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Donald M. McDonald, MD, PhD


Professor, Department of Anatomy, UCSF


Phone: (415) 476-2118 (Asst), 476-6615 (lab)
Box 0452, UCSF
San Francisco, CA 94143-0452

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Additional Websites


University of California, Berkeley, A.B., 1961, Zoology
University of California, San Francisco, M.D., 1965
University of Iowa, Iowa City, 1965-1966, Internal Medicine
NIH Graduate Division, Bethesda, 1966-1969, Cell Biology & Neuroscience
University of California, San Francisco, Ph.D., 1974, Cell Biology & Endocrinology

Professional Experience

  • 1966-67
    Staff Associate, Program Projects Branch, Extramural Programs, NHLBI, NIH, Bethesda, MD
  • 1967-69
    Staff Associate, Section on Functional Neuroanatomy, Laboratory of Neuropathology and Neuroanatomical Science, NINDS, NIH, Bethesda, MD
  • 1969-72
    NIH Special Fellowship, Cardiovascular Research Institute, UCSF
  • 1973-78
    Assistant Professor of Anatomy, UCSF
  • 1973-90
    Associate Staff, Cardiovascular Research Institute, UCSF
  • 1973-98
    Head, Pulmonary Core Microscopy Laboratory, Cardiovascular Research Institute, UCSF
  • 1978-84
    Associate Professor of Anatomy, UCSF
  • 1981-90
    Associate Director, Pulmonary Training Program, Cardiovascular Research Institute, UCSF
  • 1984-
    Professor of Anatomy, UCSF
  • 1990-98
    Senior Staff, Cardiovascular Research Institute, UCSF
  • 1999-
    Investigator, Cardiovascular Research Institute, UCSF
  • 2001-present
    Member, Comprehensive Cancer Center, UCSF

Selected Publications

  1. Yao LC, McDonald DM. Plasticity of airway lymphatics in development and disease. Adv Anat Embryol Cell Biol. 2014; 214:41-54.
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  2. Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 2013 Sep; 49(3):437-44.
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  3. Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald DM, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE. Iron administration before stem cell harvest enables MR imaging tracking after transplantation. Radiology. 2013 Oct; 269(1):186-97.
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  4. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83.
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  5. Sennino B, Ishiguro-Oonuma T, Schriver BJ, Christensen JG, McDonald DM. Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice. Cancer Res. 2013 Jun 15; 73(12):3692-703.
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  6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.
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  7. Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM. Transgenic overexpression of interleukin-1ß induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 2013 Apr; 182(4):1434-47.
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  8. Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA. Identification of pY654-ß-catenin as a critical co-factor in hypoxia-inducible factor-1a signaling and tumor responses to hypoxia. Oncogene. 2013 Oct 17; 32(42):5048-57.
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  9. Nejadnik H, Henning TD, Do T, Sutton EJ, Baehner F, Horvai A, Sennino B, McDonald D, Meier R, Misselwitz B, Link TM, Daldrup-Link HE. MR imaging features of gadofluorine-labeled matrix-associated stem cell implants in cartilage defects. PLoS One. 2012; 7(12):e49971.
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  10. Sennino B, McDonald DM. Controlling escape from angiogenesis inhibitors. Nat Rev Cancer. 2012 Oct; 12(10):699-709.
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  11. Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE. Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations. Mol Imaging. 2012 Jun; 11(3):197-209.
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  12. Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald DM. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 2012 Jun; 180(6):2561-75.
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  13. Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald DM, Blau HM. Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. FASEB J. 2012 Jun; 26(6):2486-97.
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  14. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87.
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  15. Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun. 2012; 3:1208.
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  16. McDonald DM, Yao LC, Baluk P. Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation. Proc Am Thorac Soc. 2011 Nov; 8(6):504-7.
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  17. Aftab DT, McDonald DM. MET and VEGF: synergistic targets in castration-resistant prostate cancer. Clin Transl Oncol. 2011 Oct; 13(10):703-9.
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  18. Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald DM, Brasch RC, Raatschen HJ. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur J Radiol. 2012 May; 81(5):891-6.
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  19. Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21.
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  20. Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM. Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. Am J Pathol. 2011 Jun; 178(6):2920-30.
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