Research Summary

Dr. Scheuner is an internist and medical geneticist. She is a Clinical Professor in the UCSF Department of Medicine, Division of Hematology-Oncology and in the UCSF Department of Pediatrics, Division of Medical Genetics. She is the Chief of Genomic Medicine for the Department of Veterans Affairs, Sierra-Pacific region.

Dr. Scheuner is a health services researcher and implementation scientist. Her research activities address the integration of genetic services and genetic testing into clinical practice. Areas of focus include genomic medicine care coordination, delivery models for clinical genetic services, equity in delivery of genomic medicine, and clinical validity and utility of genetic risk assessment tools.

Dr. Scheuner is a founding fellow of the American College of Medical Genetics and Genomics (ACMG). From 2013-2019 she served on the ACMG Board of Directors and was Vice President for Clinical Genetics. Since 2003, she has served as the ACMG representative to the national Blue Cross Blue Shield Association's Medical Advisory Panel. From 2014 - 2024 she served as Editor of the Health Services and Implementation Research section for the journal Genetics in Medicine.

Education

University of California, Riverside, CA, BS, 1979-82
University of California, Los Angeles, CA, MPH, 1982-84
University of California, Los Angeles, CA, MD, 1986-88

Honors & Awards

  • Faculty Development Award in Precision Medicine and Health Services Research, UCSF Center for Translational and Policy Research on Personalized Medicine (TRANSPERS) Program, 2019
  • Field-based Meeting Award, VA Precision Medicine Research Conference, VA Office of Research and Development, Health Services Research & Development Service, 2016
  • Most read manuscripts published on topic of cardiovascular risk factors, American Heart Association, Circulation Cardiovascular Genetics, 2011
  • Silver Medal Award, RAND Corporation, 2008
  • Career Development Program in Public Health Research and Practice, Genetics and Disease Prevention, Centers for Disease Control and Prevention, 2002-2005

Selected Publications

  1. Chanfreau-Coffinier C, Peredo J, Russell MM, Yano EM, Hamilton AB, Lerner B, Provenzale D, Knight SJ, Voils CI, Scheuner MT. A logic model for precision medicine implementation informed by stakeholder views and implementation science. Genet Med. 2018 Oct 23. PubMed PMID: 30353149.
  2. Vassy JL, Stone A, Callaghan JT, Mendes M, Meyer LJ, Pratt VM, Przygodzki RM, Scheuner MT, Wang-Rodriguez J, Schichman SA; VHA Clinical Pharmacogenetics Subcommittee.. Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee. Genet Med. 2018 Jun 1. PubMed PMID: 29858578; PubMed Central PMCID: PMC6274593.
  3. Patel J, Al Rifai M, Scheuner MT, Shea S, Blumenthal RS, Nasir K, Blaha MJ, McEvoy JW. Basic vs More Complex Definitions of Family History in the Prediction of Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis. Mayo Clin Proc. 2018 Sep;93(9):1213-1223. PubMed PMID: 29555305; PubMed Central PMCID: PMC6129200.
  4. Zeiger WA, Jamal NI, Scheuner MT, Pittman P, Raymond KM, Morra M, Mishra SK. Probable Diagnosis of a Patient with Niemann-Pick Disease Type C: Managing Pitfalls of Exome Sequencing. JIMD Rep. 2018;41:47-51. PubMed PMID: 29453517; PubMed Central PMCID: PMC6122056.
  5. Lerner B, Marshall N, Oishi S, Lanto A, Lee M, Hamilton AB, Yano EM, Scheuner MT. The value of genetic testing: beyond clinical utility. Genet Med. 2017 Jul;19(7):763-771. PubMed PMID: 27977007.
  6. Scheuner MT, Peredo J, Tangney K, Schoeff D, Sale T, Lubick-Goldzweig C, Hamilton A, Hilborne L, Lee M, Mittman B, Yano EM, Lubin IM. Electronic health record interventions at the point of care improve documentation of care processes and decrease orders for genetic tests commonly ordered by nongeneticists. Genet Med. 2017 Jan;19(1):112-120. PubMed PMID: 27362912.
  7. Duong HA, Le KT, Soulema AL, Yueh RH, Scheuner MT, Holick MF, Christensen R, Tajima TL, Leung AM, Mallya SM. Gnathodiaphyseal dysplasia: report of a family with a novel mutation of the ANO5 gene. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 May;121(5):e123-8. PubMed PMID: 27068316; PubMed Central PMCID: PMC4830924.
  8. Venne VL, Scheuner MT. Securing and Documenting Cancer Family History in the Age of the Electronic Medical Record. Surg Oncol Clin N Am. 2015 Oct;24(4):639-52. Review. PubMed PMID: 26363534.
  9. Patel J, Al Rifai M, Scheuner MT, Shea S, Blumenthal RS, Nasir K, Blaha MJ, McEvoy JW. Basic vs More Complex Definitions of Family History in the Prediction of Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis. Mayo Clin Proc. 2018 Sep;93(9):1213-1223. PubMed PMID: 29555305; PubMed Central PMCID: PMC6129200.
  10. Wang C, Sen A, Plegue M, Ruffin MT 4th, O'Neill SM, Rubinstein WS, Acheson LS; Family Healthware™ Impact Trial (FHITr) Group.; Family Healthware Impact Trial FHITr Group.. Impact of family history assessment on communication with family members and health care providers: A report from the Family Healthware™ Impact Trial (FHITr). Prev Med. 2015 Aug;77:28-34. PubMed PMID: 25901453; PubMed Central PMCID: PMC4508012.
  11. Oishi SM, Marshall N, Hamilton AB, Yano EM, Lerner B, Scheuner MT. Assessing multilevel determinants of adoption and implementation of genomic medicine: an organizational mixed-methods approach. Genet Med. 2015 Nov;17(11):919-26. PubMed PMID: 25741861.
  12. Scheuner MT, Peredo J, Benkendorf J, Bowdish B, Feldman G, Fleisher L, Mulvihill JJ, Watson M, Herman GE, Evans J. Reporting genomic secondary findings: ACMG members weigh in. Genet Med. 2015 Jan;17(1):27-35. PubMed PMID: 25394173.
  13. Scheuner MT, Marshall N, Lanto A, Hamilton AB, Oishi S, Lerner B, Lee M, Yano EM. Delivery ofclinical genetic consultative services in the Veterans Health Administration. Genet Med2014;16(8):609-19. PMID: 24503778
  14. Scheuner MT, Hamilton AB, Peredo J, Sale TJ, Austin C, Gilman SC, Bowen MS, Goldzweig CL, LeeM, Mittman BS, Yano EM. A cancer genetics toolkit improves access to genetic services throughdocumentation and use of the family history by primary care clinicians. Genet Med 2014;16(1):60-9.
  15. Hamilton AB, Oishi S, Yano EM, Gammage CE, Marshall NJ, Chou A, Scheuner MT. Factorsinfluencing adoption and implementation of clinical genetic services. Genet Med 2014;16(3):238-45. PMID: 23949572
  16. Scheuner MT, Edelen MO, Hilborne LH, Lubin IM. Effective communication of molecular genetic testresults to primary care providers. Genet Med 2013;15(6):444-449.
  17. Khoury MJ, Coates R, Fennell M, Glasgow R, Scheuner MT, Schully S, Williams M. Multilevelresearch and the challenges of implementing genomic medicine. J Natl Cancer Instit Monograph2012;2012(44):112-120. PMCID: PMC3482965
  18. Scheuner MT, Hilborne L, Brown J, Lubin IM. A report template for molecular genetic tests designedto improve communication between the clinician and laboratory. Genet Test Mol Biomarkers2012;16(7):761-769.
  19. Scheuner MT, McNeel TS, Freedman AN. Population prevalence of familial cancer and commonhereditary cancer syndromes. The 2005 California Health Interview Survey. Genet Med 2010;12:726-735. PMID: 20921897
  20. Scheuner MT, Setodji CM, Pankow J, Blumenthal RS, Keeler E. General Cardiovascular Risk Profileidentifies advanced coronary artery calcium and is improved by family history: the Multi-ethnic Studyof Atherosclerosis. Circ Cardiovasc Genet 2010;3:97-105. PMCID: PMC2932659
  21. Yoon PW, Scheuner MT, Jorgensen C, Khoury MJ. Developing Family Healthware, a family historyscreening tool to prevent common chronic diseases. Prev Chronic Dis 2009;6(1):A33.
  22. Scheuner MT, deVries H, Meili R, Olmstead SH, Kim B, Teleki S. Are electronic health records readyfor genomic medicine? Genet Med 2009;11:510-517.
  23. Scheuner MT, Setodji CM, Pankow J, Blumenthal RS, Keeler E. Relation of familial patterns ofcoronary heart disease, stroke and diabetes to subclinical atherosclerosis: the Multi-Ethnic Study ofAtherosclerosis. Genet Med 2008;10(12):879-887. PMCID: PMC2684807
  24. Scheuner MT, Sieverding P, Shekelle PG. Delivery of genomic medicine for common chronic adultdiseases: A systematic review. JAMA 2008;299:1320-1324. PMID: 18349093
  25. Goodarzi MO, Taylor KD, Scheuner MT, Antoine HJ, Guo X, Shah PK, Rotter JI. Haplotypes in thelipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy andprogression of atherosclerosis in coronary artery bypass grafts. Pharmacogenomics J 2007;7:66-73.

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