University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeremy F. Reiter, MD, PhD

Jeremy F. Reiter, MD, PhD

Assistant Professor, Department of Biochemistry and Biophysics, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Smith Cardiovascular Research Building

Room 352G, Box 3120

555 Mission Bay Blvd South

Hedgehog, cilia, basal cell carcinoma, medulloblastoma, stem cell, centriole, centrosome, Smoothened, transition zone, Meckel syndrome

Education

Yale College, New Haven, CT, BA, 1989-1993, Molecular Biochemistry and Biophysics
University of California, San Francisco, PhD, 1995-1999, Developmental Biology
University of California, San Francisco, MD, 1993-1995, 1999-2001, Medicine
University of California, Berkeley, Postdoctoral, 2001-2003, Developmental Biology


Professional Experience

  • 2001-2003
    Postdoctoral Fellow with Dr. William C. Skarnes, University of California, Berkeley
  • 2003-2006
    UCSF Fellow, Developmental and Stem Cell Biology Program, University of California, San Francisco
  • 2006-present
    Assistant Professor, Department of Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco

Honors & Awards

  • 1993
    Regents Scholar, University of California
  • 1999
    Achievement Award for College Scientists
  • 2001
    Alpha Omega Alpha Honors Medical Society
  • 1994-2001
    National Institutes of Health Medical Scientist Training Program
  • 2004-2006
    March of Dimes Basil O'Connor Research Award
  • 2005-2010
    Burroughs Wellcome Fund Career Award in the Biomedical Sciences
  • 2006-present
    Developmental Dynamic Editorial Board
  • 2007
    Best Faculty Talk, West Coast Society of Developmental Biology Conference
  • 2007-2012
    Packard Fellow for Science and Engineering
  • 2009
    Elected to the American Society for Clinical Investigation (ASCI)
  • 2009
    Presidential Early Career Award for Scientists and Engineers (PECASE)

Selected Publications

  1. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Aug 28.
    View on PubMed
  2. Kopinke D, Roberson EC, Reiter JF. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017 Jul 13; 170(2):340-351.e12.
    View on PubMed
  3. Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol. 2017 Sep; 18(9):533-547.
    View on PubMed
  4. Garcia-Gonzalo FR, Reiter JF. Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition. Cold Spring Harb Perspect Biol. 2017 Feb 01; 9(2).
    View on PubMed
  5. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017 Jan 12; 168(1-2):264-279.e15.
    View on PubMed
  6. Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA. Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23; 92(4):813-828.
    View on PubMed
  7. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15.
    View on PubMed
  8. Garcia G, Reiter JF. A primer on the mouse basal body. Cilia. 2016; 5:17.
    View on PubMed
  9. Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol. 2016 Mar; 14(3):e1002416.
    View on PubMed
  10. Dinsmore C, Reiter JF. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep. 2016 Feb; 17(2):156-66.
    View on PubMed
  11. Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015 Nov; 11(11):e1005627.
    View on PubMed
  12. Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22; 4.
    View on PubMed
  13. Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF. TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. J Cell Biol. 2015 Apr 13; 209(1):129-42.
    View on PubMed
  14. Yee LE, Reiter JF. Ciliary vesicle formation: a prelude to ciliogenesis. Dev Cell. 2015 Mar 23; 32(6):665-6.
    View on PubMed
  15. Vagnozzi AN, Reiter JF, Wong SY. Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration. Cell Cycle. 2015; 14(21):3408-17.
    View on PubMed
  16. Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17; 84(6):1240-57.
    View on PubMed
  17. Ye X, Zeng H, Ning G, Reiter JF, Liu A. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2164-9.
    View on PubMed
  18. Santos N, Reiter JF. A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci. 2014 Apr 01; 127(Pt 7):1500-10.
    View on PubMed
  19. de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM. Hedgehog signaling controls T cell killing at the immunological synapse. Science. 2013 Dec 06; 342(6163):1247-50.
    View on PubMed
  20. Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec; 140(24):4870-80.
    View on PubMed

Go to UCSF Profiles, powered by CTSI