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Joel M. Palefsky, MD


Professor, Departments of Laboratory Medicine and Medicine, UCSF

Phone: (415) 353-2626 (appts)
Box 0126, UCSF
San Francisco, CA 94143-0126

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Additional Websites


Mc Gill University, Montreal, Canada, M.D.,C.M., 1980, Medicine
Royal Victoria Hospital, Montreal, Canada, F.R.C.P(C), 1984, Internal Medicine
Stanford University, Stanford, CA, D.A.B.I.M. (Infec Dis), 1989, Medical Microbiology/Infectious Disease

Professional Experience

  • 1980-1983
    Residency in Internal Medicine, Royal Victoria Hospital, Montreal, Canada
  • 1983-1984
    Post-doctoral Fellow, Department of Microbiology and Immunology, McGill University, Montreal, Canada
  • 1984-1984
    Chief Medical Resident, Royal Victoria Hospital, McGill University, Montreal, Canada
  • 1985-1989
    Post-doctoral Fellow, Division of Infectious Diseases, Stanford University
  • 1989-1995
    Assistant Professor, Departments of Laboratory Medicine and Stomatology
  • 1990-present
    Director, UCSF Anal Neoplasia Clinic
  • 1996-1998
    Chair, UCSF Biosafety Committee
  • 1998-present
    Vice-Chair UCSF Biosafety Committee
  • 1999-present
    Professor, Departments of Medicine, Laboratory Medicine and Stomatology
  • 1998-present
    Program Director, UCSF General Clinical Research Center
  • 2001-present
    Program Leader Doris Duke Charitable Foundation Clinical Research Fellowhsip Program
  • 2002-2009
    Co-Chair, Cancer and Immunity Program, UCSF Helen Diller Family Comprehensive Cancer Center
  • 2003-present
    Chair, NCI AIDS Malignancy Consortium HPV Working Group
  • 2004-present
    Chair, Special Populations Working Group, American Society for Colposcopy & Cervical Pathology
  • 2006-present
    Associate Dean for Clinical and Translational Research
  • 2013 –present
    NCI Board of Scientific Advisors Ad-hoc Subcommittee on HIV/AIDS Malignancy

Honors & Awards

  • 1984-1988
    Medical Research Council of Canada Fellowship
  • 1988-1990
    American Social Health Association Fellowship
  • 2003-present
    American Society for Clinical Investigation
  • 2005 & 2008
    Award for Excellence in Small Group Teaching

Selected Publications

  1. Sharma R, Efird JT, Chein A, Holly EA, Krajden M, Berry JM, Darragh TM, Jay N, Palefsky JM. Prevalence and Risk Factors for Neutralizing Antibodies to Human Papillomavirus Types 16 and 18 in HIV-Positive Men Who Have Sex With Men. J Acquir Immune Defic Syndr. 2013 Dec 15; 64(5):479-87.
    View on PubMed
  2. Phanuphak N, Teeratakulpisarn N, Keelawat S, Pankam T, Barisri J, Triratanachat S, Deesua A, Rodbamrung P, Wongsabut J, Tantbirojn P, Numto S, Ruangvejvorachai P, Phanuphak P, Palefsky JM, Ananworanich J, Kerr SJ. Use of Human Papillomavirus DNA, E6/E7 mRNA, and p16 Immunocytochemistry to Detect and Predict anal High-Grade Squamous Intraepithelial Lesions in HIV-Positive and HIV-Negative Men Who Have Sex with Men. PLoS One. 2013; 8(11):e78291.
    View on PubMed
  3. Ortiz AP, Ortiz-Ortiz KJ, Traverso M, Ríos M, Colón-Lopez V, Palefsky J. 29. Anal cancer trends in Puerto Rico (PR) from 1985 to 2005: impact of HIV status. Sex Health. 2013 Nov; 10(6):584.
    View on PubMed
  4. Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Palefsky JM. 46. HIV-induced epithelial-mesenchymal transition in mucosal epithelium facilitates HPV paracellular penetration. Sex Health. 2013 Nov; 10(6):592.
    View on PubMed
  5. Colón-López V, Ortiz AP, Del Toro-Mejías L, Clatts MC, Palefsky JM. 6. Prevalence, genotype diversity and determinants of anal HPV infection in high-risk men attending a sexually transmitted infection clinic in Puerto Rico. Sex Health. 2013 Nov; 10(6):572-3.
    View on PubMed
  6. Sheon N, Pollack L, Palefsky J. 41. Willingness to join an anal cancer screening and prevention trial. Sex Health. 2013 Nov; 10(6):590.
    View on PubMed
  7. Wechsler EI, Tugizov S, Palefsky J. 48. Cidofovir treatment prevents invasion of invasive HPV-16-positive anal keratinocytes. Sex Health. 2013 Nov; 10(6):593.
    View on PubMed
  8. Ortiz AP, Guiot HM, Díaz-Miranda OL, Romáán L, Palefsky J, Colon-Lopez V. 30. Recognising and treating anal cancer: training medical students and physicians in Puerto Rico. Sex Health. 2013 Nov; 10(6):584-5.
    View on PubMed
  9. Berry JM, Jay N, Hernandez A, Darragh TM, Palefsky JM. 3. Outcome of excision of early invasive squamous carcinomas of the anal canal and perianus. Sex Health. 2013 Nov; 10(6):571.
    View on PubMed
  10. Palefsky J, Da Costa M, Darragh TM, Jay N, Berry JM. 32. HPV type and strain variant concordance between anal cancers and their preceding high-grade squamous intraepithelial lesions. Sex Health. 2013 Nov; 10(6):585-6.
    View on PubMed
  11. Neumark DE, Sheon N, Palefsky J. 28. Investigating motivations for participation in an anal cancer screening trial (IMPACT). Sex Health. 2013 Nov; 10(6):583-4.
    View on PubMed
  12. Tugizov SM, Herrera R, Chin-Hong P, Veluppillai P, Greenspan D, Michael Berry J, Pilcher CD, Shiboski CH, Jay N, Rubin M, Chein A, Palefsky JM. HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013 Nov; 446(1-2):378-88.
    View on PubMed
  13. Berry JM, Jay N, Cranston RD, Darragh TM, Holly EA, Welton ML, Palefsky JM. Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIV-infected men who have sex with men. Int J Cancer. 2014 Mar 1; 134(5):1147-55.
    View on PubMed
  14. Phanuphak N, Teeratakulpisarn N, Pankam T, Kerr SJ, Barisri J, Deesua A, Rodbamrung P, Hongchookiat P, Chomchey N, Phanuphak P, Sohn AH, Ananworanich J, Palefsky JM. Anal human papillomavirus infection among Thai men who have sex with men with and without HIV infection: prevalence, incidence, and persistence. J Acquir Immune Defic Syndr. 2013 Aug 1; 63(4):472-9.
    View on PubMed
  15. Hernandez AL, Efird JT, Holly EA, Berry JM, Jay N, Palefsky JM. Risk factors for anal human papillomavirus infection type 16 among HIV-positive men who have sex with men in San Francisco. J Acquir Immune Defic Syndr. 2013 Aug 1; 63(4):532-9.
    View on PubMed
  16. Hessol NA, Holly EA, Efird JT, Minkoff H, Weber KM, Darragh TM, Burk RD, Strickler HD, Greenblatt RM, Palefsky JM. Concomitant anal and cervical human papillomavirusV infections and intraepithelial neoplasia in HIV-infected and uninfected women. AIDS. 2013 Jul 17; 27(11):1743-51.
    View on PubMed
  17. Phanuphak N, Teeratakulpisarn N, Triratanachat S, Keelawat S, Pankam T, Kerr SJ, Deesua A, Tantbirojn P, Numto S, Phanuphak P, Palefsky JM, Ananworanich J. High prevalence and incidence of high-grade anal intraepithelial neoplasia among young Thai men who have sex with men with and without HIV. AIDS. 2013 Jul 17; 27(11):1753-62.
    View on PubMed
  18. Simard EP, Watson M, Saraiya M, Clarke CA, Palefsky JM, Jemal A. Trends in the occurrence of high-grade anal intraepithelial neoplasia in San Francisco: 2000-2009. Cancer. 2013 Oct 1; 119(19):3539-45.
    View on PubMed
  19. Goldstone SE, Jessen H, Palefsky JM, Giuliano AR, Moreira ED, Vardas E, Aranda C, Hillman RJ, Ferris DG, Coutlee F, Marshall JB, Vuocolo S, Haupt RM, Guris D, Garner E. Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine. 2013 Aug 20; 31(37):3849-55.
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  20. Tugizov SM, Herrera R, Palefsky JM. Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013 Jul; 87(14):8179-94.
    View on PubMed

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