Suzaynn F. Schick, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Suzaynn F. Schick, PhD

Assistant Adjunct Professor, UCSF School of Medicine, Division of Occupational and Environmental Medicine

suzaynn.schick@ucsf.edu

Phone: (415) 206-5904

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Cancer Center Membership

Associate Member » Tobacco Control» Cancer Control

Research Summary

I study the health effects of air pollution in human subjects. I focus on the chemistry and toxicity of smoke and on how smoking and using electronic cigarettes can cause heart and lung disease. My analysis of tobacco industry research showed that sidestream cigarette smoke (the primary constituent of secondhand cigarette smoke) is more toxic than the smoke that smokers inhale and that secondhand smoke becomes more toxic as it ages.

I have published three controlled human exposure studies on the health effects of secondhand cigarette smoke which show that:

1. A single 30-minute exposure to fresh sidestream cigarette smoke, at 350 micrograms of particles per cubic meter, decreases flow-mediated dilation of the brachial artery and increases plasma VEGF and endothelial progenitor cell motility. (These changes can increase the risk of heart attack.)

2. For each increase in SHS exposure by 100 µg/m3 particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. (Even a little smoke can increase the risk of heart disease.)

3. A single 30-minute exposure to aged cigarette smoke, at 1000 µg/m3 particles, increases nasal congestion in healthy human subjects. (Nasal congestion can lead to sinus infections.)

My research on the chemistry and toxicity of cigarette smoke has helped define a new health risk from smoking: thirdhand cigarette smoke. Thirdhand smoke is the tiny droplets of oils and waxes (tar) that stick to surfaces, like walls, furniture, clothing and hair. Thirdhand smoke cannot be removed by ventilation. Many of the toxins and carcinogens in smoke linger for days, months and years after the cigarettes are gone. My laboratory is funded by the California Tobacco-Related Disease Research Program to study how humans absorb thirdhand smoke from the environment. My laboratory is also funded by the FDA and the NIH to study the cardiovascular effects of tobacco and nicotine delivery products. I am member of the California Thirdhand Smoke Consortium, the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF Center for Tobacco Control Research and Education. My goals are to understand how smoke causes heart attacks and respiratory disease and to educate society on the true impact that air pollution has on human health.

Education

  • University of Washington    B.S.    1986-1989    Cell and Molecular Biology
  • University of California, San Francisco    Ph.D.    1991-2001    Biomedical Science
  • University of California, San Francisco    Postdoc    2002-2006    Public Health
  • University of California, San Francisco    Postdoc    Feb 2006-Sept 2007    Inhalation Toxicology
     

Professional Experience

  • 1989-1991    
    Research Technician, University of Washington, Department of Zoology
  • 2001
    Title X Intern, Planned Parenthood Golden Gate
  • 2007    
    Assistant Adjunct Professor, UCSF School of Medicine, Division of Occupational and Environmental Medicine
     

Honors & Awards

  • 1991
    National Science Foundation Predoctoral Fellowship

Selected Publications

  1. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2015; 5:15512.
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  2. Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(5):e0126062.
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  3. Thirdhand cigarette smoke: factors affecting exposure and remediation. PLoS One. 2014; 9(10):e108258.
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  4. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90.
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  5. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18; 26(11):1615-31.
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  6. Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tob Control. 2014 Mar; 23(2):152-9.
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  7. Thirdhand smoke causes DNA damage in human cells. Mutagenesis. 2013 Jul; 28(4):381-91.
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  8. Thirty minute-exposure to aged cigarette smoke increases nasal congestion in nonsmokers. J Toxicol Environ Health A. 2013; 76(10):601-13.
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  9. Aerosol Science and Technology. An Apparatus for Generating Aged Cigarette Smoke for Controlled Human Exposure Studies. 2012; (46):1246-1255.
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  10. The exposure-dependent effects of aged secondhand smoke on endothelial function. J Am Coll Cardiol. 2012 May 22; 59(21):1908-13.
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  11. Pilot evaluation of the nasal nitric oxide response to humming as an index of osteomeatal patency. Am J Rhinol Allergy. 2012 Mar-Apr; 26(2):123-6.
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  12. Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. Environ Health Perspect. 2011 Sep; 119(9):1218-26.
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  13. Thirdhand smoke: here to stay. Tob Control. 2011 Jan; 20(1):1-3.
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  14. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 6; 51(18):1760-71.
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  15. Pilot study of compliance with healthcare facility smoking laws in Georgia. Georgian Med News. 2008 Jan; (154):47-52.
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  16. The tobacco industry and the Data Quality Act. Science. 2007 Aug 17; 317(5840):898.
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  17. Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1547-53.
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  18. Old ways, new means: tobacco industry funding of academic and private sector scientists since the Master Settlement Agreement. Tob Control. 2007 Jun; 16(3):157-64.
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  19. Sidestream cigarette smoke toxicity increases with aging and exposure duration. Tob Control. 2006 Dec; 15(6):424-9.
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  20. Philip Morris toxicological experiments with fresh sidestream smoke: more toxic than mainstream smoke. Tob Control. 2005 Dec; 14(6):396-404.
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