Todd Nystul, PhD

Todd Nystul, PhD

Assistant Professor, Department of Anatomy, UC San Francisco

Phone: (415) 476-6883
Box 0452, UCSF
San Francisco, CA 94143-0452

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Research Summary

The goals of my research build directly on research that I began as a postdoctoral fellow in Allan Spradling’s lab at the Carnegie Institution, and have continued in my own lab over the past six years. More generally, my education and training have given me valuable skills for succeeding in basic science. As a graduate student with Mark Roth at the Fred Hutchinson Cancer Research Center, I learned to identify and develop concepts that were both innovative and medically relevant. Early in my graduate studies, we discovered suspended animation in C. elegans (Nystul, et al., Science, 2003), and my characterization of this phenomenon was a critical part of a team effort that led to several patents and the founding of Ikaria, Inc., a multi-national biomedical research company. Subsequently, as a postdoctoral fellow at the Carnegie Institution, I gained a better understanding of the importance of thinking broadly and studying multiple model organisms in developing productive research projects. I have been implementing these skills as I mentor the people in my lab and build our research program. At UCSF, I have the benefit of a rigorous, collegial scientific community, and a commitment of support from colleagues, such as my faculty mentors Drs. Zena Werb, Susan Fisher, and Diane Barber.


University of California, San Diego—La Jolla, CA, B.S., 1993-1997, Molecular Biology
University of Washington—Seattle, WA, Ph.D., 1999-2004, Molecular and Cellular Biology
Carnegie Institution of Science—Baltimore, MD, Postdoctoral, 2004-2009, Stem Cell Biology and Developmental Genetics

Professional Experience

  • 1997-1999
    Research Technician, Department of Infectious Disease, University of California, San Diego, La Jolla, CA
  • 2004
    Assistant Professor, Biology Department, Shoreline Community College, Shoreline, WA (concurrent with graduate school)
  • 2009-present
    Assistant Professor, Department of Anatomy, University of California, San Francisco, CA

Honors & Awards

  • 1999
    Honorable Mention, National Science Foundation Fellowship
  • 2000
    Training Grant (competitive slot), Molecular and Cellular Biology Program, University of Washington, Seattle, WA
  • 2005
    Life Sciences Research Foundation, HHMI Postdoctoral Scholar
  • 2007
    Keystone Symposium Scholarship, Keystone, CO

Selected Publications

  1. Johnston MJ, Bar-Cohen S, Paroush Z, Nystul TG. Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche. Development. 2016 Nov 11.
    View on PubMed
  2. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber DL, Nystul TG. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol. 2016 Nov 7; 215(3):345-355.
    View on PubMed
  3. Vlachos S, Jangam S, Conder R, Chou M, Nystul T, Harden N. A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary. Development. 2015 Jan 1; 142(1):82-91.
    View on PubMed
  4. Castanieto A, Johnston MJ, Nystul TG. EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells. Elife. 2014; 3.
    View on PubMed
  5. Huang P, Sahai-Hernandez P, Bohm RA, Welch WP, Zhang B, Nystul T. Enhancer-trap flippase lines for clonal analysis in the Drosophila ovary. G3 (Bethesda). 2014 Sep; 4(9):1693-9.
    View on PubMed
  6. Kronen MR, Schoenfelder KP, Klein AM, Nystul TG. Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary. PLoS One. 2014; 9(7):e101085.
    View on PubMed
  7. Sahai-Hernandez P, Nystul TG. A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary. Development. 2013 Nov; 140(22):4490-8.
    View on PubMed
  8. Sahai-Hernandez P, Castanieto A, Nystul TG. Drosophila models of epithelial stem cells and their niches. Wiley Interdiscip Rev Dev Biol. 2012 May-Jun; 1(3):447-57.
    View on PubMed
  9. Nystul T, Spradling A. Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary. Genetics. 2010 Feb; 184(2):503-15.
    View on PubMed
  10. Spradling AC, Nystul T, Lighthouse D, Morris L, Fox D, Cox R, Tootle T, Frederick R, Skora A. Stem cells and their niches: integrated units that maintain Drosophila tissues. Cold Spring Harb Symp Quant Biol. 2008; 73:49-57.
    View on PubMed
  11. Nystul T, Spradling A. An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. Cell Stem Cell. 2007 Sep 13; 1(3):277-85.
    View on PubMed
  12. Buszczak M, Paterno S, Lighthouse D, Bachman J, Planck J, Owen S, Skora AD, Nystul TG, Ohlstein B, Allen A, Wilhelm JE, Murphy TD, Levis RW, Matunis E, Srivali N, Hoskins RA, Spradling AC. The carnegie protein trap library: a versatile tool for Drosophila developmental studies. Genetics. 2007 Mar; 175(3):1505-31.
    View on PubMed
  13. Nystul TG, Spradling AC. Breaking out of the mold: diversity within adult stem cells and their niches. Curr Opin Genet Dev. 2006 Oct; 16(5):463-8.
    View on PubMed
  14. Roth MB, Nystul T. Buying time in suspended animation. Sci Am. 2005 Jun; 292(6):48-55.
    View on PubMed
  15. Nystul TG, Roth MB. Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9133-6.
    View on PubMed
  16. Nystul TG, Goldmark JP, Padilla PA, Roth MB. Suspended animation in C. elegans requires the spindle checkpoint. Science. 2003 Nov 7; 302(5647):1038-41.
    View on PubMed
  17. Padilla PA, Nystul TG, Zager RA, Johnson AC, Roth MB. Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans. Mol Biol Cell. 2002 May; 13(5):1473-83.
    View on PubMed
  18. Morrison HG, Roger AJ, Nystul TG, Gillin FD, Sogin ML. Giardia lamblia expresses a proteobacterial-like DnaK homolog. Mol Biol Evol. 2001 Apr; 18(4):530-41.
    View on PubMed
  19. Knodler LA, Noiva R, Mehta K, McCaffery JM, Aley SB, Svärd SG, Nystul TG, Reiner DS, Silberman JD, Gillin FD. Novel protein-disulfide isomerases from the early-diverging protist Giardia lamblia. J Biol Chem. 1999 Oct 15; 274(42):29805-11.
    View on PubMed

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