UCSF


Phone: (415) 514-0594 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

View on UCSF Profiles

Cancer Center Membership

Associate Member ยป Hematopoietic Malignancies


Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
University of California, San Francisco, Ph.D., 1993, Genetics
University of California, San Francisco, M.D., 1995, Medicine
Whitehead Institute, Cambridge, Massachusetts, Postdoctoral, 1995-1999, Signal Transduction

Professional Experience

  • 1986-1987
    Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
  • 1989-1993
    Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
  • 1995-1999
    Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
  • 1999-2005
    Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
  • 2008-present
    Professor, Dept of Biochemistry and Biophysics, UCSF

Honors & Awards

  • 1987
    Dean's Prize for Student Research, University of California, San Francisco
  • 1988
    Dean's Prize for Student Research, University of California, San Francisco
  • 1991-1992
    Chancellor's Fellowship, University of California, San Francisco
  • 1996
    Finalist, Pharmacia-Science Prize
  • 1995-1998
    Helen Hay Whitney Foundation Postdoctoral Research Fellowship
  • 1998-1999
    Burroughs-Wellcome Fund Career Development Award
  • 2000-2005
    David and Lucile Packard Foundation Fellowship for Scientists and Engineers
  • 1999-2002
    Burroughs-Wellcome Fund Career Development Award
  • 2005-2010
    Leukemia and Lymphoma Society Scholar

Selected Publications

  1. Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res. 2015 Oct 15; 43(18):9017-27.
    View on PubMed
  2. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nat Commun. 2015; 6:7121.
    View on PubMed
  3. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda). 2015; 5(7):1453-61.
    View on PubMed
  4. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 2015 Jan 15; 160(1-2):204-18.
    View on PubMed
  5. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 2014 Nov 20; 159(5):1168-87.
    View on PubMed
  6. Functional profiling of human fungal pathogen genomes. Cold Spring Harb Perspect Med. 2015 Mar; 5(3):a019596.
    View on PubMed
  7. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. MBio. 2014; 5(1):e00765-13.
    View on PubMed
  8. snRNA catalysts in the spliceosome's ancient core. Cell. 2013 Dec 5; 155(6):1213-5.
    View on PubMed
  9. Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci. 2014 Jan; 39(1):25-34.
    View on PubMed
  10. The frustrated gene: origins of eukaryotic gene expression. Cell. 2013 Nov 7; 155(4):744-9.
    View on PubMed
  11. The spliceosome as a transposon sensor. RNA Biol. 2013 Nov; 10(11):1653-60.
    View on PubMed
  12. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes Dev. 2013 Sep 1; 27(17):1851-6.
    View on PubMed
  13. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91.
    View on PubMed
  14. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
    View on PubMed
  15. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 2013 Feb 28; 152(5):957-68.
    View on PubMed
  16. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012; 8(12):e1003168.
    View on PubMed
  17. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell. 2012 Nov 13; 23(5):1059-71.
    View on PubMed
  18. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012 Jul; 13(7):619-30.
    View on PubMed
  19. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63.
    View on PubMed
  20. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011 Oct; 7(10):e1002301.
    View on PubMed

Go to UCSF Profiles, powered by CTSI