Patrick H. O'Farrell, PhD

Patrick H. O'Farrell, PhD

Professor, Department of Biochemistry and Biophysics, UCSF

Phone: (415) 476-4707
Box 2200, UCSF
San Francisco, CA 94143-2200

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Cancer Center Membership

Program Member » Non-aligned

Additional Websites


McGill University, Montreal, Quebec, B.Sc., 1969, Genetics
University of Colorado, Boulder, Ph.D., 1974, Cell & Dev Biol
University of California San Francisco, Postdoc, 1978

Professional Experience

  • 1969-1974
    Grad. Student: lab of Jacques Pene (1969-72) & David Hirsh (1973 -74). Development of 2-D gel electrophoresis; pleiotropic control. MCD Biology, University of Colorado
  • 1974-1976
    Postdoctoral studies with Gordon Tomkins. Regulation of translational accuracy; hormonal control; expression of recombinant DNA. Dept of Biochemistry, UCSF
  • 1976-1979
    Postdoctoral studies with Bruce Alberts. Stringency of gene inactivation; new preparative separation technology. Dept of Biochemistry, UCSF
  • 1979-1985
    Assistant Professor, Department of Biochemistry & Biophysics, UCSF
  • 1985-1989
    Associate Professor, Department of Biochemistry & Biophysics, UCSF
  • 1986
    Sabbatical research, with Dr. Christiane Nüsslein-Volhard, Tubingen, FRG
  • 1989-present
    Professor, Department of Biochemistry & Biophysics, UCSF
  • 1995-1996
    Sabbatical research with Dr. Gerald Rubin, University of California, Berkeley

Honors & Awards

  • 1975-78
    Fellow of the Jane Coffin Childs Memorial Fund for Medical Research
  • 1978-1979
    Senior Fellow of the California Division of the American Cancer Society
  • 1986
    Award - Sarstedt Research Prize for the development of electrophoretic separations
  • 1989
    Chairman of the Biological Regulatory Mechanism Gordon Conference
  • 1998
    Chairman of the Molecular Genetics Gordon Conference
  • 1999-2007
    Scientific Review Board, Howard Hughes Institute
  • 1998
    Advisory Panel to the NCI
  • 2006
    Outstanding mentorship award, Posdoc. Scholars Assoc. UCSF
  • 2009
    UMDF – chairman's prize for top proposal
  • 2009
    Elected to American Academy of Arts and Sciences
  • 2010
    Member of the NIH College of CSR Reviewers.
  • 2010-2020
    MERIT award from NIH/NIGMS
  • 2012
    Honorary Doctorate of Science, Univ. of Lethbridge
  • 2014
    ABRF Award for Outstanding Contributions to Biomolecular Technologies

Selected Publications

  1. Yuan K, O'Farrell PH. Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition. Curr Biol. 2015 Mar 16; 25(6):811-6.
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  2. Farrell JA, O'Farrell PH. From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition. Annu Rev Genet. 2014 Nov 23; 48:269-94.
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  3. Ma H, Xu H, O'Farrell PH. Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. 2014 Apr; 46(4):393-7.
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  4. O'Farrell PH. Two-dimensional gel electrophoresis and the beginning of proteomics. Clin Chem. 2014 Jul; 60(7):1012-3.
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  5. Yuan K, Shermoen AW, O'Farrell PH. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014 Feb 17; 24(4):R144-5.
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  6. Farrell JA, O'Farrell PH. Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling. Curr Biol. 2013 Jan 21; 23(2):118-26.
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  7. Yuan K, Farrell JA, O'Farrell PH. Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol. 2012 Sep 17; 198(6):973-80.
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  8. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 2012 Apr 1; 26(7):714-25.
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  9. DeLuca SZ, O'Farrell PH. Barriers to male transmission of mitochondrial DNA in sperm development. Dev Cell. 2012 Mar 13; 22(3):660-8.
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  10. O'Farrell PH. Quiescence: early evolutionary origins and universality do not imply uniformity. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3498-507.
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  11. Shermoen AW, McCleland ML, O'Farrell PH. Developmental control of late replication and S phase length. Curr Biol. 2010 Dec 7; 20(23):2067-77.
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  12. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23; 20(4):R141-2.
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  13. O'Farrell PH. Patrick H. O'Farrell. Curr Biol. 2010 Feb 23; 20(4):R133-4.
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  14. McCleland ML, Shermoen AW, O'Farrell PH. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009 Oct 5; 187(1):7-14.
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  15. Dijkers PF, O'Farrell PH. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Mol Biol Cell. 2009 Sep; 20(18):4083-90.
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  16. McCleland ML, Farrell JA, O'Farrell PH. Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo. J Cell Biol. 2009 Mar 9; 184(5):639-46.
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  17. Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD. Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells. Methods Mol Biol. 2009; 470:347-58.
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  18. O'Farrell PH. The pre-omics era: the early days of two-dimensional gels. Proteomics. 2008 Dec; 8(23-24):4842-52.
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  19. Xu H, DeLuca SZ, O'Farrell PH. Manipulating the metazoan mitochondrial genome with targeted restriction enzymes. Science. 2008 Jul 25; 321(5888):575-7.
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  20. Lee SJ, Feldman R, O'Farrell PH. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell. 2008 Oct; 19(10):4051-61.
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