Steven D. Rosen, PhD

Professor and Vice-Chair, Department of Anatomy, UCSF

steven.rosen@ucsf.edu

Phone: (415) 476-1579 (voice)
Box 0452, UCSF
San Francisco, CA 94143-0452

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Education

University of California, Berkeley, CA, B.A., 1966, Physics
Cornell University, Ithaca, NY, Ph.D., 1972, Neurobiology
University of California, San Diego, CA, Postdoc, 1972-76, Cell Biology

Professional Experience

• 1976-1982
  Assistant Professor, University of California, Anatomy
• 1982-1986
  Associate Professor of Anatomy, University of California, San Francisco
• 1987-present
  Professor of Anatomy, University of California, San Francisco
• 1989-present
  Member, Program in Immunology, UCSF
• 1992-present
  Member, Biomedical Sciences Program, UCSF
• 1999-present
  Investigator, Cardiovascular Research Institute, UCSF
• 2000-present
  Program Member, Comprehensive Cancer Center, UCSF
• 2001-present
  Member, Steering Committee, NIH Consortium for Functional Glycomics
• 2005-present
  Vice-Chair and Executive Committee, Dept of Anatomy

Honors & Awards

• Phi Beta Kappa
• American Cancer Society Postdoctoral Fellowship
• Phi Kappa Phi
• NIH Career Development Award
• 1993
  Feulgen Lecture
• 2005
  Keynote address to Keystone Symposium on Complex Carbohydrates
• 1996-2006
  NIH Merit Award

Selected Publications

1. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar; 23(3):381-94.
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2. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6).
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3. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24.
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4. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar 1; 122(3):911-22.
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5. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907.
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6. Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen SD. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011 Jan; 178(1):423-33.
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7. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49.
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8. Feng G, Du P, Krett NL, Tessel M, Rosen S, Kibbe WA, Lin SM. A collection of bioconductor methods to visualize gene-list annotations. BMC Res Notes. 2010; 3:10.
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9. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64.
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10. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 4; 29(5):635-46.
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11. Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen SD, Uchimura K. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. Glycobiology. 2010 Feb; 20(2):175-86.
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12. Rosen SD, Arata-Kawai H. "Home sweet home" for lymphocytes. Blood. 2009 Jul 16; 114(3):499-500.
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13. Tang R, Rosen SD. Functional consequences of the subdomain organization of the sulfs. J Biol Chem. 2009 Aug 7; 284(32):21505-14.
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14. Kerr SC, Fieger CB, Snapp KR, Rosen SD. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J Immunol. 2008 Jul 15; 181(2):1480-90.
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15. Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen SD. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol. 2008 Apr; 9(4):415-23.
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16. Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One. 2007; 2(4):e392.
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17. Alon R, Rosen S. Rolling on N-linked glycans: a new way to present L-selectin binding sites. Nat Immunol. 2007 Apr; 8(4):339-41.
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18. Veerman KM, Williams MJ, Uchimura K, Singer MS, Merzaban JS, Naus S, Carlow DA, Owen P, Rivera-Nieves J, Rosen SD, Ziltener HJ. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007 May; 8(5):532-9.
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19. Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan; 27(2):678-88.
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20. Uchimura K, Rosen SD. Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. Trends Immunol. 2006 Dec; 27(12):559-65.
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