Hilde Schjerven, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Assistant Professor, Laboratory Medicine, UCSF

Hilde.Schjerven@ucsf.edu

Phone: (415) 502-3553
Box 0451, UCSF
San Francisco, CA 94143

UCSF Profiles

Cancer Center Membership

Member » Hematopoietic Malignancies

Research Summary

The development of blood cells (hematopoiesis) depends on a complex series of events that involves many regulatory processes. Blood cancer or immunological diseases can develop if these developing cells have loss of function or gain of function mutations in genes that control development, function, growth or survival.

Ikaros (encoded by the IKZF1 gene) is a transcription factor that is required for proper development of many different blood cell lineages. It is also an important tumor suppressor in certain subtypes of pre-B ALL (leukemia) and is implicated in other human immunological diseases through recent GWAS studies.

The overall research interest is in transcriptional regulation in the immune system during development and disease, and the current ongoing and proposed future research is focused on the role of the zinc finger (ZnF) transcription factor Ikaros. Studies use in vitro and in vivo models and also include the use of genome-wide analysis of DNA-binding and chromatin status (ChIP-Seq) as well as gene expression analysis (RNA-Seq). By increasing our knowledge about the molecular mechanism of action of key transcription factors in both normal development and disease, we might guide the development of targeted therapies for diseases where known transcriptional regulators are mutated.

Education

Norwegian University of Sports, 06/92, One-Year Study
Norwegian University of Science and Technology (NTNU), Department of Chemical Engineering, M.Sc. “Sivilingeniør” (Master of Science), 06/96, Biotechnology
One year exchange student at University of Wisconsin, Madison, 06/96, One year exchange Study
University of Oslo, Norway, Faculty of Medicine, Ph.D., 06/03, Molecular Immunology


Professional Experience

  • 1997-2003
    Graduate Student, Pathology, Laboratory Medicine, University of Oslo, Norway
  • 2003-2009
    Postdoctoral Fellow, Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles (UCLA)/ Howard Hughes Medical Institute (HHMI)
  • 2009-2012
    Assistant Project Scientist, Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles (UCLA)
  • 2012-2013
    Staff Scientist, Hematology/Oncology, Children's Hospital Los Angeles (CHLA)
  • 2013-2014
    Assistant Professional Researcher, Laboratory Medicine, University of California, San Francisco (UCSF)
  • 2014-present
    Assistant Adjunct Professor, Laboratory Medicine, University of California, San Francisco (UCSF)

Honors & Awards

  • 1999
    Ph.D. scholarship , Norwegian Cancer Society
  • 2003
    Postdoctoral Fellow Grant , Norwegian Research Council
  • 2012
    Early Career Faculty Travel Grant, American Association of Immunologists (AAI)
  • 2015
    Early Career Faculty Travel Grant., American Association of Immunologists (AAI)
  • 2015 - 2107
    ANRF Scholar
  • 2015-2017
    Hellman Fellow

Selected Publications

  1. Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 Jun; 18(6):694-704.
    View on PubMed
  2. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 Feb 13; 1-5.
    View on PubMed
  3. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1(+) pre-B ALL. J Exp Med. 2017 Feb 11.
    View on PubMed
  4. Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016 Jul 19; 45(1):185-97.
    View on PubMed
  5. Arenzana TL, Schjerven H, Smale ST. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 1; 29(17):1801-16.
    View on PubMed
  6. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 8; 126(15):1813-22.
    View on PubMed
  7. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015; 6:6471.
    View on PubMed
  8. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46.
    View on PubMed
  9. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83.
    View on PubMed
  10. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36.
    View on PubMed
  11. Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005 Jul 1; 175(1):376-84.
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  12. Schjerven H, Tran TN, Brandtzaeg P, Johansen FE. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. J Immunol. 2004 Aug 1; 173(3):1849-57.
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  13. Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P. Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes. Br J Dermatol. 2003 Sep; 149(3):484-91.
    View on PubMed
  14. Schjerven H, Brandtzaeg P, Johansen FE. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003 Jun 15; 170(12):6048-56.
    View on PubMed
  15. Schjerven H, Brandtzaeg P, Johansen FE. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001 Dec 1; 167(11):6412-20.
    View on PubMed
  16. Schjerven H, Brandtzaeg P, Johansen FE. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol. 2000 Oct 1; 165(7):3898-906.
    View on PubMed
  17. Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S. Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology. Metab Eng. 1999 Jul; 1(3):262-9.
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  18. Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19(5-6):481-508.
    View on PubMed
  19. van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem. 1997 Jul 18; 272(29):18367-74.
    View on PubMed

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