William E. Seaman, MD

William E. Seaman, MD

Professor, Departments of Medicine and Microbiology/Immunology, UCSF; Program Director, Sandler Program for Asthma Research


Phone: (415) 750-2104 (voice)
VAMC 111R, San Francisco, CA 94143

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Cancer Center Membership

Associate Member » Prostate Cancer» Cancer, Immunity, and Microenvironment


Princeton University, Princeton, New Jersey, A.B., 1964, English (cum laude)
Harvard University, Boston, Massachusetts, M.D., 1969, Medicine (cum laude)

Professional Experience

  • 1969-70
    Intern and resident, Massachusetts General Hospital, Boston, Ma
  • 1971-74
    Fellow, Arthritis and Rheumatism Branch, NIAMDD, NIH, Bethesda, MD
  • 1974
    Senior Resident in Medicine, Massachusetts General Hospital
  • 1975
    Chief Resident in Medicine, Massachusetts General Hospital
  • 1976
    Clinical Fellow in Rheumatology, Massachusetts General Hospital
  • 1976-84
    Assistant Professor of Medicine, University of California San Francisco
  • 1978-2002
    Staff Physician, San Francisco VA Medical Center
  • 1981-1992
    Chief, Arthritis/Immunology Section, San Francisco VA Medical Center
  • 1984-1988
    Associate Professor of Medicine and Microbiology, UCSF
  • 1988-present
    Professor of Medicine and Microbiology/Immunology, UCSF
  • 1992-1999
    Chief, Medical Service, San Francisco VA Medical Center
  • 1999-present
    Program Director, Sandler Program for Asthma Research
  • 1999-present
    Chief, Immunology Section, San Francisco VA Medical Center
  • 2000-present
    Director, Laboratory for the Development of Signaling Assays, Alliance for Cellular Signaling

Selected Publications

  1. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5.
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  2. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22.
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  3. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS One. 2011; 6(8):e23800.
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  4. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. J Biol Chem. 2011 Jan 14; 286(2):942-51.
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  5. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J Leukoc Biol. 2010 Jun; 87(6):1041-57.
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  6. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10.
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  7. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56.
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  8. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23.
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  9. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem. 2008 Dec; 107(6):1495-505.
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  10. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008 Jun 20; 283(25):17351-61.
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  11. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47.
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  12. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13759-64.
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  13. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5.
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  14. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45.
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  15. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis Rheum. 2005 Oct 15; 53(5):800; author reply 800-1.
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  16. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65.
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  17. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9.
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  18. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 1; 64(1):117-27.
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  19. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15; 171(12):6541-8.
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  20. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9.
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