Keith Mostov, MD, PhD

Keith Mostov, MD, PhD

Professor, Departments of Anatomy and Biochemistry/Biophysics, UCSF

Phone: (415) 476-6048 (voice)
Box 2140, UCSF
San Francisco, CA 94143-2140

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Additional Websites


University of Chicago, B.A., 1976, Biology
New College, Oxford, Rhodes Scholar, 1976-77, Physiology
Rockefeller University, Ph.D., 1983, Cell Biology
Cornell University Medical College, M.D., 1984, Medicine

Professional Experience

  • 1977-1984
    MD-PhD Program, Rockefeller University and Cornell University (Advisor Günter Blobel)
  • 1984-1988
    Whitehead Fellow and Principal Investigator, Whitehead Institute
  • 1988-1992
    Assistant Professor, University of California, San Francisco
  • 1992-1998
    Associate Professor, University of California, San Francisco
  • 1997-1999
    Vice-Chairman, University of California, San Francisco, Department of Anatomy
  • 1998-present
    Professor, University of California, San Francisco, Departments of Anatomy, and Biochemistry and Biophysics, Cardiovascular Research Inst., Liver Center and Cell Biology Program

Honors & Awards

  • 1976
    Rhodes Scholar
  • 1985
    Charles Hood Foundation Award
  • 1989
    Searle Scholar
  • 1990
    Cancer Research Institute Investigator Award
  • 1991
    Charles E. Culpeper Foundation Scholar in Medical Science
  • 1991
    Edward Mallinckrodt Foundation Medical Scholar
  • 1992
    American Heart Association Established Investigator Award
  • 2002-2012

Selected Publications

  1. Peng J, Awad A, Sar S, Hamze Komaiha O, Moyano R, Rayal A, Samuel D, Shewan A, Vanhaesebroeck B, Mostov K, Gassama-Diagne A. Phosphoinositide 3-kinase p110d promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization. Nat Commun. 2015; 6:5937.
    View on PubMed
  2. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87.
    View on PubMed
  3. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62.
    View on PubMed
  4. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host Cell Polarity Proteins Participate in Innate Immunity to Pseudomonas aeruginosa Infection. Cell Host Microbe. 2014 May 14; 15(5):636-43.
    View on PubMed
  5. Kwon SH, Liu KD, Mostov KE. Intercellular Transfer of GPRC5B via Exosomes Drives HGF-Mediated Outward Growth. Curr Biol. 2014 Jan 20; 24(2):199-204.
    View on PubMed
  6. Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A. Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures. J Cell Biol. 2013 Oct 28; 203(2):359-72.
    View on PubMed
  7. Rousso T, Shewan AM, Mostov KE, Schejter ED, Shilo BZ. Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife. 2013; 2:e00666.
    View on PubMed
  8. Roignot J, Peng X, Mostov K. Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol. 2013 Feb; 5(2).
    View on PubMed
  9. Cai L, Mostov KE. Cell height: Tao rising. J Cell Biol. 2012 Dec 24; 199(7):1023-4.
    View on PubMed
  10. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49.
    View on PubMed
  11. Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N. Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug; 23(15):2845-55.
    View on PubMed
  12. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81.
    View on PubMed
  13. Eastburn DJ, Zegers MM, Mostov KE. Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. J Cell Sci. 2012 Sep 1; 125(Pt 17):4147-57.
    View on PubMed
  14. Su T, Chapin SJ, Bryant DM, Shewan AM, Young K, Mostov KE. Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. J Biol Chem. 2011 Dec 30; 286(52):44921-5.
    View on PubMed
  15. Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 1; 361(1):68-78.
    View on PubMed
  16. Shewan A, Eastburn DJ, Mostov K. Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol. 2011 Aug; 3(8):a004796.
    View on PubMed
  17. Lepanto P, Bryant DM, Rossello J, Datta A, Mostov KE, Kierbel A. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cell Microbiol. 2011 Aug; 13(8):1212-22.
    View on PubMed
  18. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109.
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  19. Engelberg JA, Datta A, Mostov KE, Hunt CA. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol. 2011 Apr; 7(4):e1002030.
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  20. Datta A, Bryant DM, Mostov KE. Molecular regulation of lumen morphogenesis. Curr Biol. 2011 Feb 8; 21(3):R126-36.
    View on PubMed

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