University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Pratik Mukherjee, MD, PhD

Pratik Mukherjee, MD, PhD

Assistant Professor, Department of Radiology, UCSF

Cancer Center Program Memberships

Affiliate Member

Research Summary

Pratik Mukherjee, MD, PhD, is a Professor in Residence in the Department Radiology and Biomedical Imaging, Bioengineering, and he is an attending neuroradiologist at the University of California, San Francisco. He is the Director of the Center for Imaging of Neurodegenerative Disease (CIND) based at the San Francisco VA Medical Center. He also directs the Neural Connectivity Laboratory (NCL) at UCSF China Basin.

Dr. Mukherjee received his PhD in Neuroscience from Rockefeller University, New York in 1994 and his MD from Cornell University, New York, in 1995. He completed his internship in Internal Medicine at New York Hospital - Cornell Medical Center, followed by a residency in Radiology and fellowship in Neuroradiology at Washington University Medical Center in St. Louis, Missouri, completed in 2002.

Dr. Mukherjee’s primary clinical research is the study of neurodevelopmental disorders and traumatic brain injury (TBI) using advanced MRI. His research has been focused on technical development, neuroscience and clinical applications of advanced imaging methods for mapping structure and function of the human brain, especially diffusion MRI, which is a popular technique for assessing the development and integrity of white matter and for mapping axonal fiber pathways.

Dr. Mukherjee has served as Principal Investigator or Co-Principal Investigator for several NIH grants. His work has also been funded by grants from the Dept. of Defense, the Simons Foundation, McDonnell Foundation, Dana Foundation, Wallace Research Foundation, GE Healthcare and the GE-NFL Head Health Initiative. He has published over 80 peer-reviewed papers.

Expertise:

Radiology, Neuroradiology, Pediatric Neuroradiology, Cognitive Neuroscience, Computational Neuroscience

Specialty:

Neuroradiology, traumatic brain injury (TBI), neurodevelopmental disorders

Professional Interests:

Brain development, computational neuroscience, connectomics, diffusion tensor imaging (DTI), epilepsy, functional MRI (fMRI), machine learning, magnetoencephalography (MEG), pediatric neuroradiology, traumatic brain injury (TBI), ultra-high field MRI, white matter tractography

Education and Training:

• Medical School: Cornell University, New York - Medicine

• Internship: New York Cornell Medical Center - Internal Medicine

• Residency: Washington University of Medical Center, St. Louis, Missouri - Radiology

• Fellowship: Washington University Medical Center, St. Louis, Missouri - Neuroradiology

• Doctor of Philosophy: Rockefeller University, New York - Neuroscience

• National Board of Medical Examiners Certificate

• American Board of Radiology Certificate

• Missouri Medical License

• California Medical License

• American Board of Radiology Certificate of Added Qualification Neuroradiology

Education

Yale University, New Haven, CT, B.A., 1988, Computer Science & Psychology
Rockefeller Univ., New York, NY, Ph.D., 1994, Neuroscience
Cornell University, New York, NY, M.D., 1995, Medicine


Professional Experience

  • 1995-1996
    Internal Medicine Internship, New York Hospital - Cornell Medical Center, New York, NY
  • 1996-2000
    Radiology Residency, Washington University Medical Center, St. Louis, MO
  • 2000-2002
    Neuroradiology Fellowship, Washington University Medical Center, St. Louis, MO
  • 2002-present
    Assistant Professor, University of California, San Francisco, CA

Honors & Awards

  • 1988-95
    Medical Scientist Training Program Grant, National Institutes of Health
  • 1994
    S. Koide Memorial Fellowship, Rockefeller University
  • 1999
    Roentgen Resident/Fellow Research Award, Radiological Society of North America
  • 2001
    Berlex/ASNR Award in Basic Science Research, American Society of Neuroradiology

Selected Publications

  1. Ngwenya LB, Gardner RC, Yue JK, Burke JF, Ferguson AR, Huang MC, Winkler EA, Pirracchio R, Satris GG, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT. Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study. Brain Inj. 2018 Jun 04; 1-8.
    View on PubMed
  2. Gardner RC, Rubenstein R, Wang KKW, Korley FK, Yue JK, Yuh EL, Mukherjee P, Valadka A, Okonkwo DO, Diaz-Arrastia R, Manley G. Age-Related Differences in Diagnostic Accuracy of Plasma GFAP and Tau For Identifying Acute Intracranial Trauma on CT: A TRACK-TBI Study. J Neurotrauma. 2018 May 02.
    View on PubMed
  3. Korley FK, Yue JK, Wilson D, Hrusovsky K, Diaz-Arrasta R, Ferguson AR, Yuh EL, Mukherjee P, Wang KKW, Valadka A, Puccio A, Okonkwo DO, Manley G. Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant TBI Biomarkers. J Neurotrauma. 2018 Apr 25.
    View on PubMed
  4. Ouyang M, Dubois J, Yu Q, Mukherjee P, Huang H. Delineation of early brain development from fetuses to infants with diffusion MRI and beyond. Neuroimage. 2018 Apr 12.
    View on PubMed
  5. Caverzasi E, Mandelli ML, Hoeft F, Watson C, Meyer M, Allen IE, Papinutto N, Wang C, Gandini Wheeler-Kingshott CAM, Marco EJ, Mukherjee P, Miller ZA, Miller BL, Hendren R, Shapiro KA, Gorno-Tempini ML. Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia. Neuroimage Clin. 2018; 18:814-821.
    View on PubMed
  6. Rubenstein R, Chang B, Yue JK, Chiu A, Winkler EA, Puccio AM, Diaz-Arrastia R, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Davies P, Agarwal S, Lin F, Sarkis G, Yadikar H, Yang Z, Manley GT, Wang KKW. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. JAMA Neurol. 2017 Sep 01; 74(9):1063-1072.
    View on PubMed
  7. Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard EG, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley GT. Apolipoprotein E epsilon 4 (APOE-e4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury. Brain Behav. 2017 Sep; 7(9):e00791.
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  8. Owen JP, Bukshpun P, Pojman N, Thieu T, Chen Q, Lee J, D'Angelo D, Glenn OA, Hunter JV, Berman JI, Roberts TP, Buckner R, Nagarajan SS, Mukherjee P, Sherr EH. Brain MR Imaging Findings and Associated Outcomes in Carriers of the Reciprocal Copy Number Variation at 16p11.2. Radiology. 2018 01; 286(1):217-226.
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  9. Yue JK, Ngwenya LB, Upadhyayula PS, Deng H, Winkler EA, Burke JF, Lee YM, Robinson CK, Ferguson AR, Lingsma HF, Cnossen MC, Pirracchio R, Korley FK, Vassar MJ, Yuh EL, Mukherjee P, Gordon WA, Valadka AB, Okonkwo DO, Manley GT. Emergency department blood alcohol level associates with injury factors and six-month outcome after uncomplicated mild traumatic brain injury. J Clin Neurosci. 2017 Nov; 45:293-298.
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  10. Subramaniam K, Gill J, Fisher M, Mukherjee P, Nagarajan S, Vinogradov S. White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia. Schizophr Res. 2018 Mar; 193:276-283.
    View on PubMed
  11. Wang MB, Owen JP, Mukherjee P, Raj A. Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease. PLoS Comput Biol. 2017 Jun; 13(6):e1005550.
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  12. Nielson JL, Cooper SR, Yue JK, Sorani MD, Inoue T, Yuh EL, Mukherjee P, Petrossian TC, Paquette J, Lum PY, Carlsson GE, Vassar MJ, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Manley GT, Ferguson AR. Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis. PLoS One. 2017; 12(3):e0169490.
    View on PubMed
  13. Palacios EM, Yuh EL, Chang YS, Yue JK, Schnyer DM, Okonkwo DO, Valadka AB, Gordon WA, Maas AIR, Vassar M, Manley GT, Mukherjee P. Resting-State Functional Connectivity Alterations Associated with Six-Month Outcomes in Mild Traumatic Brain Injury. J Neurotrauma. 2017 04 15; 34(8):1546-1557.
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  14. Yue JK, Winkler EA, Sharma S, Vassar MJ, Ratcliff JJ, Korley FK, Seabury SA, Ferguson AR, Lingsma HF, Meeuws S, Adeoye OM, Rick JW, Robinson CK, Duarte SM, Yuh EL, Mukherjee P, Dikmen SS, McAllister TW, Diaz-Arrastia R, Valadka AB, Gordon WA, Okonkwo DO, Manley GT. Temporal profile of care following mild traumatic brain injury: predictors of hospital admission, follow-up referral and six-month outcome. Brain Inj. 2017; 31(13-14):1820-1829.
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  15. Yue JK, Winkler EA, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard EG, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KK, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT. DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury. Neurogenetics. 2017 01; 18(1):29-38.
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  16. Winkler EA, Yue JK, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Tarapore PE, Burchard EG, Hu D, Eng C, Wang KK, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT. COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury. J Clin Neurosci. 2017 Jan; 35:109-116.
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  17. Owen JP, Wang MB, Mukherjee P. Periventricular White Matter Is a Nexus for Network Connectivity in the Human Brain. Brain Connect. 2016 09; 6(7):548-57.
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  18. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 01; 73(6):691-7.
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  19. Chang YS, Owen JP, Pojman NJ, Thieu T, Bukshpun P, Wakahiro ML, Marco EJ, Berman JI, Spiro JE, Chung WK, Buckner RL, Roberts TP, Nagarajan SS, Sherr EH, Mukherjee P. Reciprocal white matter alterations due to 16p11.2 chromosomal deletions versus duplications. Hum Brain Mapp. 2016 08; 37(8):2833-48.
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  20. Hinkley LB, Marco EJ, Brown EG, Bukshpun P, Gold J, Hill S, Findlay AM, Jeremy RJ, Wakahiro ML, Barkovich AJ, Mukherjee P, Sherr EH, Nagarajan SS. The Contribution of the Corpus Callosum to Language Lateralization. J Neurosci. 2016 Apr 20; 36(16):4522-33.
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