University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Joseph T. Rabban III, MD, MPH

Joseph T. Rabban III, MD, MPH

Associate Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Breast Oncology | Cancer Genetics

Research Summary

I am a surgical pathologist specializing in the diagnosis of gynecologic diseases, including cancers, benign tumors, pre-malignant lesions, infections, hormonal alterations, and developmental abnormalities of the ovaries, fallopian tubes, endometrium (uterus), myometrium, cervix, peritoneum, vagina, and vulva. I provide diagnostic pathology service for the OB/GYN, Gynecologic Oncology, and Dysplasia clinics and operating rooms at Mission Bay Hospital, Moffitt Hospital and Mt Zion Cancer Center, as well as for the Genetic Counseling service at the UCSF Hereditary Cancer Clinic and Center for BRCA Research. I also serve on our gynecologic subspecialty diagnostic consultation service, which offers consultation to pathologists, clinicians and patients outside of the UCSF Medical Center.

My clinical research focuses on 1.) diagnostic classification on gynecologic cancers, with an aim toward improvement of personalized tailoring of treatment decisions and tailoring of risk assessment for hereditary disease and 2.) early diagnosis of ovarian cancer (pelvic cancer), specifically serous tumors.

Inter-departmental collaboration is central to both my clinical service and research activity. I work closely with my UCSF colleagues in the OB/GYN, Gynecologic Oncology, Genetic Counseling, and Radiology departments.

My educational activity includes serving as the Program Director for the UCSF Gynecologic Pathology Fellowship; co-chair of the Education Committee of the International Society of Gynecologic Pathologists; and lecturer and course director of numerous continuing education courses offered by national (USCAP, ASCP, CAP) and international (IAP, ISGyP, SSI) pathology organizations.

My professional organizational service includes being Associate Editor of the International Journal of Gynecologic Pathology and Secretary on the executive board of the International Society of Gynecologic Pathologists.

Education

Harvard Medical School, MD, 1992-98, Medicine
Harvard School of Public Health, M.P.H., 1995-96, Medicine
University of California, San Francisco, Intern, 1998-99, General Surgery
University of California, San Francisco Resident, 1999-01, Anatomic Pathology
University of California, San Francisco Fellow, 2001-02, Surgical Pathology
University of California, San Francisco, Fellow, 2002-03, Cytopathology
Harvard Medical School Fellow, 2003-04, Gynecologic and Breast Pathology


Professional Experience

  • 2001-02
    Chief Resident, Anatomic Pathology, University of California, San Francisco
  • 2003-04
    Clinical Fellow in Pathology, Harvard Medical School
  • 2003-04
    Fellow in Pathology of Women's Cancer, Gillette Center for Women's Cancer, Massachusetts General Hospital
  • 2003-04
    Graduate Assistant in Pathology, Massachusetts General Hospital
  • 2004-present
    Deputy Director, Medical Student Pathology Elective, University of California, San Francisco
  • 2004-present
    Associate Director, Surgical Pathology Fellowship, University of California, San Francisco
  • 2004-2008
    Assistant Professor in Clinical Pathology, University of California, San Francisco
  • 2008-present
    Associate Professor in Clinical Pathology, University of California, San Francisco

Selected Publications

  1. Moh M, Sangoi A, Rabban JT. Angiomyomatous Hamartoma of Lymph Nodes, Revisited: Clinico-pathologic Study of 21 Cases, Emphasizing Its Distinction from Lymphangioleiomyomatosis of Lymph Nodes. Hum Pathol. 2017 Sep 09.
    View on PubMed
  2. Wolsky RJ, Price MA, Zaloudek CJ, Rabban JT. Mucosal Proliferations in Completely Examined Fallopian Tubes Accompanying Ovarian Low-grade Serous Tumors: Neoplastic Precursor Lesions or Normal Variants of Benign Mucosa? Int J Gynecol Pathol. 2017 Jul 11.
    View on PubMed
  3. Sangoi AR, Kshirsagar M, Roma AA, Horvai AE, Chivukula M, Ellenson LH, Fadare O, Folkins AK, Garg K, Hanley K, Longacre TA, Haas J, McCluggage WG, McKenney JK, Nucci MR, Oliva E, Park KJ, Parkash V, Quick CM, Rabban JT, Rutgers JKL, Soslow R, Vang R, Yemelyanova A, Zaloudek C, Beck AH. Interobserver Reproducibility Among Gynecologic Pathologists in Diagnosing Heterologous Osteosarcomatous Component in Gynecologic Tract Carcinosarcomas. Int J Gynecol Pathol. 2017 Jul; 36(4):386-392.
    View on PubMed
  4. Campbell JI, Yau C, Krass P, Moore D, Carey LA, Au A, Chhieng D, Giri D, Livasy C, Mies C, Rabban J, Sarode VR, Singh B, Esserman L, Chen YY. Comparison of residual cancer burden, American Joint Committee on Cancer staging and pathologic complete response in breast cancer after neoadjuvant chemotherapy: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat. 2017 Aug; 165(1):181-191.
    View on PubMed
  5. Nolan A, Joseph NM, Sangoi AR, Rabban J, Zaloudek C, Garg K. FOXL2 Mutation Status in Granulosa Theca Cell Tumors of the Ovary. Int J Gynecol Pathol. 2017 Mar 17.
    View on PubMed
  6. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017 Feb; 30(2):246-254.
    View on PubMed
  7. Barragan F, Irwin JC, Balayan S, Erikson DW, Chen JC, Houshdaran S, Piltonen TT, Spitzer TL, George A, Rabban JT, Nezhat C, Giudice LC. Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis. Biol Reprod. 2016 May; 94(5):118.
    View on PubMed
  8. Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT. SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type. Am J Surg Pathol. 2016 Mar; 40(3):419-32.
    View on PubMed
  9. Karnezis AN, Wang Y, Ramos P, Hendricks WP, Oliva E, D'Angelo E, Prat J, Nucci MR, Nielsen TO, Chow C, Leung S, Kommoss F, Kommoss S, Silva A, Ronnett BM, Rabban JT, Bowtell DD, Weissman BE, Trent JM, Gilks CB, Huntsman DG. Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2016 Feb; 238(3):389-400.
    View on PubMed
  10. Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39.
    View on PubMed
  11. Rabban JT, Firetag B, Sangoi AR, Post MD, Zaloudek CJ. Incidental Pelvic and Para-aortic Lymph Node Lymphangioleiomyomatosis Detected During Surgical Staging of Pelvic Cancer in Women Without Symptomatic Pulmonary Lymphangioleiomyomatosis or Tuberous Sclerosis Complex. Am J Surg Pathol. 2015 Aug; 39(8):1015-25.
    View on PubMed
  12. Rabban JT, Vohra P, Zaloudek CJ. Nongynecologic metastases to fallopian tube mucosa: a potential mimic of tubal high-grade serous carcinoma and benign tubal mucinous metaplasia or nonmucinous hyperplasia. Am J Surg Pathol. 2015 Jan; 39(1):35-51.
    View on PubMed
  13. Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Burney RO, Nezhat C, DePaolo LV, Giudice LC. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014 Dec; 155(12):4986-99.
    View on PubMed
  14. Rabban JT, Calkins SM, Karnezis AN, Grenert JP, Blanco A, Crawford B, Chen LM. Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening strategies for Lynch syndrome. Am J Surg Pathol. 2014 Jun; 38(6):793-800.
    View on PubMed
  15. Rabban JT, Garg K, Crawford B, Chen LM, Zaloudek CJ. Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery. Am J Surg Pathol. 2014 Jun; 38(6):729-42.
    View on PubMed
  16. Rabban JT, Zaloudek CJ. A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord-stromal tumours. Histopathology. 2013 Jan; 62(1):71-88.
    View on PubMed
  17. Karnezis AN, Aysal A, Zaloudek CJ, Rabban JT. Transitional cell-like morphology in ovarian endometrioid carcinoma: morphologic, immunohistochemical, and behavioral features distinguishing it from high-grade serous carcinoma. Am J Surg Pathol. 2013 Jan; 37(1):24-37.
    View on PubMed
  18. Fadare O, Parkash V, Dupont WD, Acs G, Atkins KA, Irving JA, Pirog EC, Quade BJ, Quddus MR, Rabban JT, Vang R, Hecht JL. The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features. Am J Surg Pathol. 2012 Aug; 36(8):1107-18.
    View on PubMed
  19. Aysal A, Karnezis A, Medhi I, Grenert JP, Zaloudek CJ, Rabban JT. Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability. Am J Surg Pathol. 2012 Feb; 36(2):163-72.
    View on PubMed
  20. Powell CB, Chen LM, McLennan J, Crawford B, Zaloudek C, Rabban JT, Moore DH, Ziegler J. Risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers: experience with a consecutive series of 111 patients using a standardized surgical-pathological protocol. Int J Gynecol Cancer. 2011 Jul; 21(5):846-51.
    View on PubMed

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