About UCSF Search UCSF UCSF Medical Center

Davide Ruggero, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
ruggero_davide

Professor, Department of Urology, UCSF
Helen Diller Family Endowed Chair of Basic Science in Urologic Cancer

ruggerod@urology.ucsf.edu

Phone: (415) 514-9755 (voice)
Box 3110, UCSF
San Francisco, CA 94143-3110

View on UCSF Profiles


Additional Websites


Education

University of Rome, La Sapienza, Italy, BS, magna cum laude, Molecular & Cellular Biology, 1994
University of Rome, La Sapienza, Italy, PhD, magna cum laude, Molecular & Cellular Biology, 1998


Professional Experience

  • 1998-2000
    Post-doctoral fellow in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York
  • 2001-2003
    Research Associate, in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York
  • 2004-2007
    Associate Member, Fox Chase Cancer Center, Philadelphia, PA
  • 2007-2010
    Assistant Professor, Dept. of Urology, University of California, San Francisco, CA
  • 2010-2014
    Associate Professor, Dept. of Urology, University of California, San Francisco, CA
  • 2014-present
    Professor, Dept. of Urology, University of California, San Francisco, CA

Honors & Awards

  • 1994
    Enichem Society fellowship
  • 1998-2000
    American-Italian Cancer Foundation fellowship
  • 2003
    Outstanding Research Fellow Award, Memorial Sloan Kettering Cancer Center
  • 2005
    V Foundation Scholar Grant
  • 2006
    Commonwealth Universal Research Enhancement Program Award, Pennsylvania Department of Health
  • 2008
    Gertrude B. Elion Award, American Association for Cancer Research
  • 2010
    Leukemia & Lymphoma Society Scholar Award
  • 2010
    UCSF Program for Breakthrough Biomedical Research Integrative Award
  • 2011
    Helen Diller Family Endowed Chair of Basic Science in Urologic Cancer

Selected Publications

  1. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. Cell. 2014 May 22; 157(5):1088-103.
    View on PubMed
  2. Barna M, Ruggero D. Tailor Made Protein Synthesis for HSCs. Cell Stem Cell. 2014 Apr 3; 14(4):423-4.
    View on PubMed
  3. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014 Jan; 11(1):86-93.
    View on PubMed
  4. Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D. The translational landscape of the Mammalian cell cycle. Mol Cell. 2013 Nov 21; 52(4):574-82.
    View on PubMed
  5. Cunningham JT, Ruggero D. New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. Cancer Discov. 2013 Oct; 3(10):1099-102.
    View on PubMed
  6. Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS. Assessing gene-level translational control from ribosome profiling. Bioinformatics. 2013 Dec 1; 29(23):2995-3002.
    View on PubMed
  7. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93.
    View on PubMed
  8. Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D. H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. Cell Rep. 2013 May 30; 3(5):1493-502.
    View on PubMed
  9. Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. J Allergy Clin Immunol. 2013 Jul; 132(1):223-6.
    View on PubMed
  10. Ruggero D. Translational control in cancer etiology. Cold Spring Harb Perspect Biol. 2013 Feb; 5(2).
    View on PubMed
  11. Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D. Investigating Myc-dependent translational regulation in normal and cancer cells. Methods Mol Biol. 2013; 1012:201-12.
    View on PubMed
  12. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17; 493(7432):411-5.
    View on PubMed
  13. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17; 493(7432):371-7.
    View on PubMed
  14. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec 3; 122(12):4621-34.
    View on PubMed
  15. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9; 338(6108):818-22.
    View on PubMed
  16. Ruggero D. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal. 2012; 5(241):pe38.
    View on PubMed
  17. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 May 3; 485(7396):55-61.
    View on PubMed
  18. Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell. 2011 Nov 18; 44(4):660-6.
    View on PubMed
  19. Hsieh AC, Truitt ML, Ruggero D. Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer. 2011 Jul 26; 105(3):329-36.
    View on PubMed
  20. Stumpf CR, Ruggero D. The cancerous translation apparatus. Curr Opin Genet Dev. 2011 Aug; 21(4):474-83.
    View on PubMed

Go to UCSF Profiles, powered by CTSI