University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Youngho Seo, PhD

Youngho Seo, PhD

Associate Professor, Department of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Pediatric Malignancies | Prostate Cancer

Research Summary

I am a member of both Pediatric Malignancies and Prostate Cancer programs of the HDFCCC. I have extensive experience in quantitative data analysis, as well as instrumentation and software development using ionizing radiation imaging modalities (PET, SPECT, and CT), since I joined the UCSF Physics Research Laboratory (PRL), the birthplace of the dual-modality functional-anatomical imaging system (SPECT/CT and PET/CT). My broad training and expertise in experimental particle physics and medical imaging physics, combined with my leadership roles in extramurally funded projects, have proven a strong asset to many preclinical and clinical SPECT/CT, PET/CT, and PET/MRI projects. My particular research interest is, but not limited to, to develop technologies for combined dual-modality imaging systems to assess both structure and function in human diseases. I serve as a group leader for the UCSF PRL, and co-direct the preclinical SPECT/CT and PET/CT imaging research program at the Department of Radiology and Biomedical Imaging.

Education

Korea Advanced Institute of Science and Technology, B.S., 1995, Physics
University of Alabama in Huntsville, M.S., 1997, Physics/Space Plasma
University of California, Irvine, 1998-1999, Physics/Medical Physics
University of California, Los Angeles, M.S., 2001, Physics
University of California, Los Angeles, Ph.D., 2002, Physics/Astroparticle Physics
University of California, Los Angeles, Post-doc, 2002-2003, Physics/Neutrino Physics
University of California, San Francisco, Post-doc, 2003-2006, Medical Imaging Physics


Professional Experience

  • 1993-95
    Undergraduate Research Assistant, Space Science Laboratory, Department of Physics, KAIST
  • 1995-98
    Graduate Research Assistant, Center for Space Plasma and Aeronomic Research, Department of Physics, University of Alabama in Huntsville
  • 1998-99
    Reader, Department of Physics and Astronomy, University of California, Irvine
  • 1999-00
    Teaching Fellow, Department of Physics & Astronomy, University of California, Los Angeles (UCLA)
  • 1999-02
    Graduate Student Researcher, Department of Physics and Astronomy, UCLA
  • 2000-01
    TA Consultant, Office of Instructional Development and Department of Physics and Astronomy, UCLA
  • 2002
    Part-time faculty, Natural Sciences Division, El Camino College, Torrance, California
  • 2002
    Part-time faculty, Department of Physics and Astronomy, California State University, Northridge
  • 2002-03
    Postgraduate Research Physicist, Department of Physics and Astronomy, UCLA
  • 2003
    Lecturer, Department of Physics and Astronomy, UCLA
  • 2003-06
    Associate Specialist, Department of Radiology, University of California, San Francisco (UCSF)
  • 2006-12
    Assistant Professor (Adjunct), Department of Radiology and Biomedical Imaging, UCSF
  • 2006-present
    Faculty Member (Affiliate), Joint Graduate Group in Bioengineering, UCSF and Berkeley
  • 2009-12
    Assistant Professor (Adjunct), Department of Radiation Oncology, UCSF
  • 2010-present
    Program Member, Helen Diller Family Comprehensive Cancer Center, UCSF
  • 2011-present
    Program Member (Associate), The UCSF Liver Center
  • 2011-present
    Faculty Member (Core), Master’s of Science in Biomedical Imaging Graduate Program, Department of Radiology and Biomedical Imaging, UCSF
  • 2012-present
    Associate Professor (In Residence), Departments of Radiology and Biomedical Imaging and Radiation Oncology, UCSF
  • 2012-present
    Director of Nuclear Imaging Physics, Department of Radiology and Biomedical Imaging, UCSF

Honors & Awards

  • 1992-1995
    Government Scholarship, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • 2002
    Nomination for American Physical Society’s Mitsuyoshi Tanaka Dissertation Award in Experimental Particle Physics
  • 2006-11
    Mentored Quantitative Research Career Development Award, National Cancer Institute
  • 2010
    Frost & Sullivan Technology Innovation of the Year Award, Prostate Cancer Diagnosis North America (given to Hybridyne Imaging Technologies, Inc.)
  • 2011KAMPiNA Physicist of the Year Award, Korean Association of Medical Physicists in North America

Selected Publications

  1. Jenkins NW, Talbott JF, Shah V, Pandit P, Seo Y, Dillon WP, Majumdar S. [18F]-Sodium Fluoride PET MR-Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint-Induced Disability. AJNR Am J Neuroradiol. 2017 Aug 31.
    View on PubMed
  2. Sciammarella M, Shrestha UM, Seo Y, Gullberg GT, Botvinick EH. A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT. J Nucl Cardiol. 2017 Aug 03.
    View on PubMed
  3. Lu X, Peled N, Greer J, Wu W, Choi P, Berger AH, Wong S, Jen KY, Seo Y, Hann B, Brooks A, Meyerson M, Collisson EA. MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma. Cancer Res. 2017 Aug 15; 77(16):4498-4505.
    View on PubMed
  4. Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope TA, Larson PEZ, Seo Y. Evaluation of sinus/edge corrected ZTE-based attenuation correction in brain PET/MRI. J Nucl Med. 2017 May 04.
    View on PubMed
  5. Yang J, Khalighi M, Hope TA, Ordovas K, Seo Y. Technical Note: Fast respiratory motion estimation using sorted singles without unlist processing: A feasibility study. Med Phys. 2017 May; 44(5):1632-1637.
    View on PubMed
  6. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 May; 31(4):295-303.
    View on PubMed
  7. Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope TA, Wiesinger F, Larson PE. Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI. Med Phys. 2017 Mar; 44(3):902-913.
    View on PubMed
  8. Yang J, Jian Y, Jenkins N, Behr SC, Hope TA, Larson PEZ, Vigneron D, Seo Y. Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System. Radiology. 2017 Jul; 284(1):169-179.
    View on PubMed
  9. Pampaloni MH, Shrestha UM, Sciammarella M, Seo Y, Gullberg GT, Botvinick EH. Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients. J Nucl Cardiol. 2017 Jan 30.
    View on PubMed
  10. Huber JS, Hernandez AM, Janabi M, O'Neil JP, Brennan KM, Murphy ST, Seo Y, Gullberg GT. Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT. Mol Imaging. 2017 Jan-Dec; 16:1536012117724558.
    View on PubMed
  11. Mari Aparici C, Behr SC, Seo Y, Kelley RK, Corvera C, Gao KT, Aggarwal R, Evans MJ. Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience. Mol Imaging. 2017 Jan-Dec; 16:1536012117723256.
    View on PubMed
  12. Jones EF, Ray KM, Li W, Seo Y, Franc BL, Chien AJ, Esserman LJ, Pampaloni MH, Joe BN, Hylton NM. Dedicated Breast Positron Emission Tomography for the Evaluation of Early Response to Neoadjuvant Chemotherapy in Breast Cancer. Clin Breast Cancer. 2017 Jun; 17(3):e155-e159.
    View on PubMed
  13. Behr SC, Aggarwal R, Seo Y, Aparici CM, Chang E, Gao KT, Tao DH, Small EJ, Evans MJ. A Feasibility Study Showing [68Ga]Citrate PET Detects Prostate Cancer. Mol Imaging Biol. 2016 Dec; 18(6):946-951.
    View on PubMed
  14. Tran N, Giannakidis A, Gullberg GT, Seo Y. Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging. J Med Imaging (Bellingham). 2016 Oct; 3(4):046001.
    View on PubMed
  15. Aanei IL, ElSohly AM, Farkas ME, Netirojjanakul C, Regan M, Taylor Murphy S, O'Neil JP, Seo Y, Francis MB. Biodistribution of Antibody-MS2 Viral Capsid Conjugates in Breast Cancer Models. Mol Pharm. 2016 Nov 07; 13(11):3764-3772.
    View on PubMed
  16. Choi JY, Yang J, Noworolski SM, Behr S, Chang AJ, Simko JP, Nguyen HG, Carroll PR, Kurhanewicz J, Seo Y. 18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons. Radiology. 2017 Feb; 282(2):429-436.
    View on PubMed
  17. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 Jun; 18(3):360-7.
    View on PubMed
  18. Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ. Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain. 2016 Jul; 139(Pt 7):1994-2001.
    View on PubMed
  19. Weng F, Bagchi S, Zan Y, Huang Q, Seo Y. An energy-optimized collimator design for a CZT-based SPECT camera. Nucl Instrum Methods Phys Res A. 2016 Jan 11; 806:330-339.
    View on PubMed
  20. Savic D, Pedoia V, Seo Y, Yang J, Bucknor M, Franc BL, Majumdar S. Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI. Mol Imaging. 2016 01 01; 15:1-12.
    View on PubMed

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