Patrick H. O'Farrell, PhD

Professor, Department of Biochemistry and Biophysics, UCSF

Phone: (415) 476-4707
Box 2200, UCSF
San Francisco, CA 94143-2200

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Additional Websites

• Lab Website

Education

McGill University, Montreal, Quebec, B.Sc., 1969, Genetics
University of Colorado, Boulder, Ph.D., 1974, Cell & Dev Biol
University of California San Francisco, Postdoc, 1978

Professional Experience

• 1969-1974
  Grad. Student: lab of Jacques Pene (1969-72) & David Hirsh (1973 -74). Development of 2-D gel electrophoresis; pleiotropic control. MCD Biology, University of Colorado
• 1974-1976
  Postdoctoral studies with Gordon Tomkins. Regulation of translational accuracy; hormonal control; expression of recombinant DNA. Dept of Biochemistry, UCSF
• 1976-1979
  Postdoctoral studies with Bruce Alberts. Stringency of gene inactivation; new preparative separation technology. Dept of Biochemistry, UCSF
• 1979-1985
  Assistant Professor, Department of Biochemistry & Biophysics, UCSF
• 1985-1989
  Associate Professor, Department of Biochemistry & Biophysics, UCSF
• 1986
  Sabbatical research, with Dr. Christiane Nüsslein-Volhard, Tubingen, FRG
• 1989-present
  Professor, Department of Biochemistry & Biophysics, UCSF
• 1995-1996
  Sabbatical research with Dr. Gerald Rubin, University of California, Berkeley

Honors & Awards

• Fellow of the Jane Coffin Childs Memorial Fund for Medical Research
• Senior Fellow of the California Division of the American Cancer Society
• Award - Sarstedt Research Prize for the development of electrophoretic separations
• Chairman of the Biological Regulatory Mechanism Gordon Conference
• Member NSF Developmental Biology Review Panel
• Chairman of the Molecular Genetics Gordon Conference
• Scientific Review Board, Howard Hughes Institute
• Advisory Panel to the NCI

Selected Publications

1. Farrell JA, O'Farrell PH. Mechanism and regulation of cdc25/twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
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2. Yuan K, Farrell JA, O'Farrell PH. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
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3. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 1; 26(7):714-25.
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4. DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
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5. O'Farrell PH. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
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6. Shermoen AW, McCleland ML, O'Farrell PH. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 7; 20(23):2067-77.
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7. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
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8. O'Farrell PH. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
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9. McCleland ML, Shermoen AW, O'Farrell PH. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 5; 187(1):7-14.
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10. Dijkers PF, O'Farrell PH. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
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11. McCleland ML, Farrell JA, O'Farrell PH. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 9; 184(5):639-46.
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12. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
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13. O'Farrell PH. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
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14. Xu H, DeLuca SZ, O'Farrell PH. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
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15. Lee SJ, Feldman R, O'Farrell PH. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
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16. Hickson GR, O'Farrell PH. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41.
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17. McCleland ML, O'Farrell PH. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54.
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18. Hickson GR, O'Farrell PH. Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28; 180(2):285-94.
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19. Dijkers PF, O'Farrell PH. Drosophila calcineurin promotes induction of innate immune responses. Curr Biol. 2007 Dec 4; 17(23):2087-93.
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20. Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, Andino R. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006 Aug; 8(8):793-802.
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