University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Youngho Seo, PhD

Youngho Seo, PhD

Associate Professor, Department of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Pediatric Malignancies | Prostate Cancer

Research Summary

I am a member of both Pediatric Malignancies and Prostate Cancer programs of the HDFCCC. I have extensive experience in quantitative data analysis, as well as instrumentation and software development using ionizing radiation imaging modalities (PET, SPECT, and CT), since I joined the UCSF Physics Research Laboratory (PRL), the birthplace of the dual-modality functional-anatomical imaging system (SPECT/CT and PET/CT). My broad training and expertise in experimental particle physics and medical imaging physics, combined with my leadership roles in extramurally funded projects, have proven a strong asset to many preclinical and clinical SPECT/CT, PET/CT, and PET/MRI projects. My particular research interest is, but not limited to, to develop technologies for combined dual-modality imaging systems to assess both structure and function in human diseases. I serve as a group leader for the UCSF PRL, and co-direct the preclinical SPECT/CT and PET/CT imaging research program at the Department of Radiology and Biomedical Imaging.

Education

Korea Advanced Institute of Science and Technology, B.S., 1995, Physics
University of Alabama in Huntsville, M.S., 1997, Physics/Space Plasma
University of California, Irvine, 1998-1999, Physics/Medical Physics
University of California, Los Angeles, M.S., 2001, Physics
University of California, Los Angeles, Ph.D., 2002, Physics/Astroparticle Physics
University of California, Los Angeles, Post-doc, 2002-2003, Physics/Neutrino Physics
University of California, San Francisco, Post-doc, 2003-2006, Medical Imaging Physics


Professional Experience

  • 1993-95
    Undergraduate Research Assistant, Space Science Laboratory, Department of Physics, KAIST
  • 1995-98
    Graduate Research Assistant, Center for Space Plasma and Aeronomic Research, Department of Physics, University of Alabama in Huntsville
  • 1998-99
    Reader, Department of Physics and Astronomy, University of California, Irvine
  • 1999-00
    Teaching Fellow, Department of Physics & Astronomy, University of California, Los Angeles (UCLA)
  • 1999-02
    Graduate Student Researcher, Department of Physics and Astronomy, UCLA
  • 2000-01
    TA Consultant, Office of Instructional Development and Department of Physics and Astronomy, UCLA
  • 2002
    Part-time faculty, Natural Sciences Division, El Camino College, Torrance, California
  • 2002
    Part-time faculty, Department of Physics and Astronomy, California State University, Northridge
  • 2002-03
    Postgraduate Research Physicist, Department of Physics and Astronomy, UCLA
  • 2003
    Lecturer, Department of Physics and Astronomy, UCLA
  • 2003-06
    Associate Specialist, Department of Radiology, University of California, San Francisco (UCSF)
  • 2006-12
    Assistant Professor (Adjunct), Department of Radiology and Biomedical Imaging, UCSF
  • 2006-present
    Faculty Member (Affiliate), Joint Graduate Group in Bioengineering, UCSF and Berkeley
  • 2009-12
    Assistant Professor (Adjunct), Department of Radiation Oncology, UCSF
  • 2010-present
    Program Member, Helen Diller Family Comprehensive Cancer Center, UCSF
  • 2011-present
    Program Member (Associate), The UCSF Liver Center
  • 2011-present
    Faculty Member (Core), Master’s of Science in Biomedical Imaging Graduate Program, Department of Radiology and Biomedical Imaging, UCSF
  • 2012-present
    Associate Professor (In Residence), Departments of Radiology and Biomedical Imaging and Radiation Oncology, UCSF
  • 2012-present
    Director of Nuclear Imaging Physics, Department of Radiology and Biomedical Imaging, UCSF

Honors & Awards

  • 1992-1995
    Government Scholarship, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • 2002
    Nomination for American Physical Society’s Mitsuyoshi Tanaka Dissertation Award in Experimental Particle Physics
  • 2006-11
    Mentored Quantitative Research Career Development Award, National Cancer Institute
  • 2010
    Frost & Sullivan Technology Innovation of the Year Award, Prostate Cancer Diagnosis North America (given to Hybridyne Imaging Technologies, Inc.)
  • 2011KAMPiNA Physicist of the Year Award, Korean Association of Medical Physicists in North America

Selected Publications

  1. Seo Y, Huh Y, Huang SY, Hernandez-Pampaloni JM, Hawkins RA, Gustafson WC, Vo KT, Matthay KK. Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for 131 I-MIBG therapy of neuroblastoma using 124 I-MIBG PET/CT. Med Phys. 2019 Feb 13.
    View on PubMed
  2. Yang J, Park D, Gullberg GT, Seo Y. Joint correction of attenuation and scatter in image space using deep convolutional neural networks for dedicated brain 18F-FDG PET. Phys Med Biol. 2019 Feb 11.
    View on PubMed
  3. Kim K, Kim D, Yang J, El Fakhri G, Seo Y, Fessler JA, Li Q. Time of flight PET reconstruction using nonuniform update for regional recovery uniformity. Med Phys. 2019 Feb; 46(2):649-664.
    View on PubMed
  4. Gullberg GT, Shrestha UM, Seo Y. PET imaging of glucose and fatty acid metabolism for NAFLD patients. J Nucl Cardiol. 2018 Dec 13.
    View on PubMed
  5. Lituiev DS, Trivedi H, Panahiazar M, Norgeot B, Seo Y, Franc B, Harnish R, Kawczynski M, Hadley D. Automatic Labeling of Special Diagnostic Mammography Views from Images and DICOM Headers. J Digit Imaging. 2018 Nov 21.
    View on PubMed
  6. Behr SC, Aggarwal R, Van Brocklin HF, Flavell RR, Geo K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y. First-in-Human Phase I study of CTT1057, a Novel 18F Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate Specific Membrane Antigen in Prostate Cancer. J Nucl Med. 2018 Nov 21.
    View on PubMed
  7. Gullberg GT, Fuller M, Shrestha U, Seo Y. Tensor Tomography of Dark Field Scatter using X-ray Interferometry with Bi-prisms. IEEE Nucl Sci Symp Conf Rec (1997). 2017 Oct; 2017.
    View on PubMed
  8. Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C, Behr SC, Flavell RR, Huang SY, Zalocusky KA, Nardo L, Seo Y, Hawkins RA, Hernandez Pampaloni M, Hadley D, Franc BL. A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain. Radiology. 2018 Nov 06; 180958.
    View on PubMed
  9. Behr SC, Villanueva-Meyer JE, Li Y, Wang YH, Wei J, Moroz A, Lee JK, Hsiao JC, Gao KT, Ma W, Cha S, Wilson DM, Seo Y, Nelson SJ, Chang SM, Evans MJ. Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR. JCI Insight. 2018 Nov 02; 3(21).
    View on PubMed
  10. Gong K, Guan J, Kim K, Zhang X, Yang J, Seo Y, El Fakhri G, Qi J, Li Q. Iterative PET Image Reconstruction Using Convolutional Neural Network Representation. IEEE Trans Med Imaging. 2018 Sep 12.
    View on PubMed
  11. Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ. Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI. Phys Med Biol. 2018 Sep 10; 63(18):185002.
    View on PubMed
  12. Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 06; 3(17).
    View on PubMed
  13. Mitra D, Abdalah M, Boutchko R, Chang H, Shrestha U, Botvinick E, Seo Y, Gullberg GT. Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction. Med Phys. 2018 Oct; 45(10):4493-4509.
    View on PubMed
  14. Huang SY, Franc BL, Harnish RJ, Liu G, Mitra D, Copeland TP, Arasu VA, Kornak J, Jones EF, Behr SC, Hylton NM, Price ER, Esserman L, Seo Y. Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis. NPJ Breast Cancer. 2018; 4:24.
    View on PubMed
  15. Aanei IL, Huynh T, Seo Y, Francis MB. Vascular Cell Adhesion Molecule-Targeted MS2 Viral Capsids for the Detection of Early-Stage Atherosclerotic Plaques. Bioconjug Chem. 2018 Aug 15; 29(8):2526-2530.
    View on PubMed
  16. Gong K, Yang J, Kim K, El Fakhri G, Seo Y, Li Q. Attenuation correction for brain PET imaging using deep neural network based on Dixon and ZTE MR images. Phys Med Biol. 2018 Jun 13; 63(12):125011.
    View on PubMed
  17. Behr SC, Bahroos E, Hawkins RA, Nardo L, Ravanfar V, Capbarat EV, Seo Y. Quantitative and Visual Assessments toward Potential Sub-mSv or Ultrafast FDG PET Using High-Sensitivity TOF PET in PET/MRI. Mol Imaging Biol. 2018 06; 20(3):492-500.
    View on PubMed
  18. Woo SK, Jang SJ, Seo MJ, Park JH, Kim BS, Kim EJ, Lee YJ, Lee TS, An GI, Song IH, Seo Y, Kim KI, Kang JH. Development of 64Cu-NOTA-Trastuzumab for HER2 Targeting: A Radiopharmaceutical with Improved Pharmacokinetics for Human Studies. J Nucl Med. 2019 Jan; 60(1):26-33.
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  19. Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging. 2018 Dec; 48(6):1717-1720.
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  20. Woo SK, Moon BS, Kim BS, Kim MH, Lee YJ, Jung JH, Lee KC, Seo Y, Kim W, Lim SM, Lee BC, Kim SE. Feasibility of myocardial PET imaging using a benzylguanidine analog: meta-(3-[18F]fluoropropyl)benzylguanidine ([18F]mFPBG). Nucl Med Biol. 2018 Jun; 61:63-70.
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