Hiten Madhani, MD, PhD

Education

Professional Experience

• 1986-1987
  Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
• 1989-1993
  Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
• 1995-1999
  Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
• 1999-2005
  Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
• 2008-present
  Professor, Dept of Biochemistry and Biophysics, UCSF

Honors & Awards

• 1987
  Dean's Prize for Student Research, University of California, San Francisco
• 1988
  Dean's Prize for Student Research, University of California, San Francisco
• 1991-1992
  Chancellor's Fellowship, University of California, San Francisco
• 1996
  Finalist, Pharmacia-Science Prize
• 1995-1998
  Helen Hay Whitney Foundation Postdoctoral Research Fellowship
• 1998-1999
  Burroughs-Wellcome Fund Career Development Award
• 2000-2005
  David and Lucile Packard Foundation Fellowship for Scientists and Engineers
• 1999-2002
  Burroughs-Wellcome Fund Career Development Award
• 2005-2010
  Leukemia and Lymphoma Society Scholar
• 2017
  Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

1. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLoS Pathog. 2016 Dec; 12(12):e1006051.
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2. Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD. Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics. PLoS One. 2016; 11(8):e0159292.
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3. Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA. Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic Acids Res. 2016 Nov 2; 44(19):9180-9189.
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4. Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik CS, Madhani HD. Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host Microbe. 2016 Jun 8; 19(6):849-64.
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5. Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD. Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Res. 2015 Oct 15; 43(18):9017-27.
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6. Desjardins CA, Sanscrainte ND, Goldberg JM, Heiman D, Young S, Zeng Q, Madhani HD, Becnel JJ, Cuomo CA. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nat Commun. 2015; 6:7121.
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7. Garcia JF, Al-Sady B, Madhani HD. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda). 2015 Jul; 5(7):1453-61.
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8. Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 2015 Jan 15; 160(1-2):204-18.
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9. Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 2014 Nov 20; 159(5):1168-87.
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10. Goranov AI, Madhani HD. Functional profiling of human fungal pathogen genomes. Cold Spring Harb Perspect Med. 2015 Mar; 5(3):a019596.
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11. Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. MBio. 2014; 5(1):e00765-13.
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12. Madhani HD. snRNA catalysts in the spliceosome's ancient core. Cell. 2013 Dec 5; 155(6):1213-5.
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13. Dumesic PA, Madhani HD. Recognizing the enemy within: licensing RNA-guided genome defense. Trends Biochem Sci. 2014 Jan; 39(1):25-34.
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14. Madhani HD. The frustrated gene: origins of eukaryotic gene expression. Cell. 2013 Nov 7; 155(4):744-9.
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15. Dumesic PA, Madhani HD. The spliceosome as a transposon sensor. RNA Biol. 2013 Nov; 10(11):1653-60.
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16. Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes Dev. 2013 Sep 1; 27(17):1851-6.
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17. Al-Sady B, Madhani HD, Narlikar GJ. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91.
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18. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
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19. Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 2013 Feb 28; 152(5):957-68.
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20. Brown JC, Madhani HD. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet. 2012; 8(12):e1003168.
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