Youngho Seo, PhD

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Youngho Seo, PhD

Associate Professor, Department of Radiology and Biomedical Imaging, UCSF

youngho.seo@ucsf.edu

Phone: (415) 353-9464
Box 0946, UCSF, San Francisco, CA 94143-0946

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Cancer Center Membership

Program Member » Pediatric Malignancies» Prostate Cancer

Research Summary

I am a member of both Pediatric Malignancies and Prostate Cancer programs of the HDFCCC. I have extensive experience in quantitative data analysis, as well as instrumentation and software development using ionizing radiation imaging modalities (PET, SPECT, and CT), since I joined the UCSF Physics Research Laboratory (PRL), the birthplace of the dual-modality functional-anatomical imaging system (SPECT/CT and PET/CT). My broad training and expertise in experimental particle physics and medical imaging physics, combined with my leadership roles in extramurally funded projects, have proven a strong asset to many preclinical and clinical SPECT/CT, PET/CT, and PET/MRI projects. My particular research interest is, but not limited to, to develop technologies for combined dual-modality imaging systems to assess both structure and function in human diseases. I serve as a group leader for the UCSF PRL, and co-direct the preclinical SPECT/CT and PET/CT imaging research program at the Department of Radiology and Biomedical Imaging.

Education

Korea Advanced Institute of Science and Technology, B.S., 1995, Physics
University of Alabama in Huntsville, M.S., 1997, Physics/Space Plasma
University of California, Irvine, 1998-1999, Physics/Medical Physics
University of California, Los Angeles, M.S., 2001, Physics
University of California, Los Angeles, Ph.D., 2002, Physics/Astroparticle Physics
University of California, Los Angeles, Post-doc, 2002-2003, Physics/Neutrino Physics
University of California, San Francisco, Post-doc, 2003-2006, Medical Imaging Physics


Professional Experience

  • 1993-95
    Undergraduate Research Assistant, Space Science Laboratory, Department of Physics, KAIST
  • 1995-98
    Graduate Research Assistant, Center for Space Plasma and Aeronomic Research, Department of Physics, University of Alabama in Huntsville
  • 1998-99
    Reader, Department of Physics and Astronomy, University of California, Irvine
  • 1999-00
    Teaching Fellow, Department of Physics & Astronomy, University of California, Los Angeles (UCLA)
  • 1999-02
    Graduate Student Researcher, Department of Physics and Astronomy, UCLA
  • 2000-01
    TA Consultant, Office of Instructional Development and Department of Physics and Astronomy, UCLA
  • 2002
    Part-time faculty, Natural Sciences Division, El Camino College, Torrance, California
  • 2002
    Part-time faculty, Department of Physics and Astronomy, California State University, Northridge
  • 2002-03
    Postgraduate Research Physicist, Department of Physics and Astronomy, UCLA
  • 2003
    Lecturer, Department of Physics and Astronomy, UCLA
  • 2003-06
    Associate Specialist, Department of Radiology, University of California, San Francisco (UCSF)
  • 2006-12
    Assistant Professor (Adjunct), Department of Radiology and Biomedical Imaging, UCSF
  • 2006-present
    Faculty Member (Affiliate), Joint Graduate Group in Bioengineering, UCSF and Berkeley
  • 2009-12
    Assistant Professor (Adjunct), Department of Radiation Oncology, UCSF
  • 2010-present
    Program Member, Helen Diller Family Comprehensive Cancer Center, UCSF
  • 2011-present
    Program Member (Associate), The UCSF Liver Center
  • 2011-present
    Faculty Member (Core), Master’s of Science in Biomedical Imaging Graduate Program, Department of Radiology and Biomedical Imaging, UCSF
  • 2012-present
    Associate Professor (In Residence), Departments of Radiology and Biomedical Imaging and Radiation Oncology, UCSF
  • 2012-present
    Director of Nuclear Imaging Physics, Department of Radiology and Biomedical Imaging, UCSF

Honors & Awards

  • 1992-1995
    Government Scholarship, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • 2002
    Nomination for American Physical Society’s Mitsuyoshi Tanaka Dissertation Award in Experimental Particle Physics
  • 2006-11
    Mentored Quantitative Research Career Development Award, National Cancer Institute
  • 2010
    Frost & Sullivan Technology Innovation of the Year Award, Prostate Cancer Diagnosis North America (given to Hybridyne Imaging Technologies, Inc.)
  • 2011KAMPiNA Physicist of the Year Award, Korean Association of Medical Physicists in North America

Selected Publications

  1. Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration. Phys Med Biol. 2015 Oct 9; 60(21):8275-8301.
    View on PubMed
  2. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2; 162(1):59-71.
    View on PubMed
  3. Patient-Specific Dosimetry Using Pretherapy [(124)I]m-iodobenzylguanidine ([ (124)I]mIBG) Dynamic PET/CT Imaging Before [ (131)I]mIBG Targeted Radionuclide Therapy for Neuroblastoma. Mol Imaging Biol. 2015 Apr; 17(2):284-94.
    View on PubMed
  4. Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma. Case Rep Radiol. 2015; 2015:731361.
    View on PubMed
  5. Multipinhole collimator with 20 apertures for a brain SPECT application. Med Phys. 2014 Nov; 41(11):112501.
    View on PubMed
  6. Bone Remodeling after MR Imaging-guided High-Intensity Focused Ultrasound Ablation: Evaluation with MR Imaging, CT, Na(18)F-PET, and Histopathologic Examination in a Swine Model. Radiology. 2015 Feb; 274(2):387-94.
    View on PubMed
  7. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91.
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  8. In situ compressive loading and correlative noninvasive imaging of the bone-periodontal ligament-tooth fibrous joint. J Vis Exp. 2014; (85).
    View on PubMed
  9. Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study. Am J Nucl Med Mol Imaging. 2013; 4(1):53-9.
    View on PubMed
  10. Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging. J Nucl Med. 2013 Nov; 54(11):1938-45.
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  11. Design Studies of a CZT-based Detector Combined with a Pixel-Geometry-Matching Collimator for SPECT Imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2013 10; 2013:1-4.
    View on PubMed
  12. Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications. Phys Med Biol. 2013 Oct 21; 58(20):7209-26.
    View on PubMed
  13. Preclinical SPECT and SPECT/CT. Recent Results Cancer Res. 2013; 187:193-220.
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  14. Appl Phys Lett. Energy resolved x-ray grating interferometry. 2013; 102:191113.
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  15. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42.
    View on PubMed
  16. Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: experimental study in a porcine model. J Vasc Interv Radiol. 2012 Nov; 23(11):1505-12.
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  17. Functional imaging for prostate cancer: therapeutic implications. Semin Nucl Med. 2012 Sep; 42(5):328-42.
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  18. Assessing cervical dislocation as a humane euthanasia method in mice. J Am Assoc Lab Anim Sci. 2012 May; 51(3):352-6.
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  19. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 2012 Feb 8; 15(2):157-70.
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  20. The impact of audio-visual biofeedback on 4D PET images: results of a phantom study. Med Phys. 2012 Feb; 39(2):1046-57.
    View on PubMed

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