Donald M. McDonald, MD, PhD

Donald M. McDonald, MD, PhD

Professor, Department of Anatomy, UCSF

Phone: (415) 476-2118 (Asst), 476-6615 (lab)
Box 0452, UCSF
San Francisco, CA 94143-0452

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Cancer Center Membership

Program Member ยป Cancer, Immunity, and Microenvironment

Research Summary

Research in my laboratory is examining the cellular mechanisms of lymphangiogenesis, angiogenesis, and vascular remodeling in mouse models of chronic inflammation and cancer, with a focus on the respiratory tract. We use in vivo cell biological approaches to determine how abnormalities of lymphatics and blood vessels contribute to disease pathophysiology. My current interests include developing approaches for preventing, stopping, or reversing disease-related changes in lymphatics and blood vessels and learning the consequences of these actions. Related interests include the regulation of endothelial barrier function, downstream effects of altered plasma leakage, and control mechanisms of tissue fluid and cell clearance by lymphatics. Projects in the laboratory use mouse models to dissect the role of key growth factors and receptors involved in growth and remodeling of lymphatics and blood vessels and related disease processes. VEGF-C, VEGF-A, angiopoietins, TNF-alpha, HGF, and their receptors are of current interest. In mouse models, signaling is manipulated in vivo by switchable transgenic overexpression, genetic deletion, viral vectors, or pharmacological agonists or inhibitors. Ongoing studies are using the models to examine factors that drive or modify remodeling of lymphatics and blood vessels in inflammatory conditions in the lung and airways. We are also studying favorable and potentially unfavorable effects of growing or destroying lymphatics and/or blood vessels in the lung or in tumors, reflected by tumor growth, invasion, and metastasis. The overall goal is to advance the understanding and development of strategies that can stop or reverse lymphangiogenesis and angiogenesis and to characterize the downstream benefits and consequences of these changes in inflammatory disease and cancer.


University of California, Berkeley, A.B., 1961, Zoology
University of California, San Francisco, M.D., 1965
University of Iowa, Iowa City, 1965-1966, Internal Medicine
NIH Graduate Division, Bethesda, 1966-1969, Cell Biology & Neuroscience
University of California, San Francisco, Ph.D., 1974, Cell Biology & Endocrinology

Professional Experience

  • 1966-67
    Staff Associate, Program Projects Branch, Extramural Programs, NHLBI, NIH, Bethesda, MD
  • 1967-69
    Staff Associate, Section on Functional Neuroanatomy, Laboratory of Neuropathology and Neuroanatomical Science, NINDS, NIH, Bethesda, MD
  • 1969-72
    NIH Special Fellowship, Cardiovascular Research Institute, UCSF
  • 1973-78
    Assistant Professor of Anatomy, UCSF
  • 1973-90
    Associate Staff, Cardiovascular Research Institute, UCSF
  • 1973-98
    Head, Pulmonary Core Microscopy Laboratory, Cardiovascular Research Institute, UCSF
  • 1978-84
    Associate Professor of Anatomy, UCSF
  • 1981-90
    Associate Director, Pulmonary Training Program, Cardiovascular Research Institute, UCSF
  • 1984-
    Professor of Anatomy, UCSF
  • 1990-98
    Senior Staff, Cardiovascular Research Institute, UCSF
  • 1999-
    Investigator, Cardiovascular Research Institute, UCSF
  • 2001-present
    Member, Comprehensive Cancer Center, UCSF

Selected Publications

  1. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{?}+p at sqrt[s]=200??GeV. Phys Rev Lett. 2015 Dec 11; 115(24):242501.
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  2. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec; 32(8):799-817.
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  3. Synergistic Actions of Blocking Angiopoietin-2 and Tumor Necrosis Factor-a in Suppressing Remodeling of Blood Vessels and Lymphatics in Airway Inflammation. Am J Pathol. 2015 Nov; 185(11):2949-68.
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  4. Precision Measurement of the Longitudinal Double-Spin Asymmetry for Inclusive Jet Production in Polarized Proton Collisions at sqrt[s]=200??GeV. Phys Rev Lett. 2015 Aug 28; 115(9):092002.
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  5. Observation of Charge Asymmetry Dependence of Pion Elliptic Flow and the Possible Chiral Magnetic Wave in Heavy-Ion Collisions. Phys Rev Lett. 2015 Jun 26; 114(25):252302.
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  6. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. J Am Soc Nephrol. 2016 Jan; 27(1):69-77.
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  7. Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux. PLoS One. 2015; 10(5):e0125797.
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  8. Mast Cells Present Protrusions into Blood Vessels upon Tracheal Allergen Challenge in Mice. PLoS One. 2015; 10(3):e0118513.
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  9. ?? Correlation Function in Au+Au Collisions at sqrt[s_{NN}]=200??GeV. Phys Rev Lett. 2015 Jan 16; 114(2):022301.
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  10. Observation of D0 meson nuclear modifications in Au+Au collisions at sqrt[s(NN)] = 200 GeV. Phys Rev Lett. 2014 Oct 3; 113(14):142301.
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  11. Beam energy dependence of moments of the net-charge multiplicity distributions in Au+Au collisions at RHIC. Phys Rev Lett. 2014 Aug 29; 113(9):092301.
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  12. Measurement of longitudinal spin asymmetries for weak boson production in polarized proton-proton collisions at RHIC. Phys Rev Lett. 2014 Aug 15; 113(7):072301.
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  13. Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. Phys Rev Lett. 2014 Aug 1; 113(5):052302.
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  14. Dielectron mass spectra from Au+Au collisions at v[s(NN)]=200??GeV. Phys Rev Lett. 2014 Jul 11; 113(2):022301.
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  15. Beam-energy dependence of the directed flow of protons, antiprotons, and pions in Au+Au collisions. Phys Rev Lett. 2014 Apr 25; 112(16):162301.
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  16. Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol. 2014 Jun; 184(6):1877-89.
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  17. Jet-hadron correlations in v[s(NN)]=200??GeV p+p and central Au+Au collisions. Phys Rev Lett. 2014 Mar 28; 112(12):122301.
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  18. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. Am J Pathol. 2014 May; 184(5):1577-92.
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  19. Energy dependence of moments of net-proton multiplicity distributions at RHIC. Phys Rev Lett. 2014 Jan 24; 112(3):032302.
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  20. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res. 2014 Feb 28; 114(5):806-22.
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