Joseph (Mike) McCune, MD, PhD

Joseph (Mike) McCune, MD, PhD

Professor of Medicine; Chief, Division of Experimental Medicine, UCSF

Phone: (415) 206-8101 (office)
Box 1234, UCSF
San Francisco, CA 94143-1234

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Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment

Research Summary

My lab has been involved for many years in the analysis of HIV pathogenesis, prevention, and treatment. After extensive studies at Harvard College (with Jack Strominger) and at The Rockefeller University (with Henry Kunkel and Gunter Blobel, leading to a PhD in Cell Biology and Immunology), I started to treat patients with HIV as an intern at UCSF in 1982 and have been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies with Irv Weissman at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. This work was continued in companies that I co-founded (SyStemix and Progenesys) and for which I served as a Scientific Director. In 1995, I returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (starting in 2006) as the Chief of the Division of Experimental Medicine (which I founded) at UCSF. Concomitantly, I was the founding PI and Senior Associate Dean of the Clinical and Translational Sciences Institute (CTSI) at UCSF (from 2005-08), and remain active on its Board to this date. In recent studies, I have been working with co-PIs Drs. Steven Deeks and Rafick Sekaly to direct the “DARE Collaboratory” (funded by U19 AI96109-01), aimed at testing the possibility that host inflammatory responses might drive HIV persistence.


Harvard College, A.B., 1975, Biochemistry
The Rockefeller University, Ph.D., 1981, Cell Biology/Immunology
Cornell Medical College, M.D., 1982, Medicine

Professional Experience

  • 1982-84
    Resident in Internal Medicine, University of California, San Francisco
  • 1984-86
    Infectious Disease Fellow, UCSF
  • 1985-88
    Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
  • 1986-present
    Physician, UCSF AIDS Clinic, San Francisco General Hospital (SFGH)
  • 1988-91
    Scientific Director, SyStemix, Inc.
  • 1991-94
    Vice-President, New Enterprise Research Division, SyStemix, Inc.
  • 1993-94
    Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc)
  • 1995-1999
    Associate Investigator, Gladstone Institute of Virology and Immunology (GIVI)
  • 1999-2006
    Senior Investigator, GIVI
  • 1995-1999
    Associate Professor of Medicine, UCSF
  • 1995-2006
    Associate Director, General Clinical Research Center, SFGH
  • 2003-2004
    Visiting Professor (on sabbatical), Institut Pasteur, Paris, France
  • 2006-2008
    Director and PI of the UCSF Clinical and Translational Science Institute
  • 2005-2008
    Senior Associate Dean of Clinical and Translational Research
  • 2006-present
    Chief of the Division of Experimental Medicine
  • 1999-present
    Professor of Medicine, UCSF

Honors & Awards

  • 1972-75
    National Merit Scholarship
  • 1972-75
    Harvard National Scholarship
  • 1975-76
    Michael C. Rockefeller Memorial Fellowship
  • 1986-89
    Pfizer Postdoctoral Fellowship in Infectious Diseases
  • 1987
    Diplomate, Internal Medicine
  • 1996-2000
    Elizabeth Glaser Scientist Award
  • 1999
    Member, American Society for Clinical Investigation
  • 2000
    Member, American Association of Physicians
  • 2000-2005
    Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
  • 2001
    NIH MERIT Award
  • 2004
    NIH Director's Pioneer Award
  • 2006
    NIH Clinical and Translational Science Institute Award
  • 2007
    Pediatric Fellows and Fellows Leadership and Advocacy Group Mentorship Award, nominee
  • 2007
    UCSF Postdoctoral Scholar’s Association Outstanding Mentor Award
  • Thomas M.
  • 2011
    Kelley Leadership Award, Project Inform
  • 2013
    UCSF Academic Senate Faculty Research Lectureship in Translational Science

Selected Publications

  1. Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM. Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1ß: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. J Immunol. 2015 Nov 1; 195(9):4096-105.
    View on PubMed
  2. Loke P, Favre D, Hunt PW, Leung JM, Kanwar B, Martin JN, Deeks SG, McCune JM. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood. 2010 Apr 15; 115(15):e20-32.
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  3. Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, Deeks SG. Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PLoS One. 2010; 5(1):e8886.
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  4. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31.
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  5. Lederer S, Favre D, Walters KA, Proll S, Kanwar B, Kasakow Z, Baskin CR, Palermo R, McCune JM, Katze MG. Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog. 2009 Feb; 5(2):e1000296.
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  6. Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009 Feb; 5(2):e1000295.
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  7. Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem. 2009 Mar 13; 284(11):6782-9.
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  8. Lozano Reina JM, Favre D, Kasakow Z, Mayau V, Nugeyre MT, Ka T, Faye A, Miller CJ, Scott-Algara D, McCune JM, Barré-Sinoussi F, Diop OM, Müller-Trutwin MC. Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys. J Virol. 2009 Mar; 83(6):2770-7.
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  9. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 5; 322(5907):1562-5.
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  10. Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med. 2008 Nov 24; 205(12):2763-79.
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  11. Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune JM, Martin JN, Busch MP, Deeks SG. Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J Virol. 2009 Jan; 83(1):329-35.
    View on PubMed

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