University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel M. Ramos, DDS, PhD

Daniel M. Ramos, DDS, PhD

Associate Professor, Department of Orofacial Sciences, UCSF

Cancer Center Program Memberships

Affiliate Member


California State University, Los Angeles, B.S., 1984, Biology
University of California, San Francisco, D.D.S., 1988, Dentistry
University of California, San Francisco, Ph.D., 1994, Oral Biology

Professional Experience

  • 1983-84
    Lab Assistant, Independent Research Project: Tyrosinase Levels in Avian Tissues, California State University, Los Angeles, Department of Biology, Advisor: Dr. Roger Bowers
  • 1985-94
    Postgraduate Research Dentist, University of California, San Francisco, Dept. of Stomatology, Advisor: Dr. Randall Kramer
  • 1994-97
    Adjunct Assistant Professor, University of California, San Francisco, Dept. of Stomatology
  • 1997-2003
    Assistant Professor, University of California, San Francisco, Dept. of Stomatology
  • 2003-present
    Associate Professor, University of California, San Francisco, Department of Stomatology

Honors & Awards

  • 1988-93
    Individual Dentist Scientist Award, NIH-NIDR 1K15DE00242
  • 1995-96
    Junior Faculty Development Award (Academic Senate)
  • 2001
    Dean's Creativity Award (School of Dentistry)

Selected Publications

  • Kramer, R.H., McDonald K.A., Crowley, E., Ramos, D.M., and Damsky C.H. Melanoma cell adhesion to basement membrane mediated by integrin-related complexes. Cancer Res. 49:393-402, 1989.
  • Ramos, D.M., Berston E.D. and Kramer, R.H. Identification of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells. Cancer Res. 50:728-734, 1990.
  • Ramos, D.M., Cheng, Y.F., and Kramer, R.H. Role of laminin-binding integrin in the invasion of basement membrane matrices by fibrosarcoma cells. Invasion and Metastasis, 11:125-138, 1991.
  • Kramer, R.H., Vu, M.P., Cheng, Y.F., Ramos, D.M., Timpl R., and Waleh, N. Laminin-binding integrin alpha7beta1: functional characterization and expression in normal and malignant melanocytes. Cell Regulation 2:805-817, 1991.
  • Kramer, R.H., Enenstein, J., Ramos, D.M., Vu, M.P., and Cheng, Y.F. The role of integrin receptors in tumor cell adhesion to the microvasulature. Microcirculation in Cancer Metastasis CRC Press 146-160, 1991.
  • Kramer, H.R., Vu, M.P., Cheng, Y.F. and Ramos, D.M. Integrin expression in malignant melanoma. Cancer and Metastasis Reviews 10:49-59, 1991.
  • Walton, L., Silverman, S., Ramos, D.M., and Costa, C.R. Dental student education in oncology: design and assessment of an undergraduate course. Journal of Cancer Education 7:221-225, 1992.
  • Berston, E.D., Ramos, D.M., and Kramer, R.H. Metastatic melanoma cells interact with the reticular fibers of the lymph node. Melanoma Research 4:21-27, 1994.
  • Amar, A.P., De Armond, S.J., Spencer, D.R., Coopersmith, P.F., Ramos, D.M., and Rosenblum, M.L. Development of an in vitro extracellular matrix assay for studies of brain tumor invasion. Journal of Neuro-Oncology 20:1-15, 1994.
  • Schnapp, L.M., Breuss, J., Ramos, D.M., Sheppard, D., and Pytela, R. Sequence and tissue distribution of the human integrin alpha8 subunit: a beta1-associated alpha subunit expressed in smooth muscle cells. Journal of Cell Science 108:537-544, 1995.
  • Barkhordar, R.A., Berston, E.D., and Ramos, D.M. Cervical lymph node metastasis: model for study of head/neck melanoma. Oral Oncology, European Journal of Cancer 1:49-52, 1995.
  • Schnapp, L.M., Hatch, N., Ramos, D.M., Kliminskaya, I., Sheppard, D., and Pytela, R. The human integrin alpha8beta1 functions as a receptor for tenascin, fibronectin and vitronectin. J. Biol. Chem. 270(39):23196-23202, 1995.
  • Ramos, D.M., Chen, B.L., Boylen, K.B., Stern, M., Kramer, R.H., Sheppard, D., Nishimura, S.L., Greenspan, D.G., Zardi, L., and Pytela, R. Stromal fibroblasts influence oral squamous cell carcinoma cell's interactions with tenascin-C . Int. J. of Cancer 72: 369-372, 1997.
  • Ramos, D.M., Chen, B. L., Regezi, J., Zardi, L., and Pytela, R. Tenascin-C matrix assembly in oral squamous cell carcinoma. Int. J. of Cancer 75: 680-687 1998.
  • Nishimura, S.L., Boylen, K.B., Einheber, S., Milner, T., Ramos, D.M., and Pytela, R. Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 791: 271-282, 1998
  • Liu, H., Chen, B. L., Zardi, L., and Ramos, D. M. Soluble Fibronectin Promotes Migration of Oral Squamous Cell Carcinoma Cells. Int. J. of Cancer 78: 261-267, 1998
  • Li, X., Chen, B.L., McHugh, K., Ross, F.P., Blystone, S.D., and Ramos, D.M. Differential expression of alphav integrins in K1735 melanoma cells. Invasion and Metastasis 18: 1-14, 1999
  • Ziober, B.L., Chen, Y.Q., Ramos, D.M., Waleh, N., and Kramer, R.H. Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential. Cell Growth and Differentiation 10: 479-490, 1999
  • Bordador, L.C., Li, X., Toole, B., Zardi, L., Chen, B., Regezi, J., and Ramos, D.M. Expression of EMMPRIN by oral squamous cell carcinoma. Int. J. Cancer 85, 347-352, 2000
  • Li, X., Regezi, J., Ross, F.P., Blystone, S., Leong, S.P.L., and Ramos, D.M. Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. Journal of Cell Science, 114, 2001
  • Xue, Hui, Atakilit, A., Zhu, W., Ramos, D.M., Li, X., Sheppard, D., and Pytela, R. Role of the alphavbeta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro. Biochim Biophys Res Communication 228, 610-618, 2001.
  • Regezi, J.A., Ramos, D.M., Dekker, N.P., and Jordan, R.C. Tenascin and beta6 integrin expression in floor of mouth in situ carcinomas and invasive squamous cell carcinoma (Oral Oncology, 38, 332-336, 2002)
  • Ramos, D. M., Wu, T., Schmidt, B., But, M., Regezi, J., Jordon, R., Atakilit, A., and Li, X. Expression of the integrin beta6 enhances invasive behavior in oral squamous cell carcinoma. Matrix Biology 21, 297-307,2002.
  • Regezi, J.A., Dekker, N.P., Ramos, D.M., Li, X., Macabeo-Ong, M., and Jordan, R.C. Proliferation and invasion factors in HIV-associated dysplastic and non-dysplastic oral warts, and oral squamous cell carcinoma: an immunohistochemical and RT-PCR evaluation. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod, 94, 724-731, 2002.
  • Kim, T.W., Chen, Q., Shen, X., Regezi, J.A., Ramos, D.M., Tanaka, H., Jordan, R.C., and Kramer, R.H. Oral mucosal carcinogenesis in SENCAR mice. Anticancer Research, 22, 2733-2740, 2002.
  • Yang, Y., Dang, D., Atakililit, A., Schmidt, B., Regezi, J., Li, X., Eisele, D., Ellis, D., and Ramos, DM . Specific alphav integrin receptors modulate K1735 murine melanoma cell behavior. Biochim Biophys Res Communication 308, 2003.
  • Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Atakilit, A., Ellis, D., and Ramos, D.M alphavbeta6/Fyn Signaling Promotes Oral Cancer Progression. J. Biol Chem 278:41646-53, 2003.
  • Dang, D., Yang, Y., Li., X., Atakalit, A., Regezi, J., Eisele, D., Ellis, D., and Ramos, D.M. Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. Biochim and Biophysical Research Communications 316, 937-942, 2004.