About UCSF Search UCSF UCSF Medical Center

David O. Morgan, PhD, FRS

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
morgan_david

Vice Chair and Professor, Department of Physiology; Professor, Department of Biochemistry and Biophysics; Director, UCSF Tetrad Graduate Program

david.morgan@ucsf.edu

Phone: (415) 476-6695 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

View on UCSF Profiles


Additional Websites


Education

University of Calgary, Canada, B.Sc. (Hon.), 1980, Animal Biology
University of California San Francisco, Ph.D., 1986, Endocrinology
University of California San Francisco, Post-Doc, 1986-1989, Biochemistry


Professional Experience

  • 1981-1986
    Ph.D. student in Endocrinology, Department of Physiology, UCSF, with Richard A. Roth
  • 1986-1987
    Postdoctoral fellow with William J. Rutter, Department of Biochemistry & Biophysics, UCSF
  • 1987-1989
    Postdoctoral fellow with Harold E. Varmus, Department of Microbiology & Immunology, UCSF
  • 1989-1995
    Assistant Professor, Department of Physiology, UCSF. Joint appointment in Department of Biochemistry and Biophysics as of July, 1991
  • 1995-1997
    Associate Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
  • 1997-present
    Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
  • 7/98-present
    Vice-chair, Dept. of Physiology, UCSF
  • 1/13-present   
    Director, UCSF Tetrad Graduate Program.

Honors & Awards

  • 1987-1989
    Helen Hay Whitney Foundation Postdoctoral Fellowship
  • 1990-1993
    Searle Scholar Award
  • 1990-1992
    March of Dimes Basil O'Connor Starter Scholar Award
  • 1991-1996
    Rita Allen Foundation Scholar Award
  • 2007-present
    Jack D. and DeLoris Lange Endowed Chair in Physiology
  • 1997, 2003, 2006, 2008, 2010, 2012
    UCSF Medical School Teaching Award for Outstanding Lecture Series
  • 2010
    UCSF Kaiser Award for Excellence in Teaching in the Classroom Setting
  • 2010
    UCSF Graduate Students Association Outstanding Faculty Mentorship Award
  • 2011
    MERIT award, NIGMS
  • 2012
    Fellow, Royal Society of London

Selected Publications

  1. Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol. 2014 Oct 13; 207(1):23-39.
    View on PubMed
  2. Matsusaka T, Enquist-Newman M, Morgan DO, Pines J. Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open. 2014; 3(10):904-12.
    View on PubMed
  3. Van Voorhis VA, Morgan DO. Activation of the APC/C Ubiquitin Ligase by Enhanced E2 Efficiency. Curr Biol. 2014 Jul 7; 24(13):1556-62.
    View on PubMed
  4. Naylor SG, Morgan DO. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci. 2014 Mar 1; 127(Pt 5):1128-37.
    View on PubMed
  5. Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. 2013 Dec 4; 135(48):18153-9.
    View on PubMed
  6. Morgan DO. The D box meets its match. Mol Cell. 2013 Jun 6; 50(5):609-10.
    View on PubMed
  7. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201.
    View on PubMed
  8. Foster SA, Morgan DO. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32.
    View on PubMed
  9. Yaakov G, Thorn K, Morgan DO. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36.
    View on PubMed
  10. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7.
    View on PubMed
  11. Schaefer JB, Morgan DO. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96.
    View on PubMed
  12. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Dec 1; 480(7375):128-31.
    View on PubMed
  13. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23.
    View on PubMed
  14. Lyons NA, Morgan DO. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 6; 42(3):378-89.
    View on PubMed
  15. Rodrigo-Brenni MC, Foster SA, Morgan DO. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59.
    View on PubMed
  16. Morgan DO. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6.
    View on PubMed
  17. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6.
    View on PubMed
  18. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6.
    View on PubMed
  19. Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80.
    View on PubMed
  20. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90.
    View on PubMed

Go to UCSF Profiles, powered by CTSI