Patrick H. O'Farrell, PhD

Professor, Department of Biochemistry and Biophysics, UCSF

Phone: (415) 476-4707
Box 2200, UCSF
San Francisco, CA 94143-2200

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Additional Websites

• Lab Website

Education

Professional Experience

• 1969-1974
  Grad. Student: lab of Jacques Pene (1969-72) & David Hirsh (1973 -74). Development of 2-D gel electrophoresis; pleiotropic control. MCD Biology, University of Colorado
• 1974-1976
  Postdoctoral studies with Gordon Tomkins. Regulation of translational accuracy; hormonal control; expression of recombinant DNA. Dept of Biochemistry, UCSF
• 1976-1979
  Postdoctoral studies with Bruce Alberts. Stringency of gene inactivation; new preparative separation technology. Dept of Biochemistry, UCSF
• 1979-1985
  Assistant Professor, Department of Biochemistry & Biophysics, UCSF
• 1985-1989
  Associate Professor, Department of Biochemistry & Biophysics, UCSF
• 1986
  Sabbatical research, with Dr. Christiane Nüsslein-Volhard, Tubingen, FRG
• 1989-present
  Professor, Department of Biochemistry & Biophysics, UCSF
• 1995-1996
  Sabbatical research with Dr. Gerald Rubin, University of California, Berkeley

Honors & Awards

• 1975-78
  Fellow of the Jane Coffin Childs Memorial Fund for Medical Research
• 1978-1979
  Senior Fellow of the California Division of the American Cancer Society
• 1986
  Award - Sarstedt Research Prize for the development of electrophoretic separations
• 1989
  Chairman of the Biological Regulatory Mechanism Gordon Conference
• 1998
  Chairman of the Molecular Genetics Gordon Conference
• 1999-2007
  Scientific Review Board, Howard Hughes Institute
• 1998
  Advisory Panel to the NCI
• 2006
  Outstanding mentorship award, Posdoc. Scholars Assoc. UCSF
• 2009
  UMDF – chairman's prize for top proposal
• 2009
  Elected to American Academy of Arts and Sciences
• 2010
  Member of the NIH College of CSR Reviewers.
• 2010-2020
  MERIT award from NIH/NIGMS
• 2012
  Honorary Doctorate of Science, Univ. of Lethbridge
• 2014
  ABRF Award for Outstanding Contributions to Biomolecular Technologies

Selected Publications

1. Farrell JA, O'Farrell PH. From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014 Nov 23; 48:269-94.
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2. Ma H, Xu H, O'Farrell PH. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7.
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3. O'Farrell PH. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3.
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4. Yuan K, Shermoen AW, O'Farrell PH. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5.
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5. Farrell JA, O'Farrell PH. Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
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6. Yuan K, Farrell JA, O'Farrell PH. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
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7. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 1; 26(7):714-25.
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8. DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
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9. O'Farrell PH. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
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10. Shermoen AW, McCleland ML, O'Farrell PH. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 7; 20(23):2067-77.
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11. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
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12. O'Farrell PH. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
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13. McCleland ML, Shermoen AW, O'Farrell PH. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 5; 187(1):7-14.
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14. Dijkers PF, O'Farrell PH. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
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15. McCleland ML, Farrell JA, O'Farrell PH. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 9; 184(5):639-46.
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16. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
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17. O'Farrell PH. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
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18. Xu H, DeLuca SZ, O'Farrell PH. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
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19. Lee SJ, Feldman R, O'Farrell PH. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
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20. Hickson GR, O'Farrell PH. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun; 36(Pt 3):439-41.
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