Jean L. Nakamura, MD

Jean L. Nakamura, MD

Associate Professor, Department of Radiation Oncology, UCSF

Phone: (415) 353-9807 (appts)
Box 1708, UCSF
San Francisco, CA 94143-1708

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Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies


University of Chicago, Chicago, Illinois, A.B., 1993, Biological Sciences
University of Chicago, Chicago, Illinois, M.D., 1998, Medicine
University of Chicago, Chicago, Illinois, Internship, 1999, Internal Medicine
University of California, San Francisco, Postdoctorate, 2002, Neuro-Oncology
University of California, San Francisco, Residency, 2003, Radiation Oncology

Professional Experience

  • 1998-1999
    Medical Intern, Department of Internal Medicine, University of Chicago, Chicago, Illinois
  • 1999-2003
    Resident, Department of Radiation Oncology, UCSF
  • 2001-2002
    Research Fellow, UCSF Comprehensive Cancer Center
  • 2003-2005
    Clinical Instructor, Department of Radiation Oncology, UCSF
  • 2005-2007
    Assistant Adjunct Professor, Department of Radiation Oncology, UCSF
  • 2007-present
    Assistant Professor In Residence, Department of Radiation Oncology, UCSF

Honors & Awards

  • 1990
    Illinois State Scholar
  • 1990
    National Merit Scholarship
  • 1993
    Graduated with General Honors from The University of Chicago College in the Biological Sciences
  • 1995
    Student Summer Research Award, University of Chicago, Pritzker School of Medicine
  • 1998
    Catherine Dobson Prize for Best Oral Presentation given at 52nd Annual Senior Scientific Session by a Non-PhD Student in the Area of Clinical Investigation Research done in Medical School
  • 1998
    University of Chicago Departmental Award for Outstanding Performance in the General Field of Radiation Oncology
  • 2001
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Dose conformity of gamma knife radiosurgery and risk factors for complications"
  • 2002
    Radiological Society of North America Roentgen Award for Resident Research for the paper, "Inhibition of PI3 kinase causes cell death through a PKB dependent mechanism and growth arrest through a PKB independent mechanism"
  • 2002
    American Brain Tumor Association Basic Research Fellowship Award
  • 2004
    American Society for Therapeutic Radiology and Oncology Basic Science Travel Grant to the 46th Annual Meeting in Atlanta, GA
  • 2008
    Irene Holmes Perstein Award, UCSF

Selected Publications

  1. Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. J Appl Clin Med Phys. 2015; 16(5):5502.
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  2. Mutational Analysis of Ionizing Radiation Induced Neoplasms. Cell Rep. 2015 Sep 22; 12(11):1915-26.
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  3. Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015 Jun; 11(6):e1005327.
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  4. Monoallelic loss of the imprinted gene grb10 promotes tumor formation in irradiated nf1+/- mice. PLoS Genet. 2015 May; 11(5):e1005235.
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  5. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015 Aug; 123(2):373-86.
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  6. Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long? Int J Radiat Oncol Biol Phys. 2015 Sep 1; 93(1):126-32.
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  7. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28.
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  8. Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery. Int J Radiat Oncol Biol Phys. 2014 May 1; 89(1):206-13.
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  9. Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. Neuro Oncol. 2014 Mar; 16(3):361-71.
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  10. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73.
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  11. Individual beam sharpening improves composite dose fall-off near a target for non-isocentric cyberknife radiosurgery. Technol Cancer Res Treat. 2013 Aug; 12(4):341-8.
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  12. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec; 117 Suppl:115-9.
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  13. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34.
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  14. Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy. Int J Radiat Oncol Biol Phys. 2012 May 1; 83(1):303-9.
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  15. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21; 56(22):7247-56.
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  16. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1; 71(1):106-15.
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  17. A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec; 113 Suppl:199-206.
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  18. Gamma Knife radiosurgery for brain metastases from primary breast cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4):1132-40.
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  19. Prognostic factors and grading systems for overall survival in patients treated with radiosurgery for brain metastases: variation by primary site. J Neurosurg. 2008 Dec; 109 Suppl:77-86.
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  20. S6K1 plays a key role in glial transformation. Cancer Res. 2008 Aug 15; 68(16):6516-23.
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