David O. Morgan, PhD

Vice Chair and Professor, Department of Physiology, and Professor, Department of Biochemistry and Biophysics, UCSF

david.morgan@ucsf.edu

Phone: (415) 476-6695 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

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Additional Websites

• Morgan Lab Website

Education

University of Calgary, Canada, B.Sc. (Hon.), 1980, Animal Biology
University of California San Francisco, Ph.D., 1986, Endocrinology
University of California San Francisco, Post-Doc, 1986-1989, Biochemistry

Professional Experience

• 1981-1986
  Ph.D. student in Endocrinology, Department of Physiology, UCSF, with Richard A. Roth
• 1986-1987
  Postdoctoral fellow with William J. Rutter, Department of Biochemistry & Biophysics, UCSF
• 1987-1989
  Postdoctoral fellow with Harold E. Varmus, Department of Microbiology & Immunology, UCSF
• 1989-1995
  Assistant Professor, Department of Physiology, UCSF. Joint appointment in Department of Biochemistry and Biophysics as of July, 1991
• 1995-1997
  Associate Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
• 1997-present
  Professor, Departments of Physiology and Biochemistry & Biophysics, UCSF
• 7/98-present
  Vice-chair, Dept. of Physiology, UCSF

Honors & Awards

• 1987-1989
  Helen Hay Whitney Foundation Postdoctoral Fellowship
• 1990-1993
  Searle Scholar Award
• 1990-1992
  March of Dimes Basil O'Connor Starter Scholar Award
• 1991-1996
  Rita Allen Foundation Scholar Award

Selected Publications

1. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201.
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2. Foster SA, Morgan DO. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32.
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3. Yaakov G, Thorn K, Morgan DO. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36.
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4. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7.
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5. Schaefer JB, Morgan DO. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96.
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6. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Dec 1; 480(7375):128-31.
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7. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23.
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8. Lyons NA, Morgan DO. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 6; 42(3):378-89.
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9. Rodrigo-Brenni MC, Foster SA, Morgan DO. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59.
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10. Morgan DO. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6.
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11. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6.
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12. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6.
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13. Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80.
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14. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90.
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15. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92.
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16. Tully GH, Nishihama R, Pringle JR, Morgan DO. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12.
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17. Morgan DO. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1.
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18. Morgan DO. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1.
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19. Sullivan M, Holt L, Morgan DO. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36.
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20. Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7.
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