University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jean L. Nakamura, MD

Jean L. Nakamura, MD

Associate Professor, Department of Radiation Oncology, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Education

University of Chicago, Chicago, Illinois, A.B., 1993, Biological Sciences
University of Chicago, Chicago, Illinois, M.D., 1998, Medicine
University of Chicago, Chicago, Illinois, Internship, 1999, Internal Medicine
University of California, San Francisco, Postdoctorate, 2002, Neuro-Oncology
University of California, San Francisco, Residency, 2003, Radiation Oncology


Professional Experience

  • 1998-1999
    Medical Intern, Department of Internal Medicine, University of Chicago, Chicago, Illinois
  • 1999-2003
    Resident, Department of Radiation Oncology, UCSF
  • 2001-2002
    Research Fellow, UCSF Comprehensive Cancer Center
  • 2003-2005
    Clinical Instructor, Department of Radiation Oncology, UCSF
  • 2005-2007
    Assistant Adjunct Professor, Department of Radiation Oncology, UCSF
  • 2007-present
    Assistant Professor In Residence, Department of Radiation Oncology, UCSF

Honors & Awards

  • 1990
    Illinois State Scholar
  • 1990
    National Merit Scholarship
  • 1993
    Graduated with General Honors from The University of Chicago College in the Biological Sciences
  • 1995
    Student Summer Research Award, University of Chicago, Pritzker School of Medicine
  • 1998
    Catherine Dobson Prize for Best Oral Presentation given at 52nd Annual Senior Scientific Session by a Non-PhD Student in the Area of Clinical Investigation Research done in Medical School
  • 1998
    University of Chicago Departmental Award for Outstanding Performance in the General Field of Radiation Oncology
  • 2001
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Dose conformity of gamma knife radiosurgery and risk factors for complications"
  • 2002
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Inhibition of PI3 kinase causes cell death through a PKB dependent mechanism and growth arrest through a PKB independent mechanism"
  • 2002
    American Brain Tumor Association Basic Research Fellowship Award
  • 2004
    American Society for Therapeutic Radiology and Oncology Basic Science Travel Grant to the 46th Annual Meeting in Atlanta, GA
  • 2008
    Irene Holmes Perstein Award, UCSF

Selected Publications

  1. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 Aug; 16(8):e2004624.
    View on PubMed
  2. Garcia MA, Anwar M, Yu Y, Duriseti S, Merritt B, Nakamura J, Hess C, Theodosopoulos PV, McDermott M, Sneed PK, Braunstein SE. Brain metastasis growth on preradiosurgical magnetic resonance imaging. Pract Radiat Oncol. 2018 Jun 07.
    View on PubMed
  3. Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith AJ, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels JL, Zablotska LB. Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers. Environ Health. 2018 May 02; 17(1):43.
    View on PubMed
  4. Thibodeau BJ, Lavergne V, Dekhne N, Benitez P, Amin M, Ahmed S, Nakamura JL, Davidson PR, Nakamura AO, Grills IS, Chen PY, Wobb J, Wilson GD. Mutational landscape of radiation-associated angiosarcoma of the breast. Oncotarget. 2018 Feb 09; 9(11):10042-10053.
    View on PubMed
  5. Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017 Aug 09; 7(1):7645.
    View on PubMed
  6. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 01 01; 80(1):129-139.
    View on PubMed
  7. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861.
    View on PubMed
  8. Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S. Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes. J Neurosurg. 2017 Jun; 126(6):1756-1763.
    View on PubMed
  9. Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW. Parameters influencing local control of meningiomas treated with radiosurgery. J Neurooncol. 2016 06; 128(2):357-64.
    View on PubMed
  10. Held M, Cremers F, Sneed PK, Braunstein S, Fogh SE, Nakamura J, Barani I, Perez-Andujar A, Pouliot J, Morin O. Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments. J Appl Clin Med Phys. 2016 03 08; 17(2):279-290.
    View on PubMed
  11. McGuinness CM, Gottschalk AR, Lessard E, Nakamura JL, Pinnaduwage D, Pouliot J, Sims C, Descovich M. Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. J Appl Clin Med Phys. 2015 09 08; 16(5):284–295.
    View on PubMed
  12. Sherborne AL, Davidson PR, Yu K, Nakamura AO, Rashid M, Nakamura JL. Mutational Analysis of Ionizing Radiation Induced Neoplasms. Cell Rep. 2015 Sep 22; 12(11):1915-26.
    View on PubMed
  13. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015 Jun; 11(6):e1005327.
    View on PubMed
  14. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. PLoS Genet. 2015 May; 11(5):e1005235.
    View on PubMed
  15. Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015 Aug; 123(2):373-86.
    View on PubMed
  16. Seymour ZA, Fogh SE, Westcott SK, Braunstein S, Larson DA, Barani IJ, Nakamura J, Sneed PK. Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long? Int J Radiat Oncol Biol Phys. 2015 Sep 01; 93(1):126-32.
    View on PubMed
  17. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28.
    View on PubMed
  18. Ma L, Sahgal A, Larson DA, Pinnaduwage D, Fogh S, Barani I, Nakamura J, McDermott M, Sneed P. Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):206-13.
    View on PubMed
  19. Fouse SD, Nakamura JL, James CD, Chang S, Costello JF. Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. Neuro Oncol. 2014 Mar; 16(3):361-71.
    View on PubMed
  20. Braunstein S, Nakamura JL. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73.
    View on PubMed

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