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Joseph (Mike) McCune, MD, PhD


Professor of Medicine; Chief, Division of Experimental Medicine, UCSF


Phone: (415) 206-8101 (office)
Box 1234, UCSF
San Francisco, CA 94143-1234

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Harvard College, A.B., 1975, Biochemistry
The Rockefeller University, Ph.D., 1981, Cell Biology/Immunology
Cornell Medical College, M.D., 1982, Medicine

Professional Experience

  • 1982-84
    Resident in Internal Medicine, University of California, San Francisco
  • 1984-86
    Infectious Disease Fellow, UCSF
  • 1985-88
    Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
  • 1986-present
    Physician, UCSF AIDS Clinic, San Francisco General Hospital (SFGH)
  • 1988-91
    Scientific Director, SyStemix, Inc.
  • 1991-94
    Vice-President, New Enterprise Research Division, SyStemix, Inc.
  • 1993-94
    Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc)
  • 1995-1999
    Associate Investigator, Gladstone Institute of Virology and Immunology (GIVI)
  • 1999-2006
    Senior Investigator, GIVI
  • 1995-1999
    Associate Professor of Medicine, UCSF
  • 1995-2006
    Associate Director, General Clinical Research Center, SFGH
  • 2003-2004
    Visiting Professor (on sabbatical), Institut Pasteur, Paris, France
  • 2006-2008
    Director and PI of the UCSF Clinical and Translational Science Institute
  • 2005-2008
    Senior Associate Dean of Clinical and Translational Research
  • 2006-present
    Chief of the Division of Experimental Medicine
  • 1999-present
    Professor of Medicine, UCSF

Honors & Awards

  • 1972-75
    National Merit Scholarship
  • 1972-75
    Harvard National Scholarship
  • 1975-76
    Michael C. Rockefeller Memorial Fellowship
  • 1986-89
    Pfizer Postdoctoral Fellowship in Infectious Diseases
  • 1987
    Diplomate, Internal Medicine
  • 1996-2000
    Elizabeth Glaser Scientist Award
  • 1999
    Member, American Society for Clinical Investigation
  • 2000
    Member, American Association of Physicians
  • 2000-2005
    Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
  • 2001
    NIH MERIT Award
  • 2004
    NIH Director's Pioneer Award
  • 2006
    NIH Clinical and Translational Science Institute Award
  • 2007
    Pediatric Fellows and Fellows Leadership and Advocacy Group Mentorship Award, nominee
  • 2007
    UCSF Postdoctoral Scholar’s Association Outstanding Mentor Award
  • Thomas M.
  • 2011
    Kelley Leadership Award, Project Inform
  • 2013
    UCSF Academic Senate Faculty Research Lectureship in Translational Science

Selected Publications

  1. Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM. Higher CD27(+)CD8(+) T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4(+) T Cell Recovery in Treated HIV Infection. PLoS One. 2013; 8(12):e84091.
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  2. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691.
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  3. Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J Infect Dis. 2013 Nov 1; 208(9):1436-42.
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  4. Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG. Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. J Infect Dis. 2013 Oct 15; 208(8):1202-11.
    View on PubMed
  5. Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. Dysbiosis of the gut microbiota is associated with hiv disease progression and tryptophan catabolism. Sci Transl Med. 2013 Jul 10; 5(193):193ra91.
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  6. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83.
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  7. Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog. 2012; 8(11):e1003000.
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  8. Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. J Infect Dis. 2013 Jul; 208(1):50-6.
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  9. Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM. Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase. AIDS Res Hum Retroviruses. 2013 Feb; 29(2):207-14.
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  10. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog. 2012; 8(8):e1002883.
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  11. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum. 2012 Aug; 64(8):2451-9.
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  12. Sacre K, Criswell LA, McCune JM. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther. 2012; 14(3):R155.
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  13. Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Curr Opin Immunol. 2012 Aug; 24(4):501-6.
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  14. Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM. SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Sci Transl Med. 2012 May 30; 4(136):136ra69.
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  15. Brown JN, Ortiz GM, Angel TE, Jacobs JM, Gritsenko M, Chan EY, Purdy DE, Murnane RD, Larsen K, Palermo RE, Shukla AK, Clauss TR, Katze MG, McCune JM, Smith RD. Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Mol Cell Proteomics. 2012 Sep; 11(9):605-18.
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  16. Sacre K, Hunt PW, Hsue PY, Maidji E, Martin JN, Deeks SG, Autran B, McCune JM. A role for cytomegalovirus-specific CD4+CX3CR1+ T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis. AIDS. 2012 Apr 24; 26(7):805-14.
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  17. Baum PD, Young JJ, Schmidt D, Zhang Q, Hoh R, Busch M, Martin J, Deeks S, McCune JM. Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists. Blood. 2012 Apr 12; 119(15):3469-77.
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  18. Kiem HP, Jerome KR, Deeks SG, McCune JM. Hematopoietic-stem-cell-based gene therapy for HIV disease. Cell Stem Cell. 2012 Feb 3; 10(2):137-47.
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  19. Mold JE, McCune JM. Immunological tolerance during fetal development: from mouse to man. Adv Immunol. 2012; 115:73-111.
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  20. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8.
    View on PubMed

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