Hiten Madhani, MD, PhD

Hiten Madhani, MD, PhD

Professor, Department of Biochemistry and Biophysics, UCSF


Phone: (415) 514-0594 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

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Cancer Center Membership

Associate Member » Hematopoietic Malignancies


Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
University of California, San Francisco, Ph.D., 1993, Genetics
University of California, San Francisco, M.D., 1995, Medicine
Whitehead Institute, Cambridge, Massachusetts, Postdoctoral, 1995-1999, Signal Transduction

Professional Experience

  • 1986-1987
    Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
  • 1989-1993
    Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
  • 1995-1999
    Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
  • 1999-2005
    Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
  • 2008-present
    Professor, Dept of Biochemistry and Biophysics, UCSF

Honors & Awards

  • 1987
    Dean's Prize for Student Research, University of California, San Francisco
  • 1988
    Dean's Prize for Student Research, University of California, San Francisco
  • 1991-1992
    Chancellor's Fellowship, University of California, San Francisco
  • 1996
    Finalist, Pharmacia-Science Prize
  • 1995-1998
    Helen Hay Whitney Foundation Postdoctoral Research Fellowship
  • 1998-1999
    Burroughs-Wellcome Fund Career Development Award
  • 2000-2005
    David and Lucile Packard Foundation Fellowship for Scientists and Engineers
  • 1999-2002
    Burroughs-Wellcome Fund Career Development Award
  • 2005-2010
    Leukemia and Lymphoma Society Scholar

Selected Publications

  1. Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD. Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res. 2015 Oct 15; 43(18):9017-27.
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  2. Desjardins CA, Sanscrainte ND, Goldberg JM, Heiman D, Young S, Zeng Q, Madhani HD, Becnel JJ, Cuomo CA. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nat Commun. 2015; 6:7121.
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  3. Garcia JF, Al-Sady B, Madhani HD. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda). 2015; 5(7):1453-61.
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  4. Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 2015 Jan 15; 160(1-2):204-18.
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  5. Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 2014 Nov 20; 159(5):1168-87.
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  6. Goranov AI, Madhani HD. Functional profiling of human fungal pathogen genomes. Cold Spring Harb Perspect Med. 2015 Mar; 5(3):a019596.
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  7. Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. MBio. 2014; 5(1):e00765-13.
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  8. Madhani HD. snRNA catalysts in the spliceosome's ancient core. Cell. 2013 Dec 5; 155(6):1213-5.
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  9. Dumesic PA, Madhani HD. Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci. 2014 Jan; 39(1):25-34.
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  10. Madhani HD. The frustrated gene: origins of eukaryotic gene expression. Cell. 2013 Nov 7; 155(4):744-9.
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  11. Dumesic PA, Madhani HD. The spliceosome as a transposon sensor. RNA Biol. 2013 Nov; 10(11):1653-60.
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  12. Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes Dev. 2013 Sep 1; 27(17):1851-6.
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  13. Al-Sady B, Madhani HD, Narlikar GJ. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91.
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  14. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
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  15. Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 2013 Feb 28; 152(5):957-68.
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  16. Brown JC, Madhani HD. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012; 8(12):e1003168.
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  17. Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell. 2012 Nov 13; 23(5):1059-71.
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  18. Braun S, Madhani HD. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012 Jul; 13(7):619-30.
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  19. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63.
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  20. Madhani HD. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011 Oct; 7(10):e1002301.
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