Daniel M. Ramos, DDS, PhD

Daniel M. Ramos, DDS, PhD

Associate Professor, Department of Orofacial Sciences, UCSF


Phone: (415) 502-4905 (voice)
Box 0512, UCSF
San Francisco, CA 94143-0512

View on UCSF Profiles

Cancer Center Membership

Associate Member » Non-aligned


California State University, Los Angeles, B.S., 1984, Biology
University of California, San Francisco, D.D.S., 1988, Dentistry
University of California, San Francisco, Ph.D., 1994, Oral Biology

Professional Experience

  • 1983-84
    Lab Assistant, Independent Research Project: Tyrosinase Levels in Avian Tissues, California State University, Los Angeles, Department of Biology, Advisor: Dr. Roger Bowers
  • 1985-94
    Postgraduate Research Dentist, University of California, San Francisco, Dept. of Stomatology, Advisor: Dr. Randall Kramer
  • 1994-97
    Adjunct Assistant Professor, University of California, San Francisco, Dept. of Stomatology
  • 1997-2003
    Assistant Professor, University of California, San Francisco, Dept. of Stomatology
  • 2003-present
    Associate Professor, University of California, San Francisco, Department of Stomatology

Honors & Awards

  • 1988-93
    Individual Dentist Scientist Award, NIH-NIDR 1K15DE00242
  • 1995-96
    Junior Faculty Development Award (Academic Senate)
  • 2001
    Dean's Creativity Award (School of Dentistry)

Selected Publications

  • Kramer, R.H., McDonald K.A., Crowley, E., Ramos, D.M., and Damsky C.H. Melanoma cell adhesion to basement membrane mediated by integrin-related complexes. Cancer Res. 49:393-402, 1989.
  • Ramos, D.M., Berston E.D. and Kramer, R.H. Identification of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells. Cancer Res. 50:728-734, 1990.
  • Ramos, D.M., Cheng, Y.F., and Kramer, R.H. Role of laminin-binding integrin in the invasion of basement membrane matrices by fibrosarcoma cells. Invasion and Metastasis, 11:125-138, 1991.
  • Kramer, R.H., Vu, M.P., Cheng, Y.F., Ramos, D.M., Timpl R., and Waleh, N. Laminin-binding integrin alpha7beta1: functional characterization and expression in normal and malignant melanocytes. Cell Regulation 2:805-817, 1991.
  • Kramer, R.H., Enenstein, J., Ramos, D.M., Vu, M.P., and Cheng, Y.F. The role of integrin receptors in tumor cell adhesion to the microvasulature. Microcirculation in Cancer Metastasis CRC Press 146-160, 1991.
  • Kramer, H.R., Vu, M.P., Cheng, Y.F. and Ramos, D.M. Integrin expression in malignant melanoma. Cancer and Metastasis Reviews 10:49-59, 1991.
  • Walton, L., Silverman, S., Ramos, D.M., and Costa, C.R. Dental student education in oncology: design and assessment of an undergraduate course. Journal of Cancer Education 7:221-225, 1992.
  • Berston, E.D., Ramos, D.M., and Kramer, R.H. Metastatic melanoma cells interact with the reticular fibers of the lymph node. Melanoma Research 4:21-27, 1994.
  • Amar, A.P., De Armond, S.J., Spencer, D.R., Coopersmith, P.F., Ramos, D.M., and Rosenblum, M.L. Development of an in vitro extracellular matrix assay for studies of brain tumor invasion. Journal of Neuro-Oncology 20:1-15, 1994.
  • Schnapp, L.M., Breuss, J., Ramos, D.M., Sheppard, D., and Pytela, R. Sequence and tissue distribution of the human integrin alpha8 subunit: a beta1-associated alpha subunit expressed in smooth muscle cells. Journal of Cell Science 108:537-544, 1995.
  • Barkhordar, R.A., Berston, E.D., and Ramos, D.M. Cervical lymph node metastasis: model for study of head/neck melanoma. Oral Oncology, European Journal of Cancer 1:49-52, 1995.
  • Schnapp, L.M., Hatch, N., Ramos, D.M., Kliminskaya, I., Sheppard, D., and Pytela, R. The human integrin alpha8beta1 functions as a receptor for tenascin, fibronectin and vitronectin. J. Biol. Chem. 270(39):23196-23202, 1995.
  • Ramos, D.M., Chen, B.L., Boylen, K.B., Stern, M., Kramer, R.H., Sheppard, D., Nishimura, S.L., Greenspan, D.G., Zardi, L., and Pytela, R. Stromal fibroblasts influence oral squamous cell carcinoma cell's interactions with tenascin-C . Int. J. of Cancer 72: 369-372, 1997.
  • Ramos, D.M., Chen, B. L., Regezi, J., Zardi, L., and Pytela, R. Tenascin-C matrix assembly in oral squamous cell carcinoma. Int. J. of Cancer 75: 680-687 1998.
  • Nishimura, S.L., Boylen, K.B., Einheber, S., Milner, T., Ramos, D.M., and Pytela, R. Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 791: 271-282, 1998
  • Liu, H., Chen, B. L., Zardi, L., and Ramos, D. M. Soluble Fibronectin Promotes Migration of Oral Squamous Cell Carcinoma Cells. Int. J. of Cancer 78: 261-267, 1998
  • Li, X., Chen, B.L., McHugh, K., Ross, F.P., Blystone, S.D., and Ramos, D.M. Differential expression of alphav integrins in K1735 melanoma cells. Invasion and Metastasis 18: 1-14, 1999
  • Ziober, B.L., Chen, Y.Q., Ramos, D.M., Waleh, N., and Kramer, R.H. Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential. Cell Growth and Differentiation 10: 479-490, 1999
  • Bordador, L.C., Li, X., Toole, B., Zardi, L., Chen, B., Regezi, J., and Ramos, D.M. Expression of EMMPRIN by oral squamous cell carcinoma. Int. J. Cancer 85, 347-352, 2000
  • Li, X., Regezi, J., Ross, F.P., Blystone, S., Leong, S.P.L., and Ramos, D.M. Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. Journal of Cell Science, 114, 2001
  • Xue, Hui, Atakilit, A., Zhu, W., Ramos, D.M., Li, X., Sheppard, D., and Pytela, R. Role of the alphavbeta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro. Biochim Biophys Res Communication 228, 610-618, 2001.
  • Regezi, J.A., Ramos, D.M., Dekker, N.P., and Jordan, R.C. Tenascin and beta6 integrin expression in floor of mouth in situ carcinomas and invasive squamous cell carcinoma (Oral Oncology, 38, 332-336, 2002)
  • Ramos, D. M., Wu, T., Schmidt, B., But, M., Regezi, J., Jordon, R., Atakilit, A., and Li, X. Expression of the integrin beta6 enhances invasive behavior in oral squamous cell carcinoma. Matrix Biology 21, 297-307,2002.
  • Regezi, J.A., Dekker, N.P., Ramos, D.M., Li, X., Macabeo-Ong, M., and Jordan, R.C. Proliferation and invasion factors in HIV-associated dysplastic and non-dysplastic oral warts, and oral squamous cell carcinoma: an immunohistochemical and RT-PCR evaluation. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod, 94, 724-731, 2002.
  • Kim, T.W., Chen, Q., Shen, X., Regezi, J.A., Ramos, D.M., Tanaka, H., Jordan, R.C., and Kramer, R.H. Oral mucosal carcinogenesis in SENCAR mice. Anticancer Research, 22, 2733-2740, 2002.
  • Yang, Y., Dang, D., Atakililit, A., Schmidt, B., Regezi, J., Li, X., Eisele, D., Ellis, D., and Ramos, DM . Specific alphav integrin receptors modulate K1735 murine melanoma cell behavior. Biochim Biophys Res Communication 308, 2003.
  • Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Atakilit, A., Ellis, D., and Ramos, D.M alphavbeta6/Fyn Signaling Promotes Oral Cancer Progression. J. Biol Chem 278:41646-53, 2003.
  • Dang, D., Yang, Y., Li., X., Atakalit, A., Regezi, J., Eisele, D., Ellis, D., and Ramos, D.M. Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. Biochim and Biophysical Research Communications 316, 937-942, 2004.