Joel M. Palefsky, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Joel M. Palefsky, MD

Professor of Medicine, Department of Infectious Diseases, UCSF

Phone: (415) 353-7100 (appts)
(415) 476-1574 (office)
Box 0654, UCSF
San Francisco, CA 94143-0654

UCSF Profiles | Physician Referral Directory | Infectious Diseases Faculty Profile

Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment» Cancer Control

Research Summary

I am the founder and chair of the HPV Working Group of the NCI AIDS Malignancy Consortium and the head of the AMC HPV Virology Core Lab. I have extensive experience in studying the molecular biology of HPV infection in HIV-positive men and women and in the design and implementation of clinical research trials of HPV-related disease in this population. I am the protocol chair of the ANCHOR study, an eight-year, 15-site NCI/NIH-funded randomized controlled trial designed to determine whether treatment of anal high-grade squamous intraepithelial lesions prevents anal cancer in HIV-infected men and women.
As the founder and director of the Anal Neoplasia Clinic, Research and Education Center at UCSF, I oversee training of clinicians from around the world in high-resolution anoscopy, anal biopsy, and office-based treatment. I have an active international research program, including currently active studies in India, Costa Rica and Thailand. I have published over 275 papers and am the PI on several laboratory-based and clinical research studies of HPV-associated neoplasia, particularly in the setting of HIV infection.
I am currently the president of the International Papillomavirus Society and the founder and immediate past president of the International Anal Neoplasia Society. I have been the leader of the UCSF Doris Duke Charitable Foundation Clinical Research Fellowship Program for medical students since 2001; since 2006, I have led a T32 program devoted to training pre-doctoral students in clinical and translational research. These year-out programs provide support for an intensive year of coursework and project-oriented research with the goal of stimulating pre-doctoral students to pursue further training and careers in clinical and translational research.

Education

McGill University, Montreal, Canada, M.D.,C.M., 1980, Medicine
Royal Victoria Hospital, Montreal, Canada, F.R.C.P(C), 1984, Internal Medicine
Stanford University, Stanford, CA, D.A.B.I.M. (Infec Dis), 1989, Medical Microbiology/Infectious Disease


Professional Experience

  • 1980 – 1983
    Residency in Internal Medicine, Royal Victoria Hospital, Montreal, Canada
  • 1983 – 1984
    Post-doctoral Fellow, Dept of Microbiology & Immunology, McGill Univ., Montreal, Canada
  • 1984 – 1984
    Chief Medical Resident, Royal Victoria Hospital, McGill University, Montreal, Canada
  • 1985 – 1989
    Post-doctoral Fellow, Division of Infectious Diseases, Stanford University
  • 1989 – 1995
    Assistant Professor, Departments of Laboratory Medicine and Stomatology
  • 1990 – Present
    Director, UCSF Anal Neoplasia Clinic
  • 1995 – 1999
    Associate Professor, Departments of Laboratory Medicine and Stomatology
  • 1999 – Present
    Professor, Departments of Medicine, Laboratory Medicine and Stomatology
  • 1998 – 2006
    Program Director, UCSF General Clinical Research Center
  • 2006 – 2009
    Associate Dean for Clinical and Translational Research

Honors & Awards


  • 1976
    University Scholarship McGill University
  • 1985
    Medical Research Council of Canada Fellowship Medical Research Council of Canada
  • 1988
    American Social Health Association Fellowship American Social Health Association
  • 2003
    Elected to American Society for Clinical Investigation
  • 2005
    Award for excellence in small group instruction, UCSF
  • 2006, 2012
    Award of Merit American Society for Colposcopy and Cervical Pathology
  • 2008
    Award for excellence in small group instruction, UCSF
  • 2011
    Fieldhouse-Myers Oration Christian Medical College, Vellore, India
  • 2012
    Top Doctor (US News and World Report) (Infectious Diseases)
  • 2013
    America's Top Doctor, Castle and Connelly
  • 2013
    Super Doctor, San Francisco Chronicle Sunday Magazine
  • 2014
    Elected Member American Association of Physicians

Selected Publications

  1. Palefsky JM. Human papillomavirus-associated anal and cervical cancers in HIV-infected individuals: incidence and prevention in the antiretroviral therapy era. Curr Opin HIV AIDS. 2016 Nov 8.
    View on PubMed
  2. Massad L, Keller M, Xie X, Minkoff H, Palefsky J, D'Souza G, Colie C, Villacres M, Strickler H. Multitype Infections With Human Papillomavirus: Impact of Human Immunodeficiency Virus Coinfection. Sex Transm Dis. 2016 Oct; 43(10):637-41.
    View on PubMed
  3. Hillman RJ, Cuming T, Darragh T, Nathan M, Berry-Lawthorn M, Goldstone S, Law C, Palefsky J, Barroso LF, Stier EA, Bouchard C, Almada J, Jay N. 2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors. J Low Genit Tract Dis. 2016 Oct; 20(4):283-91.
    View on PubMed
  4. Reimers LL, Mehta SD, Massad LS, Burk RD, Xie X, Ravel J, Cohen MH, Palefsky JM, Weber K, Xue X, Anastos K, Minkoff H, Atrio J, D'Souza G, Ye Q, Colie C, Zolnik CP, Spear GT, Strickler HD. The Cervicovaginal Microbiota and Its Associations with Human Papillomavirus (HPV) Detection in HIV-Infected and HIV-Uninfected Women. J Infect Dis. 2016 Aug 11.
    View on PubMed
  5. Shiboski CH, Lee A, Chen H, Webster-Cyriaque J, Seaman T, Landovitz RJ, John M, Reilly N, Naini L, Palefsky J, Jacobson MA. Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy. AIDS. 2016 Jun 19; 30(10):1573-82.
    View on PubMed
  6. Hernandez AL, Karthik R, Sivasubramanian M, Raghavendran A, Gnanamony M, Lensing S, Lee JY, Kannangai R, Abraham P, Mathai D, Palefsky JM. Prevalence of Anal HPV Infection Among HIV-Positive Men Who Have Sex With Men in India. J Acquir Immune Defic Syndr. 2016 Apr 1; 71(4):437-43.
    View on PubMed
  7. Wang CC, Palefsky JM. Human papillomavirus-related oropharyngeal cancer in the HIV-infected population. Oral Dis. 2016 Apr; 22 Suppl 1:98-106.
    View on PubMed
  8. Brickman C, Palefsky JM. Cancer in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era. Curr HIV/AIDS Rep. 2015 Dec; 12(4):388-96.
    View on PubMed
  9. Massad LS, Xie X, Burk RD, D'Souza G, Darragh TM, Minkoff H, Colie C, Burian P, Palefsky J, Atrio J, Strickler HD. Association of cervical precancer with human papillomavirus types other than 16 among HIV co-infected women. Am J Obstet Gynecol. 2016 Mar; 214(3):354.e1-6.
    View on PubMed
  10. Lahiri CD, Dugan KB, Xie X, Reimers L, Burk RD, Anastos K, Massad LS, Eltoum IE, Xue X, D'Souza G, Flowers L, Palefsky JM, Rahangdale L, Strickler HD, Ofotokun I. Oral Lopinavir Use and Human Papillomavirus Infection in HIV-Positive Women. J Acquir Immune Defic Syndr. 2015 Oct 1; 70(2):e63-6.
    View on PubMed
  11. Bennetts LE, Wagner M, Giuliano AR, Palefsky JM, Steben M, Weiss TW. Associations of Anogenital Low-Risk Human Papillomavirus Infection With Cancer and Acquisition of HIV. Sex Transm Dis. 2015 Oct; 42(10):541-4.
    View on PubMed
  12. Ortiz AP, Marrero E, Muñoz C, Pérez CM, Tortolero-Luna G, Romaguera J, Rodríguez N, González-Falero A, Palefsky J, Suárez E. Methods in HPV Surveillance: Experiences from a Population-Based Study of HPV Infection among Women in the San Juan Metropolitan Area of Puerto Rico. P R Health Sci J. 2015 Sep; 34(3):117-27.
    View on PubMed
  13. Colón-López V, Ortiz AP, Del Toro-Mejías L, Clatts M, Durán-Guzmán G, Pérez N, DaCosta M, Palefsky J. Prevalence and Correlates of Penile HPV Infection in a Clinic-Based Sample of Hispanic Males. P R Health Sci J. 2015 Sep; 34(3):128-34.
    View on PubMed
  14. Conley LJ, Bush TJ, Darragh TM, Palefsky JM, Unger ER, Patel P, Steinau M, Kojic EM, Martin H, Overton ET, Cu-Uvin S, Hammer J, Henry K, Wood K, Brooks JT. Incidence and Predictors of Abnormal Anal Cytology Findings Among HIV-Infected Adults Receiving Contemporary Antiretroviral Therapy. J Infect Dis. 2016 Feb 1; 213(3):351-60.
    View on PubMed
  15. Palefsky JM. Screening to prevent anal cancer: Current thinking and future directions. Cancer Cytopathol. 2015 Sep; 123(9):509-10.
    View on PubMed
  16. Keller MJ, Burk RD, Massad LS, Eltoum IE, Hessol NA, Castle PE, Anastos K, Xie X, Minkoff H, Xue X, D'Souza G, Flowers L, Levine AM, Colie C, Rahangdale L, Fischl MA, Palefsky JM, Strickler HD. Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test. Clin Infect Dis. 2015 Nov 15; 61(10):1573-81.
    View on PubMed
  17. Romaguera J, Caballero-Varona D, Tortolero-Luna G, Marrero E, Suárez E, Pérez CM, Muñoz C, Palefsky J, Ortiz AP. Factors Associated with HPV Vaccine Awareness in a Population-Based Sample of Hispanic Women in Puerto Rico. J Racial Ethn Health Disparities. 2016 Jun; 3(2):281-90.
    View on PubMed
  18. Jay N, Berry JM, Miaskowski C, Cohen M, Holly E, Darragh TM, Palefsky JM. Colposcopic Characteristics and Lugol's Staining Differentiate Anal High-Grade and Low-Grade Squamous Intraepithelial Lesions During High Resolution Anoscopy. Papillomavirus Res. 2015 Dec; 1:101-108.
    View on PubMed
  19. Castellsagué X, Giuliano AR, Goldstone S, Guevara A, Mogensen O, Palefsky JM, Group T, Shields C, Liu K, Maansson R, Luxembourg A, Kaplan SS. Immunogenicity and safety of the 9-valent HPV vaccine in men. Vaccine. 2015 Nov 27; 33(48):6892-901.
    View on PubMed
  20. Prendes BL, Wang SJ, Groppo ER, Eisele DW, Palefsky JM. Oral human papillomavirus infection in men who have sex with men with anal squamous intraepithelial lesions. Head Neck. 2016 Apr; 38 Suppl 1:E399-405.
    View on PubMed

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