Michael S. McGrath, MD, PhD

Professor, Departments of Laboratory Medicine, Pathology, and Medicine, UCSF

mmcgrath@hemeonc.ucsf.edu

Phone: (415) 206-8204 (voice)
Box 1317, UCSF
San Francisco, CA 94143-1317

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Education

University of Minnesota, B.S., 1974, Biology Medicine
Stanford University School of Medicine, M.D., 1980, Medicine
Stanford University School of Medicine, Ph.D., 1981, Cancer Biology

Professional Experience

• 1972-1974
  Research Assistant, Dept of Medicine with Dr. Charles Moldow, University of Minnesota: Identification and analysis of fibroblast receptors for avian tumor viruses.
• 1974-1980
  M.D./Ph.D. Predoctoral Fellow, Dept of Pathology, Stanford University School of Medicine, Stanford Medical Scientist Training Program. Enrolled in Cancer Biology Ph.D. Program with Dr. Irving Weissman. Thesis: Receptor mediated leukemogenesis.
• 1980
  ICRETT Fellowship in Cancer Research with Dr. George Klein, Karolinska Institute, Stockholm, Sweden: Relationship between leukemogenesis and chromosomal abnormalities.
• 1980-1982
  NIH Postdoctoral Fellow, Department of Pathology, Stanford University.
• 1980-1982
  Visiting Fellow, Department of Biology, California Institute of Technology with Dr. Lee Hood: Molecular Biology of Immunoglobulin and T Cell Receptor Genes.
• 1980-1982
  Hematology Fellow, Dept of Medicine, Stanford University School of Medicine.
• 1982-1984
  Residency in Internal Medicine, Stanford University.
• 1984-1985
  Fellow in Hematology, Stanford University, Department of Medicine.
• 1985
  Assistant Professor of Medicine, AIDS/Oncology Division, University of California, San Francisco/San Francisco General Hospital.
• 1985
  Ad hoc grant reviewer for NIMH, NCI, NIAID, VA
• 1985-present
  Scientific Advisory Board, The American Foundation for AIDS Research (AmFAR)
• 1991-1992
  Assistant Professor of Laboratory Medicine, UCSF/SFGH
• 1992
  Associate Professor of Laboratory Medicine and Medicine, UCSF/SFGH
• 1995
  Associate Professor of Pathology, UCSF/SFGH
• 1998-present
  Professor in Residence of Laboratory Medicine, Medicine and Pathology, UCSF/SFGH
• 1999-2000
  Sabbatical with Dr. Stefan Meuer, Institut fur Immunologie, University of Heidelberg, Germany

Honors & Awards

• 1990
  Outstanding Speaker Award, American Association for Clinical Chemistry
• 1999-2000
  Mercatur Scholar, University of Heidelberg, Germany

Selected Publications

1. Turner MR, Bowser R, Bruijn L, Dupuis L, Ludolph A, McGrath M, Manfredi G, Maragakis N, Miller RG, Pullman SL, Rutkove SB, Shaw PJ, Shefner J, Fischbeck KH. Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May; 14 Suppl 1:19-32.
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2. Zhang R, Miller RG, Madison C, Jin X, Honrada R, Harris W, Katz J, Forshew DA, McGrath MS. Systemic immune system alterations in early stages of Alzheimer's disease. J Neuroimmunol. 2013 Mar 15; 256(1-2):38-42.
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3. Lamers SL, Fogel GB, Singer EJ, Salemi M, Nolan DJ, Huysentruyt LC, McGrath MS. HIV-1 Nef in Macrophage-Mediated Disease Pathogenesis. Int Rev Immunol. 2012 Dec; 31(6):432-50.
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4. Mukhtar RA, Moore AP, Tandon VJ, Nseyo O, Twomey P, Adisa CA, Eleweke N, Au A, Baehner FL, Moore DH, McGrath MS, Olopade OI, Gray JW, Campbell MJ, Esserman LJ. Elevated Levels of Proliferating and Recently Migrated Tumor-associated Macrophages Confer Increased Aggressiveness and Worse Outcomes in Breast Cancer. Ann Surg Oncol. 2012 Nov; 19(12):3979-86.
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5. Lamers SL, Poon AF, McGrath MS. HIV-1 nef protein structures associated with brain infection and dementia pathogenesis. PLoS One. 2011; 6(2):e16659.
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6. Ayers LW, Silver S, Orenstein JM, McGrath MS, Garcia DL. The AIDS and Cancer Specimen Resource. Methods Mol Biol. 2011; 675:193-203.
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7. Lamers SL, Fogel GB, Huysentruyt LC, McGrath MS. HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis? Curr HIV Res. 2010 Dec; 8(8):638-40.
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8. Lamers SL, Gray RR, Salemi M, Huysentruyt LC, McGrath MS. HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues. Infect Genet Evol. 2011 Jan; 11(1):31-7.
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9. Zhang R, Hadlock KG, Do H, Yu S, Honrada R, Champion S, Forshew D, Madison C, Katz J, Miller RG, McGrath MS. Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol. 2011 Jan; 230(1-2):114-23.
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10. Campbell MJ, Tonlaar NY, Garwood ER, Huo D, Moore DH, Khramtsov AI, Au A, Baehner F, Chen Y, Malaka DO, Lin A, Adeyanju OO, Li S, Gong C, McGrath M, Olopade OI, Esserman LJ. Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome. Breast Cancer Res Treat. 2011 Aug; 128(3):703-11.
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11. Subimerb C, Pinlaor S, Lulitanond V, Khuntikeo N, Okada S, McGrath MS, Wongkham S. Circulating CD14(+) CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma. Clin Exp Immunol. 2010 Sep; 161(3):471-9.
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12. Subimerb C, Pinlaor S, Khuntikeo N, Leelayuwat C, Morris A, McGrath MS, Wongkham S. Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma. Mol Med Report. 2010 Jul-Aug; 3(4):597-605.
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13. Lamers SL, Fogel GB, McGrath MS. HIV-miR-H1 evolvability during HIV pathogenesis. Biosystems. 2010 Aug; 101(2):88-96.
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14. Lamers SL, Salemi M, Galligan DC, Morris A, Gray R, Fogel G, Zhao L, McGrath MS. Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain. J Neurovirol. 2010 May; 16(3):230-41.
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15. Huysentruyt LC, McGrath MS. The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma. J Leukoc Biol. 2010 Apr; 87(4):627-32.
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16. Salemi M, Lamers SL, Huysentruyt LC, Galligan D, Gray RR, Morris A, McGrath MS. Distinct patterns of HIV-1 evolution within metastatic tissues in patients with non-Hodgkins lymphoma. PLoS One. 2009; 4(12):e8153.
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17. Kim WK, Sun Y, Do H, Autissier P, Halpern EF, Piatak M, Lifson JD, Burdo TH, McGrath MS, Williams K. Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage. J Leukoc Biol. 2010 Apr; 87(4):557-67.
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18. Zhao L, Galligan DC, Lamers SL, Yu S, Shagrun L, Salemi M, McGrath MS. High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS. Sci China C Life Sci. 2009 Jul; 52(7):651-6.
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19. Yan YF, Zhao L, Wang ZY, McGrath MS, Hou XY, Zheng XM, Song YY. [Analysis of genetic diversity and biological functional site of HIV-1 gp120 from a patient with AIDS dementia complex]. Bing Du Xue Bao. 2009 May; 25(3):166-72.
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20. Lamers SL, Salemi M, Galligan DC, de Oliveira T, Fogel GB, Granier SC, Zhao L, Brown JN, Morris A, Masliah E, McGrath MS. Extensive HIV-1 intra-host recombination is common in tissues with abnormal histopathology. PLoS One. 2009; 4(3):e5065.
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