Hiten Madhani, MD, PhD

Professor, Department of Biochemistry and Biophysics, UCSF

hitenmadhani@gmail.com

Phone: (415) 514-0594 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

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Additional Websites

• Lab Website

Education

Professional Experience

• 1986-1987
  Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
• 1989-1993
  Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
• 1995-1999
  Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
• 1999-2005
  Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
• 2008-present
  Professor, Dept of Biochemistry and Biophysics, UCSF

Honors & Awards

• 1987
  Dean's Prize for Student Research, University of California, San Francisco
• 1988
  Dean's Prize for Student Research, University of California, San Francisco
• 1991-1992
  Chancellor's Fellowship, University of California, San Francisco
• 1996
  Finalist, Pharmacia-Science Prize
• 1995-1998
  Helen Hay Whitney Foundation Postdoctoral Research Fellowship
• 1998-1999
  Burroughs-Wellcome Fund Career Development Award
• 2000-2005
  David and Lucile Packard Foundation Fellowship for Scientists and Engineers
• 1999-2002
  Burroughs-Wellcome Fund Career Development Award
• 2005-2010
  Leukemia and Lymphoma Society Scholar

Selected Publications

1. Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 2014 Nov 20; 159(5):1168-87.
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2. Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, Didone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo. MBio. 2014; 5(1).
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3. Madhani HD. snRNA Catalysts in the Spliceosome's Ancient Core. Cell. 2013 Dec 5; 155(6):1213-5.
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4. Dumesic PA, Madhani HD. Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci. 2014 Jan; 39(1):25-34.
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5. Madhani HD. The frustrated gene: origins of eukaryotic gene expression. Cell. 2013 Nov 7; 155(4):744-9.
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6. Dumesic PA, Madhani HD. The spliceosome as a transposon sensor. RNA Biol. 2013 Nov 1; 10(11):1653-60.
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7. Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes Dev. 2013 Sep 1; 27(17):1851-6.
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8. Al-Sady B, Madhani HD, Narlikar GJ. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91.
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9. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
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10. Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 2013 Feb 28; 152(5):957-68.
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11. Brown JC, Madhani HD. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012; 8(12):e1003168.
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12. Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell. 2012 Nov 13; 23(5):1059-71.
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13. Braun S, Madhani HD. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012 Jul; 13(7):619-30.
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14. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63.
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15. Madhani HD. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011 Oct; 7(10):e1002301.
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16. Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol. 2011 Oct; 31(20):4193-204.
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17. El-Samad H, Madhani HD. Can a systems perspective help us appreciate the biological meaning of small effects? Dev Cell. 2011 Jul 19; 21(1):11-3.
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18. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5.
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19. Chun CD, Brown JC, Madhani HD. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe. 2011 Mar 17; 9(3):243-51.
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20. Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 2011 Jan 7; 144(1):41-54.
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