Kevin M. Shannon, MD

Professor, Department of Pediatrics, UCSF; Leader, Hematopoietic Malignancies Program, UCSF Helen Diller Family Comprehensive Cancer Center
Roma and Marvin Auerback Distinguished Professorship in Pediatric Molecular Oncology, UCSF

Phone: (415) 476-7932 (voice)
Box 3112, UCSF
San Francisco, CA 94143-3112

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Additional Websites

• Lab Website

Education

Williams College, Williamstown, MA, A.B., 1976, Biology, Liberal Arts
Cornell University, New York, NY, M.D., 1979, Medicine
University of Texas Southwestern, Dallas, TX, Resident, 1982, Pediatrics
University of California, San Francisco (UCSF), Postdoctoral, 1988, Hematology/Oncology

Professional Experience

• 1982-85
  Attending Pediatrician, Naval Hospital, Oakland, CA
• 1985-88
  Fellow in Pediatric Hematology/Oncology and Instructor in Pediatrics, UCSF
• 1988-92
  Attending Pediatric Hematologist/Oncologist, Naval Hospital, Oakland, CA
• 1992-94
  Assistant Professor of Pediatrics and Attending Pediatric Hematologist/Oncologist, UCSF
• 1989-93
  Hematopoietic Growth Factors Subcommittee, American Society of Hematology
• 1990-present
  Acute Myelogenous Leukemia Strategy Group Children's Cancer Study Group (Co-Chair 1997-99)
• 1988-93
  Cancer Biology Committee, Children's Cancer Study Group (Chair 1991-94)
• 1991-92
  Pediatric Residency Program Director, Naval Hospital, Oakland, CA
• 1994-98
  Associate Professor of Pediatrics, UCSF
• 1997-present
  Leader, Program in Hematopoietic Malignancies, UCSF Cancer Center
• 1997-present
  Professor of Pediatrics, UCSF
• 2005
  Vice Chair for Research, Department of Pediatrics, UCSF
• 2006
  Director, UCSF Medical Scientist Training Program

Honors & Awards

• 1985 and 1989
  Outstanding Teacher, Pediatrics Department, Naval Hospital, Oakland
• 1985 and 1993
  Navy Commendation Medals
• 1986
  Outstanding Fellow's Teaching Award, Pediatrics Department, UCSF
• 1988
  David W. Smith Research Award, Western Society for Pediatric Research
• 1988 and 1989
  Navy Achievement Medals
• 1992
  Winner, Navy Academic Medicine Research Competition
• 1993
  Nycomed Research Award of the International Society for Pediatric Oncology (SIOP)
• 1994
  Ross Outstanding Young Investigator Award, Western Society for Pediatric Research
• 1998
  American Academy of Pediatrics Award for Excellence in Pediatric Research
• 2000
  Roma and Marvin Auerback Distinguished Professor of Pediatric Molecular Oncology, UCSF
• 2004
  Samuel Rosenthal Prize for Excellence in Academic Pediatrics
• 2006
  National Cancer Institute MERIT Award

Selected Publications

1. Ward AF, Braun BS, Shannon KM. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406.
   View on PubMed
2. Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61.
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3. Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med. 2010 Nov 22; 207(12):2581-94.
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4. Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, Emanuel PD, Hasle H, Issa JP, van den Heuvel-Eibrink MM, Locatelli F, Stary J, Trebo M, Wlodarski M, Zecca M, Shannon KM, Niemeyer CM. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood. 2009 Aug 27; 114(9):1859-63.
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5. Moore JP, Alejos JC, Perens G, Wong S, Shannon KM. The corrected QT interval before and after heart transplantation. Am J Cardiol. 2009 Aug 15; 104(4):596-601.
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6. Maron BJ, Haas TS, Shannon KM, Almquist AK, Hodges JS. Long-term survival after cardiac arrest in hypertrophic cardiomyopathy. Heart Rhythm. 2009 Jul; 6(7):993-7.
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7. Yin B, Delwel R, Valk PJ, Wallace MR, Loh ML, Shannon KM, Largaespada DA. A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood. 2009 Jan 29; 113(5):1075-85.
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8. Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008 Oct 7; 14(4):335-43.
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9. Zhang Y, Wong J, Klinger M, Tran MT, Shannon KM, Killeen N. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood. 2009 Feb 12; 113(7):1455-63.
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10. Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 May; 40(5):600-8.
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11. Shannon KM, Le Beau MM. Cancer: hay in a haystack. Nature. 2008 Jan 17; 451(7176):252-3.
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12. Zhang Y, Diaz-Flores E, Li G, Wang Z, Kang Z, Haviernikova E, Rowe S, Qu CK, Tse W, Shannon KM, Bunting KD. Abnormal hematopoiesis in Gab2 mutant mice. Blood. 2007 Jul 1; 110(1):116-24.
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13. Kratz CP, Schubbert S, Bollag G, Niemeyer CM, Shannon KM, Zenker M. Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders. Cell Cycle. 2006 Aug; 5(15):1607-11.
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14. Stephens K, Weaver M, Leppig KA, Maruyama K, Emanuel PD, Le Beau MM, Shannon KM. Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies. Blood. 2006 Sep 1; 108(5):1684-9.
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15. Loh ML, Goldwasser MA, Silverman LB, Poon WM, Vattikuti S, Cardoso A, Neuberg DS, Shannon KM, Sallan SE, Gilliland DG. Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood. 2006 Jun 1; 107(11):4508-13.
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16. Dubin AM, Janousek J, Rhee E, Strieper MJ, Cecchin F, Law IH, Shannon KM, Temple J, Rosenthal E, Zimmerman FJ, Davis A, Karpawich PP, Al Ahmad A, Vetter VL, Kertesz NJ, Shah M, Snyder C, Stephenson E, Emmel M, Sanatani S, Kanter R, Batra A, Collins KK. Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study. J Am Coll Cardiol. 2005 Dec 20; 46(12):2277-83.
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17. Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 2005 Oct; 8(4):337-48.
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18. Curtiss NP, Bonifas JM, Lauchle JO, Balkman JD, Kratz CP, Emerling BM, Green ED, Le Beau MM, Shannon KM. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Genomics. 2005 May; 85(5):600-7.
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19. Schubbert S, Lieuw K, Rowe SL, Lee CM, Li X, Loh ML, Clapp DW, Shannon KM. Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood. 2005 Jul 1; 106(1):311-7.
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20. Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004 Dec; 6(6):547-52.
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