Director, UCSF Helen Diller Family Comprehensive Cancer Center
Associate Dean, UCSF School of Medicine
David A. Wood Distinguished Professorship of Tumor Biology and Cancer Research
Additional Websites
Education
University of Birmingham, England, B.Sc., 1972, Biochemistry
University of Cambridge, England, Ph.D., 1975, Biochemistry
Professional Experience
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1975-78
Professor Seymour S. Cohen, State University of New York at Stony Brook (Post Doctoral Fellow)
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1978-81
Dr. Alan Smith, Imperial Cancer Research Fund, London (Post Doctoral Fellow)
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1981-90
Cetus Corporation (Director of Molecular Biology)
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1990-91
Cetus Corporation (Vice President, Research)
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1991-92
Chiron Corporation (Vice President, Research)
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1992-96
Onyx Pharmaceuticals (Founder, Chief Scientific Officer)
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1996-present
Fellow of the Royal Society
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1997-2009
University of California, San Francisco, Cancer Research Institute (Director)
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1997-present
University of California, San Francisco, Dept. of Microbiology & Immunology (Professor)
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1997-
University of California, San Francisco, Cancer Center, (Director, Associate Dean)
Honors & Awards
- 1996
Fellow of the Royal Society - 2002
Bristol Myers Squibb Unrestricted Cancer Research Grant - 2002
AACR - G.H.A. Clowes Memorial Award - 2002
Novartis Drew Award in Biomedical Research - 2003
University of Chicago, Cancer Research Center, Shubitz Award - 2005
Institute of Medicine - 2010
ASCO Science of Oncology Award
Selected Publications
- McCormick F, Nwachukwu BU, Kim J, Martin SD. Autologous hamstring tendon used for revision of quadiceps tendon tears. Orthopedics. 2013 Apr 1; 36(4):e529-32.
View on PubMed - Young A, Lou D, McCormick F. Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling. Cancer Discov. 2013 Jan; 3(1):112-23.
View on PubMed - Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev. 2012 Jul 1; 26(13):1421-6.
View on PubMed - Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. PLoS One. 2012; 7(5):e37431.
View on PubMed - McCormick F. Cancer therapy based on oncogene addiction. J Surg Oncol. 2011 May 1; 103(6):464-7.
View on PubMed - Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157(2):136-46.
View on PubMed - Gysin S, Salt M, Young A, McCormick F. Therapeutic strategies for targeting ras proteins. Genes Cancer. 2011 Mar; 2(3):359-72.
View on PubMed - McCormick F. Mutant onco-proteins as drug targets: successes, failures, and future prospects. Curr Opin Genet Dev. 2011 Feb; 21(1):29-33.
View on PubMed - Lee SH, McCormick F, Saya H. Mad2 inhibits the mitotic kinesin MKlp2. J Cell Biol. 2010 Dec 13; 191(6):1069-77.
View on PubMed - Lyle C, McCormick F. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. Virol J. 2010; 7:148.
View on PubMed - Ishida S, McCormick F, Smith-McCune K, Hanahan D. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell. 2010 Jun 15; 17(6):574-83.
View on PubMed - Harris TJ, McCormick F. The molecular pathology of cancer. Nat Rev Clin Oncol. 2010 May; 7(5):251-65.
View on PubMed - Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol. 2010 May; 30(9):2264-79.
View on PubMed - Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. Am J Med Genet A. 2010 Feb; 152A(2):269-83.
View on PubMed - McCormick F. How blocking Raf activates the MAPK pathway. Pigment Cell Melanoma Res. 2010 Apr; 23(2):187-9.
View on PubMed - Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H. Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway. Oncogene. 2010 Apr 1; 29(13):1897-908.
View on PubMed - Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24.
View on PubMed - Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009; 2(55):ra4.
View on PubMed - Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72.
View on PubMed - Young A, Lyons J, Miller AL, Phan VT, Alarcón IR, McCormick F. Ras signaling and therapies. Adv Cancer Res. 2009; 102:1-17.
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