University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Tien Peng, MD

Tien Peng, MD

Assistant Professor, Division of Pulmonary, Critical Care, Allergy, and Sleep, Department of Medicine and Cardiovascular Research Institute, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Our laboratory is interested in studying how key developmental pathways continue to persist in adulthood to maintain normal homeostatic organ function. We are particularly focused on the mesenchymal cell types (e.g. fibroblasts, pericytes, and etc.) that are poorly understood and lack precise anatomical definition, but are integral to the structural integrity and function of adult organs such as the lung. Previous work focused on how the Hedgehog pathway directed mesenchymal progenitor differentiation during embryonic development, and much to our surprise, how Hedgehog continues to maintain normal mesenchymal homeostasis during adulthood. We found that cellular quiescence in the adult lung is not a default state, but rather actively maintained by epithelial-mesenchymal crosstalk coordinated by Hedgehog. This suggests that cellular quiescence is tightly regulated by the state of Hedgehog activation within the mesenchyme to regulate cellular turnover during homeostasis and injury, and that dysregulated Hedgehog signaling could lead to maladaptive remodeling and lung diseases. Our projects utilizes sophisticated murine genetic models to manipulate and characterize cellular populations in a temporally/spatially specific manner, dissecting the role of key developmental pathways in regulating adult organ structural integrity, immune homeostasis, and aging.

Education

University of Virginia, Charlottesville, VA, B.A., 05/2000, Biology/Sociology
Johns Hopkins University, Baltimore, MD, M.D., 05/2006, Medicine
Columbia University Medical Center, New York, NY, Residency, 06/2009, Internal Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA, Fellowship, 12/2012, Pulmonary and Critical Care Medicine
University of Pennsylvania School of Medicine, Philadelphia, PA, Postdoctoral research, 07/2015 Cell and Developmental Biology


Professional Experience

  • 2014-2015
    Instructor, Division of Pulmonary, Critical Care, and Allergy, Department of Medicine, Hospital of the University of Pennsylvania
  • 2015 - present
    Assistant Professor, Division of Pulmonary, Critical Care, Allergy, and Sleep, Department of Medicine and Cardiovascular Research Institute, UCSF

Honors & Awards

  • 2000
    Phi Beta Kappa, University of Virginia
  • 2003
    Clinical Research Training Program Scholar, National Institutes of Health
  • 2013
    Travel Award, Program Faculty, Keystone Symposia Conference, Lung Development, Cancer
  • and Disease
  • 2013
    Travel Award, Vascular Biology 2013, North American Vascular Biology Organization (NAVBO)
  • 2013
    Stanley E. Bradley Award for Outstanding Bench Research, Department of Medicine, University
  • of Pennsylvania
  • 2014
    Travel Award, Gordon Research Conference, Lung Development and Repair
  • 2014
    Travel Award, Moderator, Keystone Symposia Conference, Fibrosis: From Bench to Bedside
  • 2014
    Joe Rae Wright Outstanding Young Investigator Award, Federation of American Societies for
  • Experimental Biology (FASEB)
  • 2016
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2016
    NIH New Innovator Award

Selected Publications

  1. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 Nov 22; 17(9):2312-2325.
    View on PubMed
  2. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82.
    View on PubMed
  3. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79.
    View on PubMed
  4. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 05; 13(6):720-33.
    View on PubMed
  5. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92.
    View on PubMed
  6. Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8.
    View on PubMed
  7. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60.
    View on PubMed
  8. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5.
    View on PubMed
  9. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52.
    View on PubMed
  10. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158.
    View on PubMed
  11. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38.
    View on PubMed

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