University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeremy F. Reiter, MD, PhD

Jeremy F. Reiter, MD, PhD

Assistant Professor, Department of Biochemistry and Biophysics, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Smith Cardiovascular Research Building

Room 352G, Box 3120

555 Mission Bay Blvd South

Hedgehog, cilia, basal cell carcinoma, medulloblastoma, stem cell, centriole, centrosome, Smoothened, transition zone, Meckel syndrome

Education

Yale College, New Haven, CT, BA, 1989-1993, Molecular Biochemistry and Biophysics
University of California, San Francisco, PhD, 1995-1999, Developmental Biology
University of California, San Francisco, MD, 1993-1995, 1999-2001, Medicine
University of California, Berkeley, Postdoctoral, 2001-2003, Developmental Biology


Professional Experience

  • 2001-2003
    Postdoctoral Fellow with Dr. William C. Skarnes, University of California, Berkeley
  • 2003-2006
    UCSF Fellow, Developmental and Stem Cell Biology Program, University of California, San Francisco
  • 2006-present
    Assistant Professor, Department of Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco

Honors & Awards

  • 1993
    Regents Scholar, University of California
  • 1999
    Achievement Award for College Scientists
  • 2001
    Alpha Omega Alpha Honors Medical Society
  • 1994-2001
    National Institutes of Health Medical Scientist Training Program
  • 2004-2006
    March of Dimes Basil O'Connor Research Award
  • 2005-2010
    Burroughs Wellcome Fund Career Award in the Biomedical Sciences
  • 2006-present
    Developmental Dynamic Editorial Board
  • 2007
    Best Faculty Talk, West Coast Society of Developmental Biology Conference
  • 2007-2012
    Packard Fellow for Science and Engineering
  • 2009
    Elected to the American Society for Clinical Investigation (ASCI)
  • 2009
    Presidential Early Career Award for Scientists and Engineers (PECASE)

Selected Publications

  1. Garcia G, Raleigh DR, Reiter JF. How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In. Curr Biol. 2018 Apr 23; 28(8):R421-R434.
    View on PubMed
  2. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 Feb; 50(2):180-185.
    View on PubMed
  3. Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11.
    View on PubMed
  4. Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF. Hedgehog signaling drives medulloblastoma growth via CDK6. J Clin Invest. 2018 Jan 02; 128(1):120-124.
    View on PubMed
  5. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct 31; 19(11):1379.
    View on PubMed
  6. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188.
    View on PubMed
  7. Kopinke D, Roberson EC, Reiter JF. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017 Jul 13; 170(2):340-351.e12.
    View on PubMed
  8. Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol. 2017 Sep; 18(9):533-547.
    View on PubMed
  9. Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7).
    View on PubMed
  10. Garcia-Gonzalo FR, Reiter JF. Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition. Cold Spring Harb Perspect Biol. 2017 Feb 01; 9(2).
    View on PubMed
  11. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017 Jan 12; 168(1-2):264-279.e15.
    View on PubMed
  12. Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA. Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23; 92(4):813-828.
    View on PubMed
  13. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15.
    View on PubMed
  14. Garcia G, Reiter JF. A primer on the mouse basal body. Cilia. 2016; 5:17.
    View on PubMed
  15. Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol. 2016 Mar; 14(3):e1002416.
    View on PubMed
  16. Dinsmore C, Reiter JF. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep. 2016 Feb; 17(2):156-66.
    View on PubMed
  17. Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015 Nov; 11(11):e1005627.
    View on PubMed
  18. Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G, Abedin M, Schurmans S, Inoue T, Reiter JF. Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell. 2015 Aug 24; 34(4):400-409.
    View on PubMed
  19. Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22; 4.
    View on PubMed
  20. Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF. TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. J Cell Biol. 2015 Apr 13; 209(1):129-42.
    View on PubMed

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