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Jean L. Nakamura, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
nakamura_jean

Assistant Professor, Department of Radiation Oncology, UCSF

Phone: (415) 353-9807 (appts)
Box 1708, UCSF
San Francisco, CA 94143-1708

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Additional Websites


Education

University of Chicago, Chicago, Illinois, A.B., 1993, Biological Sciences
University of Chicago, Chicago, Illinois, M.D., 1998, Medicine
University of Chicago, Chicago, Illinois, Internship, 1999, Internal Medicine
University of California, San Francisco, Postdoctorate, 2002, Neuro-Oncology
University of California, San Francisco, Residency, 2003, Radiation Oncology


Professional Experience

  • 1998-1999
    Medical Intern, Department of Internal Medicine, University of Chicago, Chicago, Illinois
  • 1999-2003
    Resident, Department of Radiation Oncology, UCSF
  • 2001-2002
    Research Fellow, UCSF Comprehensive Cancer Center
  • 2003-2005
    Clinical Instructor, Department of Radiation Oncology, UCSF
  • 2005-2007
    Assistant Adjunct Professor, Department of Radiation Oncology, UCSF
  • 2007-present
    Assistant Professor In Residence, Department of Radiation Oncology, UCSF

Honors & Awards

  • 1990
    Illinois State Scholar
  • 1990
    National Merit Scholarship
  • 1993
    Graduated with General Honors from The University of Chicago College in the Biological Sciences
  • 1995
    Student Summer Research Award, University of Chicago, Pritzker School of Medicine
  • 1998
    Catherine Dobson Prize for Best Oral Presentation given at 52nd Annual Senior Scientific Session by a Non-PhD Student in the Area of Clinical Investigation Research done in Medical School
  • 1998
    University of Chicago Departmental Award for Outstanding Performance in the General Field of Radiation Oncology
  • 2001
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Dose conformity of gamma knife radiosurgery and risk factors for complications"
  • 2002
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Inhibition of PI3 kinase causes cell death through a PKB dependent mechanism and growth arrest through a PKB independent mechanism"
  • 2002
    American Brain Tumor Association Basic Research Fellowship Award
  • 2004
    American Society for Therapeutic Radiology and Oncology Basic Science Travel Grant to the 46th Annual Meeting in Atlanta, GA
  • 2008
    Irene Holmes Perstein Award, UCSF

Selected Publications

  1. Ma L, Sahgal A, Larson DA, Pinnaduwage D, Fogh S, Barani I, Nakamura J, McDermott M, Sneed P. Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery. Int J Radiat Oncol Biol Phys. 2014 May 1; 89(1):206-13.
    View on PubMed
  2. Fouse SD, Nakamura JL, James CD, Chang S, Costello JF. Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. Neuro Oncol. 2014 Mar; 16(3):361-71.
    View on PubMed
  3. Braunstein S, Nakamura JL. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73.
    View on PubMed
  4. Wahl M, Hwang A, Nakamura J, Barani I, Fogh S, Sneed P, McDermott M, Sahgal A, Ma L. Individual beam sharpening improves composite dose fall-off near a target for non-isocentric cyberknife radiosurgery. Technol Cancer Res Treat. 2013 Aug; 12(4):341-8.
    View on PubMed
  5. Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec; 117 Suppl:115-9.
    View on PubMed
  6. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34.
    View on PubMed
  7. Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW. Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy. Int J Radiat Oncol Biol Phys. 2012 May 1; 83(1):303-9.
    View on PubMed
  8. Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21; 56(22):7247-56.
    View on PubMed
  9. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1; 71(1):106-15.
    View on PubMed
  10. Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M. A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec; 113 Suppl:199-206.
    View on PubMed
  11. Kased N, Binder DK, McDermott MW, Nakamura JL, Huang K, Berger MS, Wara WM, Sneed PK. Gamma Knife radiosurgery for brain metastases from primary breast cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4):1132-40.
    View on PubMed
  12. Golden DW, Lamborn KR, McDermott MW, Kunwar S, Wara WM, Nakamura JL, Sneed PK. Prognostic factors and grading systems for overall survival in patients treated with radiosurgery for brain metastases: variation by primary site. J Neurosurg. 2008 Dec; 109 Suppl:77-86.
    View on PubMed
  13. Nakamura JL, Garcia E, Pieper RO. S6K1 plays a key role in glial transformation. Cancer Res. 2008 Aug 15; 68(16):6516-23.
    View on PubMed
  14. Nakamura JL, Haas-Kogan DA, Pieper RO. Glioma invasiveness responds variably to irradiation in a co-culture model. Int J Radiat Oncol Biol Phys. 2007 Nov 1; 69(3):880-6.
    View on PubMed
  15. Kased N, Huang K, Nakamura JL, Sahgal A, Larson DA, McDermott MW, Sneed PK. Gamma knife radiosurgery for brainstem metastases: the UCSF experience. J Neurooncol. 2008 Jan; 86(2):195-205.
    View on PubMed
  16. Nakamura JL. The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. Expert Opin Ther Targets. 2007 Apr; 11(4):463-72.
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  17. Panner A, Nakamura JL, Parsa AT, Rodriguez-Viciana P, Berger MS, Stokoe D, Pieper RO. mTOR-independent translational control of the extrinsic cell death pathway by RalA. Mol Cell Biol. 2006 Oct; 26(20):7345-57.
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  18. Gottschalk AR, Doan A, Nakamura JL, Stokoe D, Haas-Kogan DA. Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. Int J Radiat Oncol Biol Phys. 2005 Nov 15; 63(4):1221-7.
    View on PubMed
  19. Gottschalk AR, Doan A, Nakamura JL, Haas-Kogan DA, Stokoe D. Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism. Int J Radiat Oncol Biol Phys. 2005 Mar 15; 61(4):1183-8.
    View on PubMed
  20. Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol. 2005 Feb; 71(3):215-22.
    View on PubMed

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