William E. Seaman, MD

William E. Seaman, MD

Professor, Departments of Medicine and Microbiology/Immunology, UCSF; Research Director, American Asthma Foundation


Phone: (415) 750-2104 (voice)
VAMC 111R, San Francisco, CA 94143

UCSF Profiles

Cancer Center Membership

Associate Member » Prostate Cancer» Cancer, Immunity, and Microenvironment


Princeton University, Princeton, New Jersey, A.B., 1964, English (cum laude)
Harvard University, Boston, Massachusetts, M.D., 1969, Medicine (cum laude)

Professional Experience

  • 1969-70
    Intern and resident, Massachusetts General Hospital, Boston, Ma
  • 1971-74
    Fellow, Arthritis and Rheumatism Branch, NIAMDD, NIH, Bethesda, MD
  • 1974
    Senior Resident in Medicine, Massachusetts General Hospital
  • 1975
    Chief Resident in Medicine, Massachusetts General Hospital
  • 1976
    Clinical Fellow in Rheumatology, Massachusetts General Hospital
  • 1976-84
    Assistant Professor of Medicine, University of California San Francisco
  • 1978-2002
    Staff Physician, San Francisco VA Medical Center
  • 1981-1992
    Chief, Arthritis/Immunology Section, San Francisco VA Medical Center
  • 1984-1988
    Associate Professor of Medicine and Microbiology, UCSF
  • 1988-present
    Professor of Medicine and Microbiology/Immunology, UCSF
  • 1992-1999
    Chief, Medical Service, San Francisco VA Medical Center
  • 1999-present
    Research Director, American Asthma Foundation
  • 1999-present
    Chief, Immunology Section, San Francisco VA Medical Center
  • 2000-present
    Director, Laboratory for the Development of Signaling Assays, Alliance for Cellular Signaling

Selected Publications

  1. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5.
    View on PubMed
  2. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22.
    View on PubMed
  3. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS One. 2011; 6(8):e23800.
    View on PubMed
  4. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. J Biol Chem. 2011 Jan 14; 286(2):942-51.
    View on PubMed
  5. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J Leukoc Biol. 2010 Jun; 87(6):1041-57.
    View on PubMed
  6. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10.
    View on PubMed
  7. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56.
    View on PubMed
  8. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23.
    View on PubMed
  9. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem. 2008 Dec; 107(6):1495-505.
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  10. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008 Jun 20; 283(25):17351-61.
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  11. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47.
    View on PubMed
  12. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13759-64.
    View on PubMed
  13. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5.
    View on PubMed
  14. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45.
    View on PubMed
  15. Seaman WE. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis Rheum. 2005 Oct 15; 53(5):800; author reply 800-1.
    View on PubMed
  16. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65.
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  17. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9.
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  18. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 1; 64(1):117-27.
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  19. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15; 171(12):6541-8.
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  20. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9.
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