Youngho Seo, PhD

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Youngho Seo, PhD

Associate Professor, Department of Radiology and Biomedical Imaging, UCSF

youngho.seo@ucsf.edu

Phone: (415) 353-9464
Box 0946, UCSF, San Francisco, CA 94143-0946

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Cancer Center Membership

Program Member » Pediatric Malignancies» Prostate Cancer

Research Summary

I am a member of both Pediatric Malignancies and Prostate Cancer programs of the HDFCCC. I have extensive experience in quantitative data analysis, as well as instrumentation and software development using ionizing radiation imaging modalities (PET, SPECT, and CT), since I joined the UCSF Physics Research Laboratory (PRL), the birthplace of the dual-modality functional-anatomical imaging system (SPECT/CT and PET/CT). My broad training and expertise in experimental particle physics and medical imaging physics, combined with my leadership roles in extramurally funded projects, have proven a strong asset to many preclinical and clinical SPECT/CT, PET/CT, and PET/MRI projects. My particular research interest is, but not limited to, to develop technologies for combined dual-modality imaging systems to assess both structure and function in human diseases. I serve as a group leader for the UCSF PRL, and co-direct the preclinical SPECT/CT and PET/CT imaging research program at the Department of Radiology and Biomedical Imaging.

Education

Korea Advanced Institute of Science and Technology, B.S., 1995, Physics
University of Alabama in Huntsville, M.S., 1997, Physics/Space Plasma
University of California, Irvine, 1998-1999, Physics/Medical Physics
University of California, Los Angeles, M.S., 2001, Physics
University of California, Los Angeles, Ph.D., 2002, Physics/Astroparticle Physics
University of California, Los Angeles, Post-doc, 2002-2003, Physics/Neutrino Physics
University of California, San Francisco, Post-doc, 2003-2006, Medical Imaging Physics


Professional Experience

  • 1993-95
    Undergraduate Research Assistant, Space Science Laboratory, Department of Physics, KAIST
  • 1995-98
    Graduate Research Assistant, Center for Space Plasma and Aeronomic Research, Department of Physics, University of Alabama in Huntsville
  • 1998-99
    Reader, Department of Physics and Astronomy, University of California, Irvine
  • 1999-00
    Teaching Fellow, Department of Physics & Astronomy, University of California, Los Angeles (UCLA)
  • 1999-02
    Graduate Student Researcher, Department of Physics and Astronomy, UCLA
  • 2000-01
    TA Consultant, Office of Instructional Development and Department of Physics and Astronomy, UCLA
  • 2002
    Part-time faculty, Natural Sciences Division, El Camino College, Torrance, California
  • 2002
    Part-time faculty, Department of Physics and Astronomy, California State University, Northridge
  • 2002-03
    Postgraduate Research Physicist, Department of Physics and Astronomy, UCLA
  • 2003
    Lecturer, Department of Physics and Astronomy, UCLA
  • 2003-06
    Associate Specialist, Department of Radiology, University of California, San Francisco (UCSF)
  • 2006-12
    Assistant Professor (Adjunct), Department of Radiology and Biomedical Imaging, UCSF
  • 2006-present
    Faculty Member (Affiliate), Joint Graduate Group in Bioengineering, UCSF and Berkeley
  • 2009-12
    Assistant Professor (Adjunct), Department of Radiation Oncology, UCSF
  • 2010-present
    Program Member, Helen Diller Family Comprehensive Cancer Center, UCSF
  • 2011-present
    Program Member (Associate), The UCSF Liver Center
  • 2011-present
    Faculty Member (Core), Master’s of Science in Biomedical Imaging Graduate Program, Department of Radiology and Biomedical Imaging, UCSF
  • 2012-present
    Associate Professor (In Residence), Departments of Radiology and Biomedical Imaging and Radiation Oncology, UCSF
  • 2012-present
    Director of Nuclear Imaging Physics, Department of Radiology and Biomedical Imaging, UCSF

Honors & Awards

  • 1992-1995
    Government Scholarship, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • 2002
    Nomination for American Physical Society’s Mitsuyoshi Tanaka Dissertation Award in Experimental Particle Physics
  • 2006-11
    Mentored Quantitative Research Career Development Award, National Cancer Institute
  • 2010
    Frost & Sullivan Technology Innovation of the Year Award, Prostate Cancer Diagnosis North America (given to Hybridyne Imaging Technologies, Inc.)
  • 2011KAMPiNA Physicist of the Year Award, Korean Association of Medical Physicists in North America

Selected Publications

  1. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 Jun; 18(3):360-7.
    View on PubMed
  2. Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ. Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain. 2016 Jul; 139(Pt 7):1994-2001.
    View on PubMed
  3. Weng F, Bagchi S, Zan Y, Huang Q, Seo Y. An energy-optimized collimator design for a CZT-based SPECT camera. Nucl Instrum Methods Phys Res A. 2016 Jan 11; 806:330-339.
    View on PubMed
  4. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and (99m)Tc-tetrofosmin: Method and validation. J Nucl Cardiol. 2015 Dec 29.
    View on PubMed
  5. Yang J, Jian Y, Tohme M, Behr S, Vigneron D, Majumdar S, Seo Y. Impact of atlas-CT-based bone anatomy compensation on MR-based attenuation correction for brain PET imaging in a time-of-flight PET/MRI system: A direct comparison to a patient-CT-based approach. EJNMMI Phys. 2015 Dec; 2(Suppl 1):A68.
    View on PubMed
  6. Shrestha UM, Seo Y, Botvinick EH, Gullberg GT. Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration. Phys Med Biol. 2015 Nov 7; 60(21):8275-301.
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  7. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2; 162(1):59-71.
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  8. Huang SY, Bolch WE, Lee C, Van Brocklin HF, Pampaloni MH, Hawkins RA, Sznewajs A, DuBois SG, Matthay KK, Seo Y. Patient-specific dosimetry using pretherapy [¹²4I]m-iodobenzylguanidine ([¹²4I]mIBG) dynamic PET/CT imaging before [¹³¹I]mIBG targeted radionuclide therapy for neuroblastoma. Mol Imaging Biol. 2015 Apr; 17(2):284-94.
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  9. Barajas RF, Pampaloni MH, Clarke JL, Seo Y, Savic D, Hawkins RA, Behr SC, Chang SM, Berger M, Dillon WP, Cha S. Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma. Case Rep Radiol. 2015; 2015:731361.
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  10. Lee TC, Ellin JR, Huang Q, Shrestha U, Gullberg GT, Seo Y. Multipinhole collimator with 20 apertures for a brain SPECT application. Med Phys. 2014 Nov; 41(11):112501.
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  11. Bucknor MD, Rieke V, Seo Y, Horvai AE, Hawkins RA, Majumdar S, Link TM, Saeed M. Bone remodeling after MR imaging-guided high-intensity focused ultrasound ablation: evaluation with MR imaging, CT, Na(18)F-PET, and histopathologic examination in a swine model. Radiology. 2015 Feb; 274(2):387-94.
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  12. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91.
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  13. Jang AT, Lin JD, Seo Y, Etchin S, Merkle A, Fahey K, Ho SP. In situ compressive loading and correlative noninvasive imaging of the bone-periodontal ligament-tooth fibrous joint. J Vis Exp. 2014; (85).
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  14. Alhassen F, Nguyen N, Bains S, Gould RG, Seo Y, Bacharach SL, Song X, Shao L, Gullberg GT, Aparici CM. Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study. Am J Nucl Med Mol Imaging. 2013; 4(1):53-9.
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  15. Hernandez AM, Huber JS, Murphy ST, Janabi M, Zeng GL, Brennan KM, O'Neil JP, Seo Y, Gullberg GT. Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging. J Nucl Med. 2013 Nov; 54(11):1938-45.
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  16. Weng F, Bagchi S, Huang Q, Seo Y. Design Studies of a CZT-based Detector Combined with a Pixel-Geometry-Matching Collimator for SPECT Imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2013 10; 2013:1-4.
    View on PubMed
  17. Bowen JD, Huang Q, Ellin JR, Lee TC, Shrestha U, Gullberg GT, Seo Y. Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications. Phys Med Biol. 2013 Oct 21; 58(20):7209-26.
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  18. Seo Y, Jiang H, Franc BL. Preclinical SPECT and SPECT/CT. Recent Results Cancer Res. 2013; 187:193-220.
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  19. Thuering T, Barber WC, Seo Y, Alhassen F, Stampanoni M. Energy resolved x-ray grating interferometry. Appl Phys Lett. 2013; 102:191113.
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  20. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42.
    View on PubMed

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