Joseph (Mike) McCune, MD, PhD


Professor of Medicine; Chief, Division of Experimental Medicine, UCSF

Phone: (415) 206-8101 (office)
Box 1234, UCSF
San Francisco, CA 94143-1234

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Harvard College, A.B., 1975, Biochemistry
The Rockefeller University, Ph.D., 1981, Cell Biology/Immunology
Cornell Medical College, M.D., 1982, Medicine

Professional Experience

  • 1982-84
    Resident in Internal Medicine, University of California, San Francisco
  • 1984-86
    Infectious Disease Fellow, UCSF
  • 1985-88
    Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
  • 1986-present
    Physician, UCSF AIDS Clinic, San Francisco General Hospital (SFGH)
  • 1988-91
    Scientific Director, SyStemix, Inc.
  • 1991-94
    Vice-President, New Enterprise Research Division, SyStemix, Inc.
  • 1993-94
    Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc)
  • 1995-1999
    Associate Investigator, Gladstone Institute of Virology and Immunology (GIVI)
  • 1999-2006
    Senior Investigator, GIVI
  • 1995-1999
    Associate Professor of Medicine, UCSF
  • 1995-2006
    Associate Director, General Clinical Research Center, SFGH
  • 2003-2004
    Visiting Professor (on sabbatical), Institut Pasteur, Paris, France
  • 2006-2008
    Director and PI of the UCSF Clinical and Translational Science Institute
  • 2005-2008
    Senior Associate Dean of Clinical and Translational Research
  • 2006-present
    Chief of the Division of Experimental Medicine
  • 1999-present
    Professor of Medicine, UCSF

Honors & Awards

  • 1972-75
    National Merit Scholarship
  • 1972-75
    Harvard National Scholarship
  • 1975-76
    Michael C. Rockefeller Memorial Fellowship
  • 1986-89
    Pfizer Postdoctoral Fellowship in Infectious Diseases
  • 1987
    Diplomate, Internal Medicine
  • 1996-2000
    Elizabeth Glaser Scientist Award
  • 1999
    Member, American Society for Clinical Investigation
  • 2000
    Member, American Association of Physicians
  • 2000-2005
    Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
  • 2001
    NIH MERIT Award
  • 2004
    NIH Director's Pioneer Award
  • 2006
    NIH Clinical and Translational Science Institute Award
  • 2007
    Pediatric Fellows and Fellows Leadership and Advocacy Group Mentorship Award, nominee
  • 2007
    UCSF Postdoctoral Scholar’s Association Outstanding Mentor Award
  • Thomas M.
  • 2011
    Kelley Leadership Award, Project Inform
  • 2013
    UCSF Academic Senate Faculty Research Lectureship in Translational Science

Selected Publications

  1. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial. PLoS One. 2014; 9(12):e116306.
    View on PubMed
  2. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2014 Nov 9.
    View on PubMed
  3. Palmer CS, Anzinger JJ, Zhou J, Gouillou M, Landay A, Jaworowski A, McCune JM, Crowe SM. Glucose Transporter 1-Expressing Proinflammatory Monocytes Are Elevated in Combination Antiretroviral Therapy-Treated and Untreated HIV+ Subjects. J Immunol. 2014 Dec 1; 193(11):5595-603.
    View on PubMed
  4. Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. AIDS Res Ther. 2014; 11:27.
    View on PubMed
  5. Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG. Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease. AIDS. 2014 Jul 31; 28(12):1749-58.
    View on PubMed
  6. Krow-Lucal ER, McCune JM. Distinct functional programs in fetal T and myeloid lineages. Front Immunol. 2014; 5:314.
    View on PubMed
  7. Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, Mccune JM, Tarantal AF. Myeloid-Lymphoid Ontogeny in the Rhesus Monkey (Macaca mulatta). Anat Rec (Hoboken). 2014 Aug; 297(8):1392-406.
    View on PubMed
  8. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality. PLoS Pathog. 2014 May; 10(5):e1004078.
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  9. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Low Proportions of CD28- CD8+ T cells Expressing CD57 Can Be Reversed by Early ART Initiation and Predict Mortality in Treated HIV Infection. J Infect Dis. 2014 Aug 1; 210(3):374-82.
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  10. Byakwaga H, Boum Y, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW. The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy. J Infect Dis. 2014 Aug 1; 210(3):383-91.
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  11. Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging. PLoS One. 2014; 9(2):e89444.
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  12. Krow-Lucal ER, Kim CC, Burt TD, McCune JM. Distinct functional programming of human fetal and adult monocytes. Blood. 2014 Mar 20; 123(12):1897-904.
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  13. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production. PLoS One. 2014; 9(2):e87877.
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  14. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance Between Peripheral and Colonic Markers of Inflammation During Suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 1; 65(2):133-41.
    View on PubMed
  15. Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM. Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection. AIDS. 2014 Jan 28; 28(3):297-309.
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  16. Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM. Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease. PLoS One. 2014 Jan 21; 9(1):e85613.
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  17. Bakkour S, Baker CA, Tarantal AF, Wen L, Busch MP, Lee TH, McCune JM. Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms. Chimerism. 2014 Jan 1; 5(1):6-15.
    View on PubMed
  18. Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM. Higher CD27(+)CD8(+) T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4(+) T Cell Recovery in Treated HIV Infection. PLoS One. 2013; 8(12):e84091.
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  19. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. Monocyte Activation by Interferon a Is Associated With Failure to Achieve a Sustained Virologic Response After Treatment for Hepatitis C Virus Infection. J Infect Dis. 2014 May; 209(10):1602-12.
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  20. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691.
    View on PubMed

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