Joseph (Mike) McCune, MD, PhD

Professor of Medicine; Chief, Division of Experimental Medicine, UCSF

mike.mccune@ucsf.edu

Phone: (415) 206-8101 (office)
Box 1234, UCSF
San Francisco, CA 94143-1234

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Education

Harvard College, A.B., 1975, Biochemistry
The Rockefeller University, Ph.D., 1981, Cell Biology/Immunology
Cornell Medical College, M.D., 1982, Medicine

Professional Experience

• 1982-84
  Resident in Internal Medicine, University of California, San Francisco
• 1984-86
  Infectious Disease Fellow, UCSF
• 1985-88
  Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
• 1986-present
  Physician, UCSF AIDS Clinic, San Francisco General Hospital (SFGH)
• 1988-91
  Scientific Director, SyStemix, Inc.
• 1991-94
  Vice-President, New Enterprise Research Division, SyStemix, Inc.
• 1993-94
  Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc)
• 1995-1999
  Associate Investigator, Gladstone Institute of Virology and Immunology (GIVI)
• 1999-2006
  Senior Investigator, GIVI
• 1995-1999
  Associate Professor of Medicine, UCSF
• 1995-2006
  Associate Director, General Clinical Research Center, SFGH
• 2003-2004
  Visiting Professor (on sabbatical), Institut Pasteur, Paris, France
• 2006-2008
  Director and PI of the UCSF Clinical and Translational Science Institute
• 2005-2008
  Senior Associate Dean of Clinical and Translational Research
• 2006-present
  Chief of the Division of Experimental Medicine
• 1999-present
  Professor of Medicine, UCSF

Honors & Awards

• 1972-75
  National Merit Scholarship
• 1972-75
  Harvard National Scholarship
• 1975-76
  Michael C. Rockefeller Memorial Fellowship
• 1986-89
  Pfizer Postdoctoral Fellowship in Infectious Diseases
• 1987
  Diplomate, Internal Medicine
• 1996-2000
  Elizabeth Glaser Scientist Award
• 1999
  Member, American Society for Clinical Investigation
• 2000
  Member, American Association of Physicians
• 2000-2005
  Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
• 2001
  NIH MERIT Award
• 2004
  NIH Director's Pioneer Award
• 2006
  NIH Clinical and Translational Science Institute Award
• 2007
  Pediatric Fellows and Fellows Leadership and Advocacy Group Mentorship Award, nominee
• 2007
  UCSF Postdoctoral Scholar’s Association Outstanding Mentor Award

Selected Publications

1. Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog. 2012 Nov; 8(11):e1003000.
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2. Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM. Preclinical Evaluation of HIV Eradication Strategies in the Simian Immunodeficiency Virus-Infected Rhesus Macaque: A Pilot Study Testing Inhibition of Indoleamine 2,3-Dioxygenase. AIDS Res Hum Retroviruses. 2013 Feb; 29(2):207-14.
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3. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog. 2012; 8(8):e1002883.
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4. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum. 2012 Aug; 64(8):2451-9.
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5. Sacre K, Criswell LA, McCune JM. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther. 2012; 14(3):R155.
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6. Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Curr Opin Immunol. 2012 Aug; 24(4):501-6.
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7. Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM. SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Sci Transl Med. 2012 May 30; 4(136):136ra69.
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8. Brown JN, Ortiz GM, Angel TE, Jacobs JM, Gritsenko M, Chan EY, Purdy DE, Murnane RD, Larsen K, Palermo RE, Shukla AK, Clauss TR, Katze MG, McCune JM, Smith RD. Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Mol Cell Proteomics. 2012 Sep; 11(9):605-18.
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9. Sacre K, Hunt PW, Hsue PY, Maidji E, Martin JN, Deeks SG, Autran B, McCune JM. A role for cytomegalovirus-specific CD4+CX3CR1+ T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis. AIDS. 2012 Apr 24; 26(7):805-14.
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10. Baum PD, Young JJ, Schmidt D, Zhang Q, Hoh R, Busch M, Martin J, Deeks S, McCune JM. Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists. Blood. 2012 Apr 12; 119(15):3469-77.
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11. Kiem HP, Jerome KR, Deeks SG, McCune JM. Hematopoietic-stem-cell-based gene therapy for HIV disease. Cell Stem Cell. 2012 Feb 3; 10(2):137-47.
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12. Mold JE, McCune JM. Immunological tolerance during fetal development: from mouse to man. Adv Immunol. 2012; 115:73-111.
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13. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28; 25(18):2243-8.
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14. Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM. Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans. Genes Immun. 2012 Apr; 13(3):258-67.
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15. Kitchen CM, Yeghiazarian L, Hoh R, McCune JM, Sinclair E, Martin JN, Deeks SG. Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection. PLoS One. 2011; 6(6):e21190.
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16. Bacchetti P, Deeks SG, McCune JM. Breaking free of sample size dogma to perform innovative translational research. Sci Transl Med. 2011 Jun 15; 3(87):87ps24.
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17. Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS. 2011 May; 6(3):221-7.
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18. Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011 Apr 1; 203(7):960-8.
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19. Baum PD, Young JJ, McCune JM. Measurement of absolute T cell receptor rearrangement diversity. J Immunol Methods. 2011 May 31; 368(1-2):45-53.
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20. Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG. A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One. 2011; 6(1):e15924.
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