Steven D. Rosen, PhD

Steven D. Rosen, PhD

Professor and Vice-Chair, Department of Anatomy, UCSF

Phone: (415) 476-1579 (voice)
Box 0452, UCSF
San Francisco, CA 94143-0452

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Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment


University of California, Berkeley, CA, B.A., 1966, Physics
Cornell University, Ithaca, NY, Ph.D., 1972, Neurobiology
University of California, San Diego, CA, Postdoc, 1972-76, Cell Biology

Professional Experience

  • 1976-1982
    Assistant Professor, University of California, Anatomy
  • 1982-1986
    Associate Professor of Anatomy, University of California, San Francisco
  • 1987-present
    Professor of Anatomy, University of California, San Francisco
  • 1989-present
    Member, Program in Immunology, UCSF
  • 1992-present
    Member, Biomedical Sciences Program, UCSF
  • 1999-present
    Investigator, Cardiovascular Research Institute, UCSF
  • 2000-present
    Program Member, Comprehensive Cancer Center, UCSF
  • 2001-present
    Member, Steering Committee, NIH Consortium for Functional Glycomics
  • 2005-present
    Vice-Chair and Executive Committee, Dept of Anatomy

Honors & Awards

  • Phi Beta Kappa
  • American Cancer Society Postdoctoral Fellowship
  • Phi Kappa Phi
  • NIH Career Development Award
  • 1993
    Feulgen Lecture
  • 2005
    Keynote address to Keystone Symposium on Complex Carbohydrates
  • 1996-2006
    NIH Merit Award

Selected Publications

  1. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 2; 440:72-8.
    View on PubMed
  2. Rosen SD, Daneman R. High endothelial venules through a transcriptomics lens. Nat Immunol. 2014 Oct; 15(10):906-8.
    View on PubMed
  3. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8.
    View on PubMed
  4. Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642.
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  5. Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen SD. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13; 288(37):26533-45.
    View on PubMed
  6. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71.
    View on PubMed
  7. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar; 23(3):381-94.
    View on PubMed
  8. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6).
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  9. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24.
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  10. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar 1; 122(3):911-22.
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  11. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907.
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  12. Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen SD. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011 Jan; 178(1):423-33.
    View on PubMed
  13. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49.
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  14. Feng G, Du P, Krett NL, Tessel M, Rosen S, Kibbe WA, Lin SM. A collection of bioconductor methods to visualize gene-list annotations. BMC Res Notes. 2010; 3:10.
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  15. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64.
    View on PubMed
  16. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 4; 29(5):635-46.
    View on PubMed
  17. Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen SD, Uchimura K. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. Glycobiology. 2010 Feb; 20(2):175-86.
    View on PubMed
  18. Rosen SD, Arata-Kawai H. "Home sweet home" for lymphocytes. Blood. 2009 Jul 16; 114(3):499-500.
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  19. Tang R, Rosen SD. Functional consequences of the subdomain organization of the sulfs. J Biol Chem. 2009 Aug 7; 284(32):21505-14.
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  20. Kerr SC, Fieger CB, Snapp KR, Rosen SD. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J Immunol. 2008 Jul 15; 181(2):1480-90.
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