Patrick H. O'Farrell, PhD


Professor, Department of Biochemistry and Biophysics, UCSF

Phone: (415) 476-4707
Box 2200, UCSF
San Francisco, CA 94143-2200

View on UCSF Profiles

Additional Websites


McGill University, Montreal, Quebec, B.Sc., 1969, Genetics
University of Colorado, Boulder, Ph.D., 1974, Cell & Dev Biol
University of California San Francisco, Postdoc, 1978

Professional Experience

  • 1969-1974
    Grad. Student: lab of Jacques Pene (1969-72) & David Hirsh (1973 -74). Development of 2-D gel electrophoresis; pleiotropic control. MCD Biology, University of Colorado
  • 1974-1976
    Postdoctoral studies with Gordon Tomkins. Regulation of translational accuracy; hormonal control; expression of recombinant DNA. Dept of Biochemistry, UCSF
  • 1976-1979
    Postdoctoral studies with Bruce Alberts. Stringency of gene inactivation; new preparative separation technology. Dept of Biochemistry, UCSF
  • 1979-1985
    Assistant Professor, Department of Biochemistry & Biophysics, UCSF
  • 1985-1989
    Associate Professor, Department of Biochemistry & Biophysics, UCSF
  • 1986
    Sabbatical research, with Dr. Christiane Nüsslein-Volhard, Tubingen, FRG
  • 1989-present
    Professor, Department of Biochemistry & Biophysics, UCSF
  • 1995-1996
    Sabbatical research with Dr. Gerald Rubin, University of California, Berkeley

Honors & Awards

  • 1975-78
    Fellow of the Jane Coffin Childs Memorial Fund for Medical Research
  • 1978-1979
    Senior Fellow of the California Division of the American Cancer Society
  • 1986
    Award - Sarstedt Research Prize for the development of electrophoretic separations
  • 1989
    Chairman of the Biological Regulatory Mechanism Gordon Conference
  • 1998
    Chairman of the Molecular Genetics Gordon Conference
  • 1999-2007
    Scientific Review Board, Howard Hughes Institute
  • 1998
    Advisory Panel to the NCI
  • 2006
    Outstanding mentorship award, Posdoc. Scholars Assoc. UCSF
  • 2009
    UMDF – chairman's prize for top proposal
  • 2009
    Elected to American Academy of Arts and Sciences
  • 2010
    Member of the NIH College of CSR Reviewers.
  • 2010-2020
    MERIT award from NIH/NIGMS
  • 2012
    Honorary Doctorate of Science, Univ. of Lethbridge
  • 2014
    ABRF Award for Outstanding Contributions to Biomolecular Technologies

Selected Publications

  1. Ma H, Xu H, O'Farrell PH. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7.
    View on PubMed
  2. O'Farrell PH. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3.
    View on PubMed
  3. Yuan K, Shermoen AW, O'Farrell PH. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5.
    View on PubMed
  4. Farrell JA, O'Farrell PH. Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
    View on PubMed
  5. Yuan K, Farrell JA, O'Farrell PH. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
    View on PubMed
  6. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 1; 26(7):714-25.
    View on PubMed
  7. DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
    View on PubMed
  8. O'Farrell PH. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
    View on PubMed
  9. Shermoen AW, McCleland ML, O'Farrell PH. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 7; 20(23):2067-77.
    View on PubMed
  10. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
    View on PubMed
  11. O'Farrell PH. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
    View on PubMed
  12. McCleland ML, Shermoen AW, O'Farrell PH. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 5; 187(1):7-14.
    View on PubMed
  13. Dijkers PF, O'Farrell PH. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
    View on PubMed
  14. McCleland ML, Farrell JA, O'Farrell PH. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 9; 184(5):639-46.
    View on PubMed
  15. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
    View on PubMed
  16. O'Farrell PH. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
    View on PubMed
  17. Xu H, DeLuca SZ, O'Farrell PH. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
    View on PubMed
  18. Lee SJ, Feldman R, O'Farrell PH. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
    View on PubMed
  19. Hickson GR, O'Farrell PH. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41.
    View on PubMed
  20. McCleland ML, O'Farrell PH. RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr Biol. 2008 Feb 26; 18(4):245-54.
    View on PubMed

Go to UCSF Profiles, powered by CTSI