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Keith Mostov, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
mostov_keith

Professor, Departments of Anatomy and Biochemistry/Biophysics, UCSF

keith.mostov@ucsf.edu

Phone: (415) 476-6048 (voice)
Box 2140, UCSF
San Francisco, CA 94143-2140

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Additional Websites


Education

University of Chicago, B.A., 1976, Biology
New College, Oxford, Rhodes Scholar, 1976-77, Physiology
Rockefeller University, Ph.D., 1983, Cell Biology
Cornell University Medical College, M.D., 1984, Medicine


Professional Experience

  • 1977-1984
    MD-PhD Program, Rockefeller University and Cornell University (Advisor Günter Blobel)
  • 1984-1988
    Whitehead Fellow and Principal Investigator, Whitehead Institute
  • 1988-1992
    Assistant Professor, University of California, San Francisco
  • 1992-1998
    Associate Professor, University of California, San Francisco
  • 1997-1999
    Vice-Chairman, University of California, San Francisco, Department of Anatomy
  • 1998-present
    Professor, University of California, San Francisco, Departments of Anatomy, and Biochemistry and Biophysics, Cardiovascular Research Inst., Liver Center and Cell Biology Program

Honors & Awards

  • 1976
    Rhodes Scholar
  • 1985
    Charles Hood Foundation Award
  • 1989
    Searle Scholar
  • 1990
    Cancer Research Institute Investigator Award
  • 1991
    Charles E. Culpeper Foundation Scholar in Medical Science
  • 1991
    Edward Mallinckrodt Foundation Medical Scholar
  • 1992
    American Heart Association Established Investigator Award
  • 2002-2012
    NIAID MERIT Award

Selected Publications

  1. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host Cell Polarity Proteins Participate in Innate Immunity to Pseudomonas aeruginosa Infection. Cell Host Microbe. 2014 May 14; 15(5):636-43.
    View on PubMed
  2. Kwon SH, Liu KD, Mostov KE. Intercellular Transfer of GPRC5B via Exosomes Drives HGF-Mediated Outward Growth. Curr Biol. 2014 Jan 20; 24(2):199-204.
    View on PubMed
  3. Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A. Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures. J Cell Biol. 2013 Oct 28; 203(2):359-72.
    View on PubMed
  4. Rousso T, Shewan AM, Mostov KE, Schejter ED, Shilo BZ. Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife. 2013; 2:e00666.
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  5. Roignot J, Peng X, Mostov K. Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol. 2013 Feb; 5(2).
    View on PubMed
  6. Cai L, Mostov KE. Cell height: Tao rising. J Cell Biol. 2012 Dec 24; 199(7):1023-4.
    View on PubMed
  7. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49.
    View on PubMed
  8. Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N. Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug; 23(15):2845-55.
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  9. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81.
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  10. Eastburn DJ, Zegers MM, Mostov KE. Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. J Cell Sci. 2012 Sep 1; 125(Pt 17):4147-57.
    View on PubMed
  11. Su T, Chapin SJ, Bryant DM, Shewan AM, Young K, Mostov KE. Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. J Biol Chem. 2011 Dec 30; 286(52):44921-5.
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  12. Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 1; 361(1):68-78.
    View on PubMed
  13. Shewan A, Eastburn DJ, Mostov K. Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol. 2011 Aug; 3(8):a004796.
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  14. Lepanto P, Bryant DM, Rossello J, Datta A, Mostov KE, Kierbel A. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cell Microbiol. 2011 Aug; 13(8):1212-22.
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  15. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109.
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  16. Engelberg JA, Datta A, Mostov KE, Hunt CA. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol. 2011 Apr; 7(4):e1002030.
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  17. Datta A, Bryant DM, Mostov KE. Molecular regulation of lumen morphogenesis. Curr Biol. 2011 Feb 8; 21(3):R126-36.
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  18. Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2789-94.
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  19. Kwon SH, Nedvetsky PI, Mostov KE. Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis. Curr Biol. 2011 Jan 25; 21(2):161-6.
    View on PubMed
  20. Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec; 12(12):1143-53.
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